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81. 发明授权

EP1315568B1 STRIP HOLDER FOR USE IN A TEST STRIP METER 有权
标题翻译：条夹用在测试条带规格
公开(公告)号：EP1315568B1
公开(公告)日：2005-09-28
申请号：EP01959271.6
申请日：2001-07-26
申请人： LIFESCAN, INC.
发明人： HOUSE, Allen , OLSON, Lorin
IPC分类号： B01L3/00 , G01N33/48 , G01N33/86
CPC分类号： G01N21/8483 , B01L3/5027 , B01L9/52 , B01L2200/025 , B01L2200/141 , B01L2300/0822 , B01L2400/0406 , Y10T436/25
摘要： Test strip holders for use with test strip meters are provided. The subject test strip holders include at least an opening and a lip associated with the opening. The lip element of the subject holders is capable of forming a liquid seal with the upper surface of a test strip upon insertion of the test strip into the opening. In many embodiments, the strip holder is configured to at least partially encompass a sample application region of a test strip upon insertion of the strip into the opening. Also provided are meters on which the subject test holders are present, as well as methods for using same.

82. 发明授权

EP1268063B1 CAPILLARY FLOW CONTROL IN A MEDICAL DIAGNOSTIC DEVICE 有权
标题翻译：毛细管流量控制医疗诊断设备
公开(公告)号：EP1268063B1
公开(公告)日：2005-08-03
申请号：EP01922654.7
申请日：2001-03-23
申请人： LIFESCAN, INC.
发明人： SHARTLE, Robert, Justice
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2300/0645 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , B01L2400/0688
摘要： A medical diagnostic device for measuring an analyte concentration in a sample of a biological fluid includes a capillary flow channel in the device to convey the sample from an inlet to a second region. The flow channel has a capillary dimension in at least one direction. A stop junction in the flow channel has a boundary region that has a dimension that is greater in that direction and forms an angle that points toward the sample inlet.

83. 发明授权

EP0960946B1 Test Strip for the determination of glucose 失效
标题翻译：测试条用于测定葡萄糖
公开(公告)号：EP0960946B1
公开(公告)日：2005-07-27
申请号：EP99202765.6
申请日：1987-08-07
申请人： LIFESCAN, INC.
发明人： Phillips, Roger , Underwood, Ray , McGarraugh, Geoffrey , Jurik, Frank
IPC分类号： C12Q1/54 , G01N33/52 , G01N21/86 , C12Q1/00
CPC分类号： G01N21/8483 , C12Q1/54 , G01N21/314 , G01N21/4738 , G01N33/52 , G01N33/521 , G01N33/523 , G01N33/66 , G01N35/1016 , G01N2021/4757 , G06F19/00 , Y02A90/26 , Y10S435/805 , Y10S435/808 , Y10S435/81 , Y10T436/112499 , Y10T436/144444
摘要： A method for determining the presence of an analyte in a fluid is described along with an apparatus specifically designed to carry out the method. The method involves taking a reflectance reading from one surface (15) of an inert porous matrix (11) impregnated with a reagent that will interact with the analyte to produce a light-absorbing reaction product when the fluid being analysed is applied to another surface (16) and migrates through the matrix to the surface being read. Reflectance measurements are made at two separate wavelengths in order to eliminate interferences, and a timing circuit is triggered by an initial decrease in reflectance by the wetting of the surface whose reflectance is being measured by the fluid which passes through the inert matrix. The method and apparatus are particularly suitable for the measurement of glucose levels in blood without requiring separation of red blood cells from serum or plasma.

84. 发明授权

EP1280602B1 CAPILLARY FLOW CONTROL IN A FLUIDIC DIAGNOSTIC DEVICE 有权
标题翻译： KAPILLARDURCHFLUSSREGELUNG在流体诊断设备
公开(公告)号：EP1280602B1
公开(公告)日：2005-05-11
申请号：EP01937160.8
申请日：2001-03-22
申请人： LIFESCAN, INC.
发明人： SHARTLE, Robert, Justice
IPC分类号： B01L3/00
CPC分类号： G01N33/4905 , Y10T436/2575
摘要： A medical diagnostic device for measuring an analyte concentration or property of a biological fluid includes capillary flow channels to convey a sample of the fluid from an inlet to a branching point, and then to a measurement area and , alternatively, through a bypass channel to an overflow region. A first stop junction stops fluid flow after it enters the measurement area. The bypass channel has a capillary dimension in at least one direction. A second stop junction, in the bypass channel, has a boundary region that has a dimension that is greater in that direction and forms an angle that points toward the branching point. With this construction, the second stop junction initially prevents flow to the overflow region, but permits the flow after the measurement area is filled. The device is particularly suited for measuring coagulation time of blood.

85. 发明公开

EP1324038A3 Method for producing reagent coated test strip 有权
标题翻译：一种用于生产反应性包层测试条的过程
公开(公告)号：EP1324038A3
公开(公告)日：2005-04-20
申请号：EP02258168.0
申请日：2002-11-27
申请人： LIFESCAN, INC.
发明人： Dick, Kenneth W. , Otake, Gary , Jessen, Aaron
IPC分类号： G01N33/49 , B05D3/02
CPC分类号： G01N27/3272
摘要： A system for drying chemical reagents on material, particularly for producing product used in making reagent test strips is described. By drying selected chemicals on substrate drawn past a radiant energy source (preferably an IR source), rapid drying may be achieved while obtaining high-quality product. Airflow sufficient to break or disturb a vapor boundary layer above drying solution may be provided to increase drying speeds. Any airflow provided should not disturb the surface of the solution. Still, air-impingement drying techniques may be employed in the system to finish drying reagent material once it is sufficiently dry to be stable in shape. The substrate upon which chemicals are dried may include a reflective coating to facilitate its use with high levels of radiant energy. A metallic or metalized substrate is advantageously used in producing electrochemical test strips. Such test strips may be used in conjunction with various kits and be conveniently read using known hand-held meters.

86. 发明公开

EP1318399A3 Passive sample detection to initiate timing of an assay 审中-公开
标题翻译：在分析开始评估被动样本
公开(公告)号：EP1318399A3
公开(公告)日：2005-04-20
申请号：EP02258481.7
申请日：2002-12-09
申请人： Lifescan, Inc.
发明人： Kermani, Mahyar Z. , Ohara, Timothy , Teodorczyk, Maria
IPC分类号： G01N33/487
CPC分类号： G01N27/3273
摘要： The present invention provides methods and systems for passively and automatically detecting the presence of a sample (the "sample detection phase") upon application of the sample to a biosensor, identifying the sample detection time and then initiating the measurement of a targeted characteristic, e.g. , the concentration of one or more analytes, of the sample (the "measurement phase"), immediately upon sample detection. The subject methods and systems do not employ or involve the application of an electrical signal from an external source to the electrochemical cell for purposes of performing the sample detection phase and are, thus, less complicated and involve fewer steps and components.

87. 发明公开

EP1510171A1 Analytical device with prediction module and related methods 审中-公开
标题翻译： Analytische Einrichtung mit Vorhersagemodul undzugehörigesVerfahren
公开(公告)号：EP1510171A1
公开(公告)日：2005-03-02
申请号：EP04255207.5
申请日：2004-08-27
申请人： LIFESCAN, INC.
发明人： Stout, Phil , Melander, Todd
IPC分类号： A61B5/00 , A61B5/15
CPC分类号： A61B5/0002 , A61B5/022 , A61B5/14532 , A61B5/1455 , A61B5/1486 , A61B5/150022 , A61B5/150358 , A61B5/157 , A61B5/6824 , A61B2560/0431 , A61B2562/0295 , Y10T436/11
摘要： An analytical device for predicting a subject's whole blood analyte concentration based on the subject's interstitial fluid (ISF) analyte concentration includes an ISF sampling module, an analysis module and a prediction module. The ISF sampling module is configured to sequentially extract a plurality of ISF samples from a subject. The analysis module is configured to sequentially determining an ISF analyte concentration (e.g., ISF glucose concentration) in each of the ISF samples, resulting in a series of ISF analyte concentrations. The prediction module is configured for storing the series of ISF analyte concentrations and predicting the subject's whole blood analyte concentration based on the series by performing at least one algorithm. A method for predicting a subject's whole blood analyte concentration based on the subject's interstitial fluid analyte concentration includes extracting a plurality of interstitial fluid (ISF) samples from a subject in a sequential manner and sequentially determining an ISF analyte concentration in each of the plurality of ISF samples to create a series of ISF analyte concentrations. The subject's blood analyte concentration is then predicted based on the series of ISF analyte concentrations by performing at least one algorithm.
摘要翻译：基于受试者的间质液（ISF）分析物浓度来预测受试者的全血分析物浓度的分析装置包括ISF采样模块，分析模块和预测模块。 ISF采样模块被配置为从对象顺序地提取多个ISF样本。分析模块被配置为依次确定每个ISF样品中的ISF分析物浓度（例如，ISF葡萄糖浓度），得到一系列ISF分析物浓度。预测模块被配置为存储一系列ISF分析物浓度，并且通过执行至少一种算法来基于该系列预测受试者的全血分析物浓度。基于受试者的间质液分析物浓度来预测受试者的全血分析物浓度的方法包括以顺序方式从受试者中提取多个间质液样品，并依次确定多个ISF中的每一个的ISF分析物浓度样品产生一系列ISF分析物浓度。然后通过执行至少一种算法，基于ISF分析物浓度的一系列来预测受试者的血液分析物浓度。

88. 发明公开

EP1492457A1 AUTOMATICALLY OPENING MEDICAL DEVICE PACKAGE AND METHOD OF MANUFACTURE 有权
标题翻译：包装的医疗设备自动打开，和方法
公开(公告)号：EP1492457A1
公开(公告)日：2005-01-05
申请号：EP04702585.3
申请日：2004-01-15
申请人： Lifescan, Inc.
发明人： ALLEN, John, J.
IPC分类号： A61B10/00 , B65D75/26 , A61B19/02
CPC分类号： A61B50/3001 , A61B5/150022 , A61B5/150297 , A61B5/150305 , A61B5/150412 , A61B5/150503 , A61B5/150534 , A61B2050/314
摘要： An automatically opening medical device package that includes upper and lower flexible sheet portions, each having distal and proximal ends and first and second peripheral edges. These flexible sheet portions are adapted to be detachably sealed together along their peripheral edges, thereby providing for the enclosure of a medical device. Also included is a collar attached to the distal ends such that a relative movement of the collar and the proximal ends, that decreases a distance therebetween, causes the flexible sheet portions to pull apart, opening the package. A method of manufacturing an automatically opening medical device package containing a medical device includes positioning a medical device on an upper surface of a flexible sheet of material that also has a lower surface, and first and second ends. Upper and lower collar precursors are attached to the lower surfaces of the first and second ends, respectively. The flexible sheet of material is subsequently folded end-over-end about the medical device, thereby forming upper and lower flexible sheet portions (each with distal and proximal ends) that enclose the medical device. The flexible sheet portions are then detachably sealed together. The collar precursors are rolled-back across the flexible sheet portions, operatively aligned, and sealed together to form a collar that is attached to the distal ends such that a relative movement of the collar and the proximal ends, that decreases a distance therebetween, results in a pulling apart of the flexible sheet portions, thereby exposing at least a portion of the medical device.

89. 发明授权

EP1130111B1 Diagnostics based on tetrazolium compounds 有权
标题翻译：成立于四唑诊断
公开(公告)号：EP1130111B1
公开(公告)日：2004-10-06
申请号：EP01301670.4
申请日：2001-02-23
申请人： LIFESCAN, INC.
发明人： Ouyang, Tianmei , Yu, Yeung Siu
IPC分类号： C12Q1/54 , G01N33/52 , C12Q1/26
CPC分类号： C12Q1/32 , C12Q1/26 , C12Q1/54 , G01N33/525 , G01N33/64 , Y10S435/962 , Y10S435/97 , Y10T436/173076

90. 发明公开

EP1266609A3 Percutaneous biological fluid sampling and analyte measurement devices and methods 审中-公开
标题翻译：经皮生物流体取样和分析物测量装置和方法
公开(公告)号：EP1266609A3
公开(公告)日：2004-09-22
申请号：EP02254052.0
申请日：2002-06-11
申请人： Lifescan, Inc.
发明人： Kiser, Ernest , Leong, Koon-Wah
IPC分类号： A61B5/15
CPC分类号： A61B5/1486 , A61B5/14532
摘要： A device for sampling a biological fluid and measuring at least one target constituent within the biological fluid. The device has at least one electrochemical cell having an inner electrode and an outer electrode in a concentrically-spaced relationship. In a preferred embodiment, the outer electrode has a cylindrical configuration having an open distal end and the inner electrode has an elongated configuration positioned co-axially within the outer electrode and a distal end configured to penetrate the skin. The spacing between the electrodes exerts a capillary force on biological fluid present at the open distal end of the outer electrode. A system is also provided which includes a control unit in electrical communication with the electrochemical cell for controlling the selection and measurement of the target constituent. Methods of sampling of biological fluids within the skin and measuring the sampled fluids are also provided, as well as kits comprising one or more of the inventive devices and/or systems.

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