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1. 发明公开

EP3427597A1 METHOD AND APPARATUS FOR PRODUCING INSTANT FRIED NOODLE 审中-公开
公开(公告)号：EP3427597A1
公开(公告)日：2019-01-16
申请号：EP17762914.4
申请日：2017-02-22
申请人： Nissin Foods Holdings Co., Ltd.
发明人： Kitano, Sho , Tanahashi, Maiko , Hibi, Takaaki , Higashida, Yasuhiro , Hayakawa, Koji , Shingai, Taisuke , Takizawa, Hideki , Tanaka, Mitsuru
IPC分类号： A23L7/113 , A47J37/12
摘要： [Problem to be Solved]
The present invention relates to instant fried noodles having a small number of coarse or dense portions and homogeneously fried.
[Solution]
In the present invention, frying is performed in two stages so as to dip a retainer in frying oil at a prescribed dipping ratio and then to dip the whole of the retainer in the frying oil, and in addition, flow rates of the frying oil supplied from an upstream side and a downstream side of a frying oil tank and a surface level of the frying oil are controlled. Therefore, a noodle lump can be prevented from peeling off and floating from the bottom of the retainer before fixing the shape of the noodle lump due to a pressure applied by the frying oil so as not to impair the shape of the noodle lump, and as a result, frying efficiency or production efficiency can be improved. Besides, a noodle lump that has a very small number of coarse or dense portions in a distribution of noodle strings can be stably produced. A difference in density of noodle strings between an upper half portion and a lower half portion of a dried noodle lump is preferably at least 13% or less.

2. 发明公开

EP3409659A1 ADAMANTANE DERIVATIVE AND USE THEREOF 有权转让
公开(公告)号：EP3409659A1
公开(公告)日：2018-12-05
申请号：EP17744327.2
申请日：2017-01-26
申请人： Tohoku University
发明人： MORIGUCHI, Shigeki , FUKUNAGA, Koji , IWABUCHI, Yoshiharu
IPC分类号： C07C233/47 , A61K31/198 , A61K31/221 , A61K31/223 , A61K31/655 , A61P3/10 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C07C229/28 , C07C247/14 , C07D213/40
CPC分类号： A61K31/198 , A61K31/221 , A61K31/223 , A61K31/655 , C07C229/28 , C07C233/47 , C07C247/14 , C07D213/40
摘要： The present invention provides a pharmaceutical composition for treating or preventing a cognitive disease or disorder, containing a compound represented by Formula (I), an enantiomer thereof, a diastereomer thereof, or a pharmaceutically acceptable salt thereof.

3. 发明公开

EP3361252A1 PIVKA-II ASSAY METHOD AND METHOD FOR MANUFACTURING REAGENT OR KIT FOR PIVKA-II IMMUNOASSAY 审中-公开
公开(公告)号：EP3361252A1
公开(公告)日：2018-08-15
申请号：EP16853698.5
申请日：2016-10-06
申请人： Fujirebio Inc. , Sekisui Medical Co., Ltd.
发明人： KITAMURA, Yoshiyuki , AOYAGI, Katsumi
IPC分类号： G01N33/53 , C07K16/36 , C07K16/40 , C12N15/02 , C12P21/08
CPC分类号： G01N33/573 , C07K16/36 , C07K16/40 , C12N15/02 , G01N33/53 , G01N2333/96433
摘要： Disclosed is a means of enabling the construction of a more accurate PIVKA-II immunoassay system using monoclonal antibodies against human prothrombin. The PIVKA-II assay method according to the present invention comprises measuring PIVKA-II in a sample by an immunoassay using an anti-PIVKA-II antibody or an antigen-binding fragment thereof which specifically binds to PIVKA-II and a mixture of a first anti-prothrombin antibody or an antigen-binding fragment thereof which recognizes hydrophilic PIVKA-II molecules and a second anti-prothrombin antibody or an antigen-binding fragment thereof which recognizes hydrophobic PIVKA-II molecules.

4. 发明公开

EP3357349A1 FRIED INSTANT NOODLES 审中-实审
公开(公告)号：EP3357349A1
公开(公告)日：2018-08-08
申请号：EP16843284.7
申请日：2016-07-20
申请人： Nissin Foods Holdings Co., Ltd.
发明人： Kitano, Sho , Tanahashi, Maiko , Kanai, Eriko , Hazama, Hidenobu , Tanaka, Mitsuru
IPC分类号： A23L7/113
CPC分类号： A23L7/111 , A23L5/11 , A23L7/113
摘要： [Problem to be Solved]
An object of the present invention is to provide instant fried noodles having a lower fat or oil content than general instant fried noodles.
[Solution]
Instant fried noodles having a porous structure including a smaller number of pores and having a lower porosity are provided by inhibiting formation of a layered gluten network structure within noodle strings. Thus, a fat or oil content of the fried noodles can be lowered.

5. 发明授权

EP3052647B1 CANCER BIOMARKERS AND USES THEREOF 有权
公开(公告)号：EP3052647B1
公开(公告)日：2018-07-11
申请号：EP14781645.8
申请日：2014-10-03
申请人： F-Star Biotechnology Ltd. , F-Star Biotechnologische Forschungs- und Entwicklungsges.m.b.H
发明人： LEUNG, Kinmei , SUN, Haijun , BATEY, Sarah , ROWLAND, Robert
IPC分类号： C12Q1/68
CPC分类号： C07K16/32 , A61K2039/505 , C07K2317/524 , C07K2317/526 , C07K2317/73 , C07K2317/92 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： The invention relates the use of Human Epidermal Growth Factor Receptor 2 (HER2) gene copy number and HER2 mRNA levels as biomarkers to identify cancers which will respond to treatment with a specific binding member comprising a HER2 antigen binding site engineered into a structural loop region of a constant domain, e.g. CH3 domain, of the specific binding member, and specific binding members which compete with such a binding member for binding to HER2.

6. 发明公开

EP3312291A1 SUBSTRATE SOLUTION FOR LIPASE ACTIVITY MEASUREMENT, AND METHOD AND MEASUREMENT REAGENT FOR MEASUREMENT OF LIPASE ACTIVITY IN SAMPLE 有权
标题翻译：用于脂肪酶活性测量的基质溶液以及用于测量样品中脂肪酶活性的方法和测量试剂
公开(公告)号：EP3312291A1
公开(公告)日：2018-04-25
申请号：EP16811750.5
申请日：2016-06-17
申请人： Shino-Test Corporation
发明人： IIZUKA, Naomi , HIKICHI, Atsushi
IPC分类号： C12Q1/44 , G01N33/92 , C07D265/38 , C08G77/14 , C12N9/20
摘要： This invention provides a substrate solution for measuring lipase activity, a reagent for measuring lipase activity, and an emulsion solution excellent in storage stability. This invention also provides a method for measuring lipase activity in a sample that enables accurate measurement over a long period of time. This invention further provides a method for improving storage stability of a substrate solution for measuring lipase activity and an emulsion solution. To this end, a substrate solution for measuring lipase activity comprising the emulsion solution comprising micelle particles of 1,2-o-dilauryl-rac-glycero-3-glutaric acid (6'-methylresorufin) ester and side-chain-type nonreactive polyether-modified-type modified silicone oil is used.
摘要翻译：本发明提供用于测量脂肪酶活性的底物溶液，用于测量脂肪酶活性的试剂和储存稳定性优异的乳液溶液。本发明还提供了用于测量样品中的脂肪酶活性的方法，其能够长时间进行精确测量。本发明还提供了用于提高用于测量脂肪酶活性的底物溶液和乳液溶液的储存稳定性的方法。为此，用于测量脂肪酶活性的底物溶液包含含有1,2-邻二月桂基 - 外消旋 - 甘油基-3-戊二酸（6'-甲基异芴）酯的胶束颗粒和侧链型非反应性聚醚的乳液溶液改性型改性硅油。

7. 发明公开

EP3311660A1 METHOD FOR PRODUCING BLOOD CHIMERIC ANIMAL 有权
标题翻译：生产血液嵌合体动物的方法
公开(公告)号：EP3311660A1
公开(公告)日：2018-04-25
申请号：EP16814302.2
申请日：2016-06-20
申请人： National Federation of Agricultural Cooperative Associations , The University Of Tokyo
发明人： FUKAWA, Kazuo , ITO, Tetsuya , KAMIKAWA, Mai , SENDAI, Yutaka , NAKAUCHI, Hiromitsu , YAMAZAKI, Satoshi , WATANABE, Motoo
IPC分类号： A01K67/027 , C12N5/16 , C12N15/09
CPC分类号： A01K67/0271 , A01K67/027 , A01K2207/12 , A01K2217/052 , A01K2227/108 , A01K2267/025 , C12N5/0647 , C12N15/09 , C12N2510/00 , C12N2510/02 , C12N2517/02
摘要： The present invention discloses a novel means capable of producing a blood chimeric animal in which a state of retaining blood cells originating in a heterologous animal, such as a human, at a high percentage is sustained for a long period of time, even in cases where a medium to large domestic animal is used as a recipient. The method for producing a non-human animal that retains blood cells originating in a heterologous animal, according to the present invention, comprises transplanting hematopoietic cells of a heterologous animal into a non-human animal, in which hematopoietic cells the function of a gene that acts on the hematopoietic system is modified. The gene that acts on the hematopoietic system is, for example, Lnk gene. According to the method of the present invention, when a medium to large mammal such as a pig is used as a recipient, the survival rate of hematopoietic cells originating in a heterologous animal is dramatically increased such that blood chimerism of 10% or more can be maintained even in a 16 month old animal.
摘要翻译：本发明公开了一种能够制造血液嵌合体动物的新型方法，其中以高百分比保存源自异源动物如人的血细胞的状态持续很长一段时间，即使在一个大型的家养动物被用作接受者。根据本发明的用于生产保留源自异源动物的血细胞的非人动物的方法包括将异源动物的造血细胞移植到非人动物中，其中造血细胞具有基因的功能，对造血系统的作用被修改。作用于造血系统的基因例如是Lnk基因。根据本发明的方法，当使用猪等大型哺乳动物作为受体时，源自异源动物的造血细胞的存活率显着增加，使得10％或更多的血液嵌合体可以是即使在16个月大的动物中也能保持。

8. 发明公开

EP3293200A1 METHOD FOR ENGINEERING IMMUNOGLOBULINS 审中-实审转让
标题翻译：免疫球蛋白工程方法
公开(公告)号：EP3293200A1
公开(公告)日：2018-03-14
申请号：EP17182619.1
申请日：2007-07-05
申请人： F-Star Biotechnologische Forschungs- und Entwicklungsges.m.b.H
发明人： HIMMLER, Gottfried , REDL, Gerda , RÜCKER, Florian , WOZNIAK-KNOPP, Gordana
IPC分类号： C07K16/10 , C07K16/16 , C07K16/32
CPC分类号： C12N15/1037 , C07K16/00 , C07K16/005 , C07K16/1045 , C07K16/1063 , C07K16/16 , C07K16/18 , C07K16/241 , C07K16/283 , C07K16/32 , C07K16/40 , C07K2317/21 , C07K2317/22 , C07K2317/55 , C07K2317/622
摘要： The present invention relates to a method for engineering an immunoglobulin comprising a variable domain and at least one modification in at least two structural loops of said immunoglobulin and determining the binding of said immunoglobulin to an epitope of an antigen, wherein the unmodified immunoglobulin does not significantly bind to said epitope, comprising the steps of:
- providing a nucleic acid encoding an immunoglobulin comprising at least two structural loops,
- modifying at least one nucleotide residue of each of said structural loops,
- transferring said modified nucleic acid in an expression System,
-expressing said modified immunoglobulin,
-contacting the expressed modified immunoglobulin with an epitope, and
- determining whether said modified immunoglobulin binds to said epitope, immunoglobulins produced by such a method and libraries of immunoglobulins.
摘要翻译：本发明涉及一种工程化免疫球蛋白的方法，所述免疫球蛋白包含可变结构域和所述免疫球蛋白的至少两个结构环中的至少一个修饰并确定所述免疫球蛋白与抗原表位的结合，其中所述未修饰的免疫球蛋白不显着包括以下步骤： - 提供编码免疫球蛋白的核酸，其包含至少两个结构环， - 修饰每个所述结构环的至少一个核苷酸残基， - 在表达系统中转移所述修饰的核酸， - 表达所述修饰的免疫球蛋白， - 将表达的修饰的免疫球蛋白与表位接触，以及 - 确定所述修饰的免疫球蛋白是否结合所述表位，通过这种方法产生的免疫球蛋白和免疫球蛋白库。

9. 发明公开

EP3263716A1 GENE-SPECIFIC NON-BIASED AMPLIFICATION METHOD 有权
标题翻译：基因特异性非偏置扩增方法
公开(公告)号：EP3263716A1
公开(公告)日：2018-01-03
申请号：EP16755460.9
申请日：2016-02-23
申请人： Tohoku University
发明人： OGASAWARA Koetsu
IPC分类号： C12Q1/68 , C12N15/09
摘要： The present invention is intended to provide a method of amplifying a target gene without bias and an adapter DNA use therefor. The adapter DNA of the present invention is double-stranded adapter DNA, which is used for unbiased gene amplification and has the following features: (a) the double-stranded adapter DNA has a sense strand and an antisense strand that are annealed with each other, the base length of the sense strand being equal to or longer than the base length of the antisense strand; (b) the base length of the sense strand is 15 to 40 bp; (c) the antisense strand includes a plurality of uracil bases, each uracil is removed by treating an adapter portion with uracil DNA glycosylase (UNG), and then, heat treatment is performed to degrade the antisense strand; (d) at least one end of the adapter DNA is in the form of a blunt end; (e) the other end of the adapter DNA binds to a target gene to be amplified; and (f) a part or all of the sense strand corresponds to a forward primer sequence used for gene amplification.
摘要翻译：本发明旨在提供一种无偏倚地扩增靶基因的方法以及为此使用的适配器DNA。本发明的接头DNA是用于无偏基因扩增的双链接头DNA，具有以下特征：（a）双链接头DNA具有彼此退火的有义链和反义链，有义链的碱基长度等于或长于反义链的碱基长度; （b）有义链的碱基长度为15至40bp; （c）反义链包括多个尿嘧啶碱基，通过用尿嘧啶DNA糖基化酶（UNG）处理衔接子部分除去每个尿嘧啶，然后进行热处理以降解反义链; （d）衔接头DNA的至少一个末端为钝端形式; （e）衔接头DNA的另一端结合待扩增的靶基因; 和（f）有义链的一部分或全部对应于用于基因扩增的正向引物序列。

10. 发明授权

EP2949348B1 ADHESION PREVENTING MATERIAL 有权
标题翻译：粘合防止材料
公开(公告)号：EP2949348B1
公开(公告)日：2017-11-15
申请号：EP14743521.8
申请日：2014-01-22
申请人： The University of Tokyo
发明人： MIYAJIMA, Atsushi , INAGAKI, Natsuko , INAGAKI, Fuyuki , KOKUDO, Norihiro
IPC分类号： A61L27/00 , A01K67/027 , A61K35/407 , A61L15/16
CPC分类号： A61L31/005 , A61K35/407 , A61L27/3604 , A61L27/3641 , A61L27/50 , A61L31/14 , A61L2430/28
摘要： An object of the present invention is to provide an adhesion preventing material capable of preventing adhesion safely and efficiently. The present invention provides an adhesion preventing material comprised of a cell sheet containing mesothelial cells; an adhesion preventing method and organ regeneration promoting method each using the cell sheet containing mesothelial cells.

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