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    • 9. 发明授权
    • SPRAY-DRIED CRYSTALLINE ACTIVE INGREDIENT
    • 喷雾干燥结晶活性成分
    • EP2552234B1
    • 2013-12-04
    • EP11716063.0
    • 2011-03-28
    • Firmenich S.A.
    • GREGSON, Christopher M.SKIFF, Ronald H.TRIOLO, Ferdinand M.
    • A23L1/00A23L1/22A61K8/11A61K9/14
    • A61K9/145A23L27/72A23P10/30
    • A process for preparing a spray-dried product for improving the rate of dissolution of the active ingredient. The process includes mixing a crystalline active ingredient, which has a dissolution rate in unstirred water at 25° C. of greater than 15 minutes at a concentration of 14 ppm of the active ingredient, with a starch derivative, a second carrier material, and optionally, xanthan gum, to form a suspension, dispersion or solution of the active ingredient; homogenizing the mixture at a pressure of at least 4000 psig (2.758×107 Pa); and spray-drying the homogenized mixture to provide a spray-dried active ingredient that has an increased dissolution rate in water compared to the unencapsulated active ingredient.
    • 制备用于改善活性成分溶解速率的喷雾干燥产物的方法。 该方法包括将结晶活性成分与淀粉衍生物,第二载体材料以及任选地在25℃下在未搅拌的水中溶解速率大于15分钟,浓度为14ppm的活性成分混合 ,黄原胶,以形成活性成分的悬浮液,分散液或溶液; 在至少4000psig(2.758×107Pa)的压力下均化该混合物; 和喷雾干燥均化的混合物以提供喷雾干燥的活性成分,与未包封的活性成分相比,该活性成分在水中的溶解速率增加。