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1. 发明公开

EP1825251A4 METHOD FOR ANALYZING LIPOPROTEINS 失效转让
标题翻译：法分析脂蛋白
公开(公告)号：EP1825251A4
公开(公告)日：2009-09-23
申请号：EP05811455
申请日：2005-11-24
申请人： OKAZAKI MITSUYO
发明人： OKAZAKI MITSUYO
IPC分类号： G01N30/86 , G01N30/88 , G01N33/92
CPC分类号： G01N30/8675 , G01N30/8679 , G01N33/92 , G01N2030/8813 , G01N2030/8831
摘要： A method of analysis of lipoproteins according to the present invention comprises the steps of: separating a plurality of classes of lipoproteins contained in a subject sample by liquid chromatography and then detecting signals derived from components included in the separated lipoproteins; and assuming that the lipoproteins are constituted of subclasses estimated from component peaks comprising anchor peaks and extra essential peaks and then calculating an approximated curve corresponding to summation of the component peaks using the above described detected signals.

2. 发明公开

EP1607740A1 METHOD OF LIPOPROTEIN ANALYSIS AND ANALYTICAL PROGRAM 审中-公开
标题翻译： VERFAHREN ZUR LIPOPROTEINANALYSE UND ANALYSEPROGRAMM
公开(公告)号：EP1607740A1
公开(公告)日：2005-12-21
申请号：EP04708887.7
申请日：2004-02-06
申请人： Usui, Shinichi , Okazaki, Mitsuyo , Kakuuchi, Hajime
发明人： Usui, Shinichi , Okazaki, Mitsuyo , Kakuuchi, Hajime
IPC分类号： G01N30/88 , G01N30/86
CPC分类号： G01N30/8624 , G01N2030/047
摘要： On a chromatogram wherein peaks corresponding to a plurality of classes of lipoproteins appear in a mixed form, components contained in the lipoproteins are quantitatively determined by class. The present invention comprises a first step of separating a plurality of classes of lipoproteins contained in a sample through liquid chromatography and assaying the components contained in the separated lipoproteins and a second step of dividing the chromatogram obtained in the above described first step by lipoprotein class and determining quantitatively the components contained in the lipoproteins by class.
摘要翻译：在其中对应于多种类型的脂蛋白的峰以混合形式出现的色谱图中，包含在脂蛋白中的成分通过等级进行定量测定。本发明包括通过液相色谱法分离样品中所含的多种类型的脂蛋白并分析包含在分离的脂蛋白中的组分的第一步骤，以及通过脂蛋白类和上述第一步骤获得的色谱分离的第二步骤根据课程定量测定脂蛋白中所含的成分。

3. 发明公开

EP1825251A1 METHOD FOR ANALYZING LIPOPROTEINS 失效转让
标题翻译：法分析脂蛋白
公开(公告)号：EP1825251A1
公开(公告)日：2007-08-29
申请号：EP05811455.4
申请日：2005-11-24
申请人： Okazaki, Mitsuyo
发明人： Okazaki, Mitsuyo
IPC分类号： G01N30/86 , G01N30/88
CPC分类号： G01N30/8675 , G01N30/8679 , G01N33/92 , G01N2030/8813 , G01N2030/8831
摘要： A method of analysis of lipoproteins according to the present invention comprises the steps of: separating a plurality of classes of lipoproteins contained in a subject sample by liquid chromatography and then detecting signals derived from components included in the separated lipoproteins; and assuming that the lipoproteins are constituted of subclasses estimated from component peaks comprising anchor peaks and extra essential peaks and then calculating an approximated curve corresponding to summation of the component peaks using the above described detected signals.

4. 发明授权

EP1825251B1 METHOD FOR ANALYZING LIPOPROTEINS 失效转让
公开(公告)号：EP1825251B1
公开(公告)日：2018-07-25
申请号：EP05811455.4
申请日：2005-11-24
申请人： Okazaki, Mitsuyo
发明人： Okazaki, Mitsuyo
IPC分类号： G01N30/86 , G01N30/88 , G01N33/92
CPC分类号： G01N30/8675 , G01N30/8679 , G01N33/92 , G01N2030/8813 , G01N2030/8831
摘要： A method of analysis of lipoproteins according to the present invention comprises the steps of: separating a plurality of classes of lipoproteins contained in a subject sample by liquid chromatography and then detecting signals derived from components included in the separated lipoproteins; and assuming that the lipoproteins are constituted of subclasses estimated from component peaks comprising anchor peaks and extra essential peaks and then calculating an approximated curve corresponding to summation of the component peaks using the above described detected signals.

5. 发明公开

EP3128328A4 METHOD FOR ANALYZING LIPOPROTEINS 有权
标题翻译： VERFAHREN ZUR分析VON LIPOPROTEINEN
公开(公告)号：EP3128328A4
公开(公告)日：2017-09-20
申请号：EP15772701
申请日：2015-04-02
申请人： OKAZAKI MITSUYO
发明人： OKAZAKI MITSUYO
IPC分类号： G01N33/92 , G01N30/88
CPC分类号： G01N33/92 , G01N30/8631 , G01N30/88 , G01N2030/8831
摘要： According to the present invention, the concentration of cholesterol ester or free cholesterol can be calculated using the concentrations of total cholesterol and triglyceride in lipoproteins contained in a sample. Further, according to the present invention, the concentration of lipoprotein particles in a fraction can be calculated using the lipoprotein particle size in the fraction. In the present invention, the concentrations of total cholesterol (Cho) and triglyceride (TG) contained in a subject sample are detected. Using the concentrations of Cho and TG thus detected, the concentration of cholesterol ester (CE) or free cholesterol (FC) is calculated. Further, using the concentration of cholesterol ester (CE) or free cholesterol (FC) thus calculated, the concentration of lipoprotein particles in a fraction can be calculated.
摘要翻译：根据本发明，胆固醇酯或游离胆固醇的浓度可以使用样品中所含的脂蛋白中的总胆固醇和甘油三酯的浓度来计算。此外，根据本发明，可以使用该级分中的脂蛋白粒径来计算级分中脂蛋白颗粒的浓度。在本发明中，检测对象样品中所含的总胆固醇（Cho）和甘油三酯（TG）的浓度。使用如此检测的Cho和TG的浓度，计算胆固醇酯（CE）或游离胆固醇（FC）的浓度。此外，使用如此计算的胆固醇酯（CE）或游离胆固醇（FC）的浓度，可计算一部分中脂蛋白颗粒的浓度。

6. 发明公开

EP3128328A1 METHOD FOR ANALYZING LIPOPROTEINS 有权
标题翻译： VERFAHREN ZUR ANALYZE VON LIPOPROTEINEN
公开(公告)号：EP3128328A1
公开(公告)日：2017-02-08
申请号：EP15772701.7
申请日：2015-04-02
申请人： Okazaki, Mitsuyo
发明人： Okazaki, Mitsuyo
IPC分类号： G01N33/92 , G01N30/88
CPC分类号： G01N33/92 , G01N30/8631 , G01N30/88 , G01N2030/8822 , G01N2030/8831
摘要： According to the present invention, the concentration of cholesterol ester or free cholesterol can be calculated using the concentrations of total cholesterol and triglyceride in lipoproteins contained in a sample. Further, according to the present invention, the concentration of lipoprotein particles in a fraction can be calculated using the lipoprotein particle size in the fraction. In the present invention, the concentrations of total cholesterol (Cho) and triglyceride (TG) contained in a subject sample are detected. Using the concentrations of Cho and TG thus detected, the concentration of cholesterol ester (CE) or free cholesterol (FC) is calculated. Further, using the concentration of cholesterol ester (CE) or free cholesterol (FC) thus calculated, the concentration of lipoprotein particles in a fraction can be calculated.
摘要翻译：根据本发明，可以使用样品中所含的脂蛋白中的总胆固醇和甘油三酯的浓度来计算胆固醇酯或游离胆固醇的浓度。此外，根据本发明，可以使用级分中的脂蛋白粒径来计算分数中的脂蛋白颗粒的浓度。在本发明中，检测受试样品中所含的总胆固醇（Cho）和甘油三酯（TG）的浓度。使用如此检测的Cho和TG的浓度，计算胆固醇酯（CE）或游离胆固醇（FC）的浓度。此外，使用如此计算的胆固醇酯（CE）或游离胆固醇（FC）的浓度，可以计算一部分中脂蛋白颗粒的浓度。

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