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81. 发明公开

EP0754010A1 DEVICE FOR TREATING CONSTRICTION IN A BODILY CONDUIT 失效
标题翻译：设备用于处理体动脉通道电流
公开(公告)号：EP0754010A1
公开(公告)日：1997-01-22
申请号：EP95914832.0
申请日：1995-03-31
申请人： LIPRIE, Samuel F
发明人： LIPRIE, Samuel F
IPC分类号： A61M25 , A61F2 , A61M29 , A61M36 , A61N5 , A61B17
CPC分类号： A61N5/1002 , A61B2017/22002 , A61M25/1002 , A61M25/104 , A61M2025/1047 , A61M2025/1079 , A61M2025/1086 , A61M2025/1093 , A61N2005/1003
摘要： This invention is an apparatus and method for treating an occlusion or constriction, such as a stenosis (30) in a blood vessel (26) or other conduit in the body, as well as an apparatus and method for treating a tumor or cancerous area occurring around a conduit or duct in the body. The apparatus includes a catheter (10) provided with a ribbed balloon (18) encircling a portion near its distal end (14). When inserted into the body over a guide wire (16) and transported to the site of the stenosis (30), the balloon (16) is inflated one or more times and, due to the ribbed balloon, blood perfuses around the catheter during the treatment. A radio active source of material is inserted through the catheter (10) to the site of the stenosis (30) or cancer where it is maintained in position for a period of time to reduce the occurrence of re-stenosis or cancer. A guide wire (64) provided with a removable core (54) can be utilized to properly maneuver the catheter (10) to the site of the stenosis (30) or cancer.

82. 发明公开

EP0497495A3 A minimally invasive medical device 失效
标题翻译：一个最小的入侵医疗设备
公开(公告)号：EP0497495A3
公开(公告)日：1993-04-07
申请号：EP92300538.3
申请日：1992-01-22
申请人： MED INSTITUTE, INC.
发明人： Roubin, Gareth Sidney Samuel , Fearnot, Neal Edward
IPC分类号： A61N5/10
CPC分类号： A61N5/1002 , A61B2017/22068 , A61M2025/1047 , A61N2005/1003 , A61N2005/1004 , A61N2005/1021 , A61N2005/1025
摘要： A minimally invasive intravascular medical device for providing a radiation treatment in a body passageway such as a coronary vessel of the vascular system. The device includes a flexible elongated member having distal and proximal portions. The distal portion is percutaneously insertable into a vessel and includes a distal end that is directable through the vessel to the treatment site. A radiation source is attached about the distal portion for delivering a radiation treatment to the walls a vessel having a stent positioned thereagainst. The distal portion of the elongated member includes a wire coil positioned about the tapered distal end of a mandril wire. The combination of the wire coil and the tapered distal end of the mandril wire provides variable flexibility to the distal portion of the device. The distal portion also has a predetermined curvature for directing the distal end of the device through the vessel. A safety wire is also extendable through the passageway of the wire coil to provide further flexibility to the distal portion. The radiation source is fixedly positioned about either the tapered distal end of the mandril wire or the safety wire in the passageway of the wire coil. An annular recess is included about the tapered distal end of the mandril wire to fixedly position a source of radioactive material therein.

83. 发明公开

EP0497495A2 A minimally invasive medical device 失效
标题翻译： Gerät最小化
公开(公告)号：EP0497495A2
公开(公告)日：1992-08-05
申请号：EP92300538.3
申请日：1992-01-22
申请人： MED INSTITUTE, INC.
发明人： Roubin, Gareth Sidney Samuel , Fearnot, Neal Edward
IPC分类号： A61N5/10
CPC分类号： A61N5/1002 , A61B2017/22068 , A61M2025/1047 , A61N2005/1003 , A61N2005/1004 , A61N2005/1021 , A61N2005/1025
摘要： A minimally invasive intravascular medical device for providing a radiation treatment in a body passageway such as a coronary vessel of the vascular system. The device includes a flexible elongated member having distal and proximal portions. The distal portion is percutaneously insertable into a vessel and includes a distal end that is directable through the vessel to the treatment site. A radiation source is attached about the distal portion for delivering a radiation treatment to the walls a vessel having a stent positioned thereagainst. The distal portion of the elongated member includes a wire coil positioned about the tapered distal end of a mandril wire. The combination of the wire coil and the tapered distal end of the mandril wire provides variable flexibility to the distal portion of the device. The distal portion also has a predetermined curvature for directing the distal end of the device through the vessel. A safety wire is also extendable through the passageway of the wire coil to provide further flexibility to the distal portion. The radiation source is fixedly positioned about either the tapered distal end of the mandril wire or the safety wire in the passageway of the wire coil. An annular recess is included about the tapered distal end of the mandril wire to fixedly position a source of radioactive material therein.
摘要翻译：一种用于在诸如血管系统的冠状血管的身体通道中提供放射治疗的微创血管内医疗装置。该装置包括具有远侧和近端部分的柔性细长构件。远端部分经皮可插入容器中，并且包括远端，其可通过该容器指向治疗部位。辐射源围绕远端部分附着，用于将辐射处理传送到具有定位在其上的支架的容器。细长构件的远端部分包括围绕曼尼尔丝线的锥形远端定位的线圈线圈。线圈和锥形线的锥形远端的组合为器件的远端部分提供了可变的柔性。远侧部分还具有用于将装置的远端引导通过血管的预定曲率。安全线还可以通过线圈的通道延伸，以向远端部分提供更多的灵活性。辐射源固定地定位在丝线的锥形远端或线圈通道中的安全线上。围绕曼角丝的锥形远端包围环形凹槽，以将放射性物质源固定在其中。

84. 发明授权

EP2968976B1 MULTITUBE ESOPHAGEAL BRACHYTHERAPY CATHETER 有权
标题翻译： MULTITUBE食管短程治疗导管
公开(公告)号：EP2968976B1
公开(公告)日：2017-12-06
申请号：EP14714855.5
申请日：2014-03-06
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： GRESKOVICH, John, Jr
IPC分类号： A61N5/10 , A61M25/00 , A61M25/10
CPC分类号： A61N5/1002 , A61N2005/1003 , A61N2005/1005 , A61N2005/1094
摘要： A system for delivery of radiation to a target portion of a native tissue is provided. The system includes a catheter having a main catheter body. The main catheter body includes an outer catheter surface and an inner catheter surface that defines a longitudinally oriented lumen. The lumen extends between longitudinally spaced proximal and distal catheter face surfaces extending laterally between the inner and outer catheter surfaces. A sheath covers at least a portion of the outer catheter surface. The sheath includes a tapered portion protruding substantially longitudinally distally from a portion of the distal catheter face surface. A plurality of tubes extends through the lumen towards the distal catheter face surface. Each tube of the plurality of tubes is configured to selectively guide exposure of a radiation source to the target portion of the native tissue.

85. 发明公开

EP2968976A1 MULTITUBE ESOPHAGEAL BRACHYTHERAPY CATHETER 有权
标题翻译： MULTITUBULARER KATHETERFÜRÖSOPHAGEALEBRACHYTHERAPIE
公开(公告)号：EP2968976A1
公开(公告)日：2016-01-20
申请号：EP14714855.5
申请日：2014-03-06
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： GRESKOVICH, John, Jr
IPC分类号： A61N5/10 , A61M25/00 , A61M25/10
CPC分类号： A61N5/1002 , A61N2005/1003 , A61N2005/1005 , A61N2005/1094
摘要： A system for delivery of radiation to a target portion of a native tissue is provided. The system includes a catheter having a main catheter body. The main catheter body includes an outer catheter surface and an inner catheter surface that defines a longitudinally oriented lumen. The lumen extends between longitudinally spaced proximal and distal catheter face surfaces extending laterally between the inner and outer catheter surfaces. A sheath covers at least a portion of the outer catheter surface. The sheath includes a tapered portion protruding substantially longitudinally distally from a portion of the distal catheter face surface. A plurality of tubes extends through the lumen towards the distal catheter face surface. Each tube of the plurality of tubes is configured to selectively guide exposure of a radiation source to the target portion of the native tissue.
摘要翻译：提供了用于将辐射递送到天然组织的目标部分的系统。该系统包括具有主导管主体的导管。主导管主体包括外导管表面和限定纵向定向内腔的内导管表面。内腔在内导管表面和外导管表面之间横向延伸的纵向间隔的近端和远端导管面之间延伸。护套覆盖外导管表面的至少一部分。护套包括从远端导管面表面的一部分基本上纵向远端突出的锥形部分。多个管延伸穿过内腔朝向远端导管面表面。多个管的每个管被配置成选择性地将辐射源的辐射引导到天然组织的目标部分。

86. 发明公开

EP2745875A2 Systems and methods for treating cancer using brachytherapy 有权
标题翻译： Systeme zur Behandlung von Krebs mit Brachytherapie
公开(公告)号：EP2745875A2
公开(公告)日：2014-06-25
申请号：EP13187832.4
申请日：2013-10-09
申请人： Voxel Rad, Ltd.
发明人： Rahimian, Javad
IPC分类号： A61N5/10
CPC分类号： A61N5/1016 , A61B17/0218 , A61B2017/4216 , A61N5/1007 , A61N2005/1003 , A61N2005/1058 , A61N2005/1059
摘要： Systems and methods are provided for treating cervical and/or uterine cancers in brachytherapy with an intracavitary brachytherapy applicator. The system comprises a tandem adapted for insertion into a cervix of a patient. An ovoid assembly comprises first and second inflatable ovoids and an ovoid support mechanism. The first and second inflatable ovoids are adapted for insertion within fornices of a patient. First and second retractors are adapted to be coupled to the ovoid assembly. The first retractor is adapted to be positioned to retract the bladder of a patient during treatment. The second retractor is adapted to be positioned to retract the rectum of a patient during treatment. The tandem and the first and second inflatable ovoids are adapted to be coupled to a radioactive source to deliver an implant radiation dose suitable for cancer treatment at a cancerous cervical treatment site in a patient.
摘要翻译：提供系统和方法用于治疗近距离放射治疗中的子宫颈和/或子宫癌与腔内近距离放射治疗仪。系统包括适于插入患者子宫颈的串联。卵形组件包括第一和第二可膨胀卵形体和卵球形支撑机构。第一和第二可充气卵形体适于插入患者的牙龈内。第一和第二牵开器适于联接到卵形组件。第一牵开器适于定位成在治疗期间缩回患者的膀胱。第二牵开器适于定位成在治疗期间收缩患者的直肠。串联和第一和第二可膨胀卵形体适于与放射源耦合以在患者的癌性宫颈治疗部位输送适合于癌症治疗的植入物辐射剂量。

87. 发明公开

EP1062000A4 CATHETER SYSTEM HAVING TUBULAR RADIATION SOURCE WITH MOVABLE GUIDE WIRE 审中-公开
标题翻译：导管系统与移动导丝管式辐射源
公开(公告)号：EP1062000A4
公开(公告)日：2008-09-03
申请号：EP99909703
申请日：1999-03-01
申请人： BOSTON SCIENT LTD
发明人： URICK MICHAEL J , EHR TIMOTHY G J , HASTINGS ROGER N
IPC分类号： A61F2/958 , A61M29/02 , A61M36/04 , A61N5/10 , A61N5/00
CPC分类号： A61N5/1002 , A61M25/0138 , A61M25/1002 , A61M25/104 , A61M2025/0063 , A61M2025/0656 , A61M2025/1061 , A61N2005/1003 , A61N2005/1004
摘要： A radiation source (24) for inhibiting restenosis including a radiation delivery tube (20) having a radioactive distal region (24), the tube (20) being adapted to slide over a core wire (28) within a radiation delivery catheter (42). The core wire (28) is preferably in a slidable relation with the radiation delivery catheter (42). By withdrawing the core wire (28) to a proximal position, the flexibility of a distal region of the radiation delivery catheter (42) may be increased, thereby allowing the radiation delivery catheter (42) to navigate more tortuous paths and reach more distal sites. Before the radiation delivery tube (20) is advanced into the catheter distal region, the core wire (28) is preferably slid distally to a distal position. With the core wire (28) in the distal position, the core wire (28) may provide a structure that can be used to rapidly advance the radiation source (24) to the lesion site. The core wire (28) may also help constrain lateral movement of the radiation delivery tube (20) and help center the radiation delivery tube (20) within the vessel to provide a more even radiation exposure to the vessel walls.

88. 发明公开

EP1073496A4 IMPROVED IRRADIATION CATHETER AND METHOD OF USE 审中-公开
标题翻译：辐射加热器SOWIE ANWENDUNGSVERFAHREN
公开(公告)号：EP1073496A4
公开(公告)日：2007-01-17
申请号：EP99908269
申请日：1999-02-19
申请人： TEIRSTEIN PAUL S
发明人： TEIRSTEIN PAUL S
IPC分类号： A61M25/00 , A61N5/10 , A61F2/84 , A61M25/10 , A61M36/04
CPC分类号： A61N5/1002 , A61M25/1002 , A61M2025/0183 , A61M2025/1047 , A61N2005/1003
摘要： The invention is a catheter (10) for use with a radioactive source (16) within the catheter (10) to irradiate a selected area of a blood vessel in combination with angioplasty procedures, to prevent restenosis of that area of the vessel. The catheter (10) has a guidewire channel (18) formed near its distal end to facilitate use of the cather (10) as a rapid exchange catheter, allowing insertion of the catheter (10) over a guidewire (20). The catheter (10) has a radiation lumen (14) with a sealed end to retain the radioactive source (16) within the catheter (10). The radiation lumen (14) is sufficiently longer than the guidewire channel (18), keeping the radiation source (16) segregated from the blood, allowing the use of a non-sterile radiation source. The catheter (10) can be provided with a balloon (22) or a set of wire loops (50) to center the radioactive source (16) radially within the blood vessel.
摘要翻译：本发明是与导管（10）内的放射源（16）一起使用的导管（10），用于结合血管成形术过程照射血管的选定区域，以防止血管区域的再狭窄。导管（10）具有形成在其远端附近的导丝通道（18），以便于使用捕获器（10）作为快速交换导管，从而允许导管（10）插入导丝（20）上方。导管（10）具有带密封端的辐射腔（14），以将放射源（16）保持在导管（10）内。辐射腔（14）比导丝通道（18）足够长，保持辐射源（16）与血液分离，从而允许使用非无菌辐射源。导管（10）可以设置有球囊（22）或一组线环（50），以将放射源（16）在径向集中在血管内。

89. 发明授权

EP1017442B1 CATHETER WITH STAND-OFF STRUCTURE 有权
标题翻译：具有安全距离导管结构
公开(公告)号：EP1017442B1
公开(公告)日：2005-01-12
申请号：EP98953186.8
申请日：1998-09-23
申请人： United States Surgical Corporation , Angiorad L.L.C.
发明人： LIPRIE, Samuel, F. , FUTATO, Lisa, D. , TOSO, Kenneth, E. , TOSO, Gregory, F.
IPC分类号： A61M25/01 , A61M29/02 , A61M29/00
CPC分类号： A61M25/104 , A61M25/1002 , A61M2025/0063 , A61M2025/0183 , A61N5/1002 , A61N2005/1003
摘要： A catheter (10), and a method for performing radiation treatment at a site where angio-plasty was performed, are disclosed. The catheter (10) includes a hollow, cylindrical member (12) constructed from a fairly flexible material. The catheter is maneuvered within the body by traveling over a guide wire which was initially maneuvered in the blood vessel to a position beyond the actual site of a stenosis. Stand-off structure (26) having a stand-off balloon (28) surrounds a portion (30) of the outer surface of the catheter (10). The distal end (18) of the catheter (10) includes an inner lumen plug (38), and a distal mandrel (40) extending through the inner lumen plug (38). The distal mandrel (40) is manufactured from shape memory alloy to stiffen, and reinforce the catheter when the catheter is introduced within the blood vessel.

90. 发明授权

EP0952874B1 CATHETER HAVING CENTERING MEANS 失效
标题翻译：有中心导管
公开(公告)号：EP0952874B1
公开(公告)日：2004-12-29
申请号：EP97929583.9
申请日：1997-07-04
申请人： Delft Instruments Intellectual Property B.V.
发明人： LÖFFLER, Edgar, German , VISSCHER, Arie, Luite
IPC分类号： A61N5/10 , A61M25/10
CPC分类号： A61N5/1002 , A61M25/10 , A61M25/1011 , A61M2025/1013 , A61M2025/1072 , A61N2005/1003
摘要： A catheter comprising an elongated tube having a first channel for the guiding of a radioactive element and a second channel for the passage of a guide wire for the catheter, in which the elongated tube is provided on its outer circumference near its distal end with temporarily activatable centering means, the centering means being surrounded by recanalization means, and the centering means comprising a plurality of elongated balloons which are inflatable by fluid fed through at least one third channel and, in operation, allow the recanalization means to expand to form an elongated body, with respect to which the first channel is centered.

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