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1. 发明授权

EP2592954B1 GRIPPING AID 有权转让
公开(公告)号：EP2592954B1
公开(公告)日：2019-11-20
申请号：EP11733898.8
申请日：2011-06-11
申请人： Gripaid Limited
发明人： WALSH, Stuart David
IPC分类号： A41D19/015 , A41D19/00 , A63B71/14 , B65D85/18
摘要： A wearable aid for gripping an item by hand includes a main body shaped to be worn by a user, a strap connected to a first location of the main body and a releasable retaining means at a second location of the main body that is away from the first location. When a user wearing the aid has engaged an item to be gripped, part of the strap can be passed over at least part of one or more fingers of the user's hand and secured to the releasable retaining means in a manner that aids the user in gripping the item.

2. 发明公开

EP3490495A1 DEVICE FOR REMOVING MATERIAL FROM THE ORAL CAVITY OF A PATIENT 有权
公开(公告)号：EP3490495A1
公开(公告)日：2019-06-05
申请号：EP17717172.5
申请日：2017-04-12
申请人： Wakefield, Simon Joseph
发明人： Wakefield, Simon Joseph
IPC分类号： A61C17/06 , A61C5/90

3. 发明公开

EP2827864A1 INHIBITION OF MCL-1 AND/OR BFL-1/A1 有权
标题翻译： MCL-1和/或BFL-1 / A1的抑制
公开(公告)号：EP2827864A1
公开(公告)日：2015-01-28
申请号：EP13763682.5
申请日：2013-03-14
申请人： Dana-Farber Cancer Institute, Inc.
发明人： WALENSKY, Loren D.
IPC分类号： A61K31/426 , C07D277/38 , C07D409/04 , A61P35/00
摘要： This disclosure features compounds and pharmaceutically acceptable salts thereof that inhibit MCL-1 and/or BFL-1/A1 and compositions containing the same. This disclosure also features combinations that include one or more of the MCL-1/BFL-1/A1 inhibitor compounds described herein, or a pharmaceutically acceptable salt thereof; and one or more additional therapeutic agents (e.g., one or more chemotherapeutic agents (including small molecule and/or anti-body based chemotherapy and/or radiation); e.g., one or more therapeutic agents that modulate apoptosis; e.g., one or more therapeutic agents that bind to and inhibit anti-apoptotic proteins or modulate them indirectly; e.g., one or more therapeutic agents that bind to and inhibit, or indirectly modulate, anti-apoptotic BCL-2, BCL-XL, BCL-w, MCL-1, and/or BFL-1/A1; e.g., one or more therapeutic agents that directly bind to and inhibit anti-apoptotic BCL-2/BCL-XL; e.g., agents such as ABT-199, ABT-263 and ABT-737; e.g., ABT-737), or (where applicable) a pharmaceutically acceptable salt of the one or more therapeutic agents (as well as compositions containing the same). Also featured are methods of using such compounds, salts, combinations, and compositions, e.g., for the treatment or prevention of diseases, disorders, and conditions associated with deregulated apoptosis of cells (e.g., diseased or damaged cells; e.g., insufficient apoptosis of diseased or damaged cells or reduced apoptosis of diseased or damaged cells).

4. 发明公开

EP2766065A2 CARTRIDGE AND METHOD FOR INCREASING MYOCARDIAL FUNCTION 审中-公开
标题翻译：增强心肌功能的药筒和方法
公开(公告)号：EP2766065A2
公开(公告)日：2014-08-20
申请号：EP12865238.5
申请日：2012-10-10
申请人： CytoPherx, Inc.
发明人： HUMES, H., David , BUFFINGTON, Deborah, A. , PINO, Christopher, J.
IPC分类号： A61M1/34
CPC分类号： A61M1/3486 , A61K31/00 , A61K31/194 , A61M1/16 , A61M1/1625 , A61M1/34 , A61M1/3472 , A61M1/3666 , A61M1/3679 , A61M1/3687 , A61M2202/0427 , A61M2202/0439 , A61M2205/126 , A61M2210/125
摘要： The present invention relates to a cytopheretic cartridge for use in treating and/or preventing inflammatory conditions that affect myocardial function and to related methods. The cartridge can be used in treating a subject with myocardial dysfunction, such as a subject with chronic heart failure and/or acute decompensated heart failure.
摘要翻译：本发明涉及一种用于治疗和/或预防影响心肌功能的炎性病症的眼内弹药筒及相关方法。药筒可用于治疗患有心肌功能障碍的受试者，例如患有慢性心力衰竭和/或急性失代偿性心力衰竭的受试者。

5. 发明公开

EP2721161A2 METHODS OF MAKING NYLON INTERMEDIATES FROM GLYCEROL 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG冯诺基亚WISCHENPRODUKTEN AUS AUS GLYCEROL
公开(公告)号：EP2721161A2
公开(公告)日：2014-04-23
申请号：EP12731824.4
申请日：2012-06-15
申请人： Invista Technologies S.à.r.l.
发明人： PEARLMAN, Paul, S. , CHEN, Changlin , BOTES, Adriana, L.
IPC分类号： C12P7/04 , C12P7/42 , C12P7/46 , C12P13/02 , C12P13/00 , C12P5/02 , C07K14/195 , C07K14/37 , C07K14/405 , C07K14/415 , C12N1/32 , C12N9/10 , C12N9/78 , C12N9/88 , C12N9/00
CPC分类号： C12P13/005 , C07K14/195 , C07K14/37 , C12N1/32 , C12N9/0006 , C12N9/0008 , C12N9/1022 , C12N9/1029 , C12N9/1096 , C12N9/78 , C12N9/88 , C12N15/52 , C12P5/02 , C12P5/026 , C12P7/04 , C12P7/18 , C12P7/42 , C12P7/44 , C12P7/46 , C12P13/001 , C12P13/02 , C12P17/10 , C12Y101/01004 , C12Y101/01157 , C12Y202/01006 , C12Y203/01009 , C12Y401/01005
摘要： Embodiments of the invention relate to the enzymatic conversion of bioderived feedstocks to commercially valuable chemicals. The enzymatic conversions of the embodiments of the invention offer the potential for lower cost routes to these value-added chemicals. Some of the chemicals that are useful include nylon intermediates such as caprolactam, adipic acid, 1,6-hexamethylene diamine; butanediols such as 1,4-butanediol, 1,3-butanediol, and 2,3-butanediol; butanols such as 1-butanol, and 2-butanol; succinic acid, butadiene, isoprene, and 3-hydroxypropanoic acid.
摘要翻译：本发明的实施方案涉及将生物活性原料酶催化转化成商业上有价值的化学品。本发明实施方案的酶促转化提供了对这些增值化学品的较低成本路线的潜力。一些有用的化学品包括尼龙中间体如己内酰胺，己二酸，1,6-六亚甲基二胺; 丁二醇如1,4-丁二醇，1,3-丁二醇和2,3-丁二醇; 丁醇如1-丁醇和2-丁醇; 琥珀酸，丁二烯，异戊二烯和3-羟基丙酸。

6. 发明公开

EP2699263A2 METHODS FOR REDUCING AN ADVERSE IMMUNE RESPONSE TO A FOREIGN ANTIGEN IN A HUMAN SUBJECT WITH ANTI-CD4 ANTIBODIES OR CD4-BINDING FRAGMENTS THEREOF OR CD4-BINDING MOLECULES 审中-公开
标题翻译：程序不需要的免疫反应的外来抗原在人类患者用抗CD4抗体或CD4结合片段或CD4结合分子的还原
公开(公告)号：EP2699263A2
公开(公告)日：2014-02-26
申请号：EP12773862.3
申请日：2012-04-13
申请人： Liquidation Trust
发明人： PONATH, Paul , ROSENZWEIG, Michael , VAICKUS, Lou
IPC分类号： A61K39/395
CPC分类号： A61K39/3955 , A61K39/0003 , A61K39/0005 , A61K39/12 , A61K2039/505 , A61K2039/545 , C07K16/2812 , C07K2317/24 , C07K2317/30 , C07K2317/90
摘要： Provided herein are methods of inducing tolerance or reducing an immune response to a foreign antigen in a human subject. The methods include administering anti-CD4 antibodies or CD4-binding fragments thereof or CD4-binding molecules, and the foreign antigen to the human subject.

7. 发明公开

EP2622100A1 GENE MARKER SETS AND METHODS FOR CLASSIFICATION OF CANCER PATIENTS 审中-公开
标题翻译： GENMARKERSETS和方法分类癌症患者的
公开(公告)号：EP2622100A1
公开(公告)日：2013-08-07
申请号：EP11827821.7
申请日：2011-09-29
申请人： Chipdx LLC
发明人： VAN LAAR, Ryan
IPC分类号： C12Q1/68 , G06F19/18 , G06F19/20
CPC分类号： G06F19/345 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , G06F19/20 , G06F19/24 , G16H50/20
摘要： The present invention relates to gene marker sets for use in classification of cancer patients on the basis of expression of multiple biological markers. The gene marker sets allow identification of the tissue of origin of a metastatic tumor, provide prognostic data on breast cancer recurrence, prognostic data on colon cancer recurrence in cancer patients, or prognosis of increased risk of death of lung cancer patients. The invention also provides methods of use of the gene marker sets for classification. The invention is particularly suited to the generation of microarrays and other high-throughput platforms for diagnostic and prognostic purposes.

8. 发明授权

EP1885919B1 GENE METHYLATION AND EXPRESSION 有权
标题翻译：甲基化和基因表达的影响
公开(公告)号：EP1885919B1
公开(公告)日：2013-02-13
申请号：EP06771539.1
申请日：2006-05-30
申请人： Dana-Farber Cancer Institute, Inc.
发明人： POLYAK, Kornelia , HU, Min , QIMRON, Noga , YAO, Jun
IPC分类号： C07H21/02 , C07H21/04 , C12N9/99 , C12Q1/68
CPC分类号： C12N15/1093 , C12Q1/6855 , C12Q1/6881 , C12Q2600/154 , C12Q2600/158 , C12Q2521/331

9. 发明授权

EP2064348B1 RECEPTOR FAMILY PROFILING 有权
标题翻译： PROFILING受体家族
公开(公告)号：EP2064348B1
公开(公告)日：2012-02-08
申请号：EP07838435.1
申请日：2007-09-18
申请人： Ensemble Therapeutics Corporation
发明人： LANDSMAN, Tanya , LIVINGSTON, David, J. , MARTINELLI, Richard, Allen , HUANG, Yumei , SEIGAL, Benjamin, Adam , YAN, Dingxue , COULL, James, M. , STERN, Andrew, M.
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/542 , C12Q1/6804 , G01N33/566 , G01N2333/71 , C12Q2565/101 , C12Q2563/179 , C12Q2563/131
摘要： The invention provides compositions and methods, e.g., assay technologies and their use in biodetection and diagnostics. More particularly, the invention provides compositions and methods based on nucleic acid-templated chemistry in biodetection and profiling of receptors (and their families) and proteins (and their families), and the use of same in diagnostics.

10. 发明公开

EP2236619A3 BCL2L12 polypeptide activators and inhibitors 审中-公开
标题翻译： BCL2L12多肽激活剂和抑制剂
公开(公告)号：EP2236619A3
公开(公告)日：2011-12-14
申请号：EP10003423.0
申请日：2004-04-23
申请人： Dana-Farber Cancer Institute, Inc.
发明人： Stegh, Alex , Hyung, Gee Kim , Depinho, Ronald , Chin, Lynda
IPC分类号： C12Q1/37 , A61K48/00 , C12Q1/68
CPC分类号： G01N33/5748 , A61K48/00 , C07K14/4747 , C07K14/82 , C12Q1/37 , C12Q1/6886 , C12Q2600/136 , G01N2333/96466
摘要： The invention provides methods and materials related to BCL2L12 polypeptides and the biological activities of BCL2L12 polypeptides. For example, the invention provides methods and materials related to identifying activators and inhibitors of BCL2L12 polypeptide activities such as the ability to block apoptosis and promote cell growth and transformation. The invention also provides methods and materials for treating mammals having cancer.
摘要翻译：本发明提供了与BCL2L12多肽相关的方法和材料以及BCL2L12多肽的生物学活性。例如，本发明提供了与鉴定BCL2L12多肽活性的激活剂和抑制剂相关的方法和材料，例如阻断凋亡和促进细胞生长和转化的能力。本发明还提供了用于治疗患有癌症的哺乳动物的方法和材料。

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