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81. 发明公开

EP2992377A1 ADJUSTABLE DIGITAL MICROSCOPE DISPLAY 有权转让
标题翻译： EINSTELLBARE DIGITALE MIKROSKOPANZEIGE
公开(公告)号：EP2992377A1
公开(公告)日：2016-03-09
申请号：EP14791630.8
申请日：2014-05-01
申请人： Bio-Rad Laboratories, Inc.
发明人： HSIUNG, Frank , KROEGER, Kelly , ARCHER, Robert , KORTISOVA, Veronika , RUBIO, Teresa , SHEN, Zuo Cheng , CHU, Daniel Y. , DOE, Nicholas , QUIROZ, Emmanuel
IPC分类号： G02B21/06 , G02B21/36 , G01B9/02
CPC分类号： G02B21/368 , G02B21/241 , G02B21/365
摘要： The present invention relates in general to microscopy systems. In particular, the present invention relates to microscopes rendering digital images of samples, with the capability to digitally control the focus of the microscope system, and the software used to control the operation of the digital microscope system. Further, the present invention relates to a microscope structure that allows for compact and multi-functional use of a microscope, providing for light shielding and control with samples that require specific light wavelength characteristics, such as fluorescence, for detection and imaging.
摘要翻译：本发明一般涉及显微系统。特别地，本发明涉及渲染样品的数字图像的显微镜，具有数字控制显微镜系统的焦点的能力以及用于控制数字显微镜系统的操作的软件。此外，本发明涉及一种显微镜结构，其允许显微镜的紧凑和多功能使用，为需要特定光波长特性的样品（例如荧光）用于检测和成像提供光屏蔽和控制。显微镜是可调节的，其结构可以沿着运动范围和自由度移动，以便于访问样品，屏蔽样品和操纵显示装置。

82. 发明公开

EP2989216A1 PRE-AMPLIFICATION ASSAY 有权转让
标题翻译：前置放大测定
公开(公告)号：EP2989216A1
公开(公告)日：2016-03-02
申请号：EP15786827.4
申请日：2015-05-01
申请人： Bio-rad Laboratories, Inc.
发明人： KONG, Yanhong , OKINO, Steven
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q1/6853 , C12Q2545/101
摘要： Provided herein are methods and compositions to determine the efficacy of a nucleic acid pre-amplification reaction.
摘要翻译：本文提供了确定核酸预扩增反应的功效的方法和组合物。

83. 发明公开

EP2989178A1 COMPOSITE VISIBLE COLORANT AND METHOD FOR QUANTITATIVE AMPLIFICATION 有权
标题翻译：复合可见染料和方法定量扩增
公开(公告)号：EP2989178A1
公开(公告)日：2016-03-02
申请号：EP14852807.8
申请日：2014-10-08
申请人： Bio-Rad Laboratories, Inc.
发明人： FU, Rongdian
IPC分类号： C09K11/06
CPC分类号： C09K11/06 , C09K2211/10 , C09K2211/1018 , C12Q1/6804 , C12Q1/6844 , C12Q1/6851 , C12Q2563/107 , G01N21/6408 , G01N21/6428 , G01N33/542 , C12Q2545/101 , C12Q2565/507 , C12Q2561/113 , C12Q2527/125
摘要： Stock solutions comprising at least one visually detectable inert dye and at least one passive reference dye and methods for using such stock solutions with colorless real-time PCR master mixes, are provided. This stock solution will be added to pre-made real-time qPCR master mixes that themselves can support amplification. Thus the combination of the stock solution and the master mix allows for generating a colored master mix that, while being colored for ease of tracking, will support amplification.

84. 发明公开

EP2986978A2 MINI-GEL COMB 有权
公开(公告)号：EP2986978A2
公开(公告)日：2016-02-24
申请号：EP14867041.7
申请日：2014-12-02
申请人： Bio-rad Laboratories, Inc.
发明人： STRONG, William
IPC分类号： G01N27/447
CPC分类号： G01N27/44704
摘要： Molds for casting and retaining electrophoresis gel strips are provided, along with methods, kits, and systems for performing electrophoresis, electroelution, and/or electrob lotting using these molds.
摘要翻译：提供了用于铸造和保持电泳凝胶条的模具，以及用于使用这些模具进行电泳，电洗脱和/或电击的方法，试剂盒和系统。

85. 发明公开

EP2986957A1 SERIES ABSORBANCE GLASS AND INTERFERENCE FILTERS 有权转让
标题翻译：干燥器中的REIHENABSORPTIONSGLAS
公开(公告)号：EP2986957A1
公开(公告)日：2016-02-24
申请号：EP15785338.3
申请日：2015-04-29
申请人： Bio-rad Laboratories, Inc.
发明人： THRUSH, Evan , SWIHART, Steve , BHATT, Neeraj
IPC分类号： G01J3/30 , F21V9/00
CPC分类号： G01N21/6456 , G01N21/6486 , G01N2021/6439 , G01N2021/6471 , G01N2021/6482 , G01N2201/062 , G01N2201/0627 , G01N2201/0638 , G01N2201/12
摘要： An imaging assembly and processing system that includes a sample platform having a target region which can hold a sample, where the sample can be marked with fluorescent or phosphorescent markers. The imaging assembly can have an excitation light module proximate to the sample platform that emits light to excite the markers, and a lens module positioned to receive emission light from excited markers in target region. At least one series filter assembly or interference filter can be arranged in front of, behind, or both in front of and behind the lens module. The assembly includes a light sensor and a processor and imaging module configured to process data captured by the light sensor. Images of the sample are generated based on the emission light from the sample that transmit through and are filtered by the lens assembly and series filter assembly or interference filter.
摘要翻译：一种成像组件和处理系统，其包括具有可容纳样品的目标区域的样品平台，其中可以用荧光或磷光标记物标记样品。成像组件可以具有靠近样本平台的激发光模块，其发射光以激发标记;以及透镜模块，定位成接收来自目标区域中的激发标记的发射光。至少一个串联滤波器组件或干涉滤波器可以布置在镜头模块前面，后面或者两者之间。组件包括光传感器，以及配置成处理由光传感器捕获的数据的处理器和成像模块。样品的图像基于来自透射的样品的发射光产生，并由透镜组件和串联滤光器组件或干涉滤光器滤波。

86. 发明公开

EP2986761A1 CHROMOSOME CONFORMATION CAPTURE IN PARTITIONS 有权
标题翻译：分区中的染色体构象捕获
公开(公告)号：EP2986761A1
公开(公告)日：2016-02-24
申请号：EP15748616.8
申请日：2015-02-13
申请人： Bio-rad Laboratories, Inc.
发明人： LITTERST, Claudia , TZONEV, Svilen , AGRESTI, Jeremy
IPC分类号： C40B20/00 , C40B30/04 , C12P19/34 , C07H21/02
CPC分类号： C12Q1/6809 , C12Q2521/313 , C12Q2523/101 , C12Q2563/179
摘要： Methods compositions and kits are provided for performing a chromatin or chromosome conformation capture assay in partitions.
摘要翻译：提供了用于在分区中进行染色质或染色体构象捕获测定的组合物和试剂盒。该方法包括：a）交联染色体DNA; b）用核酸内切酶消化交联的DNA产物; c）分割交联的DNA消化片段以产生多个分区; 和d）在单个分区中检测相对于基因组的一级序列远端的两个或更多个DNA序列元件的存在，其中在单个分区中检测两个或更多个DNA序列元件表明两个或更多个DNA 序列元件靠近细胞或完整的细胞核。

87. 发明公开

EP2986385A2 METHOD OF MAKING A DROPLET-GENERATING DEVICE 有权
标题翻译：制造滴落发生装置的方法
公开(公告)号：EP2986385A2
公开(公告)日：2016-02-24
申请号：EP14785487.1
申请日：2014-04-17
申请人： Bio-rad Laboratories, Inc.
发明人： CAULEY, Thomas, H., III
IPC分类号： B01L3/00
CPC分类号： B29C33/3842 , B01F3/0807 , B01F3/0861 , B01F13/0062 , B01F15/0238 , B01F15/0258 , B01L3/00 , B01L3/502707 , B01L3/502784 , B01L2200/0673 , B01L2200/0689 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487 , B29C33/3835 , B29C33/42 , Y10T29/49764 , Y10T29/49771 , Y10T29/49982 , Y10T29/49989 , Y10T29/49998
摘要： Method of making a droplet-generating device. In the method, a first-droplet generating device may be produced. The first droplet-generating device may include a molded portion created at least in part with a mold and also may include a plurality of droplet generators each formed at least in part by the molded portion. A set of droplets may be generated with each of one or more of the droplet generators. A property of at least one set of generated droplets may be determined. The mold may be modified based on the property. A second droplet-generating device may be produced that includes a molded portion created at least in part with the modified mold.
摘要翻译：制造液滴生成装置的方法。在该方法中，可以生产第一液滴生成装置。第一液滴生成装置可以包括至少部分地由模具形成的模制部分，并且还可以包括多个液滴发生器，每个液滴发生器至少部分地由模制部分形成。可以用一个或多个液滴生成器中的每一个生成一组液滴。可以确定至少一组产生的液滴的特性。模具可以根据性质进行修改。可以生产第二液滴生成装置，该第二液滴生成装置包括至少部分地由改性模具形成的模制部分。

88. 发明公开

EP2986307A1 REMOVAL OF IMPURITIES FROM PROTEIN A ELUATES 审中-公开
标题翻译： ON ON ON ON。。。。。。。。。。。。。。
公开(公告)号：EP2986307A1
公开(公告)日：2016-02-24
申请号：EP15733153.9
申请日：2015-01-05
申请人： Bio-rad Laboratories, Inc.
发明人： SNYDER, Mark
IPC分类号： A61K38/00 , C07K1/00 , C07K16/00
CPC分类号： C07K14/31 , C07K1/14 , C07K14/195 , C07K14/315 , C07K16/00 , C07K2317/10 , C07K2319/30
摘要： Modified Protein A, Protein G, Protein L, or Protein A/G that lacks antibody binding activity, and methods of the modified proteins use for purifying antibodies is provided.
摘要翻译：提供了缺乏抗体结合活性的修饰蛋白A，蛋白G，蛋白L或蛋白A / G，以及修饰蛋白用于纯化抗体的方法。

89. 发明授权

EP2150798B1 THERMOELECTRIC DEVICE AND HEAT SINK ASSEMBLY WITH REDUCED EDGE HEAT LOSS 有权
标题翻译：具有减少EDGE热损失热电装置和散热器部件
公开(公告)号：EP2150798B1
公开(公告)日：2016-02-17
申请号：EP08755447.3
申请日：2008-05-14
申请人： Bio-Rad Laboratories, Inc.
发明人： BANERJI, Sunand , BRETTON, Joseph, N. , HAY, Vorin
IPC分类号： B01L7/00 , F25B21/04
CPC分类号： B01L7/52 , B01L2300/0829 , B01L2300/1822 , F25B21/04 , F25B2321/023 , F25B2321/0251 , F25B2500/01

90. 发明公开

EP2971160A1 DIGITAL ASSAYS FOR MUTATION DETECTION 有权
标题翻译：数字测定的突变的检测
公开(公告)号：EP2971160A1
公开(公告)日：2016-01-20
申请号：EP14770183.3
申请日：2014-03-13
申请人： Bio-Rad Laboratories, Inc.
发明人： REGAN, John , COOPER, Samantha , SO, Austin , KOEHLER, Ryan , MONTESCLAROS, Luz
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q2545/114 , C12Q2561/101 , C12Q2563/159
摘要： Provided herein are methods, compositions, and kits for detecting alleles using a single probe or a single primer set. Also, provided herein are methods, compositions, and kits for detecting allelic variants using a single probe or a single primer set. Also, provided herein are methods, compositions, and kits for determining a polymerization error rate.

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