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1. 发明公开

EP2363475A4 SCREENING METHOD, COMPOSITION CONTAINING SUBSTANCE SELECTED BY THE SCREENING METHOD, AND BINDING SUBSTANCE 审中-公开
标题翻译：检查方法，成分与程序选择的材料的筛选和结合物质
公开(公告)号：EP2363475A4
公开(公告)日：2012-07-18
申请号：EP09829147
申请日：2009-11-26
申请人： REDOX BIOSCIENCE INC
发明人： YODOI JUNJI , KONDO NORIHIKO , SON AOI , KATO NORIKO , HARA TOMIJIRO , HORIBE TOMOHISA
IPC分类号： C12N15/09 , C07D307/935 , C07K5/037 , C07K14/47 , G01N21/27 , G01N33/53
CPC分类号： C12Y108/01008 , C07D307/935 , C12N9/0036 , C12N15/1055 , G01N2500/00

2. 发明公开

EP1716860A4 PREVENTIVE AND THERAPEUTIC AGENT FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE 审中-公开
标题翻译：手段防治慢性阻塞性肺疾病
公开(公告)号：EP1716860A4
公开(公告)日：2008-03-05
申请号：EP05710288
申请日：2005-02-09
申请人： REDOX BIOSCIENCE INC
发明人： YODOI JUNJI , SON AOI , NAKAMURA HAJIME
IPC分类号： A61K38/00 , A61K38/44 , A61P11/00
CPC分类号： A61K38/44
摘要： [PROBLEMS] To provide a preventive and therapeutic agent of high efficacy with reduced side effects for chronic obstructive pulmonary disease. [MEANS FOR SOLVING PROBLEMS] There is provided a preventive and therapeutic agent for chronic obstructive pulmonary disease, comprising a thioredoxin superfamily polypeptide as an active ingredient.

3. 发明公开

EP2363475A1 SCREENING METHOD, COMPOSITION CONTAINING SUBSTANCE SELECTED BY THE SCREENING METHOD, AND BINDING SUBSTANCE 审中-公开
标题翻译： FF FF EN EN UNG FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF FF
公开(公告)号：EP2363475A1
公开(公告)日：2011-09-07
申请号：EP09829147.9
申请日：2009-11-26
申请人： Redox Bioscience Inc.
发明人： YODOI Junji , KONDO, Norihiko , SON Aoi , KATO Noriko , HARA Tomijiro , HORIBE Tomohisa
IPC分类号： C12N15/09 , C07D307/935 , C07K5/037 , C07K14/47 , G01N21/27 , G01N33/53
CPC分类号： C12Y108/01008 , C07D307/935 , C12N9/0036 , C12N15/1055 , G01N2500/00
摘要： Disclosed is a screening method which can select a substance having an influence on the binding between thioredoxin and MIF. The screening method is characterized in that a test substance capable of enhancing the binding between a polypeptide belonging to the thioredoxin family and a macrophage migration inhibitory factor is selected through the steps of mixing at least one binding substance selected from the substances (1) to (4) shown below with the test substance, allowing the binding substance to bind to the macrophage migration inhibitory factor, and confirming the binding between the binding substance and the macrophage migration inhibitory factor: (1) a polypeptide belonging to the thioredoxin family; (2) a protein which comprises an amino acid sequence produced by deleting, substituting or adding one or several amino acid residues in an amino acid sequence for a polypeptide belonging to the thioredoxin family and has the same activity as that of a polypeptide belonging to the thioredoxin family; (3) a gene encoding the polypeptide (1); and (4) a gene encoding the protein (2).
摘要翻译：公开了可以选择对硫氧还蛋白与MIF结合有影响的物质的筛选方法。筛选方法的特征在于，通过以下步骤选择能够增强属于硫氧还蛋白家族的多肽与巨噬细胞迁移抑制因子之间的结合的测试物质：将至少一种选自物质（1）至（ 4），允许结合物质结合巨噬细胞迁移抑制因子，并确认结合物质与巨噬细胞迁移抑制因子之间的结合：（1）属于硫氧还蛋白家族的多肽; （2）一种蛋白质，其包含通过在属于硫氧还蛋白家族的多肽的氨基酸序列中缺失，取代或添加一个或几个氨基酸残基而产生的氨基酸序列，并且具有与属于该硫氧还蛋白家族的多肽相同的活性硫氧还蛋白家族（3）编码多肽（1）的基因; 和（4）编码蛋白质的基因（2）。

4. 发明公开

EP1716860A9 PREVENTIVE AND THERAPEUTIC AGENT FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE 审中-公开
标题翻译：预防和治疗慢性阻塞性肺疾病的药物
公开(公告)号：EP1716860A9
公开(公告)日：2008-12-10
申请号：EP05710288.1
申请日：2005-02-09
申请人： Redox Bioscience Inc.
发明人： YODOI, Junji , SON, Aoi , NAKAMURA, Hajime
IPC分类号： A61K38/00 , A61P11/00
CPC分类号： A61K38/44
摘要： [Problems]
To provide a preventive and therapeutic agent of high efficacy with reduced side effects for chronic obstructive pulmonary disease.
[Means for solving problems]
There is provided a preventive and therapeutic agent for chronic obstructive pulmonary disease, comprising a thioredoxin superfamily polypeptide as an active ingredient.
摘要翻译： [问题]提供一种对慢性阻塞性肺病的副作用降低，疗效高的预防和治疗剂。解决问题的手段提供了一种用于慢性阻塞性肺病的预防和治疗剂，其包含硫氧还蛋白超家族多肽作为活性成分。

5. 发明公开

EP1736168A4 PROTEASE INHIBITOR AND PREVENTIVES OR REMEDIES FOR DISEASES 审中-公开
标题翻译：蛋白酶抑制剂和手段预防和治疗疾病的
公开(公告)号：EP1736168A4
公开(公告)日：2008-07-09
申请号：EP05720572
申请日：2005-03-11
申请人： REDOX BIOSCIENCE INC
发明人： HOSHINO TOMOAKI , AIZAWA HISAMICHI , YODOI JUNJI , NAKAMURA HAJIME
IPC分类号： A61K38/00 , A01K67/027 , A61K45/00 , A61K45/06 , A61K48/00 , A61P9/00 , A61P9/02 , A61P11/00 , C07K14/54 , C12N9/64 , C12N15/09 , G01N33/15 , G01N33/50
CPC分类号： A61K38/57 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K45/06 , C07K14/54 , C12N9/6475
摘要： [PROBLEMS] To provide a novel protease inhibitor and curative remedies and a therapeutic method for chronic obstructive pulmonary disease, immunodeficiency syndrome, alveolar proteinosis and circulatory diseases. [MEANS FOR SOLVING PROBLEMS] A protease inhibitor and a preventive or a remedy for chronic obstructive pulmonary disease or immunodeficiency syndrome characterized by containing at least one member selected from among redox active proteins and genes encoding the same; and a preventive or a remedy for chronic obstructive pulmonary disease, alveolar proteinosis or circulatory diseases characterized by containing at least one member selected from IL-18 and a gene encoding the same.

6. 发明公开

EP1716860A1 PREVENTIVE AND THERAPEUTIC AGENT FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE 审中-公开
标题翻译：慕尼黑朱美隆大酒店芙蓉隆CH CH UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG
公开(公告)号：EP1716860A1
公开(公告)日：2006-11-02
申请号：EP05710288.1
申请日：2005-02-09
申请人： Redox Bioscience Inc.
发明人： YODOI, Junji , SON, Aoi , NAKAMURA, Hajime
IPC分类号： A61K38/00 , A61P11/00
CPC分类号： A61K38/44
摘要： [Problems]
To provide a preventive and therapeutic agent of high efficacy with reduced side effects for chronic obstructive pulmonary disease.
[Means for solving problems]
There is provided a preventive and therapeutic agent for chronic obstructive pulmonary disease, comprising a thioredoxin superfamily polypeptide as an active ingredient.
摘要翻译： [问题]提供高效率的预防和治疗剂，减少慢性阻塞性肺疾病的副作用。解决问题的手段提供一种慢性阻塞性肺疾病的预防和治疗剂，其包含硫氧还蛋白超家族多肽作为活性成分。

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