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1. 发明公开

EP2870980A3 Three-dimensional neural probe microelectrode array and method of manufacture 失效转让
标题翻译：德意志帝国主义与民主主义者赫尔斯特隆（Dreidimensionale Nervensondenmikroelektrodenanordnung und Verfahren zur Herstellung
公开(公告)号：EP2870980A3
公开(公告)日：2015-08-05
申请号：EP14192442.3
申请日：2014-11-10
申请人： NeuroNexus Technologies, Inc.
发明人： Vetter, Rio J. , Hetke, Jamille Farraye , Pellinen, David S. , Suwarato, Bencharong , Kong, Kc
IPC分类号： A61N1/05 , A61B5/04 , A61B5/00 , A61B5/0478 , A61N1/04 , H01R43/26
CPC分类号： A61N1/0529 , A61B5/04001 , A61B5/0478 , A61B5/6868 , A61B5/6882 , A61N1/0456 , A61N1/0472 , A61N1/0539 , H01R43/26 , Y10T29/49169
摘要： A three-dimensional neural probe electrode array system is described. Planar probes are microfabricated and electrically connected to flexible micro-machined ribbon cables using a rivet bonding technique. The distal end of each cable is connected to a probe with the proximal end of the cable being customized for connection to a printed circuit board. Final assembly consists of combining multiple such assemblies into a single structure. Each of the two-dimensional neural probe arrays is positioned into a micro-machined platform that provides mechanical support and alignment for each array. Lastly, a micro-machined cap is placed on top of each neural electrode probe and cable assembly to protect them from damage during shipping and subsequent use. The cap provides a relatively planar surface for attachment of a computer controlled inserter for precise insertion into the tissue.
摘要翻译：描述了三维神经探针电极阵列系统。平面探针是微制造的，并使用铆钉接合技术电连接到柔性微加工的带状电缆。每个电缆的远端连接到探针，电缆的近端被定制以连接到印刷电路板。最终组装包括将多个这样的组件组合成单个结构。每个二维神经探针阵列被定位在微加工平台中，为每个阵列提供机械支撑和对准。最后，在每个神经电极探头和电缆组件的顶部放置一个微加工帽，以防止在运输和后续使用过程中损坏它们。盖提供相对平坦的表面，用于附接计算机控制的插入器以精确地插入到组织中。

2. 发明公开

EP2870980A2 Three-dimensional neural probe microelectrode array and method of manufacture 失效转让
标题翻译：三维神经探针微电极阵列及其制造方法
公开(公告)号：EP2870980A2
公开(公告)日：2015-05-13
申请号：EP14192442.3
申请日：2014-11-10
申请人： NeuroNexus Technologies, Inc.
发明人： Vetter, Rio J. , Hetke, Jamille Farraye , Pellinen, David S. , Suwarato, Bencharong , Kong, Kc
IPC分类号： A61N1/05 , A61B5/04
CPC分类号： A61N1/0529 , A61B5/04001 , A61B5/0478 , A61B5/6868 , A61B5/6882 , A61N1/0456 , A61N1/0472 , A61N1/0539 , H01R43/26 , Y10T29/49169
摘要： A three-dimensional neural probe electrode array system is described. Planar probes are microfabricated and electrically connected to flexible micro-machined ribbon cables using a rivet bonding technique. The distal end of each cable is connected to a probe with the proximal end of the cable being customized for connection to a printed circuit board. Final assembly consists of combining multiple such assemblies into a single structure. Each of the two-dimensional neural probe arrays is positioned into a micro-machined platform that provides mechanical support and alignment for each array. Lastly, a micro-machined cap is placed on top of each neural electrode probe and cable assembly to protect them from damage during shipping and subsequent use. The cap provides a relatively planar surface for attachment of a computer controlled inserter for precise insertion into the tissue.
摘要翻译：描述了三维神经探针电极阵列系统。平面探针采用铆钉粘合技术进行微制造并与柔性微机械带状电缆电连接。每根电缆的远端连接到探针，电缆的近端定制为连接到印刷电路板。最终装配由将多个此类装配组合成单个结构组成。每个二维神经探针阵列都位于一个微机械平台中，为每个阵列提供机械支撑和对准。最后，在每个神经电极探针和电缆组件顶部放置一个微加工帽，以防止它们在运输和随后使用过程中受到损坏。帽提供相对平坦的表面用于附接计算机控制的插入器以精确插入组织中。

3. 发明公开

EP2736587A2 NEURAL DEVICE WITH MODULAR ELECTRODE ARRAY 失效转让
标题翻译：神经元VORRICHTUNG MIT MODULARER ELEKTRODENANORDNUNG
公开(公告)号：EP2736587A2
公开(公告)日：2014-06-04
申请号：EP12751636.7
申请日：2012-07-24
申请人： NeuroNexus Technologies, Inc.
发明人： Kipke, Daryl R. , Vetter, Rio J. , Kong, Kc , Hetke, Jamille , Anderson, David
IPC分类号： A61N1/05 , A61B5/0478 , A61B5/00 , A61N5/06
CPC分类号： A61N1/0476 , A61B5/0059 , A61B5/04001 , A61B5/0478 , A61B5/4064 , A61B5/4094 , A61B2562/0209 , A61B2562/046 , A61N1/0502 , A61N1/0531 , A61N1/36064 , A61N5/06 , A61N5/0622 , Y10T29/49117
摘要： An apparatus comprises a flexible substrate including a modular electrode array disposed on the flexible substrate. The modular electrode array includes a plurality of electrode modules, where an electrode module includes a plurality of electrodes. The flexible substrate also includes a spatial separation between the electrode modules of the modular electrode array, and conductive interconnect coupled to the electrodes of the plurality of electrodes.
摘要翻译：一种装置包括柔性基板，其包括设置在柔性基板上的模块化电极阵列。模块化电极阵列包括多个电极模块，其中电极模块包括多个电极。柔性基板还包括模块化电极阵列的电极模块与耦合到多个电极的电极的导电互连之间的空间间隔。

4. 发明公开

EP2712323A1 DISTRIBUTED NEURAL STIMULATION ARRAY SYSTEM 审中-公开
标题翻译：分布式神经刺激场系统
公开(公告)号：EP2712323A1
公开(公告)日：2014-04-02
申请号：EP12743606.1
申请日：2012-07-24
申请人： Neuronexus Technologies, Inc.
发明人： KIPKE, Daryl R. , ANDERSON, David , VETTER, Rio J. , HETKE, Jamille
IPC分类号： A61N1/05 , A61B5/04 , A61M5/142
CPC分类号： A61N1/0551 , A61B5/04001 , A61B2562/125 , A61M5/14276 , A61N1/0534 , A61N1/0553 , H05K13/0023 , Y10T29/49002 , Y10T29/49117
摘要： A device comprises a device carrier having a substantially cylindrical shape and including an array of neural probes. The array of neural probes extend substantially longitudinally from a distal end of the device carrier and include a plurality of central neural probes, wherein a central probe includes at least one stimulating electrode site, and a plurality of peripheral neural probes arranged at a periphery of the plurality of central neural probes, wherein a peripheral neural probe is electrically conducting.

5. 发明公开

EP2456513A1 MEDICAL DEVICE FOR ELECTRICAL STIMULATION 有权转让
标题翻译：医疗设备，电刺激
公开(公告)号：EP2456513A1
公开(公告)日：2012-05-30
申请号：EP10742283.4
申请日：2010-07-16
申请人： Sapiens Steering Brain Stimulation B.V. , Neuronexus Technologies, Inc.
发明人： HARBERTS, Dirk Willem , VETTER, Rio
IPC分类号： A61N1/05 , A61N1/37 , A61N1/08
CPC分类号： A61N1/0534 , A61N1/00 , A61N1/086 , A61N1/36082
摘要： The present invention relates to a medical device (2) for electrical stimulation. The device comprising an implantable elongated lead system (20) having a distal end (21) and a proximal end (22), the lead system comprises one or more electrical conductors (23) for connection to one or more electrodes (24). The one or more electrical conductors are wound along a length axis (25) of the lead system with a plurality of windings, and wherein the density of windings is non-uniformly distributed along the length axis. In an embodiment, the medical device is in the form of a deep brain stimulation (DBS) device.

6. 发明授权

EP3254726B1 OMNIDIRECTIONAL DEPLOYABLE MULTICHANNEL NEURAL ELECTRODE SYSTEM 有权
公开(公告)号：EP3254726B1
公开(公告)日：2020-07-08
申请号：EP17175025.0
申请日：2014-10-21
申请人： NeuroNexus Technologies, Inc.
发明人： PELLINEN, David S. , SUWARATO, Bencharong , VETTER, Rio J. , HETKE, Jamille Farraye , KIPKE, Daryl R.
IPC分类号： A61N1/05 , A61N1/36 , A61B5/04

7. 发明授权

EP2542303B1 SYSTEM FOR DETERMINING SETTINGS FOR DEEP BRAIN STIMULATION 有权转让
标题翻译：系统定义DER EINSTELLUNGENFÜRTIEFE HIRNSTIMULATION
公开(公告)号：EP2542303B1
公开(公告)日：2017-04-05
申请号：EP11713055.9
申请日：2011-02-25
申请人： Medtronic Bakken Research Center B.V. , Neuronexus Technologies, Inc.
发明人： TOADER, Emil , MARTENS, Hubert, Cécile, François , DECRE, Michel, Marcel, Jose , BUDZELAAR, Franciscus, Paulus, Maria , BLANKEN, Pieter, Gerrit , ANDERSON, David, James
IPC分类号： A61N1/36 , A61N1/05 , A61N1/00
CPC分类号： A61N1/36139 , A61N1/00 , A61N1/0534 , A61N1/36185
摘要： A method and a control system (20) are provided for determining a relation between stimulation settings for a brain stimulation probe (10) and a corresponding V-field. The brain stimulation probe (10) comprises multiple stimulation electrodes (11). The V-field is an electrical field in brain tissue surrounding the stimulation electrodes (11). The method comprises sequentially applying a test current to n stimulation electrodes (11), n being a number between 2 and the number of stimulation electrodes (11) of the brain stimulation probe (10), for each test current at one of the n stimulation electrodes (11), measuring a resulting excitation voltage at m stimulation electrodes, m being a number between 2 and the number of stimulation electrodes (11) of the brain stimulation probe (10), from the stimulation settings and the measured excitation voltages, deriving an (m*{acute over (&eegr;)}) coupling matrix, an element (q, p) in the coupling matrix reflecting an amount of electrical impedance between two of the stimulation electrodes (11), and using the coupling matrix for determining the relation between the stimulation settings and the corresponding V-field.
摘要翻译：提供了一种方法和控制系统（20），用于确定脑刺激探针（10）的刺激设置与对应的V场之间的关系。脑刺激探针（10）包括多个刺激电极（11）。 V场是围绕刺激电极（11）的脑组织中的电场。该方法包括对n个刺激电极（11）依次施加测试电流，n是在刺激探针（10）的刺激电极（11）的数量之间的数量，对于n个刺激中的一个刺激的每个测试电流电极（11），根据刺激设置和所测量的激发电压，测量m个刺激电极处的所得激励电压，m为大脑刺激探针（10）的刺激电极（11）的数量和2的数量，导出耦合矩阵中的元素（q，p），反映两个刺激电极（11）之间的电阻抗的量，并且使用用于确定的耦合矩阵刺激设置与对应的V字段之间的关系。

8. 发明公开

EP2736566A1 NEURAL DRUG DELIVERY SYSTEM WITH MICROVALVES 无效转让
标题翻译：神经元ARZNEIMITTELABGABESYSTEM MIT MIKROVENTILEN
公开(公告)号：EP2736566A1
公开(公告)日：2014-06-04
申请号：EP12746175.4
申请日：2012-07-24
申请人： NeuroNexus Technologies, Inc.
发明人： HEWITT, Nicholas D. , HETKE, Jamille , KIPKE, Daryl R. , VETTER, Rio J. , SEYMOUR, John
IPC分类号： A61M5/168 , A61M5/142 , A61M25/00 , A61N1/05
CPC分类号： A61M25/0021 , A61M5/14276 , A61M5/16881 , A61M25/0009 , A61M25/0012 , A61M25/0015 , A61M25/007 , A61M25/0075 , A61M25/0102 , A61M2025/0042 , A61M2210/0693 , A61N1/05 , Y10T29/49416
摘要： An apparatus comprises a tubular body (110) having a lumen and a distal region (115), a plurality of ports at the distal region of the tubular body, and a plurality of independently gatable microvalves (120) disposed at the plurality of ports. A port extends from internal to the lumen to outside the tubular body, and a gatable microvalve is controllable by a stimulus to provide and prevent fluidic transfer through the ports.
摘要翻译：一种装置包括具有内腔和远端区域的管状体，管状体的远端区域处的多个端口以及设置在多个端口处的多个独立的可置放的微型阀。端口从内部延伸到内腔到管状体的外部，并且可控的微型阀可以通过刺激来控制，以提供和防止通过端口的流体传输。

9. 发明公开

EP2736406A1 NEUROMODULATION TRANSFECTION SYSTEM WITH MEANS FOR ACTIVE FLUID DELIVERY AND A METHOD FOR ITS USE 有权转让
标题翻译：与设备为主动供液及其使用方法NEUROMODULATIONSTRANSFEKTIONSSYSTEM
公开(公告)号：EP2736406A1
公开(公告)日：2014-06-04
申请号：EP12743611.1
申请日：2012-07-25
申请人： Neuronexus Technologies, Inc.
发明人： SEYMOUR, John, P. , KONG, Kc , VETTER, Rio, J.
IPC分类号： A61B5/04 , A61N1/05 , A61N5/06 , A61N1/32
CPC分类号： A61N5/0622 , A61B5/04001 , A61B5/4839 , A61B5/6868 , A61B2562/046 , A61N1/0529 , A61N1/0551 , A61N1/327 , A61N2005/0612 , A61N2005/063 , A61N2005/0651 , A61N2005/067
摘要： A neural interface array including an optical waveguide, a thin film electrode array associated with the optical waveguide, the thin film electrode array having a plurality of electrodes, and a fluid delivery channel attached to at least one of the optical waveguide and the thin film electrode array. Also disclosed are methods for optical stimulation and a neural interface system with active fluid delivery.
摘要翻译：甲神经接口阵列，其包括波导光学，与光波导相关联的薄膜电极阵列，附接到所述光波导中的至少一个和所述薄膜电极具有电极的多个，并且一个流体输送通道薄膜电极阵列阵列。所以光盘游离缺失是用于光学刺激，并与活性流体递送的神经接口系统的方法。

10. 发明公开

EP2634588A2 System and method for testing electrical circuits using a photoelectrochemical effect 有权
标题翻译：系统与Verfahren zumPrüfenvon Stromkreisen mit einem photoelektrochemischen Effekt
公开(公告)号：EP2634588A2
公开(公告)日：2013-09-04
申请号：EP13157400.6
申请日：2013-03-01
申请人： NeuroNexus Technologies, Inc.
发明人： Seymour, John P. , Khurram, Abeer
IPC分类号： G01R1/067
CPC分类号： G01R31/026 , G01R1/06783
摘要： A test system for medical devices that does not require physical contact with an electrical site along a conductive path is described. Not having to physical contact an electrical site while performing an electrical continuity test avoids potential damage to the site. The test system includes a fluidic channel that dispenses an electrolytic solution onto a first electrical site on the conductive path. A light source irradiates the first site to thereby induce a photoelectrochemical (PEC) effect at an interface thereof. The PEC effect produces a change in both the potential (i.e., voltage) and current carrying ability in the conductive path. That voltage or current is measured at a second site to determine whether there is electrical continuity or discontinuity between the sites on the conductive path.
摘要翻译：描述了不需要沿着导电路径与电站物理接触的用于医疗设备的测试系统。在进行电气连续性测试时，不必物理接触电气部件，从而避免对现场造成潜在的损害。测试系统包括将电解溶液分配到导电路径上的第一电场上的流体通道。光源照射第一部位，从而在其界面处诱导光电化学（PEC）效应。 PEC效应在导电路径中产生电位（即电压）和载流能力两者的变化。在第二位置处测量该电压或电流，以确定在导电路径上的位置之间是否存在电连续性或不连续性。

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