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71. 发明公开

EP3170516A1 POLYISOBUTYLENE URETHANE, UREA AND URETHANE/UREA COPOLYMERS AND MEDICAL LEADS CONTAINING THE SAME 有权
公开(公告)号：EP3170516A1
公开(公告)日：2017-05-24
申请号：EP16206626.0
申请日：2010-09-02
申请人： Cardiac Pacemakers, Inc.
发明人： DESAI, Shrojalkumar , BODEN, Mark W. , DEROCHE, Steve , FORSTER, Arthur J. , REDDY, Shantanu
IPC分类号： A61L31/06 , A61N1/05 , C08G18/48
CPC分类号： A61N1/056 , A61L31/06 , A61N1/05 , C08G18/4854 , C08G18/698 , Y10T156/10 , Y10T428/31855 , Y10T428/31938 , C08L75/04 , C08L75/02
摘要： The present invention provides medical devices that contain polyisobutylene urethane copolymers, polyisobutylene urea copolymers and polyisobutylene urethane/urea copolymers. More particularly, the present invention provides medical leads that contain such copolymers.

72. 发明公开

EP3154602A1 SOLVENT METHOD FOR FORMING A POLYMER SCAFFOLDING 审中-公开
标题翻译： LÖSUNGSMITTELVERFAHRENZUR HERSTELLUNG EINESPOLYMERGERÜERTES
公开(公告)号：EP3154602A1
公开(公告)日：2017-04-19
申请号：EP15731450.1
申请日：2015-06-10
申请人： Abbott Cardiovascular Systems Inc.
发明人： PACETTI, Stephen D. , DING, Ni
IPC分类号： A61L31/06
摘要： Methods of making polymeric devices, such as stents, using solvent based processes. More particularly, methods of making bioabsorbable stents.
摘要翻译：使用基于溶剂的方法制备聚合物装置，例如支架的方法。更具体地，制备生物可吸收支架的方法。

73. 发明授权

EP2545906B1 COLOUR-CODED AND SIZED LOADABLE POLYMERIC PARTICLES FOR THERAPEUTIC AND/OR DIAGNOSTIC APPLICATIONS AND COLOUR-CODED SYRINGE COMPRISING THE SAME 有权转让
标题翻译：彩色编码和GRÖSSENKALIBRIERTE聚合物颗粒用于治疗和/或DIAGNOSTIZIERANWENDUNGEN和色码注射器含有该
公开(公告)号：EP2545906B1
公开(公告)日：2017-04-19
申请号：EP12188376.3
申请日：2007-10-26
申请人： Boston Scientific Limited
发明人： Fritz, Ulf , Fritz, Olaf , Gordy, Thomas. A , Wojcik, Ronald , Blummel, Jacques , Kuller, Alexander
IPC分类号： C08G79/025 , A61L31/06 , C08J3/12 , A61K9/50 , C09D185/02
CPC分类号： A61K9/5031 , A61L31/06 , A61L2430/36 , C08G79/025 , C08J3/12 , C08J2385/02 , C08L2203/02 , C09D185/02 , C08L85/02

74. 发明公开

EP3148602A1 CHITOSAN AND POLYETHYLENE GLYCOL COPOLYMERS AND METHODS AND DEVICES FOR USING SAME FOR SEALING A VASCULAR PUNCTURE 有权
标题翻译：壳聚糖和POLYETHYLENGLYKOLCOPOLYMERE以及其用于密封血管穿刺方法和装置
公开(公告)号：EP3148602A1
公开(公告)日：2017-04-05
申请号：EP15728994.3
申请日：2015-05-28
申请人： Access Closure, Inc.
发明人： MYLONAKIS, Andreas , LIM, Florencia
IPC分类号： A61L31/04 , A61L31/06 , A61L31/14
CPC分类号： A61B17/0057 , A61B2017/00623 , A61B2017/0065 , A61L24/0031 , A61L24/08 , A61L31/042 , A61L31/06 , A61L31/145 , A61L31/148 , A61L2400/04 , C08L5/08 , C08L71/02
摘要： A sealant is provided for sealing a puncture through tissue that comprises an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The first section comprises chitosan and at least one additional polymer. The second section may be formed from a solid mass of non-freeze-dried, non-cross-linked hydrogel precursors. The precursors are in an unreactive state until exposed to an aqueous physiological environment, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. The second section may further comprise chitosan. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided.
摘要翻译：密封剂提供了一种用于通过组织密封的穿刺做细长的第一部分，其包括近端，远端，和一个横截面尺寸适于递送到穿过组织的穿刺，和第二部分从所述远端延伸的包括首节。所述第一部分可以由冷冻干燥的水凝胶可以形成没有展开时的穿刺内暴露于生理流体。所述第一区段包括脱乙酰壳多糖和至少一种另外的聚合物。第二部分可以由非冷冻干燥的，非交联的水凝胶前体的固体物质而形成。该前体是在非反应性状态，直到在wässrige生理环境，其中在所述前体中原位经历与彼此交联，以提供与粘合剂结合到所述第一部分层暴露于。所述第二部分可以包含另外的脱乙酰壳多糖。因此，提供装置和用于通过组织递送密封剂到穿刺方法。

75. 发明公开

EP3120834A1 SUSTAINED RELEASE DELIVERY OF ACTIVE AGENTS TO TREAT GLAUCOMA AND OCULAR HYPERTENSION 审中-公开
标题翻译：青光眼或高眼压症的治疗活性物质的延迟释放
公开(公告)号：EP3120834A1
公开(公告)日：2017-01-25
申请号：EP16187646.1
申请日：2012-08-29
申请人： Mati Therapeutics Inc.
发明人： CADDEN, Suzanne , HAO, Yong , UTKHEDE, Deepank , RUBINCHIK, Valery , KJELLBOTN, Charles Richard
IPC分类号： A61K9/00 , A61F2/02 , A61K31/5575 , A61L31/06 , A61L31/16 , A61M31/00 , A61F9/00
CPC分类号： A61K31/5575 , A61F9/0017 , A61F9/00772 , A61F9/00781 , A61K9/0051 , A61K9/0092 , A61K31/216
摘要： A method of decreasing intraocular pressure (IOP) in an eye of a patient in need thereof includes implanting a first lacrimal implant through a first punctum and into a first lacrimal canaliculus of the eye of the patient. The method may further comprise implanting a second lacrimal implant through a second punctum and into a second lacrimal canaliculus of the eye of the patient, and releasing, on a sustained basis a therapeutically effective amount of an intraocular pressure-reducing therapeutic agent.
摘要翻译：通过第一泪点并进入患者的第一只眼睛的泪小管中降低了在需要其的患者包括注入第一泪腺植入物的眼睛的眼内压（IOP）的方法。该方法可包括通过第二泪点并进入患者的眼睛的第二泪小管此外注入第二泪管植入物，和释放，持续的基础上一个治疗有效量的降低眼内压的治疗剂。

76. 发明公开

EP2999427A4 PARA-XYLENE FILMS AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译： PARAXYOLOL膜及其治疗用途
公开(公告)号：EP2999427A4
公开(公告)日：2016-11-16
申请号：EP14800460
申请日：2014-05-21
申请人： UNIV NORTHWESTERN , UNIV MARYLAND , ANN AND ROBERT H LURIE CHILDREN S HOSPITAL OF CHICAGO
发明人： KAUSHAL SUNJAY , HO DEAN , ROBINSON ERIK M , MCCARTHY PATRICK M
IPC分类号： A61F2/00 , A61L31/06
CPC分类号： A61L31/16 , A61K9/7007 , A61K31/343 , A61K31/573 , A61L29/085 , A61L31/06 , A61L31/082 , A61L31/10 , A61L2300/41 , A61L2300/424 , A61L2300/45 , A61L2400/18 , A61L2430/20 , C08L65/04
摘要： The present invention provides single sheet and compound para-xylene films for therapeutic uses. For example, the present invention provides single sheet para-xylene films useful as tissue separators and/or adhesion barriers in a subject, where the top and/or bottom surfaces of such films have a water contact angle between 75 and 95 degrees (e.g., to prevent adhesion formation). The present invention also provides compound films composed of at least two para-xylene polymer films with a therapeutic molecule layer in between. Such compound films, when used in vivo (e.g., as a tissue separator and to treat inflammation or atrial fibrillation) allow either therapeutic molecule elution through one of the para-xylene layers, or therapeutic molecule release when the compound film is pierced, such as when it is sutured in place.

77. 发明授权

EP2586469B1 Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers 有权
标题翻译：用聚-4-羟基丁酸酯和共聚物的取向膜的医疗器械
公开(公告)号：EP2586469B1
公开(公告)日：2016-11-16
申请号：EP12199776.1
申请日：2007-11-16
申请人： Tepha, Inc.
发明人： Rizk, Said , Martin, David P. , Ho, Kicherl , Williams, Simon F.
IPC分类号： A61L31/06 , A61L31/10 , A61L27/18 , A61L27/34 , B29C55/04 , B29C55/12 , C08J5/22
CPC分类号： A61L27/34 , A61L27/18 , A61L31/10 , B29C55/005 , B29C55/04 , B29C55/12 , B29K2067/00 , B29K2067/046 , B29K2995/006 , C08L67/04

78. 发明公开

EP3082888A1 ABSORBABLE POLYMERIC BLEND COMPOSITIONS BASED ON COPOLYMERS PREPARED FROM MONO- AND DI-FUNCTIONAL POLYMERIZATION INITIATORS, PROCESSING METHODS, AND MEDICAL DEVICES THEREFROM 有权转让
标题翻译：吸收的聚合物共混物组合物基于OFF MONO制造双官能化的聚合引发剂共聚物，加工和医疗设备THEREOF
公开(公告)号：EP3082888A1
公开(公告)日：2016-10-26
申请号：EP14825033.5
申请日：2014-12-17
申请人： Ethicon, Inc
发明人： ANDJELIC, Sasa , JAMIOLKOWSKI, Dennis D. , KELLY, Brian M. , DEFELICE, Christopher , STEIGER, Daniel
IPC分类号： A61L27/18 , A61L29/06 , A61L31/06 , A61L17/12 , C08G63/664 , C08L67/04 , A61B17/064
摘要： Novel absorbable polymeric blends made from components wherein at least one of the components is synthesized using mixtures of mono- and di-functional initiators are disclosed. The blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide and a second component that is either poly(p-dioxanone) homopolymer, or a poly(p-dioxanone-co-glycolide) copolymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.

79. 发明公开

EP3079735A1 ABSORBABLE BIMODAL POLYMERIC BLEND COMPOSITIONS, PROCESSING METHODS, AND MEDICAL DEVICES THEREFROM 有权
标题翻译：可吸收BI MODAL聚合物共混物组合物，加工和医疗器械THEREOF
公开(公告)号：EP3079735A1
公开(公告)日：2016-10-19
申请号：EP14824981.6
申请日：2014-12-08
申请人： Ethicon, Inc
发明人： JAMIOLKOWSKI, Dennis D. , ANDJELIC, Sasa , KELLY, Brian M. , DEFELICE, Christopher
IPC分类号： A61L27/18 , A61L29/06 , A61L31/06 , A61L17/12 , C08G63/664 , C08L67/04 , A61B17/064
摘要： Novel absorbable polymeric blends having bimodal molecular weight distribution are disclosed. The bimodal blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide having a bimodal molecular weight distribution, and a second component that is a poly(p-dioxanone) polymer of unimodal or bimodal molecular weight distribution. Alternately, the bimodal blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide having a unimodal molecular weight distribution, and a second component that is a poly(p-dioxanone) polymer of bimodal molecular weight distribution. The novel polymeric bimodal molecular weight blends provide medical devices having improved dimensional stability. Also disclosed are novel absorbable medical devices made from these novel bimodal polymer blends, as well as novel methods of manufacture.

80. 发明授权

EP2750660B1 SUSTAINED RELEASE DELIVERY OF ACTIVE AGENTS TO TREAT GLAUCOMA AND OCULAR HYPERTENSION 有权
标题翻译：青光眼或高眼压症的治疗活性物质的延迟释放
公开(公告)号：EP2750660B1
公开(公告)日：2016-10-12
申请号：EP12827871.0
申请日：2012-08-29
申请人： Mati Therapeutics Inc.
发明人： CADDEN, Suzanne , HAO, Yong , UTKHEDE, Deepank , RUBINCHIK, Valery , KJELLBOTN, Charles Richard
IPC分类号： A61K9/00 , A61F2/02 , A61K31/5575 , A61L31/06 , A61L31/16 , A61M31/00 , A61F9/00
CPC分类号： A61K31/5575 , A61F9/0017 , A61F9/00772 , A61F9/00781 , A61K9/0051 , A61K9/0092 , A61K31/216
摘要： A method of decreasing intraocular pressure (IOP) in an eye of a patient in need thereof includes implanting a first lacrimal implant through a first punctum and into a first lacrimal canaliculus of the eye of the patient. The method may further comprise implanting a second lacrimal implant through a second punctum and into a second lacrimal canaliculus of the eye of the patient, and releasing, on a sustained basis a therapeutically effective amount of an intraocular pressure-reducing therapeutic agent.

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