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1. 发明授权

EP2687841B1 Sensor strip and manufacture method thereof and system thereof 有权
公开(公告)号：EP2687841B1
公开(公告)日：2019-11-27
申请号：EP12198648.3
申请日：2012-12-20
申请人： Apex Biotechnology Corporation
发明人： Huang, Ying-Che , Chu, Ching-Yuan , Huang, Lan-Hsiang
IPC分类号： G01N27/327 , C12Q1/00

2. 发明授权

EP2591858B1 Reaction cassette and assay device 有权
标题翻译：反应盒和测定装置
公开(公告)号：EP2591858B1
公开(公告)日：2017-10-04
申请号：EP12192021.9
申请日：2012-11-09
申请人： Apex Biotechnology Corporation
发明人： Chen, Sz-Hau , Lin, Yueh-Hui , Chen, Chun - Ju
IPC分类号： B01L3/00 , G01N33/50 , G01N21/07
CPC分类号： B01L3/502 , B01L2200/026 , B01L2200/0621 , B01L2300/044 , B01L2300/069 , B01L2300/0867 , B01L2300/087 , B01L2400/0457 , B01L2400/0683 , B01L2400/086 , G01N21/07

3. 发明公开

EP2873969A1 Hematocrit measurement system and measurement method using the same 有权
标题翻译：哈佛大学系统教授Messverfahren
公开(公告)号：EP2873969A1
公开(公告)日：2015-05-20
申请号：EP14003223.6
申请日：2014-09-17
申请人： Apex Biotechnology Corporation
发明人： Cheng, Chu-Ming , Wu, Lee Tent Yi , Chu, Ching-Yuan
IPC分类号： G01N27/327
CPC分类号： G01N27/327 , G01N27/3274
摘要： A hematocrit (HCT) measurement system and measurement method using the same are disclosed. The hematocrit (HCT) measurement system comprises a test strip and a measurement apparatus comprising: a connector transmitting an initial signal generated from a blood sample to the measurement apparatus, a capacitive reactance adjustor disposed between the test strip and the measurement apparatus, a calculation unit for calculating concentration and HCT value of the blood sample, an A/D convertor transforming the corresponding initial signal to a digital signal, and a signal processor processing the digital reacted signal and showing measured results on a display, wherein the HCT value is calculated by voltage partition to prevent the signal waveform voltage being saturated or cutoff, thereby resulting in measured signal distortion.
摘要翻译：公开了血细胞比容（HCT）测量系统和使用其的测量方法。血细胞比容（HCT）测量系统包括测试条和测量装置，包括：将从血液样品产生的初始信号传输到测量装置的连接器，设置在测试条和测量装置之间的电容性电抗调节器，计算单元用于计算血液样本的浓度和HCT值，A / D转换器将相应的初始信号转换为数字信号，以及信号处理器处理数字反应信号并在显示器上显示测量结果，其中HCT值由电压分配，以防止信号波形电压饱和或截止，从而导致测量信号失真。

4. 发明公开

EP1376115A8 Portable multi-functional electrochemical sensor 审中-公开
标题翻译：便携式多功能电化学传感器
公开(公告)号：EP1376115A8
公开(公告)日：2004-05-26
申请号：EP03253940.5
申请日：2003-06-23
申请人： Apex Biotechnology Corporation
发明人： Yang, Mark, 3F, No. 86, Alley 27, Lane 372 , Huang, River, 4F, No. 6, Innovation Road II , Huang, Bin, 4F, No. 6, Innovation Road II , Chu, Shame, 4F, No. 6, Innovation Road II , Lin, Yueh-Hui, 4F, No. 6, Innovation Road II , Shen, Benjamin Cheng-Yu, 4F No.6, Innovation Rd II , Shen, Thomas Y.S., 4F, No. 6, Innovation Road II
IPC分类号： G01N27/403 , G01N33/487
CPC分类号： G01N27/3273
摘要： A portable multi-functional electrochemical biosensor system comprises a plurality of sample cells, pluggable information memories and a multi-functional signal analysis processor. The biosensor system uses a set of sample cell and pluggable information memory to detect the concentration of a corresponding selected analyte. Each sample cell has a reaction zone on which a chemical substance is placed to react with the corresponding analyte and has at least two independent electrodes. During detection, each corresponding pluggable information memory can provide parameters used for analysis. The multi-functional signal analysis processor has a microprocessor, an electrically erasable programmable read/write memory and an environmental temperature sensor. The concentration of the selected analyte is calculated by using the electrochemical reaction signal output from the sample cell and the parameters with cooperation of the environmental temperature sensor, and then an analysis result is output.

5. 发明公开

EP1225449A1 Non-enzymatic disposable electrode strip comprising a surfactant for detecting uric acid or hemoglobin; method for producing the same and its use 有权
标题翻译：类似地，非酶，含有一次性电极条用于检测尿酸或血红蛋白和过程的生产和应用洗涤剂
公开(公告)号：EP1225449A1
公开(公告)日：2002-07-24
申请号：EP01300476.7
申请日：2001-01-19
申请人： Apex Biotechnology Corporation
发明人： Lin, Yueh-Hui , Shen, Thomas Y.S.
IPC分类号： G01N33/49 , G01N33/72 , G01N33/52 , G01N27/26
CPC分类号： G01N33/5308 , G01N33/526 , G01N33/726
摘要： The present invention relates to a disposable electrode article eg. a strip that directly and non-enzymatically detects the concentration of biomolecules such as uric acid and hemoglobin in liquid sample. The strip detects the concentration of biomolecules in a sample by catching signals generated by a redox current of a redox electron mediator in the presence of a surfactant. When such electrode strip is applied to detect the concentration of biomolecules in human body, it avoids interference signals caused from any other components in blood. The invention also provides a method for producing such electrode strip and a detecting equipment containing such a strip.
摘要翻译：本发明涉及一种一次性电极制品例如条带确实直接和非酶检测生物分子的浓度：如液体样品中的尿酸和血红蛋白。带材通过捕捉通过在表面活性剂的存在下的氧化还原电子介体的氧化还原电流产生信号，检测样品中的生物分子的浓度。当寻求电极带被施加到检测人体生物分子的浓度，它避免了从血液中的任何其他部件引起的干扰信号。因此，本发明提供了用于产生寻电极条的方法和含寻求条的检测设备。

6. 发明授权

EP2873969B1 Hematocrit measurement system and measurement method using the same 有权
公开(公告)号：EP2873969B1
公开(公告)日：2021-06-30
申请号：EP14003223.6
申请日：2014-09-17
发明人： Cheng, Chu-Ming , Wu, Lee Tent Yi , Chu, Ching-Yuan
IPC分类号： G01N27/327

7. 发明公开

EP3162440A3 REACTION CASSETTE AND ASSAY DEVICE 有权
标题翻译：反应试剂盒和测定装置
公开(公告)号：EP3162440A3
公开(公告)日：2017-09-27
申请号：EP16001962.6
申请日：2016-09-08
申请人： Apex Biotechnology Corporation
发明人： Chen, Sz Hau , Hsu, Ming Chang , Wu, Ya Chun , Lin, Tin En
IPC分类号： B01L3/00 , B01F11/00 , B01F15/00
CPC分类号： B01L3/5023 , B01F11/0002 , B01F15/00883 , B01F15/0295 , B01L3/502 , B01L3/50273 , B01L3/502746 , B01L3/502753 , B01L2200/0605 , B01L2200/0621 , B01L2200/16 , B01L2300/069 , B01L2300/0816 , B01L2300/12 , B01L2400/0409 , B01L2400/0457 , B01L2400/086
摘要： A reaction cassette and a biochemical assay device are disclosed. The reaction cassette for biochemical assay comprises a housing with structural walls defining a liquid mixing space for accommodating at least one mixing zone, wherein the at least one mixing zones comprises at least one blending structures for generating a vortex phenomenon in liquid, thereby improving the degree of mixture of a liquid sample and a dried reagent.
摘要翻译：公开了反应盒和生物化学测定装置。用于生化测定的反应盒包括具有限定用于容纳至少一个混合区的液体混合空间的结构壁的壳体，其中所述至少一个混合区包括用于在液体中产生涡流现象的至少一个混合结构，液体样品和干燥试剂的混合物。

8. 发明公开

EP3153857A1 BIOCHEMICAL TEST CHIP 审中-公开
标题翻译： CHIPFÜRBIOCHEMISCHEN测试
公开(公告)号：EP3153857A1
公开(公告)日：2017-04-12
申请号：EP16182537.7
申请日：2016-08-03
申请人： Apex Biotechnology Corporation
发明人： Lu, Yi-Chen , Kuan, Tang-Ching
IPC分类号： G01N33/52 , G01N21/78 , G01N33/543 , G01N31/22
CPC分类号： G01N27/327 , G01N21/78 , G01N21/8483 , G01N27/3271 , G01N27/3272 , G01N31/222 , G01N31/225 , G01N31/229 , G01N33/52 , G01N33/5438
摘要： Provided is a biochemical test chip including an insulating substrate, an electrode unit, a first insulating septum, a reactive layer, a second insulating septum, and a color-changing layer. The electrode unit is located on the insulating substrate. The first insulating septum is located on the electrode unit and has an opening. The opening exposes a portion of the electrode unit. The reactive layer is located in the opening. The second insulating septum is located on the first insulating septum. The color-changing layer is located at least on a region outside the reactive layer. The color of the color-changing layer is changed with a change in an environmental factor.
摘要翻译：提供了包括绝缘基板，电极单元，第一绝缘隔膜，反应层，第二绝缘隔膜和变色层的生化测试芯片。电极单元位于绝缘基板上。第一绝缘隔膜位于电极单元上并具有开口。开口露出电极单元的一部分。反应层位于开口中。第二绝缘隔膜位于第一绝缘隔膜上。变色层至少位于反应层外的区域上。颜色变化层的颜色随环境因素的变化而改变。

9. 发明授权

EP2341341B1 Electrochemical test strip, electrochemical test system, and measurement method using the same 有权
标题翻译：电化学测试条，电化学检测系统和测量技术，以便
公开(公告)号：EP2341341B1
公开(公告)日：2016-11-16
申请号：EP10015713.0
申请日：2010-12-16
申请人： Apex Biotechnology Corporation
发明人： Chen, Guan-Ting , Lin, Yueh-Hui , Teng, Kai-Tsung , Chen, Sz-Hau , Shen, Thomas Y.S.
IPC分类号： G01N27/327
CPC分类号： G01N27/3274

10. 发明公开

EP2591858A3 Reaction cassette and assay device 有权
标题翻译： Reaktionskassette和Assay-Vorrichtung
公开(公告)号：EP2591858A3
公开(公告)日：2015-02-18
申请号：EP12192021.9
申请日：2012-11-09
申请人： Apex Biotechnology Corporation
发明人： Chen, Sz-Hau , Lin, Yueh-Hui , Chen, Chun - Ju
IPC分类号： B01L3/00 , G01N33/50 , G01N21/07
CPC分类号： B01L3/502 , B01L2200/026 , B01L2200/0621 , B01L2300/044 , B01L2300/069 , B01L2300/0867 , B01L2300/087 , B01L2400/0457 , B01L2400/0683 , B01L2400/086 , G01N21/07
摘要： A reaction cassette for biochemical assay, a biochemical assay device (100) including a first space (130) configured to accommodate liquid, having a first opening and rounding edges, a direction of the first opening being directed upward. A second space (132) includes a second opening, a direction of the second opening being perpendicular to the direction of the first opening, wherein the first space (130) and the second space (132) are disposed such that when the reaction cassette (100) is rotated allowing the liquid to drain into the second space. A third space (134) is located below the first space and having a third opening, a direction of the third opening being upward such that when the reaction cassette (100) is reversibly rotated allowing the liquid to drain into the third space (134), wherein an array of bumps (137) is disposed in the third space (134) to create turbulence of the liquid. An inner partition wall, connected with the second opening and the third opening, acts as a liquid flow channel between the second space (132) and the third space (134).
摘要翻译：一种用于生物化学测定的反应盒，包括构造成容纳液体的第一空间（130）的生物化学测定装置（100），所述第一空间具有第一开口和圆形边缘，所述第一开口的方向指向上。第二空间（132）包括第二开口，第二开口的方向垂直于第一开口的方向，其中第一空间（130）和第二空间（132）设置成使得当反应盒（ 100）旋转，允许液体排入第二空间。第三空间（134）位于第一空间下方并且具有第三开口，第三开口的方向向上，使得当反作用盒（100）可逆地旋转允许液体排入第三空间（134）时，，其中在所述第三空间（134）中布置有凸起阵列（137），以产生液体的湍流。与第二开口和第三开口连接的内部分隔壁用作第二空间（132）和第三空间（134）之间的液体流动通道。

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