专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明公开

EP2411513A1 MUTANT CyaA POLYPEPTIDES AND POLYPEPTIDE DERIVATIVES SUITABLE FOR THE DELIVERY OF IMMUNOGENIC MOLECULES INTO A CELL 有权
标题翻译：突变CyaA多肽和-POLYPEPTIDDERIVATE健身喂养免疫原性分子在细胞
公开(公告)号：EP2411513A1
公开(公告)日：2012-02-01
申请号：EP10713874.5
申请日：2010-03-23
申请人： Institut Pasteur , Institute Of Physiology Of AS CR, V.V.I.
发明人： SEBO, Peter , OSICKOVA, Adriana , MASIN, Jiri , FAYOLLE, Catherine , KRUSEK, Jan , BASLER, Marek , LECLERC, Claude , OSICKA, Radim
IPC分类号： C12N9/88
CPC分类号： C12N9/88
摘要： The invention relates to mutant CyaA/E570Q+K860 polypeptides suitable for use as proteinaceous vectors for delivering one or more molecules of interest into a cell, in particular into a cell expressing the CD11b receptor. The invention further relates to polypeptide derivatives suitable for eliciting an immune response in a host. The invention is more particularly directed to polypeptides derived from an adenylate cyclase protein (CyaA) either under the form of a toxin or of a toxoid, which are mutant polypeptides. Said mutant polypeptides are capable of retaining the binding activity of native CyaA to a target cell and preferably of also retaining the translocating activity of native CyaA through its N-terminal domain into target cells and furthermore have a pore-forming activity which is reduced or suppressed as compared to that of the native CyaA toxin.

82. 发明公开

EP2402428A1 METHOD FOR PRODUCING YEAST WITH HIGH GLUTAMIC ACID CONTENT 有权
标题翻译：生产高谷氨酸含量酵母的方法
公开(公告)号：EP2402428A1
公开(公告)日：2012-01-04
申请号：EP09827308.9
申请日：2009-10-30
申请人： Asahi Breweries, Ltd.
发明人： SHIBUYA, Ichiro , OKANO, Hiroaki , KANAOKA, Yoshitomo , TAKESUE, Nobuchika
IPC分类号： C12N1/16 , A23L1/221 , A23L1/28 , A23L1/39
CPC分类号： C12N1/16 , A23L2/56 , A23L23/00 , A23L27/22 , A23L33/145 , A23L33/175 , C12N1/18
摘要： Provided is a method for producing a yeast containing glutamic acid at a high concentration. In the method for culturing a yeast, a yeast in a stationary growth phase is subjected to liquid culture under the conditions that the pH of a liquid medium is 7.5 or higher and lower than 11. After the pH of the liquid medium for the yeast in a stationary growth phase is adjusted to 7.5 or higher and lower than 11, the yeast is further cultured, whereby a yeast with a high glutamic acid content can be produced. In the invention, as the yeast, Saccharomyces cerevisiae or Candida utilis can be used. Therefore, by using the yeast with a high glutamic acid content obtained by the above-said method and the extract obtained by extraction from the yeast, a seasoning composition and a food or drink with a high glutamic acid content can be provided.
摘要翻译：提供一种高浓度含有谷氨酸的酵母的制造方法。在培养酵母的方法中，将静止生长期的酵母在液体培养基的pH为7.5以上且小于11的条件下进行液体培养。在培养基中添加酵母的液体培养基的pH 通过将静止生长期调整为7.5以上且低于11，进一步培养酵母，由此能够制造谷氨酸含量高的酵母。在本发明中，作为酵母，可以使用酿酒酵母或产朊假丝酵母。因此，通过使用通过上述方法获得的谷氨酸含量高的酵母和从酵母中提取得到的提取物，可以提供具有高谷氨酸含量的调味组合物和食物或饮料。

83. 发明公开

EP2385107A1 Lentiviral vector based immunological compounds against malaria 有权转让
标题翻译：野生型病毒基因组免疫学动物Verbindungen gegen疟疾
公开(公告)号：EP2385107A1
公开(公告)日：2011-11-09
申请号：EP10290238.4
申请日：2010-05-03
申请人： Institut Pasteur
发明人： Charneau, Piere Alain , Coutant, Frédéric
IPC分类号： C12N7/04 , C12N15/869 , A61K39/015 , C12N15/867 , C07K14/445
CPC分类号： C07K14/445 , A61K39/015 , A61K2039/525 , A61K2039/5256 , A61K2039/5258 , C12N7/00 , C12N15/86 , C12N15/867 , C12N2740/15023 , C12N2740/15043 , C12N2740/16023 , C12N2740/16043 , C12N2810/6081 , Y02A50/412
摘要： The invention relates to lentiviral vector particles pseudotyped with a determined heterologous viral envelope protein or viral envelope proteins originating from a RNA virus and which comprise in its genome at least one recombinant polynucleotide encoding at least one polypeptide(s) carrying epitope(s) of an antigen of a Plasmodium parasite capable of infecting a mammalian host. The lentiviral vector particles are used in order to elicit an immunological response against malaria parasites.
摘要翻译：本发明涉及用确定的异源病毒包膜蛋白或源自RNA病毒的病毒包膜蛋白假型包装的慢病毒载体颗粒，并且在其基因组中包含至少一个重组多核苷酸，所述重组多核苷酸编码至少一个携带表位的多肽能够感染哺乳动物宿主的疟原虫寄生虫的抗原。使用慢病毒载体颗粒以引发针对疟疾寄生虫的免疫应答。

84. 发明公开

EP2322932A3 Detection of tuberculosis and infection by mycobacterium tuberculosis using HBHA 失效
标题翻译：通过HBHA的手段肺结核和结核分枝杆菌感染的检测
公开(公告)号：EP2322932A3
公开(公告)日：2011-11-09
申请号：EP10190616.2
申请日：2005-06-30
申请人： INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , Université Libre de Bruxelles , UNIVERSITE DU DROIT ET DE LA SANTE (LILLE II)
发明人： Locht, Camille , Mascart, Françoise , Temmerman, Stéphane , Hougardy, Jean-Michel , Place, Sammy , Sergheraert, Christian
IPC分类号： G01N33/569
CPC分类号： G01N33/5695
摘要： The present invention concerns methods for in vitro detection of an infection by Mycobacterium tuberculosis in mammals, and methods for in vitro distinction between mammals infected with Mycobacterium tuberculosis in which the disease is declared (active form) and mammals which are infected but asymptomatic for tuberculosis (latent form), and a method for in vitro distinction between mammals presenting an active form of tuberculosis and mammals not infected by M tuberculosis or presenting a latent form of tuberculosis. The present invention also pertains to kits for detection and distinction between infected mammals presenting tuberculosis symptoms and infected mammals with no disease development, and a kit for distinguishing between mammals presenting an active form of tuberculosis and mammals not infected by M. tuberculosis or presenting a latent form of tuberculosis.

85. 发明授权

EP2227324B1 PROCEDE UTILISANT L'ENERGIE THERMIQUE SOLAIRE COUPLEE A DES PLASMAS POUR PRODUIRE UN CARBURANT LIQUIDE ET DU DIHYDROGENE A PARTIR DE BIOMASSE OU DE CHARBON FOSSILE (PROCEDE P-SL ET P-SH) 有权
标题翻译：使用方法太阳能，微波PLASMATA制备液态燃料和获得氢气生物质或化石煤
公开(公告)号：EP2227324B1
公开(公告)日：2011-06-29
申请号：EP08878657.9
申请日：2008-11-14
申请人： Ugolin, Nicolas
发明人： Ugolin, Nicolas
IPC分类号： B01J19/12 , B01J19/08 , B01J19/10 , B01J8/00 , B01J8/44 , B01J19/18 , B01J19/20 , C10J3/02 , C10J3/20 , F24J2/00 , C10J3/54
CPC分类号： B01J19/129 , B01J8/0055 , B01J8/44 , B01J19/088 , B01J19/10 , B01J19/126 , B01J19/127 , B01J19/18 , B01J19/1806 , B01J19/20 , B01J19/2405 , B01J19/26 , B01J2208/00884 , B01J2219/0809 , B01J2219/0815 , B01J2219/082 , B01J2219/0826 , B01J2219/0828 , B01J2219/083 , B01J2219/0833 , B01J2219/0841 , B01J2219/0852 , B01J2219/0854 , B01J2219/0856 , B01J2219/0858 , B01J2219/086 , B01J2219/0866 , B01J2219/0867 , B01J2219/0869 , B01J2219/0871 , B01J2219/0879 , B01J2219/0892 , B01J2219/0896 , B01J2219/0898 , B01J2219/1215 , B01J2219/1227 , B01J2219/1239 , B01J2219/1242 , B01J2219/1245 , B01J2219/1266 , B01J2219/1269 , B01J2219/1272 , B01J2219/1284 , B01J2219/1296 , B01J2219/185 , B01J2219/1943 , C10B19/00 , C10J3/487 , C10J3/66 , C10J2300/0916 , C10J2300/094 , C10J2300/1284 , C10J2300/16 , C10L9/083 , Y02E50/15 , Y02E60/364 , Y02P20/134 , Y02P20/145 , Y02T50/678
摘要： A method for gasifying carbon compounds (I) to produce synthesis gas (II) involves: (A) pyrolyzing (I) to give carbon (III) and gas (IV) in a solar-microwave reactor (1), using thermal energy from (i) heating of the reactor wall (1a) by solar radiation and (ii) 1-300 GHz microwaves; and (B) converting (III) and (IV) into (II) by oxidoreductive reactions in a cyclone reactor, with superimposed or nested cyclone units, heated directly by microwaves. A method for gasifying carbon compounds (I) to produce synthesis gas (II) involves: (A) pyrolyzing (I) to give carbon (III) and gas (IV) in a solar-microwave reactor (1), using a synergistic combination of thermal energy from (i) heating of the reactor wall (1a) by solar radiation concentrated, by convergence or reflection, onto the wall surfaces and (ii) 1-300 GHz microwaves directed into the reactor interior and (I); and (B) converting (III) and (IV) into (II) by oxidoreductive reactions in a cyclone reactor, with at least two superimposed or nested cyclone units, in which (i) a gaseous vortex entrains and oxidizes particles of (III) utilizing combustion of (IV) or an additional gas, (ii) heated gas (or gaseous mixture) is injected into the cyclone components and (iii) gas present in the reactor is heated by microwaves directed into the reactor.

86. 发明公开

EP2329844A1 Recombinant plasmodium falciparum merozoite surface proteins 4 and 5 and their use 审中-公开
标题翻译：重组疟原虫Merozoit-Oberflächenproteine4 und 5 und deren Verwendung
公开(公告)号：EP2329844A1
公开(公告)日：2011-06-08
申请号：EP10188189.4
申请日：2006-11-23
申请人： INSTITUT PASTEUR
发明人： Longacre, Shirley , Polson, Hannah , Perraut, Ronald , Nato, Farida
IPC分类号： A61K39/015 , C07K14/445 , C07K16/20
CPC分类号： C07K14/445 , A61K39/00 , A61K39/015 , A61K2039/505 , C07K16/205 , C12N2799/026 , G01N33/6893 , Y02A50/412
摘要： The invention provides constructs in which the nucleic acids encoding Plasmodium falciparum MSP4 and MSP5, and the resulting polypeptides, have been modified. More particularly, this invention provides constructs encoding recombinant MSP4 and MSP5 polypeptides, which are expressed as soluble, secreted polypeptides in a baculovirus-insect cell expression system. It was surprisingly found that the recombinant polypeptides contain an EGF-like domain at the C-terminus that is properly folded in the polypeptide.
摘要翻译：本发明提供了编码恶性疟原虫MSP4和MSP5的核酸以及所得多肽已被修饰的构建体。更具体地，本发明提供编码重组MSP4和MSP5多肽的构建体，其在杆状病毒 - 昆虫细胞表达系统中表达为可溶性分泌多肽。惊奇地发现重组多肽在C-末端含有适当折叠在多肽中的EGF样结构域。

87. 发明公开

EP2297325A1 METHODS OF STRATIFYING, PROGNOSING AND DIAGNOSING SCHIZOPHRENIA, MUTANT NUCLEIC ACID MOLECULES AND POLYPEPTIDES 审中-公开
标题翻译：程序分层，预测和精神分裂症的诊断，突变分子和多肽的核酸
公开(公告)号：EP2297325A1
公开(公告)日：2011-03-23
申请号：EP09753383.0
申请日：2009-05-29
申请人： CHUM
发明人： ROULEAU, Guy, A. , DRAPEAU, Pierre , GAUTHIER, Martine , MARINEAU, Claude
IPC分类号： C12N15/12 , C07K14/47 , C07K14/78 , C12Q1/68 , G01N33/53 , G01N33/68
CPC分类号： C07K14/47 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/5008 , G01N33/6896 , G01N2800/302
摘要： A method for diagnosing the presence of schizophrenia or predicting the risk of developing schizophrenia in a human subject, comprising detecting the presence or absence of a defect in the SHANK3 gene encoding a SHANK3 polypeptide, in a nucleic acid sample of the subject, whereby the detection of the defect is indicative that the subject has schizophrenia or is at risk of developing schizophrenia.

88. 发明公开

EP2285424A1 INSTRUMENT HOLDER AND CONNECTOR 审中-公开
标题翻译：仪器支架和连接器THEREFOR
公开(公告)号：EP2285424A1
公开(公告)日：2011-02-23
申请号：EP09747559.4
申请日：2009-05-14
申请人： Steris, Inc.
发明人： ROBERT, Maxime , PARENT, Ghislain
IPC分类号： A61L2/00
CPC分类号： A61L2/26 , A61B90/70 , A61B2090/701 , A61L2/18 , A61L2202/24 , B08B3/024 , B08B9/021 , Y10T428/1393
摘要： A pressure/flow regulator includes a device having an input end that is connectable to a source of fluid, and an output end that is fluidly connected to a medical instrument. The device has a passage running from the input end to the output end to carry the fluid therethrough. A polymeric sleeve is disposed on the device. The polymeric sleeve covers at least one aperture that communicates with the passage. The polymeric sleeve has a resiliency capable of retaining the fluid within the at least one aperture until a predetermined pressure of the fluid within the aperture is attained at which point the sleeve deforms releasing pressure of the fluid within the device and preventing pressure damage to the medical instrument.

89. 发明授权

EP1538222B1 Oligonucléotides pour la détection de salmonella 失效
标题翻译：寡核苷酸用于检测沙门氏菌
公开(公告)号：EP1538222B1
公开(公告)日：2011-02-02
申请号：EP04078201.3
申请日：1996-01-15
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： Popoff, Michel Yvan , Le Guern Fellous, Muriel
IPC分类号： C12Q1/68 , C07K14/255
CPC分类号： C12Q1/689 , Y02A50/59

90. 发明公开

EP2233569A1 Mutant CyaA polypeptides and polypeptide derivatives suitable for the delivery of immunogenic molecules into a cell 有权
标题翻译：突变CyaA多肽和多肽衍生物，其是适用于递送的免疫原性分子的引入细胞
公开(公告)号：EP2233569A1
公开(公告)日：2010-09-29
申请号：EP09155929.4
申请日：2009-03-23
申请人： Institut Pasteur
发明人： Sebo, Peter , Leclerc, Claude , Osickova, Adriana , Fayolle, Catherine , Masin, Jiri , Krusek, Jan , Osicka, Radim , Basler, Marek
IPC分类号： C12N9/88
CPC分类号： C12N9/88 , C12Y406/01001
摘要： The invention relates to mutant CyaA/E570Q+K860 polypeptides suitable for use as proteinaceous vectors for delivering one or more molecules of interest into a cell, in particular into a cell expressing the CD11b receptor. The invention further relates to polypeptide derivatives suitable for eliciting an immune response in a host.
The invention is more particularly directed to polypeptides derived from an adenylate cyclase protein (CyaA) either under the form of a toxin or of a toxoid, which are mutant polypeptides. Said mutant polypeptides are capable of retaining the binding activity of native CyaA to a target cell and preferably of also retaining the translocating activity of native CyaA through its N-terminal domain into target cells and furthermore have a pore-forming activity which is reduced or suppressed as compared to that of the native CyaA toxin.
摘要翻译：本发明涉及适合于用作用于递送的一种或多种目的分子引入细胞中，特别是到表达CD11受体的细胞蛋白质载体突变CyaA / E570Q + K860多肽。本发明还涉及一种适用于在宿主免疫应答的引发多肽衍生物。本发明更特别地涉及从腺苷酸环化酶蛋白（的CyaA）任何下一个毒素的形式，或类毒素，其突变体多肽的衍生的多肽。所述突变体多肽能够保留天然CyaA的结合活性的靶细胞，并且优选地通过其N端结构域，从而保持天然CyaA的易位活性入靶细胞并进一步具有一个孔形成活性的所有这些被减少或抑制相比于天然CyaA毒素做的。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式