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1. 发明授权

EP3064214B1 SEPARATION AND PURIFICATION METHOD FOR VANCOMYCIN HYDROCHLORIDE OF HIGH PURITY 有权
公开(公告)号：EP3064214B1
公开(公告)日：2019-08-07
申请号：EP14857463.5
申请日：2014-10-27
申请人： Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： LI, Enmin , ZHUANG, Yiyun , WANG, Jue , SUN, Xinqiang , LAO, Xuejun , JIANG, Biwang
IPC分类号： A61K38/14 , C07K9/00 , C07K1/22

2. 发明公开

EP3363532A1 METHOD FOR GRANULATING, FORMING, AND DRYING FAT SOLUBLE NUTRIENT MICROCAPSULE PARTICLES 有权
公开(公告)号：EP3363532A1
公开(公告)日：2018-08-22
申请号：EP15905988.0
申请日：2015-10-12
申请人： Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： XU, Xinde , ZHOU, Di , ZHANG, Lihua , SHAO, Bin
IPC分类号： B01J13/04
CPC分类号： B01J13/04
摘要： The present invention provides a method for drying high-stability microcapsule particles containing multiple double bonds fat soluble nutrients comprises: a) preparing a microcapsule emulsion containing multiple double bonds fat soluble nutrients, performing spray granulation on the microcapsule emulsion in a spray system (1), and meanwhile blasting air into the spray system (1), the blasted air wrapping adsorption materials, and the microcapsule emulsion being immediately solidified and sized after coming into contact with the air, so as to obtain liquid droplets having surfaces to which adsorption materials are adsorbed; b) performing fluidized drying on the liquid droplets having surfaces to which the adsorption materials are adsorbed in the step a) in a multi-stage fluidized bed system (5); c) collecting non-adsorbed adsorption materials by means of an adsorption material dust removal, recovery and circulation system; and d) collecting microcapsule particle products.

3. 发明公开

EP3202876A1 FIXED BED DECOLORIZATION PROCESS FOR UNSATURATED FATTY ACID 有权
标题翻译：不饱和脂肪酸的固定床脱色工艺
公开(公告)号：EP3202876A1
公开(公告)日：2017-08-09
申请号：EP15840668.6
申请日：2015-09-09
申请人： Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： XIANG, Xuebing , XU, Xinde , SHAO, Bin , LI, Chong
IPC分类号： C11B3/00
CPC分类号： A23L5/49 , A23L33/12 , A23V2002/00 , C11B3/00 , C11B3/10
摘要： The present invention relates to a fixed bed decolorization process for an polyunsaturated fatty acid, comprising a polyunsaturated fatty acid or a polyunsaturated fatty acid solution is either passed directly through a filler of the fixed bed or recycled in a filler of the fixed bed, a colorless or light-colored polyunsaturated fatty acid product is ultimately produced, at the same time, other than the color, other qualities of the polyunsaturated fatty acid remain unaffected. The decolorization process allows continuous operation or intermittent operation. The filler of the fixed bed comprises one or a mixture of activated carbon, diatomite, carclazyte, silicone and an ion-exchange resin. An upper or a middle or a bottom or a combination thereof is employed to feed a polyunsaturated fatty acid feedstock or a polyunsaturated fatty acid solution. The filler in the fixed bed can be used repeatedly. The filler can be reused after being washed when decolorization effects thereof become deteriorated or ineffective.
摘要翻译：本发明涉及用于多不饱和脂肪酸的固定床脱色方法，其包含多不饱和脂肪酸或多不饱和脂肪酸溶液直接通过固定床的填料或循环到固定床的填料中，无色或最终产生浅色多不饱和脂肪酸产物，同时，除了颜色之外，多不饱和脂肪酸的其他品质不受影响。脱色过程允许连续操作或间歇操作。固定床的填料包含活性炭，硅藻土，carlozyte，硅酮和离子交换树脂中的一种或混合物。采用上部或中部或底部或其组合来供给多不饱和脂肪酸原料或多不饱和脂肪酸溶液。固定床中的填充物可以重复使用。当其脱色效果变差或无效时，填料可以在清洗后重新使用。

4. 发明公开

EP3181544A1 METHOD FOR PREPARING HIGH-CONTENT CONJUGATED LINOLEIC ACID THROUGH PURIFICATION OF VEGETABLE OIL AS RAW MATERIAL 有权
标题翻译：用于生产高浓度的共轭亚油酸BY植物油为原料CLEANING
公开(公告)号：EP3181544A1
公开(公告)日：2017-06-21
申请号：EP15841810.3
申请日：2015-09-17
申请人： ZheJiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： PENG, Yongjian , XU, Xinde , SHAO, Bin , ZHANG, Lihua
IPC分类号： C07C57/12 , C07C51/09 , C11C3/10
CPC分类号： C07C51/09 , C07C67/02 , C11B7/0041 , C11B7/0058 , C11C1/08 , C11C1/10 , C11C3/003 , C11C3/10 , G01N30/02 , G01N2030/027
摘要： This invention involves a method for preparing high-contentconjugated linoleic acid (CLA) products with common vegetable oil. This invention includes alcoholysis, purification and isomerization of vegetable oil. Alcoholysis is for preparing correspondingmethyl ester or ethyl ester with glyceride; purification of methyl ester or ethyl ester is for obtaining methyl linoleate or ethyl linoleate of content over 85% through silver-basedsilicagel columnchromatography; high-content CLA is obtained after alkali-catalyzed conjugation of methyl linoleate or ethyl linoleate, and CLA products are prepared as needed. This invention changes the status quo of preparing high-content CLA with safflower oil alone, expands sources of CLA, and develops an efficient technology for separation and purification of linoleic acid. The CLA obtained is of high purity and meets applications in pharmaceutical, health care products and other industries.
摘要翻译：本发明包括一种制备高contentconjugated亚油酸（CLA）的产品与普通植物油的方法。本发明包括醇解，纯化和植物油的异构化反应。醇解是制备correspondingmethyl酯或乙基酯与甘油酯; 甲基酯或乙基酯的纯化是用于获得亚油酸甲酯或通过银basedsilicagel柱色谱超过85％的亚油酸乙酯含量; 含量高CLA是亚油酸甲酯或亚油酸乙酯的碱催化偶联后获得，并且根据需要CLA产品制备。本发明改变制备高含量的CLA与红花油现状单独，Expand的CLA的来源，和高效的技术开发出的亚油酸的分离和纯化。获得该CLA是高纯度的，满足药物应用，保健品等行业。

5. 发明授权

EP2799418B1 PREPARATION METHOD OF LYCOPENE INTERMEDIATE 3-METHYL-4,4-DIALKOXY-1-BUTYRALDEHYDE 有权
标题翻译： PROCESS FOR番茄红素中间体3-甲基-4,4-二烷氧基-1-丁醛的制备
公开(公告)号：EP2799418B1
公开(公告)日：2017-04-12
申请号：EP12862813.8
申请日：2012-12-10
申请人： Nanjing University Of Technology , Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： LV, Chunlei , PI, Shiqing , CHEN, Jianhui , LU, Dingqiang , OUYANG, Pingkai
IPC分类号： C07C45/00 , C07C45/51 , C07C47/198
CPC分类号： C07C45/30 , C07C41/22 , C07C45/00 , C07C45/516 , C07C47/198

6. 发明公开

EP3072883A1 CAROTENOID COMPOUND COMING FROM PLANT AND CONTAINING NATURAL ASTAXANTHIN, PREPARATION METHOD THEREFOR, AND COMPOSITION 有权
标题翻译：与天然虾青素，类胡萝卜素工艺产品蔬菜产生和组成
公开(公告)号：EP3072883A1
公开(公告)日：2016-09-28
申请号：EP14848508.9
申请日：2014-09-23
申请人： Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： XU, Xinde , SHAO, Bin , PENG, Yongjian , WANG, Shengnan
IPC分类号： C07C403/24 , A23L33/10 , A23K20/00
CPC分类号： A61K31/122 , A23K20/179 , A23L33/105 , A61K8/97 , A61K36/71 , A61K2236/33 , A61K2236/37 , A61K2236/51 , A61K2236/53 , A61K2800/10 , A61K2800/43 , A61Q19/00 , C07C403/24 , C07C2601/14 , C07C2601/16
摘要： The present invention provides a high-content carotenoid compound from adonis amurensis. The content of the total carotenoid of the carotenoid compound is higher than 95%. The content of all-trans (3S, 3'S)-carotenoid is higher than 80%. The carotenoid crystals have a high purity, and can be used in multiple forms in the fields of a dietary supplement of a human being, a food additive, a feed additive and a cosmetic product. In addition, the present invention also provides a method for manufacturing the compound.
摘要翻译：本发明提供了从冰凉花高含量的类胡萝卜素化合物。类胡萝卜素化合物的总类胡萝卜素的含量高于95％。全反式的含量（3S，3'S）-carotenoid是高于80％。类胡萝卜素晶体具有高纯度，并且可以在一个人，食品添加剂，饲料添加剂和化妆品产品的膳食补充剂的字段的多个形式使用。此外，本发明因此提供了用于制造该化合物的方法。

7. 发明公开

EP2883544A1 COMPOSITION USED FOR IMPROVING MACULAR PIGMENT DENSITY IN EYES AND PREVENTING OR TREATING AGE-RELATED MACULAR DEGENERATION 有权
标题翻译：组成眼睛和预防或治疗年龄相关性黄斑变性在改善黄斑色素密度
公开(公告)号：EP2883544A1
公开(公告)日：2015-06-17
申请号：EP13827670.4
申请日：2013-08-08
申请人： Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： XU, Xinde , ZHANG, Lihua , SUN, Xiaoxia
IPC分类号： A61K31/375 , A61K31/355 , A61K31/353 , A61K31/07 , A61K31/047 , A61K33/34 , A61K33/30 , A61K33/04 , A61P27/02
CPC分类号： A61K36/82 , A61K31/015 , A61K31/045 , A61K31/047 , A61K31/05 , A61K31/07 , A61K31/353 , A61K31/355 , A61K31/375 , A61K33/00 , A61K33/04 , A61K33/30 , A61K33/34 , A61K2300/00
摘要： The present invention provides a composition for improving macular pigment optical density and preventing or treating age-related macular optical degeneration. The composition comprises lutein, zeaxanthin and tea extracts, wherein the weight ratio of zeaxanthin to lutein is more than or equal to 1. The composition may prevent formation of choroidal neovascularization to achieve effects on comprehensively preventing or treating age-related macular optical degeneration (AMD).
摘要翻译：本发明提供了改善黄斑色素的光密度和预防或治疗年龄相关性黄斑变性的光学的组合物。所述组合物包含叶黄素，玉米黄素和茶提取物，玉米黄质worin叶黄素的重量比大于或等于1的组合物，可以防止形成脉络膜新血管形成，以实现全面上预防或治疗年龄相关性黄斑变性的光学效应的（AMD ）。

8. 发明授权

EP2578563B1 INTERMEDIATE OF LYCOPENE AND PREPARATION METHOD OF INTERMEDIATE THEREOF 有权
标题翻译：产品之间番茄红素和方法中间体
公开(公告)号：EP2578563B1
公开(公告)日：2015-03-18
申请号：EP11789038.4
申请日：2011-01-30
申请人： Shaoxing University , Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： SHEN, Runpu , LV, Chunlei , JIANG, Xiaoyue , LAO, Xuejun , YE, Weidong , LIU, Luo , SONG, Xiaohua , WU, Chunlei
IPC分类号： C07C43/03 , C07C41/48 , C07F9/28 , C07B47/00
CPC分类号： C07C41/50 , C07B47/00 , C07C41/48 , C07C43/303 , C07F9/4015 , C07F9/4078

9. 发明公开

EP2799420A1 METHOD FOR SYNTHESIZING 2,7-DIMETHYL-2,4,6-OCTATRIENE-1,8-DIALDEHYDE 有权
标题翻译： VERFAHREN ZUR SYNTHESE VON 2,7-二甲基-2,4,6-OCTATRIEN-1,8-DIALDEHYD
公开(公告)号：EP2799420A1
公开(公告)日：2014-11-05
申请号：EP12863035.7
申请日：2012-12-10
申请人： Nanjing University Of Technology , Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： CHEN, Jianhui , LV, Chunlei , PI, Shiqing , LU, Dingqiang , OUYANG, Pingkai
IPC分类号： C07C45/52 , C07C47/21
CPC分类号： C07C45/42 , C07C1/324 , C07C41/06 , C07C41/18 , C07C41/22 , C07C45/52 , C07F9/38 , C07C47/21
摘要： Provided in the present invention is a method for synthesizing 2,7-dimethyl-2,4,6-octatriene-1,8-dialdehyde. The synthesis method comprises the following steps: (1) adding acetaldehyde diethyl acetal and ethyl-(1-propenyl)-ether under the effect of a catalyst to produce 1,1,3-triethoxy-2-methyl-butane; (2) pyrolysis synthesizing 1,1,3-triethoxy-2-methyl-butane under the catalytic effects of isoquinoline and p-Toluenesulfonic acid to produce 1-methoxy-2-methyl-1,3-butadiene; (3) dissolving 1-methoxy-2-methyl-1,3-butadiene in anhydrous ethanol solvent for synthesis with a phase transfer catalyst, cetyl-trimethyl ammonium bromide, and a chlorinating agent, trichloroisocyanuric acid, to generate 4,4-diethoxy-3-methyl-1- chloro-butene; (4) combining 4,4-diethoxy-3-methyl-1-chloro-butene with a triphenylphosphine salt to produce a phosphonium salt; and (5) condensing the phosphonium salt under the effects of hydrogen peroxide in conjunction with sodium carbonate solution to generate 1,1,8,8-tetramethyl-2,7-dimethyl-2,4,6-octatriene; then hydrolyzing under acidic conditions to synthesize 2,7-dimethyl-2,4,6-octatriene-1,8- dialdehyde. The present invention has a simple process route, is easy to operate, and has mild conditions, great yield, and great industrial value.
摘要翻译：本发明提供了合成2,7-二甲基-2,4,6-辛二烯-1,8-二醛的方法。合成方法包括以下步骤：（1）在催化剂作用下加入乙醛缩二乙醇和乙基（1-丙烯基） - 醚，制得1,1,3-三乙氧基-2-甲基 - 丁烷; （2）在异喹啉和对甲苯磺酸的催化作用下热解合成1,1,3-三乙氧基-2-甲基 - 丁烷，得到1-甲氧基-2-甲基-1,3-丁二烯; （3）将1-甲氧基-2-甲基-1,3-丁二烯溶于无水乙醇溶剂中，用相转移催化剂，十六烷基三甲基溴化铵和氯化剂三氯异氰脲酸合成，得到4,4-二乙氧基 -3-甲基-1-氯 - 丁烯; （4）将4,4-二乙氧基-3-甲基-1-氯 - 丁烯与三苯基膦盐结合以产生鏻盐; 和（5）在过氧化氢与碳酸钠溶液的作用下将鏻盐缩合，生成1,1,8,8-四甲基-2,7-二甲基-2,4,6-辛三烯; 然后在酸性条件下水解合成2,7-二甲基-2,4,6-辛二烯-1,8-二醛。本发明工艺路线简单，操作方便，条件温和，产量大，工业价值高。

10. 发明公开

EP2799418A1 PREPARATION METHOD OF LYCOPENE INTERMEDIATE 3-METHYL-4,4-DIALKOXY-1-BUTALDEHYDE 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG DES LYCOPIN-ZWISCHENPRODUKTS 3-甲基-4,4-二甲氧基-1-丁氧基
公开(公告)号：EP2799418A1
公开(公告)日：2014-11-05
申请号：EP12862813.8
申请日：2012-12-10
申请人： Nanjing University Of Technology , Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： LV, Chunlei , PI, Shiqing , CHEN, Jianhui , LU, Dingqiang , OUYANG, Pingkai
IPC分类号： C07C45/00 , C07C47/198
CPC分类号： C07C45/30 , C07C41/22 , C07C45/00 , C07C45/516 , C07C47/198
摘要： Disclosed is a preparation method of the lycopene intermediate 3-methyl-4,4-dialkoxy-1-butaldehyde. The preparation method comprises the following steps: (1) reacting 2-methyl-3,3-dialkoxy-1-halopropane with magnesium powder in the solvent of anhydrous tetrahydrofuran at a temperature of 45~65°C to generate a mixture of Grignard reagents under the protection of an inert gas; and (2) adding N,N-disubstituted carboxamide to the mixture of Grignard reagents and reacting at a temperature of 10°C~35°C to obtain 3-methyl-4,4-dialkoxy-1-butaldehyde. The process route of the present invention is simple and direct, the operation is easy, the conditions are mild and the yield is good, and thus the invention has commercial value.
摘要翻译：公开了番茄红素中间体3-甲基-4,4-二烷氧基-1-丁醛的制备方法。制备方法包括以下步骤：（1）将4-甲基-3,3-二烷氧基-1-卤代丙烷与镁粉末在无水四氢呋喃的溶剂中在45〜65℃的温度下反应，生成格氏试剂在惰性气体的保护下; 和（2）将N，N-二取代的甲酰胺加入到格氏试剂混合物中，并在10℃〜35℃的温度下反应，得到3-甲基-4,4-二烷氧基-1-丁醛。本发明的工艺路线简单直接，操作容易，条件温和，产量好，因此本发明具有商业价值。

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