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1. 发明授权

EP1437146B1 Measurement of liquid phase gastric emptying 失效
标题翻译：排空胃的液体内容物的测量
公开(公告)号：EP1437146B1
公开(公告)日：2006-11-02
申请号：EP04006804.1
申请日：1997-08-19
申请人： Advanced Breath Diagnostics LLC
发明人： Klein, Peter D.
IPC分类号： A61K51/12
CPC分类号： A61K51/1206

2. 发明公开

EP1632777A2 Polysaccharide structure and sequence determination 审中-公开
标题翻译： Bestimm der der Struktur und Sequenz von Polysacchariden
公开(公告)号：EP1632777A2
公开(公告)日：2006-03-08
申请号：EP05023256.0
申请日：2000-05-04
申请人： Procognia (Israel) Ltd.
发明人： Markman, Ofer
IPC分类号： G01N33/53 , C12Q1/34
CPC分类号： G01N33/66 , C12Q1/34 , G01N33/5308 , G01N2333/42 , G01N2333/924 , G01N2400/00 , G01N2400/02 , G01N2400/10 , Y10T436/143333
摘要： A method for the structural analysis of a saccharide is disclosed, comprising: a) providing on a surface a plurality of essentially sequence- and/or site-specific binding agents; b) contacting said surface with a saccharide to be analyzed, or with a mixture comprising a plurality of fragments of said saccharide; c) washing or otherwise removing unbound saccharide or saccharide fragments; d) adding to the surface obtained in step c) an essentially sequence- and/or site-specific marker, or a mixture of essentially sequence- and/or site-specific markers; e) acquiring one or more images of the markers that are bound to said surface; and f) deriving information related to the identity of the saccharide being analyzed from said image. The invention further provides a solid support comprising in a pre-defined order a plurality of visual or otherwise detectable markers representative of a saccharide or saccharide sequence or fragment, as well as methods and software for choosing a set of essentially sequence-specific markers for use in the method of the invention, methods for obtaining structure-related data of saccharides, and methods and apparatus for analyzing the structure of a saccharide by sequential digestion using a glycosidase or an equivalent thereof.
摘要翻译：公开了一种用于糖的结构分析的方法，包括：a）在表面上提供多个基本上序列和/或位点特异性结合剂; b）使所述表面与待分析的糖接触，或与包含所述糖的多个片段的混合物接触; c）洗涤或以其他方式去除未结合的糖或糖片段; d）向步骤c）中获得的表面添加基本上序列和/或位点特异性标记或基本上序列和/或位点特异性标记的混合物; e）获取结合到所述表面的标记的一个或多个图像; 以及f）从所述图像导出与正在分析的糖的身份有关的信息。本发明进一步提供一种固体支持物，其以预定义的顺序包含多个视觉或其他可检测的代表糖或糖序列或片段的标记物，以及用于选择一组基本上序列特异性标记物用于使用的方法和软件在本发明的方法中，获得糖的结构相关数据的方法，以及通过使用糖苷酶或其等同物通过连续消化来分析糖的结构的方法和装置。

3. 发明公开

EP1613155A2 TREATMENT OF DEMYELINATING CONDITIONS 审中-公开
标题翻译：病证治疗中ENTMYELINATIERENDEN
公开(公告)号：EP1613155A2
公开(公告)日：2006-01-11
申请号：EP04758563.3
申请日：2004-03-29
申请人： Neuromolecular Inc.
发明人： LIPTON, Stuart , WENT, Greg , MEYERSON, Lawrence
IPC分类号： A01N33/02 , A61K31/135
CPC分类号： A61K31/135 , A61K31/13
摘要： The present invention provides novel methods and compositions for the treatment of multiple sclerosis.

4. 发明公开

EP1594981A2 DOUBLE ENDED SEQUENCING 有权
标题翻译：二DIGE测序
公开(公告)号：EP1594981A2
公开(公告)日：2005-11-16
申请号：EP04706053.8
申请日：2004-01-28
申请人： 454 Corporation
发明人： CHEN, Yi-Ju , LEAMON, John, H. , LOHMAN, Kenton , RONAN, Michael T. , SRINIVASAN, Maithreyan , ROTHBERG, Jonathan , WEINER, Michael
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/686 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/5085 , B01L7/52 , B01L2300/0636 , B01L2300/0819 , B01L2300/0877 , C07H21/00 , C12N15/1075 , C12N15/1093 , C12Q1/6806 , C12Q1/6834 , C12Q1/6844 , C12Q1/6865 , C12Q1/6867 , C12Q1/6869 , C12Q1/6874 , G01N21/253 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N2021/6484 , G01R33/1269 , Y02P20/582 , Y10T436/143333 , C12Q2565/119 , C12Q2531/113 , C12Q2565/537 , C12Q2547/107 , C12Q2547/101 , C12Q2537/143 , C12Q2527/125 , C12Q2525/186 , C12Q2565/301 , C12Q2563/149 , C12Q2531/125 , C12Q2537/149 , C12Q2535/119
摘要： This invention relates to methods of sequencing DNA. More specifically, this invention relates to methods of sequencing both the sense and antisense strands of DNA through the use of blocked and unblocked sequencing primers. In brief, these methods include the steps of annealing an unblocked primer to a first strand of nucleic acid; annealing a second blocked primer to a second strand of nucleic acid; elongating the nucleic acid along the first strand with a polymerase; terminating the first sequencing primer; deblocking the second primer; and elongating the nucleic acid along the second strand.

5. 发明公开

EP1594980A2 BEAD EMULSION NUCLEIC ACID AMPLIFICATION 有权转让
标题翻译：核酸扩增基于BEAD EMULSION
公开(公告)号：EP1594980A2
公开(公告)日：2005-11-16
申请号：EP04706051.2
申请日：2004-01-28
申请人： 454 Corporation
发明人： BERKA, Jan , CHEN, Yi-Ju , LEAMON, John, H. , LEFKOWITZ, Steven , LOHMAN, Kenton , MAKHIJANI, Vinod , SARKIS, Gary, J. , ROTHBERG, Jonathan , WEINER, Michael , SRINIVASAN, Maithreyan
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/686 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/5085 , B01L7/52 , B01L2300/0636 , B01L2300/0819 , B01L2300/0877 , C07H21/00 , C12N15/1075 , C12N15/1093 , C12Q1/6806 , C12Q1/6834 , C12Q1/6844 , C12Q1/6865 , C12Q1/6867 , C12Q1/6869 , C12Q1/6874 , G01N21/253 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N2021/6484 , G01R33/1269 , Y02P20/582 , Y10T436/143333 , C12Q2565/119 , C12Q2531/113 , C12Q2565/537 , C12Q2547/107 , C12Q2547/101 , C12Q2537/143 , C12Q2527/125 , C12Q2525/186 , C12Q2565/301 , C12Q2563/149 , C12Q2531/125 , C12Q2537/149 , C12Q2535/119
摘要： Disclosed are methods for nucleic acid amplification wherein nucleic acid templates, beads, and amplification reaction solution are emulsified and the nucleic acid templates are amplified to provide clonal copies of the nucleic acid templates attached to the beads. Also disclosed are kits and apparatuses for performing the methods of the invention.

6. 发明公开

EP1594950A2 METHOD FOR PREPARING SINGLE-STRANDED DNA LIBRARIES 审中-公开
标题翻译：用于生产单链DNA文库
公开(公告)号：EP1594950A2
公开(公告)日：2005-11-16
申请号：EP04706080.1
申请日：2004-01-28
申请人： 454 Corporation
发明人： COSTA, Gina, L. , WEINER, Michael, P. , LEAMON, John , ROTHBERG, Jonathan
IPC分类号： C12N1/00
CPC分类号： C12Q1/686 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/5085 , B01L7/52 , B01L2300/0636 , B01L2300/0819 , B01L2300/0877 , C07H21/00 , C12N15/1075 , C12N15/1093 , C12Q1/6806 , C12Q1/6834 , C12Q1/6844 , C12Q1/6865 , C12Q1/6867 , C12Q1/6869 , C12Q1/6874 , G01N21/253 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N2021/6484 , G01R33/1269 , Y02P20/582 , Y10T436/143333 , C12Q2565/119 , C12Q2531/113 , C12Q2565/537 , C12Q2547/107 , C12Q2547/101 , C12Q2537/143 , C12Q2527/125 , C12Q2525/186 , C12Q2565/301 , C12Q2563/149 , C12Q2531/125 , C12Q2537/149 , C12Q2535/119
摘要： This invention relates to methods of generating single stranded DNA libraries for use in amplification and sequencing reactions. In various aspects, the disclosed methods include: fragmenting DNA; polishing the fragments' ends; lighting the fragments to universal adapters; performing strand displacement and extension of the nicked fragments; purifying the double-stranded libation products; capturing the double-stranded libation products onto a solid support; and isolating single stranded DNA library fragments, and binding these fragments to another solid support.

8. 发明公开

EP1572922A2 THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF USE 审中-公开
标题翻译：治疗用多肽，编码核酸及使用方法
公开(公告)号：EP1572922A2
公开(公告)日：2005-09-14
申请号：EP03726032.0
申请日：2003-03-06
申请人： Curagen Corporation
发明人： ALSOBROOK, John, P., II , ANDERSON, David, W. , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CHAUDHURI, Amitabha , COLMAN, Steven, D. , EDINGER, Shlomit, R. , ETTENBERG, Seth , GANGOLLI, Esha, A. , GERLACH, Valerie, L. , GORMAN, Linda , GUO, Xiaojia , KEKUDA, Ramesh , LI, Li , MACLACHLAN, Timothy , MALYANKAR, Uriel, M. , MEZES, Peter, S. , MILLER, Charles, E. , MILLET, Isabelle , PATTURAJAN, Meera , PEYMAN, John
IPC分类号： C12N1/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to novel polypeptides, and the nucleic acids encoding them, having properties related to stimulation of biochemical or physiological responses in a cell, a tissue, an organ or an organism. More particularly, the novel polypeptides are gene products of novel genes, or are specified biologically active fragments or derivatives thereof. Methods of use encompass diagnostic and prognostic assay procedures as well as methods of treating diverse pathological conditions.
摘要翻译：本发明涉及新的多肽和编码它们的核酸，其具有与刺激细胞，组织，器官或生物体中的生化或生理反应有关的性质。更具体地说，新多肽是新基因的基因产物，或者是特定的生物活性片段或衍生物。使用方法包括诊断和预后测定程序以及治疗不同病理状况的方法。

9. 发明公开

EP1570085A2 METHOD FOR IN VITRO SELECTION OF 2'-SUBSTITUTED NUCLEIC ACIDS 审中-公开
标题翻译：方法的体外选择2'-取代NUCLEIC
公开(公告)号：EP1570085A2
公开(公告)日：2005-09-07
申请号：EP03812519.1
申请日：2003-12-03
申请人： Archemix Corporation
发明人： KEEFE, Anthony , WILSON, Charles , BURMEISTER, Paula , KEENE, Sara Chesworth
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02
CPC分类号： C12N15/1048 , C12N9/1247 , C12N15/115 , C12N2310/16 , C12N2310/321 , C12N2310/322 , C12N2320/13 , C12N2330/30 , C12N2310/3521
摘要： Materials and methods are provided for producing aptamer therapeutics having modified nucleotide triphosphates incorporated into their sequence. The aptamers produced by the methods of the invention have increased stability and half life.

10. 发明公开

EP1539807A2 THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF USE 审中-公开
标题翻译：治疗性多肽的编码这些和方法使用核酸
公开(公告)号：EP1539807A2
公开(公告)日：2005-06-15
申请号：EP03785086.4
申请日：2003-08-07
申请人： Curagen Corporation
发明人： ZHONG, Mei , JI, Weizhen , GUO, Xiaojia , RIEGER, Daniel, K. , PADIGARU, Muralidhara , MALCOLM, Rachel , SPYTEK, Kimberly, A. , ANDERSON, David, W. , GORMAN, Linda , CATTERTON, Elina , MACDOUGALL, John, R. , STONE, David, J. , EDINGER, Shlomit, R.
IPC分类号： C07K14/00 , C07H21/02 , C12N15/00 , A61K38/04
CPC分类号： C07K14/47
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

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