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1. 发明授权

EP1539039B1 METHOD AND APPARATUS FOR LOADING A BENEFICIAL AGENT INTO AN EXPANDABLE MEDICAL DEVICE 无效
标题翻译：方法和设备用于充填治疗剂引入医疗设备，可膨胀
公开(公告)号：EP1539039B1
公开(公告)日：2016-01-20
申请号：EP03754807.0
申请日：2003-09-22
申请人： Conor Medsystems, Inc.
发明人： DIAZ, Stephen, Hunter , SHANLEY, John F , PARK, Kinam
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2/91 , A61F2/915 , A61F2002/061 , A61F2002/821 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91541 , A61F2002/91558 , A61F2250/0068 , A61L31/146 , A61L31/16 , A61L2300/252 , A61L2300/416 , B01D1/18

2. 发明授权

EP1772122B1 Expandable medical device for delivery of beneficial agent 有权
标题翻译：用于递送有益剂的可扩张医疗装置
公开(公告)号：EP1772122B1
公开(公告)日：2015-12-09
申请号：EP07001394.1
申请日：2002-06-05
申请人： Conor Medsystems, Inc.
发明人： Shanley, John F. , Eigler, Neal L. , Park, Kinam , Edelman, Elazar R.
IPC分类号： A61L31/10 , A61L31/14 , A61L31/16 , A61F2/91 , A61F2/915
CPC分类号： A61L31/10 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2210/0004 , A61F2210/0076 , A61F2250/003 , A61F2250/0031 , A61F2250/0068 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/42 , A61L2300/602 , A61L2300/622
摘要： Expandable medical device comprising: elongated struts (18) joined together to form a cylindrical device (12) which is expandable from a cylinder having a first diameter to a cylinder with a second diameter, struts having width and thickness in a radial direction, at least one opening (16) in at least one of the struts, and at least one beneficial agent provided in the at least one opening in layers, is new. Expandable medical device comprises: (a) elongated struts(18) , elongated struts joined together to form a cylindrical device (12) which is expandable from a cylinder having a first diameter to a cylinder with a second diameter; (b) struts each having strut width in a circumferential direction and a strut thickness in a radial direction; (c) at least one opening (16) in at least one of the struts; and (d) at least one beneficial agent provided in the at least one opening in layers Independent claims are also included for the following: (1) an expandable medical device for treating cardiac arrhythmias, comprising: an expandable cylindrical device having struts with openings containing a chemically ablative, the openings being configured to deliver the ablative to tissue surrounding the device without permanently trapping any agent in the openings; and (2) a method of forming an expandable medical device by providing the device with struts joined together to form a device which is expandable from a cylinder with a first diameter to a cylinder with a second diameter; forming at least one opening in at least one of the struts, and delivering at least one beneficial agent into the at least one opening in layers.

3. 发明授权

EP1551473B1 THERAPEUTIC AGENT DELIVERY DEVICE WITH PROTECTIVE SEPARATING LAYER 有权
标题翻译： DEVICE对于治疗剂与结束分娩切割保护涂层
公开(公告)号：EP1551473B1
公开(公告)日：2015-12-09
申请号：EP03759501.4
申请日：2003-09-22
申请人： Conor Medsystems, Inc.
发明人： SHANLEY, John F. , PARKER, Theodore, L.
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61F2/91 , A61F2/2493 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2210/0004 , A61F2250/003 , A61F2250/0031 , A61F2250/0068 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/604 , A61L2300/608
摘要： An implantable medical device is disclosed, comprising: an implantable device body 10 having a plurality of through holes 20 therein; a barrier layer 66 formed in the plurality of through holes 20, the barrier layer 66 formed of a biodegradable copolymer having a copolymer ratio; a drug filled portion 60, 62 formed in the plurality of through holes 20 adjacent the barrier layer 66; and a cap layer 64 formed in the plurality of holes 20 adjacent the drug filled portion 60, 62, wherein said cap layer 64 is different from said barrier layer 66.

4. 发明公开

EP2263619A3 Expandable medical advice for delivery of beneficial agent 审中-公开
标题翻译：用于递送有益剂的可扩张医疗装置
公开(公告)号：EP2263619A3
公开(公告)日：2012-02-29
申请号：EP10010592.3
申请日：2002-06-05
申请人： Conor Medsystems, Inc.
发明人： Park, Kinam , Shanley, John F. , Edelman, Elazer R. , Eigler, Neal L.
IPC分类号： A61F2/90 , A61L31/14 , A61L31/16 , A61L31/10
CPC分类号： A61L31/10 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2210/0004 , A61F2210/0076 , A61F2250/003 , A61F2250/0031 , A61F2250/0068 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/42 , A61L2300/602 , A61L2300/622
摘要： A drug delivery device comprises an exterior surface; an interior surface; a plurality of openings traversing said exterior surface and said interior surface, said openings having a barrier layer (52) arranged at a radially intermediate position with respect to said exterior surface and said interior surface; at least one first therapeutic agent (62, 64) in a therapeutic layer disposed at a radially exterior position with respect to said barrier layer (52); and at least one second therapeutic agent (60) in a therapeutic layer disposed at a radially interior position with respect to said barrier layer (52).

5. 发明公开

EP1768735A4 METHOD AND APPARATUS FOR LOADING A BENEFICIAL AGENT INTO AN EXPANDABLE MEDICAL DEVICE 有权转让
标题翻译：方法和设备，用于加载的有益物质为张开的医疗设备
公开(公告)号：EP1768735A4
公开(公告)日：2011-08-17
申请号：EP05761968
申请日：2005-06-15
申请人： CONOR MEDSYSTEMS INC
发明人： SHANLEY JOHN F , DIAZ STEPHEN HUNTER
IPC分类号： A61F2/24 , A61F2/00 , A61F2/06 , A61F2/90 , A61M25/00
CPC分类号： A61L31/16 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2240/001 , A61F2250/0068 , A61L2300/63

6. 发明公开

EP2289571A1 Implantable medical device with beneficial agent concentration gradient 有权
标题翻译：可植入的医疗装置，其包含治疗物质KONTINUERLICHEM梯度
公开(公告)号：EP2289571A1
公开(公告)日：2011-03-02
申请号：EP10010594.9
申请日：2004-03-29
申请人： Conor Medsystems, Inc.
发明人： Park, Kinam , Shanley, John F. , Parker, Theodore L.
IPC分类号： A61L27/34 , A61L29/08 , A61L29/16 , A61L31/12
CPC分类号： A61L31/08 , A61L31/041 , A61L31/10 , A61L31/16 , A61L2300/60 , A61L2300/604
摘要： A method of forming an implantable medical device configured to release at least one therapeutic agent therefrom comprises disposing the therapeutic agent in a matrix affixed to a body of the implantable medical device, wherein a concentration of the at least one therapeutic agent in the matrix varies as a continuous gradient relative to a surface of the implantable medical device body, the method comprising: forming a homogeneous solution comprising a polymeric binder and a solvent; evaporating the solvent in the homogeneous solution, thereby forming a matrix; exposing the matrix to a solution comprising the therapeutic agent for a time sufficient to produce a partial diffusion of the therapeutic agent into the matrix such that the concentration of the therapeutic agent varies in the matrix; and affixing the matrix to the implantable medical device body.
摘要翻译：形成被配置为从包括释放至少一种治疗剂有设置在固定到所述可植入医疗装置的主体上的基体中的治疗剂的可植入医疗装置的，worin所述至少一种治疗剂的浓度在基质中那样变化的方法连续相对于所述可植入医疗设备主体的表面上的梯度，所述方法包括：形成一均匀的溶液，其包含聚合物粘合剂和溶剂; 蒸发在均匀溶液中的溶剂，由此形成基质; 基质暴露于溶液，其包含足够的时间，以产生所述的治疗剂的局部扩散到检查做治疗剂的浓度在基质中而变化的矩阵的治疗剂; 以及将所述基质的可植入医疗装置主体。

7. 发明公开

EP2272544A1 Implantable medical device with beneficial agent concentration gradient 审中-公开
标题翻译：可植入的医疗装置，其包括在一个浓度梯度的治疗性物质。
公开(公告)号：EP2272544A1
公开(公告)日：2011-01-12
申请号：EP10010593.1
申请日：2004-03-29
申请人： Conor Medsystems, Inc.
发明人： Park, Kinan , Shanley, John F. , Parker, Theodore L.
IPC分类号： A61L27/34 , A61L29/08 , A61L29/16 , A61L31/12
CPC分类号： A61L31/08 , A61L31/041 , A61L31/10 , A61L31/16 , A61L2300/60 , A61L2300/604
摘要： An implantable medical device comprises: an implantable device body having a mural surface (26) and a luminal surface (24) and a plurality of holes (20) traversing both the mural and luminal surface; a therapeutic agent, a matrix (40), and a barrier layer (30) contained in each of the plurality of holes; wherein the holes each have a luminal opening and a mural opening and the barrier layer is positioned across the luminal opening, and the therapeutic agent is primarily delivered through the mural opening of the hole; wherein the therapeutic agent is present in both the barrier layer and the matrix, at different local concentrations, and the matrix is created in a stepwise manner, such that a concentration gradient of the therapeutic agents exists in the matrix.
摘要翻译：到具有壁的表面（26）和内腔表面（24）和孔的多个（20）穿过两者壁画和内腔表面;:一种植入式医疗装置包括可植入装置主体包含在每个孔的多个治疗剂，基质（40）和阻挡层（30）; worin每个孔有一个管腔开口和壁画开口和阻挡层跨越腔开口定位，并且所述治疗剂通过孔的开口壁画主要递送; worin所述治疗剂是存在于这两个阻挡层和基体，在不同的局部浓度，并以步进的方式被产生的矩阵，求做治疗剂的浓度梯度在基质中存在。

8. 发明公开

EP1858442A4 EXPANDABLE MEDICAL DEVICE WITH OPENINGS FOR DELIVERY OF MULTIPLE BENEFICIAL AGENTS 审中-公开
标题翻译：随着对递送多种有益物质开口张开的医疗设备
公开(公告)号：EP1858442A4
公开(公告)日：2010-09-01
申请号：EP06736688
申请日：2006-03-01
申请人： CONOR MEDSYSTEMS INC
发明人： SHANLEY JOHN F , LITVACK FRANK , PARKER THEODORE L , NGUYEN THAI MINH
IPC分类号： A61F2/06 , A61F2/00 , A61F2/90 , A61L31/14 , A61L31/16
CPC分类号： A61F2/856 , A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91541 , A61F2002/91558 , A61F2250/0035 , A61F2250/0068 , A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/416 , A61L2300/45 , A61L2300/602

9. 发明公开

EP1758638A4 RAPID EXCHANGE BALLOON CATHETER WITH BRAIDED SHAFT 有权转让
标题翻译：快速更换型气球编织导管
公开(公告)号：EP1758638A4
公开(公告)日：2009-05-20
申请号：EP05732485
申请日：2005-03-01
申请人： CONOR MEDSYSTEMS INC
发明人： FISHER BEAU M
IPC分类号： A61M29/00 , A61F2/06 , A61M25/00 , A61M29/02
CPC分类号： A61M25/104 , A61M25/0045 , A61M25/005 , A61M25/0053 , A61M2025/0059 , A61M2025/018 , A61M2025/0183
摘要： A balloon catheter for use alone or as a stmt delivery system includes a balloon segment and a shaft segment having a varying flexibility. The shaft segment includes a polymer encased braid which extends along substantially the entire length of the shaft segment for added pushability and kink resistance. A flexible distal tip extends from the balloon for improved trackability.

10. 发明公开

EP1753451A4 LOCAL DELIVERY OF GROWTH FACTORS FOR STEM CELL TRANSPLANTATION 审中-公开
标题翻译：干细胞移植生长因子局部分布
公开(公告)号：EP1753451A4
公开(公告)日：2008-11-12
申请号：EP05760250
申请日：2005-06-07
申请人： CONOR MEDSYSTEMS INC
发明人： LITVACK FRANK
IPC分类号： C12N5/00 , A61F2/00 , A61F2/06 , A61F2/90 , A61K38/18 , A61K38/19 , A61L27/38 , A61L27/54 , A61L31/10 , A61L31/16
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2250/0068 , A61K35/34 , A61K38/18 , A61K38/193 , A61K38/195 , A61L27/3826 , A61L27/383 , A61L27/3843 , A61L27/3873 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/414 , A61L2300/45 , C08L89/00 , A61K2300/00

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