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81. 发明公开

EP1644517A1 MICRO AND NANO SCALE FABRICATION AND MANUFACTURE BY SPATIALLY SELECTIVE DEPOSITION 审中-公开
标题翻译：制作与生产微型和纳米尺度上按地域选择性分离
公开(公告)号：EP1644517A1
公开(公告)日：2006-04-12
申请号：EP04737485.5
申请日：2004-06-30
申请人： Raustech Pty Ltd.
发明人： HASTWELL, Peter, John , KAETHNER, Timothy, Mark
IPC分类号： C12Q1/68 , C12M1/34 , G01N33/48
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00286 , B01J2219/0043 , B01J2219/00432 , B01J2219/00441 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00628 , B01J2219/00637 , B01J2219/00641 , B01J2219/00653 , B01J2219/00675 , B01J2219/00711 , B01J2219/00713 , B01J2219/00722 , B01J2219/00754 , H01L27/322
摘要： A method of fabrication or manufacture at micrometer and nanometer scale by spatially selective deposition of chemical substances so as to form a solid phase array on a substrate (10) which includes the steps of defining a region (15) on the substrate by forming an electrostatic charge on that region which is different from the electrostatic charge on other regions of the substrate such as by formation of a latent electrostatic image thereon, applying an emulsion to the substrate. The emulsion (16) has an electrically charged discontinuous phase and a component to be selectively deposited carried in or comprising the discontinuous phase. The discontinuous phase of the emulsion is attracted to the preselected region by attraction by the electrostatic charge on the region and deposition obtained with or without reaction. The electrostatic image may be formed by the use of photoconductor. The array formed may be for flat screen display panels, for manufacture of DNA chips, printed circuits, semiconductor chips, nanotechnology, micro-electromechanical systems, flexible printed circuits or the like.

82. 发明公开

EP1282734A4 DIFFERENTIABLE SPECTRAL BAR CODE METHODS AND SYSTEMS 有权
标题翻译：不同SPEKTRALBARKODE过程和系统
公开(公告)号：EP1282734A4
公开(公告)日：2006-02-08
申请号：EP01928376
申请日：2001-04-06
申请人： QUANTUM DOT CORP
发明人： EMPEDOCLES STEPHEN A , TREADWAY JOSEPH A , WATSON ANDREW R
IPC分类号： G01J3/28 , G01N33/53 , B01L3/00 , B82B1/00 , C40B40/06 , C40B60/14 , G01J3/443 , G01N15/00 , G01N15/14 , G01N21/25 , G01N21/31 , G01N21/64 , G01N35/00 , G06F3/00 , G06F13/42 , G06K7/00 , G06K7/12 , G06K19/06
CPC分类号： G01N21/272 , B01J2219/00317 , B01J2219/00432 , B01J2219/005 , B01J2219/00574 , B01J2219/00576 , B01J2219/00578 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00657 , B01J2219/00659 , B01J2219/00677 , B01J2219/00707 , B01J2219/00722 , B01J2219/00743 , B01L3/5025 , B01L3/502715 , B01L3/502761 , B01L3/5085 , B01L3/545 , B01L2200/0668 , B01L2300/021 , B01L2300/0819 , B01L2300/0829 , B01L2400/0454 , B01L2400/0457 , B82Y30/00 , C40B40/06 , C40B60/14 , G01N21/25 , G01N21/253 , G01N21/274 , G01N21/278 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/6489 , G01N33/54373 , G01N2015/0092 , G01N2015/1472 , G01N2015/1497 , G01N2021/6441 , G01N2021/6482 , G01N2035/00158 , G01N2035/00742 , G01N2035/00752 , G01N2201/04 , G01N2201/06113 , G01N2201/12
摘要： Devices, systems, methods (as depicted in figure 1a), and compositions of matter can track and/or identify a library of elements, particularly for use with fluids, particulates, cells, and the like. Signals from one or more semiconductor nanocrystals may be combined to define spectral codes. Separation of signal wavelengths within dedicated wavelength ranges or windows facilitates differentiation of spectral codes, while calibration signals within the spectral codes can avoid ambiguity. Modeling based on prior testing can help derive libraries of acceptable codes.

83. 发明公开

EP1586378A2 Sample-analyzing device and process for manufacturing the same 审中-公开
标题翻译： Vorrichtung zum Analysieren einer Probe und Verfahren zu deren Herstellung
公开(公告)号：EP1586378A2
公开(公告)日：2005-10-19
申请号：EP05008166.0
申请日：2005-04-14
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.
发明人： Mino, Norihisa
IPC分类号： B01L3/00
CPC分类号： B01L3/5088 , B01J19/0046 , B01J2219/00283 , B01J2219/00317 , B01J2219/0036 , B01J2219/00364 , B01J2219/00378 , B01J2219/00382 , B01J2219/00385 , B01J2219/00432 , B01J2219/00441 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00734 , B01J2219/00743 , B01L3/5085 , B01L2200/12 , B82Y30/00 , C03C17/38 , C40B40/06 , C40B40/10 , C40B60/14 , G01N21/253
摘要： Sample-analyzing device 100 has a substrate 1 having a sample-loading face F1 having two or more dents 3 each formed for independently storing two or more droplets containing an analyte. The sample-loading face F1 is divided at least into a first area F11 coated with a hydrophobic organic molecular film 2 and two or more second areas F12 of which the inside is not coated with the organic molecular film 2 and the entire peripheral area is surrounded by the first area. Each of the bottom face of the dents 3 constitutes the second area F12 and each of the peripheral area of the dents 3 including its internal side surface is formed with the organic molecular film 2 coating the first area. The organic molecular film 2 is formed by using an organic molecule and bound to the face F1 via covalent bonds.
摘要翻译：样品分析装置100具有基板1，该基板1具有具有两个或更多个凹部3的样品加载面F1，每个凹部3形成为用于独立地存储包含分析物的两个或更多个液滴。样品装载面F1至少分为涂布有疏水性有机分子膜2的第一区域F11和内部未涂覆有机分子膜2的两个以上的第二区域F12，并且整个周边区域被包围由第一个区域。凹痕3的每个底面构成第二区域F12，并且包括其内侧表面的凹痕3的周边区域中的每一个形成有涂覆第一区域的有机分子膜2。有机分子膜2通过使用有机分子形成，并通过共价键与面F 1结合。

84. 发明公开

EP1487568A4 MICROCAPILLARY HYBRIDIZATION CHAMBER 审中-公开
标题翻译：微毛细管杂交室
公开(公告)号：EP1487568A4
公开(公告)日：2005-10-05
申请号：EP03714122
申请日：2003-03-12
申请人： SYNGENTA PARTICIPATIONS AG
发明人： PASZKOWSKI JERZY , GUTTMAN ANDRAS , WANG XUN
IPC分类号： B01L3/00 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B40/12 , C40B50/14 , C40B60/14 , G01N33/53 , B01J2/00
CPC分类号： B82Y30/00 , B01J2219/00378 , B01J2219/00432 , B01J2219/00497 , B01J2219/0052 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00639 , B01J2219/00657 , B01J2219/00675 , B01J2219/00677 , B01J2219/00707 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00743 , B01L3/5027 , B01L2200/16 , B01L2300/0636 , B01L2300/0838 , B01L2300/087 , C12Q1/6825 , C12Q1/6837 , C40B40/06 , C40B40/10 , C40B40/12 , C40B50/14 , C40B60/14 , C12Q2565/631 , C12Q2565/629
摘要： The invention provides a microcapillay hybridization chamber made of a narrow bore tubing with probe segments. Each probe segment has oligonucleotide probes covalently attached to the inner wall of the tubing and the oligonucleotide probes within each segment have identical, known sequences. Many oligonucleotide probe segments can be present within a single centimeter of tubing. The invention further provides methods fo using the microcapillary hybridization chambers in hybridization assays.

85. 发明公开

EP1520619A3 Biochannel assay for hybridization with biomaterial 审中-公开
标题翻译：在一个Biokanal生物材料杂交试验
公开(公告)号：EP1520619A3
公开(公告)日：2005-09-21
申请号：EP04027973.9
申请日：2000-11-09
申请人： MOTOROLA, INC.
发明人： Shieh, Chan Long , Barenburg, Barbara Foley , Yu, Huisnan , Choong, Vi-En
IPC分类号： B01L3/00 , C12Q1/68 , B01J19/00
CPC分类号： B01L3/5027 , B01J2219/00317 , B01J2219/00351 , B01J2219/00416 , B01J2219/00418 , B01J2219/00421 , B01J2219/00432 , B01J2219/0052 , B01J2219/00522 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00621 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01L3/502707 , B01L7/525 , B01L2300/0636 , B01L2300/0816 , B01L2300/087 , B01L2400/0415 , B01L2400/043 , B01L2400/049 , B82Y30/00 , C12Q1/6834 , C40B40/06 , C40B40/10 , C40B60/14 , Y10S366/02 , Y10S435/81 , C12Q2565/629
摘要： The invention relates to a microfluidic device with microchannels that have separated regions which have a member of a specific binding pair member such as DNA or RNA bound to porous polymer, beads or structures fabricated into the microchannel. The microchannels of the invention are fabricated from plastic and are operatively associated with a fluid propelling component and detector.

86. 发明公开

EP1514595A3 Microchip, process of manufacturing the same, and analytical method using the same 审中-公开
标题翻译：微芯片，其制备和分析方法，用于其使用过程
公开(公告)号：EP1514595A3
公开(公告)日：2005-09-14
申请号：EP04020406.7
申请日：2004-08-27
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.
发明人： Mino, Norihisa
IPC分类号： B01J19/00 , B01L3/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00283 , B01J2219/00317 , B01J2219/0036 , B01J2219/00364 , B01J2219/00378 , B01J2219/00382 , B01J2219/00385 , B01J2219/00432 , B01J2219/00441 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00734 , B01J2219/00743 , B01L3/5085 , B01L3/5088 , B01L2300/0819 , B01L2300/0887 , B01L2300/165 , C03C17/30 , C03C2218/111 , C03C2218/31 , C03C2218/328 , C03C2218/34 , C40B40/06 , C40B40/10 , C40B60/14
摘要： A microchip comprising a substrate and a plurality of areas capable of storing a liquid containing at least one of sample, reagent and solvent thereon, wherein: regions surrounding said areas capable of storing a liquid on the surface of said substrate are coated with a monolayer; said monolayer is more less-compatible with a liquid than the areas capable of storing a liquid; and said monolayer is connected to said substrate via a covalent bond, enabling analysis superior in sensitivity and accuracy and miniaturization of analytical instruments.

87. 发明授权

EP1117478B1 TRÄGER FÜR ANALYTBESTIMMUNGSVERFAHREN UND VERFAHREN ZUR HERSTELLUNG DES TRÄGERS 有权
标题翻译：载体分析物和制造方法CARRIER
公开(公告)号：EP1117478B1
公开(公告)日：2005-06-01
申请号：EP99944538.0
申请日：1999-08-27
申请人： Febit AG
发明人： STÄHLER, Cord, F. , STÄHLER, Peer, F. , MÜLLER, Manfred , STÄHLER, Fritz , LINDNER, Hans
IPC分类号： B01J19/00 , C07H21/00 , C07K1/04
CPC分类号： G01N21/6454 , B01J19/0046 , B01J19/0093 , B01J2219/00317 , B01J2219/00432 , B01J2219/00436 , B01J2219/00439 , B01J2219/00441 , B01J2219/00448 , B01J2219/00479 , B01J2219/00497 , B01J2219/00511 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00603 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00702 , B01J2219/00704 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01L3/502715 , B01L3/5085 , B01L2300/0654 , B01L2300/069 , B01L2300/0816 , B01L2300/0864 , B82Y30/00 , C12N15/10 , C12P19/34 , C40B40/06 , C40B40/10 , C40B50/14 , G01N21/253 , G01N33/551 , G03F7/70216 , Y10S435/97 , Y10S435/973
摘要： The invention relates to a support (40) for a method for determining analytes comprising a multitude of channels (1), especially capillary channels. A multitude of different receptors is immobilized in the channels (1) by, in particular, exposure to light. The invention also relates to a method for producing such a support. The support (40) also preferably comprises reservoirs (T, G, A, C) for the individual feed materials, a gas inlet (3), a valve (5), a sample feed (7) and an entrance (9) for additional synthesis chemicals.

89. 发明公开

EP1471035A2 A carrier of a diamond fine particle for immobilizing virus 审中-公开
标题翻译： f il il chen chen chen ung ung ung ung ung ung ung ung ung ung ung ung ung ung
公开(公告)号：EP1471035A2
公开(公告)日：2004-10-27
申请号：EP03252612.1
申请日：2003-04-24
申请人： Tadamasa Fujimura
发明人： Fujimura, Tadamasa , Akashi, Mituru , Watanabe, Junji , Sone, Masato
IPC分类号： C01B31/06 , B01J3/08 , A61K39/21 , A61K39/385 , B01J19/00
CPC分类号： B82Y30/00 , A61K39/12 , A61K39/21 , A61K2039/525 , A61K2039/5252 , A61K2039/541 , A61K2039/545 , A61K2039/60 , A61K2039/6093 , A61K2039/62 , B01J19/0046 , B01J2219/00387 , B01J2219/00432 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00722 , C01B32/25 , C01B32/28 , C12N2740/16034 , C40B40/06 , C40B50/14 , C40B60/14
摘要： The present invention provides a carrier for immobilizing a bio-derived polymer, and especially, the present invention provides a carrier of diamond fine particle for immobilizing a DNA, RNA, protein and peptide, as well as a DNA chip substrate, a carrier for holding virus and a vaccine. The carrier is prepared by the steps comprising: preparing an initial mixture including a diamond and a non-diamond by means of explosion of a detonating agent; subjecting the initial mixture to an oxidation treatment to obtain a suspension solution including the diamond; and separating a phase including the diamond. According to the present invention, after the oxidation treatment, a basic material having per se volatility or to generate a decomposed material having volatility is added, to neutralize with nitric acid, and thereby obtained diamond fine particle has a functional group on the surface thereof.
摘要翻译：本发明提供了一种用于固定生物衍生聚合物的载体，特别地，本发明提供了用于固定DNA，RNA，蛋白质和肽的金刚石微粒的载体，以及DNA芯片基底，用于保持的载体病毒和疫苗。载体通过以下步骤制备，包括：通过爆炸剂的爆炸制备包括金刚石和非金刚石的初始混合物; 对初始混合物进行氧化处理以获得包括金刚石的悬浮液; 并分离包括金刚石的相。根据本发明，在氧化处理之后，加入具有挥发性的本来具有挥发性的碱性物质或产生具有挥发性的分解材料，用硝酸中和，得到的金刚石微粒在其表面具有官能团。

90. 发明公开

EP1457782A1 SUBSTRATE FOR BIOMOLECULE MICROARRAY, PROCESS FOR PRODUCING THE SAME, BIOMOLECULE MICROARRAY AND METHOD OF COLLECTING DATA ON BIOMOLECULE MICROARRAY 审中-公开
标题翻译：底物生物分子微阵列，方法ITS，生物分子微阵列和方法收集数据上的生物分子微阵列
公开(公告)号：EP1457782A1
公开(公告)日：2004-09-15
申请号：EP02781822.8
申请日：2002-11-21
申请人： Riken
发明人： TASHIRO, Hideo , KONDOH, Yasumitsu , KITSUNAI, Tokuji , HONDA, Kaori
IPC分类号： G01N33/53 , G01N37/00 , G01N21/64
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00432 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , C40B40/06 , C40B40/10 , C40B60/14
摘要： A biomolecular microarray substrate having a spot for fixing a biomolecular probe on a surface thereof. The spot of light-reflecting layer is present between the biomolecular probe-fixing spot and the substrate surface. A method of manufacturing the biomolecular microarray substrate. A biomolecular microarray having a biomolecular probe-fixing spot in which a biomolecular probe is fixed by a biomolecular probe-fixing spot having the biomolecular microarray substrate. A data collection method for biomolecular arrays. Fluorescently labeled target biomolecules is interacted with a biomolecular microarray having, on a substrate surface, biomolecular probe-fixing spots that fix biomolecular probes on light-reflecting layer spots; excitation light is directed onto the biomolecular microarray obtained and reflected light and fluorescence are simultaneously measured from the biomolecular microarray; a biomolecular probe-fixing spot present on a light-reflecting layer spot is specified from differences in the intensity of the light reflecting off of the biomolecular microarray; and fluorescence data are obtained from within the scope of the specified spot. Alternatively, light is directed onto the biomolecular microarray obtained and reflected light is measured from the biomolecular microarray; a biomolecular probe-fixing spot having a light-reflecting layer spot is specified from differences in the intensity of the light reflecting off of the biomolecular microarray; excitation light is directed only onto the scope of the specified biomolecular probe-fixing spot and measuring the fluorescence; and fluorescence data are obtained from the scope of the specified spot.
摘要翻译：具有用于在其表面上固定生物分子样品的斑点生物分子微阵列的底物。光反射层的光点是生物分子探针固定点和所述基板表面之间。制造该生物分子的微阵列基片的方法。具有生物分子探针固定点，其中，生物分子样品由具有生物分子的微阵列基片生物分子探针固定点固定生物分子微阵列。用于生物分子阵列的一种数据采集方法。荧光标记的靶生物分子相互作用是与具有生物分子的微阵列，在一个表面的基材，生物分子探针固定点确实固定在光反射层的生物分子斑点的探针; 激励光被引导到获得生物分子微阵列和反射光及荧光同时从生物分子微阵列测量; 存在于光反射层斑生物分子探针固定点从在光反射离开生物分子微阵列的强度的差异指定; 和荧光数据从指定点的范围内得到。可替代地，光被引导到获得生物分子微阵列和反射的光从生物分子微阵列测量; 具有光反射层斑生物分子探针的固定点从在光反射离开生物分子微阵列的强度的差异指定; 激发光被引导只有走上的范围指定的生物分子探针固定点和测量荧光; 和荧光数据从指定点的范围获得。

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