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81. 发明公开

EP2400035A1 Methods and compositions for diagnosing gastrointestinal stromal tumors 审中-公开
标题翻译： Verfahren und Zusammensetzungen zur诊断呕吐肠胃炎Stromatumoren
公开(公告)号：EP2400035A1
公开(公告)日：2011-12-28
申请号：EP10167588.2
申请日：2010-06-28
申请人： Technische Universität München , Universität Leipzig
发明人： von Bubnoff, Nikolas , Lange, Thoralf , Maier, Jacqueline
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/68 , C12Q2600/156 , C12Q2600/16
摘要： The present invention relates to an in vitro method for diagnosing and/or monitoring in a subject a gastrointestinal stromal tumor or a predisposition to develop a gastrointestinal stromal tumor, comprising detecting and/or analyzing in a test sample derived from the subject one or more mutations in any one or both of the marker genes cKIT (GenBank acc. no. NM_000222.2) and PDGFRA (GenBank acc. no. NM_006206.4), wherein the presence of any one of the mutations detected in the test sample is indicative of a gastrointestinal stromal tumor or a predisposition to develop a gastrointestinal stromal tumor in the subject. The present invention is also directed to a corresponding kit-of-parts for diagnosing and/or monitoring a gastrointestinal stromal tumor or a predisposition to develop a gastrointestinal stromal tumor, comprising means for detecting and/or analyzing one or more mutations as defined herein, as well as to the use of one or more mutations as defined herein as a panel of molecular markers for diagnosing and/or monitoring a gastrointestinal stromal tumor or a predisposition to develop a gastrointestinal stromal tumor.
摘要翻译：本发明涉及一种用于诊断和/或监测受试者的胃肠道间质肿瘤或发展胃肠道间质瘤的倾向的体外方法，其包括在来自受试者的测试样品中检测和/或分析一种或多种突变在任何一个或两个标记基因cKIT（GenBank acc.No.NM_000222.2）和PDGFRA（GenBank，编号NM_006206.4）中，其中在测试样品中检测到的任何一种突变的存在表明胃肠道间质肿瘤或在受试者中发展胃肠道间质瘤的倾向。本发明还涉及用于诊断和/或监测胃肠道间质肿瘤或发展胃肠道基质肿瘤的倾向的相应试剂盒，其包括用于检测和/或分析本文定义的一种或多种突变的方法，以及本文定义的一种或多种突变作为分子标记用于诊断和/或监测胃肠道间质瘤或倾向于发展胃肠道间质瘤的用途。

82. 发明授权

EP2103933B1 Device and method for measuring impedance in organotypic tissues 有权
标题翻译：装置和方法，用于测量在有机组织的阻抗
公开(公告)号：EP2103933B1
公开(公告)日：2011-07-27
申请号：EP08003365.7
申请日：2008-02-25
申请人： Universität Leipzig
发明人： Robitzki, Andrea , Rothermel, Andrée , Jahnke, Heinz-Georg , Sternberger, Ina , Striggow, Frank , Mack, Till
IPC分类号： G01N33/487
CPC分类号： G01N33/4836 , G01N27/041
摘要： The present invention refers to a device for measuring impedance in organotypic tissue comprising at least one recording chamber with a liquid permeable membrane supporting the organotypic tissue, at least one bottom electrode and at least one top electrode, wherein the liquid permeable membrane divides the recording chamber into a top chamber and a bottom chamber, wherein at least the bottom chamber contains culture medium for the organotypic tissue, and the bottom electrode(s) is/are located in the bottom chamber and the top electrode(s) is/are located in the top chamber, and wherein the organotypic tissue is located between the bottom electrode(s) and the top electrode(s). The present invention also refers to the use of the device according to the present invention for measuring impedance in organotypic tissue. Furthermore, the present invention relates to a method for analyzing the effect of test compounds on pathological and non-pathological organotypic tissue by meassuring the impedance of the organotypic tissue, wherein the organotypic tissue is cultured in a culture medium during the time of the analysis and the impedance of the organotypic tissue is measured at least once before and at least once after treating the organotypic tissue with the test compound or the impedance of the organotypic tissue treated with the test compound is compared to a non-treated organotypic tissue, wherein the impedance is measured using at least one electrode at each of two opposing sides of the organotypic tissue, and the electrodes are contacted with the culture medium or the tissue during measuring the impedance.

83. 发明公开

EP2218784A1 Vector(s) containing an inducible gene encoding a CDK4/CD6 inhibitor useful for treating neurodegenerative disorders 审中-公开
标题翻译：向量（一个或多个）编码CDK4 / CD6抑制剂诱导的基因为神经变性疾病的治疗
公开(公告)号：EP2218784A1
公开(公告)日：2010-08-18
申请号：EP09001521.5
申请日：2009-02-04
申请人： Universität Leipzig
发明人： Arendt, Thomas , Ueberham, Uwe Dr.
IPC分类号： C12N15/63 , A61P25/28 , A61K38/18
CPC分类号： A61K48/0058 , A61K38/1709 , C07K14/245 , C07K14/4738 , C12N15/1135 , C12N15/635 , C12N2310/14
摘要： Described are vectors containing (a) a gene encoding (i) a CDK4/CDK6 inhibitor, preferably p16 INK4a , or (ii) an RNA interfering with CDK4 and/or CDK6 expression and/or activity, under the control of an inducible promoter and (b) a gene encoding a transactivator protein for said promoter useful for treating neurodegenerative disorders. These vectors can be transferred into cells where they will exert a protective function to (i) prevent cell death or to (ii) slow down progression of cell death. These vectors can be used in therapeutic applications to prevent neurodegenerative disorders or to slow down their progression with therapeutic efficacy.
摘要翻译：描述的是含有（a）的基因编码（I）的CDK4 / CDK6抑制剂，优选P16 INK4A，或（ii）与CDK4和/或CDK6表达和/或活性的RNA干扰，诱导型启动子的控制下的载体和（b）编码对所述启动子用于治疗神经变性性疾病中有用的反式激活蛋白的基因。这些载体可被转移到其中theywill发挥保护作用（ⅰ）防止细胞死亡或与（ii）减缓细胞死亡的进展的细胞。这些载体可在治疗性应用中使用，以防止神经变性病症或它们与治疗功效的进展变慢。

84. 发明公开

EP2201105A1 USE OF THE OPPOSITE CELL DIFFERENTIATION PROGRAM (OCDP) FOR THE TREATMENT OF DEGENERATED ORGANS IN THE PATHOLOGICAL STATE 有权转让
标题翻译： OCDP（OPPOSITE细胞分化节目）的用于疾病状态中的治疗退化BODIES USE
公开(公告)号：EP2201105A1
公开(公告)日：2010-06-30
申请号：EP08735329.8
申请日：2008-04-18
申请人： Universität Leipzig
发明人： BUNIATIAN, Gayane , GEBHARDT, Rolf , GLEITER, Christoph , DANIELYAN, Lusine , PROKSCH, Barbara
IPC分类号： C12N5/06
CPC分类号： C12N5/0622 , A61K35/12 , C12N2502/14
摘要： The present invention relates to a method for the treatment of organs which are degenerative and/or in the pathological state by means of the use of cells, which are phenotypically stably differentiating or differentiated but not necessarily ultimately predetermined with respect to development, from a donor organ selected according to the principles of the opposite cell differentiation program (OCDP) and also to the use of cells of this type for the treatment or for the production of a drug for treatment of the same. Furthermore, the present invention relates to pharmaceutical agents comprising suitable phenotypically stable cells, cells of a first organ which is different from the second organ with respect to organ type thereby being used, which, in the normal physiological state with respect to a predetermined set of expressed genes and/or phenotypical properties, have opposite properties to the second cells in the normal physiological state.

85. 发明公开

EP2143787A1 A method for the formation of megamitochondria 审中-公开
标题翻译： Verfahren zur Formierung von Megamitochondrien
公开(公告)号：EP2143787A1
公开(公告)日：2010-01-13
申请号：EP08012596.6
申请日：2008-07-11
申请人： Universität Leipzig
发明人： Seibel, Peter
IPC分类号： C12N5/00 , C07H19/00
CPC分类号： C07H19/00
摘要： The present invention relates to an in-vitro method for the formation of megamitochondria in cells, wherein the cells are grown in a suitable fermentation medium acidulated with lactic acid to pH values between 5.3 and 6.7. The invention further concerns H + ionophores, ionophores which catalyze the electroneutral exchange of K + for H + and inhibitors of actin polymerisation for the prevention or treatment of a disease in which inhibiting or reducing the formation of megamitochondria has a beneficial effect.
摘要翻译：本发明涉及在细胞中形成巨细胞线粒体的体外方法，其中细胞在合适的用乳酸酸化的发酵培养基中生长至pH值在5.3和6.7之间。本发明还涉及H +离子载体，催化K +用于H +的电中性交换的离子载体和用于预防或治疗抑制或减少巨细胞线粒体形成具有有益效果的疾病的肌动蛋白聚合抑制剂的离子载体。

86. 发明公开

EP2039758A1 Cell culture medium and method for culturing stem cells and progenitor cells 有权
标题翻译：细胞培养基和方法，用于培养干细胞和祖细胞
公开(公告)号：EP2039758A1
公开(公告)日：2009-03-25
申请号：EP07018574.9
申请日：2007-09-21
申请人： Universität Leipzig
发明人： Cross, Michael, Dr. , Alt, Rüdiger
IPC分类号： C12N5/06 , C12N5/08
CPC分类号： C12N5/0647 , C12N2500/14 , C12N2500/16 , C12N2500/32 , C12N2500/34 , C12N2500/35 , C12N2500/38 , C12N2500/40 , C12N2501/23
摘要： The invention relates to a stem cell culture medium that is deficient in both glucose and inositol. As expected most cells die rapidly as in media deficient in both glucose and inositol. However, in particular somatic stem cells and germ line stem cells are surprisingly capable of survival and growth under these conditions, while maintaining their regenerative potential Thus, the cell culture medium according to the invention allows not only culturing and amplifying but also purification and enrichment of the above mentioned stem cells as most differentiated cells will not survive in the medium
摘要翻译：本发明涉及干细胞培养基所做的是在葡萄糖和肌醇缺陷。正如所预期的大多数细胞迅速如在葡萄糖和肌醇媒体缺乏。然而，特别是成体干细胞和生殖系干细胞是令人惊讶的能力的合成的条件下存活和生长，而由此保持它们的再生潜能，细胞培养基雅丁到本发明允许不仅培养和扩增，但如此纯化和富集上述干细胞作为最分化的细胞不会在培养基中生存

87. 发明公开

EP1820804A1 Lipidated oligonucleotides 审中-公开
标题翻译：亲脂寡核苷酸
公开(公告)号：EP1820804A1
公开(公告)日：2007-08-22
申请号：EP06003440.2
申请日：2006-02-20
申请人： Humboldt-Universität zu Berlin , Universität Leipzig
发明人： Herrmann, Andreas , Liebscher, Jürgen , Huster, Daniel , Kurz, Anke , Bunge, Andreas , Kaczmarek, Oliver , Flasche, Wolfgang
IPC分类号： C07H21/00
CPC分类号： C07H21/00
摘要： The present invention relates to lipidated oligonucleotides, methods of synthesis and uses thereof.
摘要翻译：本发明涉及脂化寡核苷酸，其合成方法及其应用。

88. 发明公开

EP1675458A1 EXTRAKORPORALE ORGANAUFBEWAHRUNG 有权
标题翻译：体外器官滞留
公开(公告)号：EP1675458A1
公开(公告)日：2006-07-05
申请号：EP04762731.0
申请日：2004-09-02
申请人： Technische Universität Dresden , Universität Leipzig
发明人： ARZT, Joachim , GNÜCHTEL, Albrecht , THIELE, Christine , SCHÖN, Michael
IPC分类号： A01N1/02
CPC分类号： A01N1/0247 , A01N1/02
摘要： The invention relates to an arrangement for extracorporeal organ conservation. Said type of arrangements are used to artificially preserve or to regenerate vital functions of organs, said organs also having extremities and tissue lobes. The inventive arrangement for extracorporeal organ conservation is made of at least one organ perfusion chamber (1) provided with an adjustable temperature device (3). An organ (2) is arranged in said organ perfusion chamber (1), said organ being surrounded by a protective covering (21). Said type of protected organ (2) is stored in a totally suspended manner in a bearing liquid (4). According to the invention, the bearing liquid (4) is a dialysate which is a component of a life-conserving circuit (5).

89. 发明公开

EP4217498A1 CHIMERIC SENSOR PROTEIN AND METHODS OF USE THEREOF 审中-实审
公开(公告)号：EP4217498A1
公开(公告)日：2023-08-02
申请号：EP21783434.0
申请日：2021-09-23
申请人： Universität Leipzig
发明人： LANGENHAN, Tobias , SCHOLZ, Nicole
IPC分类号： C12N15/62 , C07K14/705 , C07K14/47

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