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81. 发明公开

EP3124973A4 AFLATOXIN NANOBODY IMMUNOABSORBENT AND IMMUNOAFFINITY COLUMN AND PREPARATION METHOD AND USE THEREOF 有权
标题翻译： AFLATOXIN-NANOKÖRPER-IMMUNOADSORBENS UNDIMMUNAFFINITÄTSSUMUSOWIE HERSTELLUNGSVERFAHREN UND VERWENDUNG DAVON
公开(公告)号：EP3124973A4
公开(公告)日：2017-08-30
申请号：EP14887513
申请日：2014-08-27
申请人： OILCROPS RES INST OF CHINESE ACAD OF AGRICULTURE SCIENCES
发明人： LI PEIWU , ZHANG QI , WANG YANRU , ZHANG ZHAOWEI , DING XIAOXIA
IPC分类号： G01N33/569 , C07K16/14 , G01N33/531 , G01N33/544
CPC分类号： C07K16/14 , C07K1/22 , C07K2317/22 , C07K2317/565 , C07K2317/569 , C07K2317/92 , C07K2317/94 , G01N33/56961 , G01N2333/38
摘要： An aflatoxin nanobody immunoabsorbent and immunoaffinity column and preparation method and use thereof. The immunoabsorbent comprises a solid phase carrier and aflatoxin B1 nanobody 2014AFB-G15 coupled with the solid phase carrier. The 50% inhibiting concentration IC 50 of aflatoxin B1 nanobody 2014AFB-G15 to aflatoxin B1 is 0.66 ng/mL, and the cross-reactivity of aflatoxin B1 nanobody 2014AFB-G15 to aflatoxins B2, G1, G2, and M1 are respectively 22.6%, 10.95%, 32.1% and 26%. The amino acid sequence of aflatoxin B1 nanobody 2014AFB-G15 is as depicted by SEQ ID NO: 7, and the coding gene sequence thereof is as depicted by SEQ ID NO: 8. The aflatoxin nanobody immunoaffinity column can be used for purification and concentration of sample extract prior to computer testing, and the immunoaffinity column can be reused repeatedly.
摘要翻译：一种黄曲霉纳米抗体免疫吸附和免疫亲和柱及其制备方法和用途。免疫吸附剂包含固相载体和与固相载体偶联的黄曲霉毒素B1纳米抗体2014AFB-G15。黄曲霉毒素B1纳米抗体2014AFB-G15对黄曲霉毒素B1的50％抑制浓度IC 50为0.66ng / mL，黄曲霉毒素B1纳米抗体2014AFB-G15对黄曲霉毒素B2，G1，G2和M1的交叉反应性分别为22.6％ 10.95％，32.1％和26％。黄曲霉毒素B1纳米抗体2014AFB-G15的氨基酸序列如SEQ ID NO：7所示，并且其编码基因序列如SEQ ID NO：8所示。黄曲霉毒素纳米抗体免疫亲和柱可用于纯化和浓缩样品提取物在计算机测试之前，并且免疫亲和柱可以重复使用。

82. 发明授权

EP2311895B1 BIOMATERIALS FORMED BY NUCLEOPHILIC ADDITION REACTION TO CONJUGATED UNSATURATED GROUPS 有权
标题翻译：通过亲核响应于共轭不饱和基团引入生物材料中加入
公开(公告)号：EP2311895B1
公开(公告)日：2017-04-12
申请号：EP10181654.4
申请日：2000-02-01
申请人： Eidgenössische Technische Hochschule Zürich , Universität Zürich
发明人： Hubbel, Jeffrey, A. , Elbert, Donald , Lütolf, Matthias , Pratt, Alison , Schoenmakers, Ronald , Tirelli, Nicola , Vernon, Brent
IPC分类号： C08G63/48 , C08G63/91 , C12N11/02 , C12N11/04 , C12N11/06 , C12N11/08 , G01N33/544 , G01N33/545 , G01N33/546 , G01N33/549 , A61K9/00 , A61K9/06 , A61L24/00 , A61L24/04 , A61L26/00 , A61L27/26 , A61L27/52 , A61L31/04 , A61L31/14 , C08G81/00
CPC分类号： A61K9/0024 , A61K9/06 , A61K47/6903 , A61L24/0031 , A61L24/043 , A61L26/0052 , A61L26/008 , A61L27/26 , A61L27/52 , A61L31/041 , A61L31/145 , C08G81/00 , Y10S524/916

83. 发明公开

EP3066471A1 METHODS FOR IMPROVING ANALYTE DETECTION USING PHOTOCHEMICAL REACTIONS 有权
标题翻译：方法改进的分析物通过化学反应PHOTO
公开(公告)号：EP3066471A1
公开(公告)日：2016-09-14
申请号：EP14859021.9
申请日：2014-11-02
申请人： Allied Innovative Systems, LLC
发明人： BYSTRYAK, Simon , SANTOCKYTE, Rasa
IPC分类号： G01N33/533 , G01N33/544 , G01N33/535 , G01N21/75
CPC分类号： G01N33/533 , C12Q1/28 , C12Q1/6816 , C12Q1/682 , C12Q1/703 , C12Q2600/158 , G01N33/5306 , G01N33/542 , G01N33/569 , G01N33/56911 , G01N33/56983 , G01N33/56988 , G01N33/56994 , Y02A50/52 , Y02A50/59 , C12Q2563/103 , C12Q2563/125
摘要： An improved assay for detecting an analyte in a fluid sample includes a step of conducting a photochemical reaction, in which a substrate conversion catalyzed by a photosensitizer into a product of the photochemical reaction is temporary inhibited when the reaction mixture is irradiated with a light at a wavelength within a light absorption spectrum of the photosensitizer. The photosensitizer (or an enzyme to catalyze producing thereof) is attached to an entity having an affinity to the analyte, such entity is bound to the analyte prior to irradiation. To achieve temporary inhibition, certain additives are used such as ascorbic acid or its derivatives. The assay may increase the sensitivity of ELISA 20- to 100-fold.

84. 发明公开

EP2951585A4 CAPTURE AND RELEASE OF PARTICLES FROM LIQUID SAMPLES 有权
标题翻译： ERFASSUNG UND FREISETZUNG VON TEILCHEN AUSFLÜSSIGENPROBEN
公开(公告)号：EP2951585A4
公开(公告)日：2016-09-07
申请号：EP14745825
申请日：2014-02-03
申请人： GEN HOSPITAL CORP
发明人： REATEGUI EDUARDO , STOTT SHANNON , TONER MEHMET
IPC分类号： G01N33/543 , G01N33/544 , G01N33/569
CPC分类号： G01N33/54393 , G01N33/54366 , G01N33/544 , G01N33/56966 , G01N33/57492 , G01N2333/71 , G01N2400/00
摘要： Systems, methods, and devices for selective capture and release of target particles, e.g., living cells, from liquid samples, e.g., blood, are provided. The particle capture systems include a substrate; a first layer of gelatin bound to the substrate by physical adsorption, wherein the gelatin is functionalized with a plurality of first members of a binding pair; a second layer of gelatin wherein the gelatin is functionalized with a plurality of the first members of the binding pair and the second layer is bound to the first layer via a plurality of second members of the binding pair that are associated with the first members of the binding pair on both the first and the second layers; and a plurality of nanostructures bound to the second members of the binding pair and to one or more particle-binding moieties that selectively bind to the target particles.
摘要翻译：提供了用于从液体样品（例如血液）中选择性捕获和释放靶细胞（例如活细胞）的系统，方法和装置。颗粒捕获系统包括基底; 明胶通过物理吸附结合到基底上的第一层明胶，其中明胶用多个结合对的第一成员官能化; 明胶的第二层，其中所述明胶被所述结合对的多个所述第一成员功能化，并且所述第二层通过所述结合对的多个第二成员与所述第一层结合，所述第二成员与所述第一成员第一层和第二层上的结合对; 以及与结合对的第二个成员结合的多个纳米结构和选择性结合靶颗粒的一个或多个颗粒结合部分。

85. 发明公开

EP2804634A4 CHROMATOGRAPHIC MEDIA FOR STORAGE AND DELIVERY OF THERAPEUTIC BIOLOGICS AND SMALL MOLECULES 有权转让
标题翻译：层析介质进行存储和分发的治疗性生物材料和小分子
公开(公告)号：EP2804634A4
公开(公告)日：2015-07-22
申请号：EP13739077
申请日：2013-01-18
申请人： NATRIX SEPARATIONS INC
发明人： CHICKOSKY JOHN A , HONEYMAN CHARLES H , MCGLAUGHLIN MOLLY S , RAGHEB AMRO
IPC分类号： A61K47/30 , A61K9/08 , A61K9/16 , A61K39/395 , G01N33/544
CPC分类号： A61K47/48776 , A61K9/7007 , G01N33/544
摘要： Described are composite materials and methods of making and using them for the storage and delivery of unstable drugs or biologics. In certain embodiments, the composite material comprises a support member, comprising a plurality of pores extending through the support member; a macroporous cross-linked gel, comprising a plurality of macropores; a therapeutic agent; and a stabilizing agent.
摘要翻译：描述的是复合材料和制备和使用它们的储存和不稳定药物或生物制剂递送方法。在某些实施方案中，复合材料包括支撑构件，其包括孔穿过支撑构件延伸的多元性; 大孔交联的凝胶，包括大孔的多元性; 治疗剂; 和稳定剂。

86. 发明公开

EP2198302A4 SOL-GEL PHASE-REVERSIBLE HYDROGEL TEMPLATES AND USES THEREOF 有权
标题翻译： SOL-GEL-PHASEN-REVERSIBY HYDROGELMATRIZEN UND VERWENDUNGEN DAVON
公开(公告)号：EP2198302A4
公开(公告)日：2013-09-25
申请号：EP08833994
申请日：2008-09-27
申请人： SAMYANG BIOPHARMACEUTICALS
发明人： PARK KINAM , ACHARYA GHANASHYAM , PARK HAESUN
IPC分类号： G01N33/544 , A61K9/50 , A61K31/00
CPC分类号： A61K9/1682 , A61K9/1647 , A61K9/5031 , A61K9/5089 , A61K31/00 , Y10S977/773 , Y10S977/887 , Y10S977/89 , Y10S977/906

87. 发明公开

EP2507278A1 PREPARATION OF MOLECULARLY IMPRINTED POLYMERS 有权转让
标题翻译： MANUFACTURING分子印迹聚合物
公开(公告)号：EP2507278A1
公开(公告)日：2012-10-10
申请号：EP10795037.0
申请日：2010-12-01
申请人： Cranfield University
发明人： PILETSKY. Sergey, Anatoliyovich , GUERREIRO. Antonio, Ricardo, Leonardo , WHITCOMBE. Michael, James
IPC分类号： C08F293/00 , G01N33/544
CPC分类号： C08F293/005 , B01J20/268 , C08F2438/03 , G01N2600/00
摘要： A polymerisation process, preferably a living radical polymerisation process, is carried out in the presence of a template substance, to produce molecularly imprinted polymers ("MIPs"). It is controlled so that the products are quite small (500 - 10
6 Daltons) so that they are soluble or form colloidal suspensions. The template substances are immobilised templates, which can be re-used. Immobilised templates are also useful for purification of MIP solutions/suspensions by affinity chromatography.

88. 发明公开

EP2487490A1 Heterogener Bindungsassay mit verbesserter optischer Auswertbarkeit oder poröse Festphase für Bindungsassays mit verbesserter optischer Auswertbarkeit 审中-公开
标题翻译：具有改进的光学可读性或多孔性固相异质性结合测定法用于具有改进的光学可读性结合测定
公开(公告)号：EP2487490A1
公开(公告)日：2012-08-15
申请号：EP11154128.0
申请日：2011-02-11
申请人： FZMB GmbH Forschungszentrum für Medizintechnik und Biotechnologie
发明人： Miethe, Peter , Henze, Stephan
IPC分类号： G01N33/544 , G01N33/552
CPC分类号： G01N33/54373
摘要： Poröser Träger für heterogene Bindungsassays, wobei der Träger Poren aufweist, die ein Porenvolumen besitzen und die Poren in einer festen Phase angeordnet sind, mit der Maßgabe, dass die feste Phase einen Brechungsindex aufweist und das Porenvolumen einen Brechungsindex aufweist, dadurch gekennzeichnet, dass eine Differenz des Brechungsindex der festen Phase und des Brechungsindex des Porenvolumens
摘要翻译：多孔载体包括固定的结合分子对所述分析物或缀合物和孔，其具有的孔体积和的孔被在固相上排列的结合。固相和孔体积的折射率的折射率的差小于0:05，特别是小于0时02分以下。所述载体包括多孔聚合物材料，特别是氟化的或全氟化的聚合物，纳米多孔二氧化硅，聚乙烯，纤维素，硝化纤维素，聚酰胺，聚甲基丙烯酸酯或无机玻璃。

89. 发明公开

EP2367851A1 ANTIBODY-TARGETED CARRIER FOR CONTRAST AGENTS 审中-公开
标题翻译：对造影剂抗体的支撑件
公开(公告)号：EP2367851A1
公开(公告)日：2011-09-28
申请号：EP09828508.3
申请日：2009-11-26
申请人： National Research Council of Canada
发明人： ABULROB, Abednelnasser , STANIMIROVIC, Danica , IQBAL, Umar , NIEH, Muping , KATSARAS, John
IPC分类号： C07K17/02 , A61K49/00 , A61K49/16 , A61K51/10 , C07K16/00 , C07K16/26 , C07K16/28 , G01N33/544
CPC分类号： A61K49/0032 , A61K49/0002 , A61K49/0084 , A61K49/1812 , A61K51/1227 , A61K51/1234 , B82Y5/00 , C07K16/00 , C07K16/3053 , C07K2317/56 , C07K2317/565 , C07K2317/569 , G01N33/586
摘要： A nanoconjugate is formed from a self-assembled unilamellar vesicle (ULV), at least one contrast agent which may be a MRI contrast agent, a radioisotope or a fluorophore, and at least one antibody, which may be an IgG or an antibody fragment such as a single-domain antibody. The nanoconjugate be targetted with the antibody to receptors specific to certain disease states, and thus be used in diagnostic and imaging methods using the properties o contrast agent.

90. 发明公开

EP2311895A1 Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups 有权
标题翻译：通过亲核响应于共轭不饱和基团引入生物材料中加入
公开(公告)号：EP2311895A1
公开(公告)日：2011-04-20
申请号：EP10181654.4
申请日：2000-02-01
申请人： Eidgenössische Technische Hochschule Zürich , Universität Zürich
发明人： Hubbel, Jeffrey, A. , Elbert, Donald , Lutolf, Matthias , Pratt, Alison , Schoenmakers, Ronald , Tirelli, Nicola , Vernon, Brent
IPC分类号： C08G63/48 , C08G63/91 , C12N11/02 , C12N11/04 , C12N11/06 , C12N11/08 , G01N33/544 , G01N33/545 , G01N33/546 , G01N33/549 , A61K9/00 , A61K9/06 , A61K47/48 , A61L24/00 , A61L24/04 , A61L26/00 , A61L27/26 , A61L27/52 , A61L31/04 , A61L31/14 , C08G81/00
CPC分类号： A61K9/0024 , A61K9/06 , A61K47/6903 , A61L24/0031 , A61L24/043 , A61L26/0052 , A61L26/008 , A61L27/26 , A61L27/52 , A61L31/041 , A61L31/145 , C08G81/00 , Y10S524/916
摘要： The invention features polymeric biomaterials formed by nucleophilic addition reactions to conjugated unsaturated groups. These biomaterials may be used for medical treatments.
摘要翻译：本发明的特征通过亲核加成反应来共轭不饱和基团形成的聚合生物材料。这些生物材料可用于医疗。

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