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    • 8. 发明公开
    • FIBER-TREATING AGENT
    • FASERBEHANDLUNGSMITTEL
    • EP2653606A4
    • 2017-10-04
    • EP11848125
    • 2011-12-13
    • KAO CORP
    • SATO TOMOYAINOUE KATSUHISAOHISHI SHUNNOMURA MASATO
    • D06M13/165D06M13/17D06M13/224D06M15/53
    • D06M23/02C10M105/34D06M13/165D06M13/17D06M13/224D06M15/53
    • The present invention discloses a fiber treatment agent containing an ester compound represented by the formula (1): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR 1 -O-((EO) l -(PO) m )-(EO) n -CO-R 2 €ƒ€ƒ€ƒ€ƒ€ƒ(1) wherein, R 1 represents a hydrocarbon group containing 8 to 24 carbon atoms; R 2 represents an alkyl, alkenyl or cycloalkyl group having 7 to 23 carbon atoms; EO represents an ethyleneoxy group; PO represents a propyleneoxy group; l and n each represent an average reacted mole number of ethyleneoxy groups, 1 ranging from 0 to 15 and n ranging from 1 to 20; m represents an average reacted mole number of propyleneoxy groups, ranging from 0.5 to 20; and ((EO) l -(PO) m ) and (EO) n are arranged in block in this order, while (EO) l and (PO) m in ((EO) l -(PO) m ) may be arranged at random or in block.
    • 本发明公开了一种纤维处理剂,其含有式(1)所示的酯化合物:R 1 -O-((EO)l - (PO)m ) - (EO)n -CO-R 2(1)其中,R 1表示含有8-24个碳原子的烃基; R 2表示具有7至23个碳原子的烷基,烯基或环烷基; EO代表亚乙氧基; PO代表亚丙基氧基; l和n各自表示亚乙氧基的平均反应摩尔数,1为0-15,n为1-20; m代表丙烯氧基的平均反应摩尔数,为0.5至20; 和((EO)l - (PO)m)和(EO)n按顺序嵌段排列,而((EO)l - (PO)m)中的(EO) 随机或分块。
    • 9. 发明公开
    • METHOD FOR EVALUATING OR SELECTING GIP RISE INHIBITOR
    • VERFAHREN ZUR BEURTEILUNG ODER AUSWAHL VON EINES GIP-ANSTIEGSHEMMERS
    • EP3124966A4
    • 2017-09-27
    • EP15769760
    • 2015-03-06
    • KAO CORP
    • KOGA YOSHITAKAOSAKI NORIKOWATANABE MANABU
    • C12Q1/68G01N33/92
    • G01N33/5023C12Q1/68G01N33/92G01N2500/10G01N2800/042
    • A method for evaluating or selecting an agent for suppressing GIP level elevation, comprising the following steps (A) to (D): (A) contacting a test substance with a mammal-derived tissue or cell capable of expressing an FABP4 gene or FABP5 gene, or an FABP4 protein or FABP5 protein; (B) measuring an expression level of the FABP4 gene or FABP5 gene, an expression level of the FABP4 protein or FABP5 protein, or an activity of the FABP4 protein or FABP5 protein in the mammal-derived tissue or cell; (C) comparing the expression level or activity measured in the above (B) with an expression level of an FABP4 gene or FABP5 gene, an expression level of an FABP4 protein or FABP5 protein, or an activity of an FABP4 protein or FABP5 protein in a control group; and (D) evaluating or selecting a test substance which reduces the expression level of the FABP4 gene or FABP5 gene, the expression level of the FABP4 protein or FABP5 protein, or the activity of the FABP4 protein or FABP5 protein as an agent suppressing GIP level elevation based on results of the above (C).
    • (A)〜(D):(A)使被检物质与能够表达FABP4基因或FABP5基因的哺乳动物来源的组织或细胞接触 ,或FABP4蛋白或FABP5蛋白; (B)测量哺乳动物来源的组织或细胞中FABP4基因或FABP5基因的表达水平,FABP4蛋白质或FABP5蛋白质的表达水平,或FABP4蛋白质或FABP5蛋白质的活性; (C)将上述(B)中测定的表达水平或活性与FABP4基因或FABP5基因的表达水平,FABP4蛋白质或FABP5蛋白质的表达水平,或FABP4蛋白质或FABP5蛋白质的活性 对照组; (D)评估或选择降低FABP4基因或FABP5基因的表达水平,FABP4蛋白或FABP5蛋白的表达水平,或作为抑制GIP水平的药剂的FABP4蛋白或FABP5蛋白的活性的测试物质 基于上述(C)的结果的高程。