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1. 发明公开

EP1757319A1 Apparatus and method for separating a composite liquid into at least two components 有权转让
标题翻译：用于分离复合液体分成至少两种组分的装置
公开(公告)号：EP1757319A1
公开(公告)日：2007-02-28
申请号：EP06076580.7
申请日：2006-08-16
申请人： Gambro, Inc.,
发明人： Hagström, Johan-Petter , Holmes, Brian M. , Hake, Charles L.
IPC分类号： A61M1/36 , B04B5/04
CPC分类号： B04B5/0428 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M1/3698 , B04B2005/0435
摘要： A bag loading means (87) is for loading and unloading at least one satellite bag (2, 3, 4) into and from the central compartment (34) of a rotor (32, 33, 34, 35) of an apparatus for separating a composite liquid into at least two components. The bag loading means (87) comprises an upper part comprising securing means (92) for removably securing an upper portion of at least one satellite bag (2, 3, 4) to the bag loading means (87); a lower part comprising a receptacle (96) for containing a lower portion of at least one satellite bag (2, 3, 4); and an intermediate part connecting the upper part to the lower part and exposing an intermediate portion of a satellite bag (2, 3, 4) having an upper portion secured to the upper part of the loading means (87) and a lower portion inserted in the receptacle.

2. 发明公开

EP1709983A2 Apparatus and method for separating a volume of whole blood into at least three components 有权
标题翻译： Apparat und Methode zur Separate einer Menge Blut in vier Komponenten
公开(公告)号：EP1709983A2
公开(公告)日：2006-10-11
申请号：EP05077728.3
申请日：2005-11-25
申请人： Gambro, Inc.,
发明人： Felt, Thomas , Gibbs, Bruce , Holmes, Brian
IPC分类号： A61M1/36
CPC分类号： A61M1/3693 , A61M1/0218 , A61M1/0231 , A61M1/3633 , A61M1/3696 , A61M1/3698 , A61M1/38 , A61M2205/331 , B04B5/0428 , B04B5/0442 , B04B13/00 , B04B2013/006
摘要： A method for separating a volume of whole blood contained in a separation bag (1) into at least three components comprises:
- Centrifuging the separation bag (1) so as to separate therein a first inner layer comprising plasma, a second intermediate layer comprising platelets, a third intermediate layer comprising lymphocytes, monocytes and granulocytes and a fourth outer layer comprising red blood cells, wherein at least the third and fourth layers partially overlap;
- Transferring, into a plasma component bag (2) connected to the separation bag (1), a plasma component substantially comprising a first fraction of the first layer; and
- Transferring, into a mononuclear cell component bag (3a) connected to the separation bag (1), a mononuclear cell component comprising at least a fraction of the third layer comprising lymphocytes and monocytes.
摘要翻译：将包含在分离袋（1）中的全血体积分成至少三个组分的方法包括： - 离心分离袋（1），以分离包含等离子体的第一内层，包含血小板的第二中间层包含淋巴细胞，单核细胞和粒细胞的第三中间层和包含红细胞的第四外层，其中至少第三和第四层部分重叠; - 转移到连接到分离袋（1）的等离子体组分袋（2）中;等离子体组分，其基本上包含第一层的第一部分; 和 - 转移到连接到分离袋（1）的单核细胞组分袋（3a）中，包含至少一部分包含淋巴细胞和单核细胞的第三层的单核细胞组分。

3. 发明公开

EP1680156A1 FLUID DISTRIBUTION MODULE AND EXTRACORPOREAL BLOOD CIRCUIT INCLUDING SUCH A MODULE 有权
标题翻译：液体分布模块和体外血液循环这样的模块
公开(公告)号：EP1680156A1
公开(公告)日：2006-07-19
申请号：EP04791037.7
申请日：2004-10-29
申请人： Gambro Lundia AB
发明人： DANNENMAIER, Jürgen , GOEHL, Hermann , ERTL, Thomas , CHEVALLET, Jacques , RIBOLZI, Francesco
IPC分类号： A61M1/36
CPC分类号： A61M1/3627 , A61M1/1008 , A61M1/1039 , A61M1/1086 , A61M1/16 , A61M1/3639 , A61M1/3641 , A61M2205/12 , B01D61/30 , B01D63/02
摘要： A fluid distribution module (1) for causing and monitoring the circulation of fluids from and to a patient through an extracorporeal blood treatment device, comprises a degassing device (11) connected to a connecting structure (10). The degassing device (11) comprises a first chamber (12) having a lower inlet (13) for a liquid and a second chamber (14) having an upper opening (79) closed by a hydrophobic membrane (78) and an outlet (15) for discharging the liquid. The connecting structure (10) has at least a first and a second conduits (20, 21) defined therein, wherein the first conduit (20) comprises a first end for connection to a discharge tube (7) from the treatment device and a second end connected to the inlet (13) of the first chamber (12) of the degassing device (11), and the second conduit (21) comprises a first end connected to the outlet (15) of the second chamber (14) of the degassing device (11) and a second end for connection to a blood return tube (6) to a patient.

4. 发明公开

EP1531883A2 METHODS AND APPARATUSES FOR BLOOD COMPONENT SEPARATION 有权转让
标题翻译：袋设置用于从多个组件在离心分离液体
公开(公告)号：EP1531883A2
公开(公告)日：2005-05-25
申请号：EP03751900.6
申请日：2003-08-25
申请人： Gambro, Inc.
发明人： HOLMES, Brian, M. , HAGSTRÖM, Johan- Peter , LUNDBERG, Per-Olov , VAN WAEG, Geert , NORDGREN, Peter
IPC分类号： A61M1/36 , A61M1/02 , B04B9/14 , B04B5/04
CPC分类号： A61M1/0209 , A61M1/3693 , A61M1/3696 , A61M1/3698 , B04B5/0428 , B04B5/0442 , B04B13/00 , B04B2005/045
摘要： A system for separating a composite fluid into component parts thereof, including: a centrifuge having a rotor with aseparation space and at least two valve members disposed thereon and a container set having a separation container adapted to be disposed in the separation space of the rotor and first and second collection containers connected to the separation container by a first and a second tubes. The tubes are adapted to be disposed in operative relationship with the valve members so that flow through the tubes may be controlled thereby. Three components of the composite fluid may be separated therefrom by the present system and two components may be moved to the collection containers. The container set may further include a third collection container connected to the separation container by a tube, and a third component may thus be moved to this third container.

5. 发明授权

EP0797461B1 DISPOSITIF DE RECUEIL D'UN ECHANTILLON DE LIQUIDE DE DIALYSE USE 失效
标题翻译： VORRICHTUNG ZUR PROBENENTNAHME VON VERBRAUCHTEM DIALYSAT
公开(公告)号：EP0797461B1
公开(公告)日：2003-09-10
申请号：EP96931933.4
申请日：1996-10-10
申请人： GAMBRO HOSPAL (Schweiz) AG
发明人： NUCCIO, Antonino
IPC分类号： A61M1/16 , G01N1/20
CPC分类号： A61M1/16 , A61M1/1619 , A61M1/165 , A61M1/341 , A61M2205/3334 , A61M2205/50 , G01N1/2035 , G01N2001/1093 , Y10S210/929

6. 发明公开

EP1201293A1 Bundle of hollow fibres for a device for extracorporeal treatment of blood and plasma, and process for its production 审中-公开
标题翻译： Hohlfaserbündelzur extrakorporalen Blut- und Plasmabehandlung und Herstellungsverfahren
公开(公告)号：EP1201293A1
公开(公告)日：2002-05-02
申请号：EP01204054.9
申请日：2001-10-24
申请人： HOSPAL INDUSTRIE
发明人： Boivin, Didier , Farjaud, Jean
IPC分类号： B01D63/02 , G01N15/08 , A61M1/34
CPC分类号： B01D63/02 , B01D63/021 , B01D65/10 , B01D2319/06 , G01N15/0826 , G01N2015/084
摘要： The invention relates to a bundle of hollow fibres intended to constitute the membrane of a device for treating blood or plasma by extracorporeal circulation, in which:

the hydraulic permeability of the hollow fibres in the bundle is heterogeneous; and
the ratio of the highest hydraulic permeability measured on some hollow fibres of the bundle to the lowest hydraulic permeability measured on other hollow fibres in the same bundle is at least about 5.

The invention also relates to a method for producing such a bundle, and a device comprising such a bundle.
摘要翻译：本发明涉及用于构成用于通过体外循环治疗血液或血浆的装置的膜的中空纤维束，其中：束中的中空纤维的水硬性渗透性是异质的; 并且将在束的一些中空纤维上测量的最高水力渗透率与在同一束中的其它中空纤维上测量的最低水力渗透率的比率至少为约5.本发明还涉及一种生产这种束的方法，包括这种束的装置。

7. 发明公开

EP1154809A1 DEVICE AND A METHOD FOR DETERMINING BLOOD RECIRCULATION IN A VASCULAR ACCESS 有权
标题翻译： DEVICE再次确定血液轮脉管接入装置
公开(公告)号：EP1154809A1
公开(公告)日：2001-11-21
申请号：EP00979876.0
申请日：2000-12-18
申请人： HOSPAL AG
发明人： BOSETTO, Antonio , PAOLINI, Francesco , FAVA, Massimo
IPC分类号： A61M1/16
CPC分类号： A61M1/16 , A61M1/3609 , A61M1/3658 , A61M2230/65
摘要： A method is described for determining recirculation of blood in a vascular access (11) of a patient undergoing dialysis treatment by means of a dialysis machine (10) comprising an arterial line (24) for withdrawing blood from the patient's body, a dialysis filter (16), and a venous line (26) for returning the blood to the patient's body. The present method consists in inducing, in the blood flowing in the venous line (26), a disturbance of a magnitude such as to bring the system into a transient state and determining blood recirculation in the vascular access (11) during the transient state as a function of the magnitude of the disturbance induced in the arterial line (24). In particular, the aforesaid disturbance consists of the variation of the haemoglobin concentration in the blood flowing in the venous line (26) and the variation is caused by controlling a change in the ultrafiltration flow in dialysis filter (16).

8. 发明授权

EP0829265B1 Method for priming a circuit for multiple blood extracorporeal treatments 失效
标题翻译： Entlüftungsmethodeeines Kreislaufsfürextrakorporale Mehrzweckbehandlungen von Blut
公开(公告)号：EP0829265B1
公开(公告)日：2001-09-05
申请号：EP97120159.5
申请日：1994-02-01
申请人： HOSPAL INDUSTRIE
发明人： Truitt, Lori , Miller, Douglas P. , Johnson, Steven H. , Corbin, Frank, III , Manica, Keith , Leppert, Lawrence L. , Lobdell, Donn D. , Eilers, Georges
IPC分类号： A61M1/16 , A61M1/34 , A61M1/36
CPC分类号： A61M1/16 , A61M1/1643 , A61M1/34 , A61M1/3403 , A61M1/3413 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3451 , A61M1/3468 , A61M1/36 , A61M1/3607 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/365 , A61M1/3672 , A61M2205/12 , A61M2205/13 , A61M2205/15 , A61M2205/18 , A61M2205/3331 , A61M2205/3344 , A61M2205/3393 , A61M2205/50 , A61M2205/505 , A61M2205/52 , A61M2209/084 , C07K14/4711 , C07K16/40 , C12N9/6421 , G01N33/573 , G01N33/6896 , Y10S210/929

9. 发明公开

EP1115436A2 FILTRATION UNIT FOR A DIALYSIS MACHINE 有权
标题翻译：过滤单元用于透析机
公开(公告)号：EP1115436A2
公开(公告)日：2001-07-18
申请号：EP00948193.8
申请日：2000-07-27
申请人： HOSPAL AG
发明人： VINCI, Luca
IPC分类号： A61M1/14 , B01D65/00
CPC分类号： B01D63/02 , A61M1/16 , A61M2209/082 , B01D61/20 , B01D61/30 , B01D65/00 , B01D2201/4023 , B01D2313/06 , B01D2313/90
摘要： A filtration unit (1) for a dialysis machine, comprises : a filter (2) that has a casing (5) provided with a number of first connecting elements (11, 12, 13, 14) arranged on the same side of the casing (5) with respective axes (B, C, D, E) parallel to one another, and a support (3) provided with a number of second connecting elements (28, 29, 30, 31) that can interact with the first connecting elements (11, 12, 13, 14), and with releasable locking means (35) for locking the filter (2) on the support (3) in an operating position in which the first and second connecting elements (11, 12, 13, 14; 28, 29, 30, 31) are in mutual engagement.

10. 发明公开

EP1083941A1 PROCEDE ET DISPOSITIF POUR STERILISER ET DISPENSER UN LIQUIDE A USAGE MEDICAL 审中-公开
标题翻译： PROCEDE ET ET DISPOSITIF POUR STERILISER ET DISPENSER UN LIQUIDE A USAGE MEDICAL
公开(公告)号：EP1083941A1
公开(公告)日：2001-03-21
申请号：EP00903927.2
申请日：2000-02-24
申请人： HOSPAL INDUSTRIE
发明人： CHEVALLET, Jacques , COURT, Thierry , DUNKLEY, Michael, John , FRUGIER, Alain , JÖNSSON, Lennart , RADA, Hiram , KERRY, Nicholas John , ROMARIE, Jean-Louis
IPC分类号： A61L2/04 , C02F1/02 , C02F1/04
CPC分类号： A61L2/04 , C02F1/02 , C02F1/045
摘要： A device for the preparation of a sterile liquid, comprising the following: adjustable main heating means(80) that can increase the temperature of a liquid inside an enclosed heating chamber (511), a main circuit comprising a first line (1) having one end which can be connected to a source of liquid that is to be sterilized and another end which is connected to an inlet of the heating chamber (511), in addition to comprising a second line (2) having one end which is connected to an outlet of the heating chamber (511) and another end which is linked to a connector (90) having a first outlet for delivering a sterile liquid, first pumping means (40) so that said liquid can circulate in the main circuit (1, 2), means (36) preventing bubbles from forming during the production of sterile liquid comprising first means (36) for adjusting the pressure of the liquid to a pressure value above the pressure for vaporization of said liquid irrespective of the temperature of the liquid, whereby the first means (36) for adjusting the pressure of the liquid are disposed on the second line (2) of the main circuit.
摘要翻译：一种用于制备无菌液体的装置，包括：可调节的主加热装置（80），其能够增加封闭加热腔室（511）内的液体的温度;主电路，其包括具有一个其可以连接到待灭菌的液体源，并且另一端连接到加热室（511）的入口，除了包括第二管线（2），所述第二管线的一端连接到所述加热室（511）的出口和连接到具有用于输送无菌液体的第一出口的连接器（90）的另一端，第一泵送装置（40）使得所述液体可以在主回路（1,2）中循环，），在生产无菌液体期间防止气泡形成的装置（36），包括第一装置（36），用于将液体的压力调节至高于所述液体的蒸发压力的压力值，而不管液体的温度如何 f 用于调节液体压力的第一装置（36）设置在主回路的第二管线（2）上。

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