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81. 发明授权

EP2802334B1 HOST CELLS WITH ARTIFICIAL ENDOSYMBIONTS 有权
标题翻译：宿主细胞与人造内皮细胞
公开(公告)号：EP2802334B1
公开(公告)日：2018-03-07
申请号：EP13736256.2
申请日：2013-01-14
申请人： Bell Biosystems, Inc.
发明人： BELL, Caleb B., III , BAZAROV, Alexey
IPC分类号： C12N5/071 , C12N5/074 , C12N5/095 , C12N5/26 , C12N5/28
CPC分类号： C12N5/166 , C12N1/00 , C12N5/00 , C12N5/16 , C12N9/88 , C12N15/02 , C12N15/03 , C12Q1/6897 , C12Y406/01001
摘要： The present invention relates to eukaryotic mammalian host cells comprising an artificial endosymbiont belonging to the class ±-Proteobacteria, wherein the host cell is selected from the group consisting of human cancer cells, inducible pluripotent stem (IPS) cells, hematopoietic stem cells, neural stem cells, epidermal neural crest stem cells, mammary stem cells, intestinal stem cells, mesenchymal stem cells, olfactory adult stem cells, testicular cells, and human cells found in the circulatory system.

82. 发明授权

EP2649176B1 FEED MIXING DEVICE AND ITS USE 失效
标题翻译：饲料混合装置及其用途
公开(公告)号：EP2649176B1
公开(公告)日：2018-01-17
申请号：EP11790633.9
申请日：2011-12-05
申请人： F. Hoffmann-La Roche AG
发明人： BAUMANN, Sylvia , HOFFMANN, Jens , JOCKWER, Alexander , KLINGER, Christian , TROEBS, Thomas
IPC分类号： C12N5/00
CPC分类号： C12P21/005 , B01F15/0479 , B01F2215/044 , C07K16/244 , C07K2317/14 , C12M29/26 , C12M41/26 , C12N5/00 , C12N2500/60
摘要： Herein is reported a feed mixing device for adding feed solutions with a non-physiologically pH value to a cell cultivation vessel comprising a chamber for mixing the feed solutions prior to their addition to the cell cultivation vessel as well as its use. With the feed mixing device as reported herein feed components can be provided in solution at a pH value at which they have good solubility and/or good stability whereby the pH value can be clearly different from the pH value of the cultivation medium, i.e. different from the physiological pH value. This allows performing the cultivation with more flexibility compared to a cultivation in which the pH value of the feed solution is limited to a small range around the pH value of the cultivation.

83. 发明公开

EP3263696A1 HOST CELLS WITH ARTIFICIAL ENDOSYMBIONTS 审中-公开
标题翻译：宿主细胞与人造内皮细胞
公开(公告)号：EP3263696A1
公开(公告)日：2018-01-03
申请号：EP17001355.1
申请日：2013-01-14
申请人： Bell Biosystems, Inc.
发明人： Bell, Caleb B., III , Bazarov, Alexey
IPC分类号： C12N5/071 , C12N5/074 , C12N5/095 , C12N5/26 , C12N5/28
CPC分类号： C12N5/166 , C12N1/00 , C12N5/00 , C12N5/16 , C12N9/88 , C12N15/02 , C12N15/03 , C12Q1/6897 , C12Y406/01001
摘要： The present invention relates to eukaryotic mammalian host cells comprising an artificial endosymbiont belonging to the class α-Proteobacteria, wherein the host cell is selected from the group consisting of human cancer cells, inducible pluripotent stem (IPS) cells, hematopoietic stem cells, neural stem cells, epidermal neural crest stem cells, mammary stem cells, intestinal stem cells, mesenchymal stem cells, olfactory adult stem cells, testicular cells, and human cells found in the circulatory system.
摘要翻译：本发明涉及真核生物哺乳动物宿主细胞，其包含属于α-Proteobacteria类的人造内共生细胞，其中宿主细胞选自人癌细胞，诱导性多能干（IPS）细胞，造血干细胞，神经干细胞细胞，表皮神经嵴干细胞，乳房干细胞，肠干细胞，间充质干细胞，嗅觉成体干细胞，睾丸细胞和循环系统中发现的人细胞。

84. 发明公开

EP3252144A1 METHOD FOR PREPARING BONE MARROW CELL AGGREGATE 审中-公开
标题翻译：制备骨髓细胞聚集体的方法
公开(公告)号：EP3252144A1
公开(公告)日：2017-12-06
申请号：EP16743116.2
申请日：2016-01-14
申请人： Public University Corporation Yokohama City University
发明人： KOJIMA, Nobuhiko
IPC分类号： C12N5/00 , A61L27/00 , C12M3/00
CPC分类号： C12N5/0669 , A61L27/00 , C12M3/00 , C12N5/00 , C12N2513/00 , C12N2533/70 , C12N2533/78 , C12N2539/00
摘要： The present invention provides a technique which enables organization of bone marrow cells by a simple method in a short period of time.
A method for preparing a bone marrow cell aggregate, comprising adding a liquid containing a bone marrow cell population to a medium containing a swellable material and culturing the bone marrow cell population in the presence of the swellable material. A method for reassembling a bone marrow tissue, comprising adding a liquid containing a bone marrow cell population to a medium containing a swellable material and culturing the bone marrow cell population in the presence of the swellable material.
According to common knowledge in the art, it has been considered difficult to reorganize once disintegrated bone marrow tissue without changing the cell composition (that is, without adding any adherent cell or extracellular matrix which will work as a "connecting material (binder)"). Indeed, it was impossible to aggregate bone marrow cells by conventional methods. As a result of its achievement, the present invention changes such conventional thought and results and provides a major breakthrough technique pertaining to 3D culture of bone marrow cells. It has also been confirmed that culture of a bone marrow-like tissue reassembled by the method of the present could be continued up to day 14 in the MC medium.
摘要翻译：本发明提供了一种能够通过简单的方法在短时间内组织骨髓细胞的技术。一种制备骨髓细胞聚集体的方法，包括将含有骨髓细胞群体的液体加入含有可溶胀材料的培养基中并在可溶胀材料存在下培养骨髓细胞群体。一种重新组装骨髓组织的方法，包括将含有骨髓细胞群体的液体加入到含有可溶胀材料的培养基中，并在可溶胀材料存在下培养骨髓细胞群体。根据本领域的常识，已经认为难以在不改变细胞组成的情况下重新组织一次崩解的骨髓组织（即，不添加任何将用作“连接材料（结合剂）”的粘附细胞或细胞外基质）。事实上，用传统方法聚集骨髓细胞是不可能的。作为其成果的结果，本发明改变了这种常规思想和结果，并提供了关于骨髓细胞3D培养的重大突破技术。还已经证实，通过本发明的方法重新组装的骨髓样组织的培养可以在MC培养基中持续至第14天。

85. 发明公开

EP3252140A1 CELL CULTURING METHOD AND CELL CULTURING DEVICE 有权
标题翻译：细胞培养方法和细胞培养装置
公开(公告)号：EP3252140A1
公开(公告)日：2017-12-06
申请号：EP16742901.8
申请日：2016-01-04
申请人： Toyo Seikan Group Holdings, Ltd.
发明人： HATA, Norihiko , MURAI, Masahiro
IPC分类号： C12N1/00 , C12M1/00 , C12M3/00 , C12N5/00
CPC分类号： C12M35/04 , C12M23/26 , C12M23/34 , C12M25/06 , C12M29/10 , C12N1/00 , C12N5/00 , C12N5/0625 , C12N5/0634 , C12N5/0662 , C12N5/0696 , C12N2501/20
摘要： A bottom surface of a container 1 formed of a flexible material is partially raised to be partitioned it into plural compartments 10, and cells are cultured in each compartment 10. In due time, the compartments 10 are removed to expand a culture area in the container. As a result, the cell density at the time of culture can be maintained at an appropriate level, and an operation of transferring cells from one culture container to another culture container at the time of proliferating cells in a large amount can be eliminated, whereby damage on cells and risk of contamination can be reduced.
摘要翻译：由柔性材料形成的容器1的底面被部分地升起以被分隔成多个隔室10，并且细胞在每个隔室10中被培养。在适当的时候，隔室10被移除以扩大容器中的培养区域。其结果，能够将培养时的细胞密度维持在适当的水平，能够消除大量增殖细胞时从一个培养容器向另一个培养容器移送细胞的操作，对细胞和污染的风险可以降低。

86. 发明公开

EP3239292A1 CELL CULTURE SUPERNATANT FLUID DERIVED FROM LUNG TISSUE 无效
标题翻译：细胞培养上清液来源于肺组织
公开(公告)号：EP3239292A1
公开(公告)日：2017-11-01
申请号：EP15873195.0
申请日：2015-12-24
申请人： Ube Industries, Ltd. , National University Corporation Chiba University
发明人： HAGIHARA, Masahiko , KASUYA, Yoshitoshi , TANAKA, Kensuke , FUJITA, Tetsuo
IPC分类号： C12N5/00 , A61K35/42 , A61P9/12 , A61P11/00 , C12N5/02
CPC分类号： A61K35/42 , A61K38/395 , A61P11/00 , A61P11/06 , A61P11/08 , A61P11/10 , A61P11/12 , C12N5/00 , C12N5/0688
摘要： The purpose of the present invention is to provide a highly safe and highly effective pharmaceutical composition and the like for the prevention and treatment of respiratory diseases. The present invention provides a pharmaceutical composition with which it is possible to effectively repair damaged lung tissue by including a cell culture supernatant fluid derived from lung tissue. The present invention also provides a method and a kit for using said culture supernatant fluid to induce differentiation into lung surfactant protein positive cells.
摘要翻译：本发明的目的是提供用于预防和治疗呼吸疾病的高度安全和高效的药物组合物等。本发明提供了一种药物组合物，利用该药物组合物可以通过包含源自肺组织的细胞培养上清液来有效修复受损肺组织。本发明还提供了使用所述培养上清液诱导分化为肺表面活性蛋白阳性细胞的方法和试剂盒。

87. 发明授权

EP2783743B1 Method for processing a fluid 有权转让
标题翻译：处理流体的方法
公开(公告)号：EP2783743B1
公开(公告)日：2017-10-25
申请号：EP14173779.1
申请日：2011-01-19
申请人： Life Technologies Corporation
发明人： Staheli, Clinton , Jones, Nephi , Goodwin, Michael
IPC分类号： B01F3/04 , B01F7/00 , B01F7/16 , B01F7/18 , B01F15/00 , C12M1/00 , C12M1/06 , C12M1/12 , B01F15/06
CPC分类号： C12M23/14 , B01D5/0072 , B01D47/05 , B01F3/04241 , B01F3/04531 , B01F7/00691 , B01F7/1695 , B01F7/18 , B01F7/22 , B01F15/00071 , B01F15/00831 , B01F15/0085 , B01F15/065 , B01F2003/04191 , B01F2003/04297 , B01F2003/04673 , B01F2003/04865 , B01F2003/04872 , B01F2003/04879 , B01F2003/04893 , B01F2003/04921 , B01F2015/061 , B01F2215/0073 , C12M23/26 , C12M23/34 , C12M27/02 , C12M29/00 , C12M29/06 , C12M29/24 , C12M37/00 , C12M41/14 , C12M41/18 , C12N1/10 , C12N1/12 , C12N1/14 , C12N1/20 , C12N5/00 , C12N5/04 , C12N5/10 , F28B1/02 , F28F3/12 , F28F21/06 , F28F2255/02
摘要： Method for processing a fluid, the method comprising sparging a fluid within the compartment of a container with an initial gas so that the initial gas passes through a portion of the fluid to form a humid gas, passing the humid gas out of the compartment of the container and into a condenser bag, cooling the humid gas within the condenser bag so as to separate the humid gas within the condenser bag into a condensed fluid and a dehumidified gas, and returning the condensed fluid back to the compartment of the container or collecting the condensed fluid at a separate location.

88. 发明公开

EP3222711A1 PRODUCTION OF ARTIFICIAL TISSUES COMPRISING MAGNETIC PARTICLES 有权转让
标题翻译：包含磁性颗粒的人造组织的生产
公开(公告)号：EP3222711A1
公开(公告)日：2017-09-27
申请号：EP15860074.2
申请日：2015-11-21
申请人： Universidad de Granada , Servicio Andaluz de Salud , Universidad Nacional De Cordoba
发明人： LÓPEZ LÓPEZ, Modesto Torcuato , GARCÍA LÓPEZ-DURÁN, Juan de Dios , ALAMINOS MINGORANCE, Miguel , RODRÍGUEZ, Ismael Ángel , SCIONTI, Giuseppe
IPC分类号： C12N5/00 , C12N5/07 , A61F2/00 , A61F2/02
CPC分类号： A61K47/02 , A61F2/00 , A61F2/02 , A61K9/5026 , A61K35/33 , A61L27/042 , A61L27/34 , A61L27/50 , A61L2300/44 , A61L2400/12 , C12N5/00 , C12N5/0656 , C12N2501/998 , C12N2501/999 , C08L33/08
摘要： The invention is comprised in the field of biomedicine, and more specifically, the field of tissue engineering. The invention specifically relates to the use of multiple magnetic domain particles that have a mean diameter greater than 25 nm, to compositions and biomaterials comprising same, and to an in vitro method for producing an artificial tissue with the magnetic particles, to the artificial tissue that can be produced by said method, and to the use of said artificial tissue for partially or completely increasing, restoring or replacing the functional activity of a damaged organ or tissue.
摘要翻译：本发明包含在生物医学领域，并且更具体地涉及组织工程领域。本发明具体涉及具有大于25nm平均直径的多个磁畴颗粒的用途，包含它们的组合物和生物材料，以及涉及用该磁性颗粒生产人造组织的体外方法，可以通过所述方法产生，并且涉及所述人造组织用于部分或完全增加，恢复或替换受损器官或组织的功能活性。

89. 发明公开

EP3219322A1 MUSCULAR DYSTROPHY THERAPEUTIC AGENT CONTAINING PLURIPOTENT STEM CELLS DERIVED FROM DENTAL PULP 审中-公开
标题翻译：含牙胶的多功能肌萎缩症治疗剂
公开(公告)号：EP3219322A1
公开(公告)日：2017-09-20
申请号：EP15859662.7
申请日：2015-11-13
申请人： JCR Pharmaceuticals CO., LTD. , Nippon Medical School Foundation , National Center of Neurology and Psychiatry
发明人： OKADA, Takashi , KASAHARA, Yuko , IMAGAWA, Kiwamu
IPC分类号： A61K35/32 , A61P21/00 , C12N5/0775
CPC分类号： C12N5/0664 , A61K35/00 , A61K35/32 , C12N5/00 , C12N5/0607 , C12N2533/52 , C12N2533/54 , C12N2535/00
摘要： Disclosed are a therapeutic agent for muscular dystrophy employing pluripotent stem cells obtained from dental pulp and a method for preparation thereof. The therapeutic agent for muscular dystrophy comprises pluripotent stem cell-enriched human dental pulp-derived cells as the active ingredient, and is prepared by a method of preparation comprising the steps of: (a) adding dental pulp-derived cells contained in a dental pulp suspension, in a culture vessel containing feeder cells whose proliferative ability is suppressed, onto a membrane having micropores that can block feeder cells from passing therethrough and supported within the vessel in a manner that avoids direct contact of the lower side face thereof with the feeder cells, and culturing the dental pulp-derived cells on the membrane while preventing direct contact with the feeder cells, and (b) recovering the cells having grown on the membrane as the pluripotent stem cell-enriched human dental pulp-derived cells.
摘要翻译：公开了使用从牙髓得到的多能干细胞的肌营养不良症治疗剂及其制备方法。该肌营养不良症治疗剂包含富含多能干细胞的人类牙髓来源的细胞作为有效成分，并且通过包括以下步骤的制备方法来制备：（a）添加牙髓中含有的牙髓来源的细胞悬浮在含有抑制增殖能力的饲养细胞的培养容器中，悬浮在具有可阻断饲养细胞的微孔的膜上，并以避免其下侧面与饲养细胞直接接触的方式支持在容器内并且在防止与饲养细胞直接接触的同时在膜上培养牙髓源细胞，以及（b）回收已经在膜上生长的细胞作为富含多能干细胞的人牙髓来源的细胞。

90. 发明公开

EP3196288A4 INKJET HEAD AND INKJET DEVICE 有权
标题翻译： TINTENSTRAHLKOPF UND TINTENSTRAHLVORRICHTUNG
公开(公告)号：EP3196288A4
公开(公告)日：2017-09-20
申请号：EP15842010
申请日：2015-09-04
申请人： PANASONIC IP MAN CO LTD
发明人： YOSHIDA HIDEHIRO , FUKADA KAZUKI , YAMAMOTO KENICHI , KITA TAKESHI
IPC分类号： C12M1/00 , B05C5/00 , B41J2/14 , B41J2/195 , C12N5/00
CPC分类号： B41J2/14233 , B05C5/00 , B41J2/14 , B41J2/14201 , B41J2/17566 , B41J2/18 , B41J2/195 , B41J25/001 , B41J2002/14306 , B41J2002/14419 , B41J2202/12 , C12M1/00 , C12N5/00
摘要： An inkjet head, includes: a pressure chamber communicating with an ink flow channel; a diaphragm linked to the pressure chamber; a piezoelectric element linked to the diaphragm; a nozzle communicating with the pressure chamber; and a vibrating mechanism placed in the ink flow channel and vibrates a supplied ink. Further provided is an inkjet device, including: the above inkjet head; a holding unit that holds a coating object; a moving mechanism that causes relative movement between the inkjet head and the holding unit; and a control unit that controls the inkjet head, the holding unit, and the moving mechanism.
摘要翻译：喷墨头包括：与墨流路连通的压力室; 连接到压力室的隔膜; 连接到隔膜的压电元件; 与压力室连通的喷嘴; 以及放置在油墨流动通道中并振动供给的油墨的振动机构。还提供了一种喷墨装置，包括：上述喷墨头; 保持涂布物的保持部; 移动机构，其使喷墨头与保持部之间相对移动; 以及控制单元，其控制喷墨头，保持单元和移动机构。

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