专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明公开

EP1984081A2 OXIDATIVE TREATMENT METHOD 审中-公开
标题翻译：氧化处理工艺
公开(公告)号：EP1984081A2
公开(公告)日：2008-10-29
申请号：EP07762522.6
申请日：2007-01-25
申请人： The Administrators of The Tulane Educational Fund
发明人： OLAIYA, Charles O. , HOLLAND, Jennifer E. , ALEXANDER, Donald H. , REIMERS, Robert S.
IPC分类号： A62D3/00 , C02F1/72 , C02F1/78 , D21H23/00
CPC分类号： C02F1/72 , C02F1/30 , C02F1/307 , C02F1/32 , C02F1/722 , C02F1/725 , C02F1/78 , C02F2101/006 , C02F2101/163 , C02F2101/22
摘要： A method for oxidizing a substance (e.g., in a waste stream, dringing water, a paper pulp slurry, or on a surface), which uses free radicals and reactive species generated from multiple oxidants. The method comprises combining peroxynitrite or peroxynitrous acid and at least one additional oxidizing agent. These oxidants may be introduced in combination or in series for a period of time sufficient to oxidize at least one selected component. The yield of free radicals and reactive species, which are the intermediate species that perform the oxidation may be increased by addition of catalysts, electromagnetic radiation, sonic waves, and/or electrolysis. The methods of the present invention optionally utilize existing energy sources (such as Υ -radiation from radioactive waste components), preexisting concentrations of oxidant precursors (such as nitrate), as well as the nature (e.g., chemical reactivity) of the constituents requiring oxidation in the media being treated.

82. 发明公开

EP1804789A2 METHOD OF TREATING HUMAN PREECLAMPSIA EMPLOYING RESIBUFAGENIN 有权
标题翻译：方法将人类先兆子痫RESIBUFAGENIN的治疗
公开(公告)号：EP1804789A2
公开(公告)日：2007-07-11
申请号：EP05802853.1
申请日：2005-09-23
申请人： The Administrators of the Tulane Educational Fund
发明人： PUSCHETT, Jules B.
IPC分类号： A61K31/385 , A01N45/00 , C07D215/04
CPC分类号： A61K31/353 , A61K2300/00
摘要： A method of treating preeclampsia including administering a therapeutically effective dose of resibufagenin to a patient having preeclampsia. Effecting the determination of the presence of preeclampsia may be by determining whether there has been a substantial elevation in marinobufagenin which may be blood-derived or urine-derived and if such elevation does exist, concluding that preeclampsia does exist. The method may advantageously be practiced by employing urine, blood serum or blood plasma as the body specimen containing the protein in determining whether a patient has preeclampsia. In another embodiment, bufodienolide derivatives other than resibufagenin may be employed in lieu of thereof or in combination therewith. In another embodiment, resibufagenin analogues may be employed in the treatment of preeclampsia.

83. 发明授权

EP1011716B9 NEUROMEDIN B RECEPTOR ANTAGONISTS 失效
标题翻译： NEURO MEDIN乙受体的拮抗剂
公开(公告)号：EP1011716B9
公开(公告)日：2004-03-03
申请号：EP95943375.6
申请日：1995-12-07
申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S.
发明人： COY, David, H. , TAYLOR, John, E.
IPC分类号： A61K38/31 , C07K7/00 , C07K14/655
CPC分类号： A61K38/31 , C07K14/6555

84. 发明授权

EP0873518B1 A METHOD FOR DETECTING ANTIPOLYMER ANTIBODIES AND A DIAGNOSTIC TEST KIT FOR USE IN AIDING THE DIAGNOSIS OF SILICONE RELATED DISEASES 失效
标题翻译：方法抗聚合物抗体的检测及诊断试剂盒硅依赖性疾病鉴定
公开(公告)号：EP0873518B1
公开(公告)日：2003-03-12
申请号：EP96934107.2
申请日：1996-10-08
申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
发明人： GARRY, Robert, F. , TENENBAUM, Scott, A. , PLYMALE, Douglas, R.
IPC分类号： G01N33/53 , G01N33/564 , G01N33/545 , G01N33/68
CPC分类号： G01N33/53 , G01N33/5308 , G01N33/545 , G01N33/564 , G01N33/68 , G01N2430/60 , G01N2800/102 , Y10S435/975 , Y10S436/811
摘要： The present invention provides for a test kit and method of detecing antipolymer antibodies, and a test kit and method for detecting silicone related disease, fibromyalgia, and chronic fatigue syndrome. The methods of the present invention involve a) providing a sample to be tested for a antipolymer antibody and d) combining a polymer selected from the group consisting of polyacrylamide (particularly partially polymerized polyacrylamide), silicone, and collagen, with said sample for a time sufficient for an antipolymer antibody to react with said polymer, to form a complex. An indicator reagent is added to the material resulting from step b) to indicate the presence or absence of an antipolymer antibody in said sample.

85. 发明公开

EP1152243A1 DIagnosis of Sjögren's syndrome, systemic lupus erythematosis, and scleroderma via detection of anti-retroviral antibodies 失效
标题翻译：诊断vonSjögren综合征，系统性红斑狼疮，硬皮病，Nachweis von anti-retroviralenAntikörpern
公开(公告)号：EP1152243A1
公开(公告)日：2001-11-07
申请号：EP01103784.3
申请日：1991-05-20
申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
发明人： Garry, Robert F. Jr. , Fermin, Cesar D. , Alexander, Steve S, Jr.
IPC分类号： G01N33/564 , G01N33/569
CPC分类号： C07K14/005 , A61K31/7072 , A61K31/7076 , A61K39/00 , C12N7/00 , C12N2740/10022 , C12N2740/15021 , C12N2740/15022 , C12N2740/15051 , G01N33/564 , G01N33/56988 , G01N2800/101 , G01N2800/102 , G01N2800/24 , Y10S930/221
摘要： The present invention relates to a method of diagnosing and retroviral immune disease (including Sjögren's syndrome), by testing for the presence of serum anti-retroviral antibodies.
摘要翻译：本发明涉及通过测试血清抗逆转录病毒抗体的存在来诊断和逆转录病毒免疫疾病（包括Sj？gren综合征）的方法。

86. 发明授权

EP0734396B1 ANALOGUES OF hGH-RH (1-29)NH2 HAVING ANTAGONISTIC ACTIVITY 失效
标题翻译：具有拮抗活性的hGH-RH（1-29）NH2的类似物
公开(公告)号：EP0734396B1
公开(公告)日：2000-11-08
申请号：EP95904767.1
申请日：1994-11-28
申请人： The Administrators of The Tulane Educational Fund
发明人： SCHALLY, Andrew V. , ZARANDI, Marta
IPC分类号： C07K14/60 , A61K38/25
CPC分类号： C07K14/60 , A61K38/00
摘要： Synthetic analogues of hGH-RH(1-29)NH2 having substitutions of various amino acids and acylated at the N-terminus, and exhibiting prolonged antagonistic duration. Embodiments include analogues of the formula: X-R -R -R -R -R -R -Thr-R -Ser-Tyr-R -R -Val-Leu-R -Gln-Leu-Ser-R -R -R -Leu-Leu-Gln-Asp-Ile-R -R -R , wherein X is nil, H, Ac, IAc, BrProp, For, Ibu, Nac, 2-Nac, 1- or 2-Npt, 1- or 2-Npr or Aqc; R is Tyr, His, Glu or Glt; R is D-Arg, D-Cit, D-Har, D-Lys or D-Orn; R is Asp, Ala or Gly; R is Ala or Gly; R is Ile, Ala or Gly; R is Phe, Ala, Pro, Tpi, Nal or Phe(Y), in which Y is F, Cl, Br, NO2, CH3 or OCH3; R is Asn, Ser, Val, Ile, Ala, Abu, Nle or Aib; R is Arg, D-Arg or Cit; R is Lys, D-Lys Cit or Ala; R is Gly, Ala, Abu or Gln; R is Ala or Abu; R is Arg, D-Arg or Cit; R is Lys, D-Lys or Cit; R is Met, Nle or Abu; R is Ser, Asn, Asp or Abu; R is Agm, Arg-NH2, Arg-OH, Cit-NH2, Cit-OH, Har-NH2 or Har-OH; provided that when R is Glt, X is nil and when X is H, R is other than Gly, and pharmaceutically acceptable acid addition salts thereof.
摘要翻译： hGH-RH（1-29）NH2的合成类似物具有各种氨基酸的取代并在N-末端被酰化，并表现出延长的拮抗持续时间。实施方案包括下式的类似物：XR 1 -R 2 -R 3 -R 4 -R 5 -R 6 -Thr-R 8 -Ser-Tyr- 11> -R <12> -Val-LEU-R <15> -Gln-LEU-SER-R <19> -R <20> -R <21> -Leu-LEU-GLN-ASP-岛-R < 其中X为无，H，Ac，IAc，BrProp，For，Ibu，Nac，2-Nac，1-或2-Npt，1-或2-Npr或 AQC; R 1是Tyr，His，Glu或Glt; R 2是D-Arg，D-Cit，D-Har，D-Lys或D-Orn; R 3是Asp，Ala或Gly; R 4是Ala或Gly; R 5是Ile，Ala或Gly; R 6是Phe，Ala，Pro，Tpi，Nal或Phe（Y），其中Y是F，Cl，Br，NO 2，CH 3或OCH 3; R 8是Asn，Ser，Val，Ile，Ala，Abu，Nle或Aib; R 11是Arg，D-Arg或Cit; R 12是Lys，D-Lys Cit或Ala; R 15是Gly，Ala，Abu或Gln; R 19是Ala或Abu; R 20是Arg，D-Arg或Cit; R 21是Lys，D-Lys或Cit; R 27是Met，Nle或Abu; R 28是Ser，Asn，Asp或Abu; R 29为Agm，Arg-NH 2，Arg-OH，Cit-NH 2，Cit-OH，Har-NH 2或Har-OH; 条件是当R 1为Glt时，X为零且当X为H时，R 15不为Gly，且其药学上可接受的酸加成盐。

87. 发明公开

EP1047773A1 CUBILIN PROTEIN, DNA SEQUENCES ENCODING CUBILIN AND USES THEREOF 审中-公开
标题翻译：立方蛋白蛋白，立方蛋白编码DNA序列及其用途
公开(公告)号：EP1047773A1
公开(公告)日：2000-11-02
申请号：EP99904167.6
申请日：1999-01-21
申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , INSTITUT NATIONAL DE LA SANTE ETDE LA RECHERCHE MEDICALE (INSERM)
发明人： Hammond, Timothy, G. , Verroust, Pierre J.
IPC分类号： C12N15/00 , C12N15/12 , C07K14/705 , C07K14/435
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides novel renal receptors for ligands. Cubilin and megalin are representative examples of such renal receptors. Also provided are potential uses of these renal receptors for treating toxicity in various tissues and for detecting renal damage.

88. 发明公开

EP0956296A2 SOMATOSTATIN ANTAGONISTS 失效
标题翻译：生长抑素拮抗剂
公开(公告)号：EP0956296A2
公开(公告)日：1999-11-17
申请号：EP97949758.0
申请日：1997-12-04
申请人： SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) , The Administrators of The Tulane Educational Fund
发明人： MORGAN, Barry , MURPHY, William , COY, David, H.
IPC分类号： A61K38 , A61P5 , C07K7 , C07K14
CPC分类号： C07K14/6555
摘要： The invention features somatostatin antagonists having a D-amino acid at the second residue.

89. 发明公开

EP0833646A1 MULTI-TYROSINATED SOMATOSTATIN ANALOGS 失效
标题翻译：多tyrosinated生长抑素ANALOG
公开(公告)号：EP0833646A1
公开(公告)日：1998-04-08
申请号：EP96917939.0
申请日：1996-06-03
申请人： The Administrators of The Tulane Educational Fund , THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION , The Louisiana State University Medical Center Foundation , CHILDREN'S HOSPITAL, INC.
发明人： COY, David, H. , WOLTERING, Eugene, A. , O'DORISIO, M., Sue , O'DORISIO, Thomas, M. , MURPHY, William, A.
IPC分类号： A61K38 , A61K51 , A61P5 , C07K7 , C07K14 , G01N33
CPC分类号： C07K14/655 , A61K38/00
摘要： Disclosed are methods and compositions for the diagnosis and treatment of diseases associated with aberrant expression of a somatostatin receptor (e.g., cancer) or with increased production of a factor regulatable by somatostatin (e.g., acromegaly). The compounds of the invention are of the general formulae: a) (Y)n+1P, b) (Y)n-Ala-Y-P, or c) (I), wherein P is a somatostatin peptide analog which binds to a somatostatin receptor, Y is D-tyrosine, L-tyrosine, or desamino-tyrosine, n is an integer from 1 to 32, inclusive, each q, independently, is an integer from 1 to 32, inclusive, and each s, independently, is an integer from 1 to 32, inclusive, where q and s can be the same or different, and X is of the formula D-NH2-CH(CH2)mNH2-CO2H or L-NH2-CH(CH2)mNH2-CO2H, wherein m is an integer from 1 to 10, inclusive.

90. 发明公开

EP0822827A1 ANTAGONISTS OF LHRH 失效
标题翻译： LHRH受体拮抗剂
公开(公告)号：EP0822827A1
公开(公告)日：1998-02-11
申请号：EP96913829.0
申请日：1996-04-26
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
发明人： BOWERS, Cyril, Y. , FOLKERS, Karl, A. , JANECKA, Anna
IPC分类号： A61K38 , C07K7
CPC分类号： C07K7/23 , A61K38/00
摘要： LHRH analogs and congeners with high water solubility have been synthesized. These new analogs had 0 %-100 % antiovulatory activity at a 0.5 νg dosage and 0 %-80 % at 0.25 νg. The ED50 for histamine release was 30.5 νg/ml- > 300 νg/ml.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式