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1. 发明授权

EP1383752B1 DEUTERIERTE 3-PIPERIDINOPROPIOPHENONE SOWIE DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL 有权
标题翻译：氘化3-piperidinopropiophenones及药物含有它们的
公开(公告)号：EP1383752B1
公开(公告)日：2005-06-22
申请号：EP02727303.6
申请日：2002-04-29
申请人： Turicum Drug Development AG
发明人： ALKEN, Rudolf-Giesbert , STABINGIS, Thomas
IPC分类号： C07D295/10 , C07B59/00 , A61K31/4453 , A61P9/08
CPC分类号： C07D295/108 , C07B59/00 , C07B2200/07
摘要： The invention relates to deuterated 3-piperidinopropiophenone and their physiologically acceptable salts. The invention also relates to the use of deuterated 3-piperidinopropiophenone in the treatment of muscular diseases and in the production of medicaments for the treatment of muscular diseases. The invention further relates to pharmaceutical compositions containing deuterated 3-piperidinopropiophenone and their physiologically acceptable salts for the treatment of muscular diseases, in addition to their pharmaceutically acceptable adjuvants and/or additives.

2. 发明授权

EP1371144B1 SCHALTUNGSANORDNUNG ZUM KOMPENSIEREN DER DÄMPFUNG IN EINEM ANTENNENZULEITUNGSKABEL FÜR EIN MOBILFUNKGERÄT 有权
标题翻译： SCHALTUNGSANORDNUNG ZUM KOMPENSIEREN DERDÄMPFUNGIN EINEM ANTENNENZULEITUNGSKABELFÜREINMOBILFUNKGERÄT
公开(公告)号：EP1371144B1
公开(公告)日：2005-05-18
申请号：EP02737751.4
申请日：2002-03-21
申请人： Funkwerk Dabendorf GmbH
发明人： NAST, Helmut , JACOBI, Raimo
IPC分类号： H04B1/38
CPC分类号： H04B1/3877 , H04B1/406 , H04B1/48
摘要： The invention relates to a circuit arrangement for compensation of the damping in an antenna feed cable for a mobile radio device. The circuit arrangement is suitable for operation in a radio network, whereby, within a frequency band, either the upper or lower of two defined frequency regions within the frequency band may be selected for transmission and the other frequency region used for receiving the radio signals. The arrangement comprises at least one signal branch for the amplification of HF signals for transmission in a corresponding circuit part, with a broadband type power amplifier, a signal branch for the amplification of received signals, with a broadband receiver amplifier, two filter and switch units arranged on the upstream and downstream sides of both signal branches of said circuit part, each with a frequency crossover and a signal switch and a detection and control unit for control of the signal switch. In the base state of the circuit part provided for transmission of the corresponding frequency region, received HF signals are always routed through the receiver amplifier irrespective of whether said signals belong in the upper or lower frequency region of the frequency band.
摘要翻译：本发明涉及一种用于补偿移动无线电设备的天线馈电电缆中的阻尼的电路装置。该电路装置适合于在无线电网络中操作，由此在频带内，可以选择频带内的两个定义的频率区域中的较高或较低的频率区域用于传输，并选择用于接收无线电信号的另一个频率区域。该装置包括至少一个信号分支，用于放大用于在对应电路部分中传输的HF信号，具有宽带类型功率放大器，用于放大接收信号的信号分支，具有宽带接收机放大器，两个滤波器和开关单元布置在所述电路部分的两个信号分支的上游侧和下游侧，每个信号分支具有频率跨接和信号开关以及用于控制信号开关的检测和控制单元。在用于传输相应频率区域的电路部分的基本状态中，接收到的HF信号总是通过接收机放大器路由，而不管所述信号是属于频带的上部还是下部频率区域。

3. 发明公开

EP1488008A1 METHOD AND DEVICES FOR DNA METHYLATION ANALYSIS 有权
标题翻译：检测方法的DNA甲基化
公开(公告)号：EP1488008A1
公开(公告)日：2004-12-22
申请号：EP03744855.2
申请日：2003-03-25
申请人： Epigenomics AG
发明人： BERLIN, Kurt
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , B01L7/52 , B01L2400/0487 , C12Q2565/518 , C12Q2523/125 , C12Q2521/125
摘要： The invention outlines a method for the methylation pattern retaining amplification of nucleic acid molecules. Furthermore the invention describes several devices for use in the methylation pattern retaining amplification of nucleic acid molecules.

4. 发明公开

EP1488003A1 METHOD FOR THE ANALYSIS OF METHYLATION PATTERNS WITHIN NUCLEIC ACIDS BY MEANS OF MASS SPECTROMETRY 审中-公开
标题翻译： PROCEDURE用于使用质谱仪的PATTERN甲基化核酸
公开(公告)号：EP1488003A1
公开(公告)日：2004-12-22
申请号：EP03724930.7
申请日：2003-03-25
申请人： Epigenomics AG
发明人： BERLIN, Kurt
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q2565/627 , C12Q2537/164 , C12Q2521/125
摘要： The present invention describes a method for the analysis of methylation patterns comprising the following steps: a) isolation of genomic nucleic acids from a biological sample, b) amplification of one or more target nucleic acids of said genomic nucleic acids in a manner whereby the methylation patterns of said genomic nucleic acids are maintained in the amplificate nucleic acid, c) performing mass spectrometry on said amplified nucleic acid or fragments thereof to obtain mass spectra; d) evaluating the obtained mass spectra and e) determining the methylation pattern and/or methylation status of the sample. The disclosed invention provides novel methods for the analysis of cytosine methylation patterns within genomic DNA samples. Said method comprises a methylation retaining enzymatic amplification of a test nucleic acid sample, followed by mass spectrometric analysis of the amplificate nucleic acids.

5. 发明公开

EP1460993A1 LOW PROFILE ADAPTOR FOR USE WITH A MEDICAL CATHETER 有权
标题翻译： LOW PROFILE适配器医用导管
公开(公告)号：EP1460993A1
公开(公告)日：2004-09-29
申请号：EP02799072.0
申请日：2002-12-23
申请人： Boston Scientific Limited
发明人： CHU, Michael, S. H. , BOUPHAVICHITH, Laddvanh
IPC分类号： A61J15/00
CPC分类号： A61J15/0015 , A61J15/0026 , A61J15/0057 , A61J2205/30 , A61M39/1011 , A61M39/12 , A61M39/22 , A61M39/26 , Y10S128/912 , Y10S604/905
摘要： Low profile adaptor (11) for use with a medical catheter, such as a gastrostomy feeding tube. In a preferred embodiment, the adaptor comprises a body (13) having a lower portion (15) and an upper portion. A first channel (25) is provided in the lower portion, and a second channel (37,39,41) is provided in the upper portion, the first and second channels being per-pendicular to and in fluid communication with one an-other. A generally cylindrical stem (71) is coaxially posi-tioned within the second channel, the stem being rotata-bly mounted about its longitudinal axis. The stem is hollow and has an open front end (73), a closed rear end (75) and a hole (85) in its side wall, the hole being rotatably alignable with the first channel. To facilitate rotational align-ment of the hole with the first channel, a stop is formed on the exterior of the stem, the stop being engageable with a surface (59) positioned within the second channel. The front end of the stem is recessed relative to the front end of the second channel to prevent unwanted rotation of the stem. Rotation of the stem from a closed position to an open position is achieved by screwing a syringe onto the front end of the stem. The proximal end of the gas-trostomy feeding tube is inserted over the lower portion of the body and is secured thereto with a nut (91).

6. 发明授权

EP1390529B1 METHOD OF ANALYSING DNA METHYLATION USING FLUORESCENCE POLARISATION 有权
标题翻译： DNA甲基化分析方法采用荧光偏振
公开(公告)号：EP1390529B1
公开(公告)日：2004-09-29
申请号：EP02704676.2
申请日：2002-01-29
申请人： Epigenomics AG
发明人： BERLIN, Kurt
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q2523/125

7. 发明公开

EP1456192A1 DEUTERIERTE SUBSTITUIERTE DIHYDROFURANONE SOWIE DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL 审中-公开
标题翻译：氘取代dihydrofuranones及药物含有它们的
公开(公告)号：EP1456192A1
公开(公告)日：2004-09-15
申请号：EP02795002.1
申请日：2002-12-11
申请人： Turicum Drug Development AG
发明人： ALKEN, Rudolf-Giesbert
IPC分类号： C07D307/32 , A61K31/341
CPC分类号： A61K31/365 , C07D307/32
摘要： The invention relates to deuterated substituted dihydrofuranones and to medicaments containing these compounds. The invention also relates to the use of deuterated substituted dihydrofuranones for treating symptoms associated with irritated states of degenerative joint diseases, of acute pains and of primary dysmenorrhoea. The invention additionally discloses pharmaceutical compositions containing deuterated substituted dihydrofuranones and to their physiologically compatible salts in addition to pharmaceutically compatible adjuvants and/or additives for treating symptoms associated with irritated states of degenerative joint diseases, of acute pains and of primary dysmenorrhoea.

8. 发明公开

EP1449154A1 PREDICTING QUALITY OF MEAT AND/oR MEAT YIELD OF AN ANIMAL CARCASS 审中-公开
标题翻译：肉质和/或肉的预测产量的动物体内
公开(公告)号：EP1449154A1
公开(公告)日：2004-08-25
申请号：EP02801747.3
申请日：2002-10-15
申请人： VISION FOR YOU LLC
发明人： HAAGENSEN, Peter , EGER, Horst , KOOHMARAIE, Mohammed , SHACKELFORD, Steven, D. , WHEELER, Tommy, L.
IPC分类号： G06K9/00
CPC分类号： A22B5/007 , G01N33/12 , G06T7/0004 , G06T2207/30128
摘要： An image analysis system and method for grading of meat, predicting quality of meat and/or predicting meat yield of an animal. One aspect of the invention captures an image of the 12th rib cross section of the ribeye and perform an image analysis of the ribeye for grading purposes. The image capture camera portion (100) of the system has a wedged shaped camera housing (106) for ease of insertion into the ribbed incision. The image capturing portion (100) of the system further comprises a camera with a flash for consistent lighting. The camera is positioned such that it views the ribeye cross section at an angle to accommodate the wedge shape of the camera housing (106). The camera housing also has various alignment means (104, 108) to facilitate the user's ability to capture images in a consistent manner. Once the image is captured, an image analysis is performed on the image to determine parameters such as the percentage lean, total area of the ribeye, total fat area, total lean area, percent marbling, and thickness of fat adjacent to the ribeye, and other parameters. These parameters are used to predict value determining traits of the carcass.

9. 发明授权

EP1228247B1 VERFAHREN ZUR KONTROLLIERBAREN DURCHFÜHRUNG KOMPLEXER PCR-AMPLIFIKATIONEN 有权
标题翻译：方法的复杂PCR扩增可控的实现
公开(公告)号：EP1228247B1
公开(公告)日：2004-08-04
申请号：EP00987122.9
申请日：2000-11-12
申请人： Epigenomics AG
发明人： BERLIN, Kurt
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6837 , C12Q2600/16 , C12Q2537/143
摘要： The invention relates to a method for the controlled implementation of complex PCR amplifications, which comprises at least the following steps: a) PCR amplification using at least 50 primers of a first type (type 1) which have different sequences and complement an arbitrary strand of a DNA sample, said amplification containing a primer or a primer library of a second type (type 2), which complements the other strand of the DNA sample used, the primers of type 2 having a first label (label 1), b) Hybridisation of the amplificates to an oligomer array which contains oligonucleotides, the latter hybridising to the primers used in the PCR reaction, or to oligonucleotides which complement said primers; or hybridisation of the amplificates to an oligomer array, which contains oligomers that complement the primers used in the PCR reaction; c) Determination of the length of the amplificates that are bound to the array using a second label (label 2) which is different from the first label (label 1) in step a) and can be correlated with the length of the respective DNA fragment and d) Quantification of the signals emanating from label 1 and label 2 at each point on the oligonucleotide array that is relevant to the analysis.

10. 发明公开

EP1438436A2 VERFAHREN ZUR ANALYSE GENOMISCHER METHYLIERUNGSMUSTER 有权
标题翻译：程序用于分析基因组甲基化
公开(公告)号：EP1438436A2
公开(公告)日：2004-07-21
申请号：EP02802273.9
申请日：2002-10-25
申请人： Epigenomics AG
发明人： BERLIN, Kurt , ROY, Debjani
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6858 , C12Q2523/125 , C12Q2531/125 , C12Q2533/107
摘要： The invention relates to a method for analysis of methylation models in genomic DNA. In contrast to conventional methods for the analysis of methylation models, said method comprises a two-part method, whereby the genomic DNA is firstly subjected to a methylation specific treatment followed by an isothermal replication step.

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