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71. 发明公开

EP1332216A1 VARIANTS OF SOLUBLE PYRROLOQUINOLINE QUINONE-DEPENDENT GLUCOSE DEHYDROGENASE 有权
标题翻译：可溶性PYRROLOQUINOLIN醌依赖性葡萄糖脱氢酶的变异研究
公开(公告)号：EP1332216A1
公开(公告)日：2003-08-06
申请号：EP01988775.1
申请日：2001-10-20
申请人： Roche Diagnostics GmbH , F. HOFFMANN-LA ROCHE AG
发明人： KRATZSCH, Peter , SCHMUCK, Rainer , BUNK, Daniela , SHAO, Zhixin , THYM, Detlef , KNAPPE, Wolfgang-Reinhold
IPC分类号： C12N15/53 , C12N9/04 , C12Q1/32 , C12Q1/54
CPC分类号： C12N9/0006
摘要： The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH), to genes encoding mutated s-GDH, to mutant proteins of s-GDH with improved substrate specificity for glucose, and to different applications of these s-GDH variants, particularly for determining concentrations of sugar, especially of glucose in a sample.

72. 发明公开

EP1328794A1 METHOD FOR THE PREDICTION OF STARCH DIGESTION 审中-公开
标题翻译：方法预测强度消化系统
公开(公告)号：EP1328794A1
公开(公告)日：2003-07-23
申请号：EP01977026.2
申请日：2001-10-19
申请人： Metcon Medicin AB
发明人： HANSSON, Henri , SPEGEL, Christer
IPC分类号： G01N21/25 , G01N21/78 , C12Q1/40 , C12Q1/54 , G01N33/10
CPC分类号： C12Q1/40
摘要： The degradation resistance properties of native starch are studied in vitro using a photometrical method. The reducing sugars, formed by the enzymatic degradation of the starch molecules, form complexes with 3,5-dinitro salicylate, the concentration of which can be spectrophoto-metrically determined. The method has exhibited good accuracy and high reproducibility. The obtained results can be used to predict the enzymatic degradation behaviour in vivo, e.g for predicting the degradation profile of various native starch formulations.

73. 发明授权

EP0891554B1 METHOD OF MEASURING BILIRUBIN 失效
标题翻译：法测量胆红素的
公开(公告)号：EP0891554B1
公开(公告)日：2003-06-18
申请号：EP97920142.3
申请日：1997-04-04
申请人： Beckman Coulter, Inc.
发明人： SCHULTZ, Cecilia, Z. , YEIN, Fredrick, S.
IPC分类号： G01N33/72 , C12Q1/26 , C12Q1/54 , C12Q1/60 , C12Q1/61 , C12Q1/62
CPC分类号： C12Q1/54 , C12Q1/26 , C12Q1/60 , C12Q1/61 , C12Q1/62 , G01N33/728 , Y10S435/81

74. 发明授权

EP0769558B1 Blood glucose strip having reduced sensitivity to hematocrit 失效
标题翻译：血糖试纸与血细胞比容的敏感性降低
公开(公告)号：EP0769558B1
公开(公告)日：2003-04-02
申请号：EP96307522.1
申请日：1996-10-16
申请人： LIFESCAN, INC.
发明人： Yu, Yeung S.
IPC分类号： C12Q1/54
CPC分类号： G01N33/523 , C12Q1/54 , G01N33/526 , Y10T436/144444

75. 发明公开

EP1242440A4 USE OF NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD) AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (NADP) ANALOGS TO MEASURE ENZYME ACTIVITIES, METABOLITES AND SUBSTRATES 有权
标题翻译：使用烟酰胺腺嘌呤二核苷酸（NAD）和测量酶活性和代谢物衬底的烟酰胺腺嘌呤二核苷酸腺嘌呤磷酸（NADP）模拟
公开(公告)号：EP1242440A4
公开(公告)日：2003-01-15
申请号：EP00990352
申请日：2000-12-27
申请人： SPECIALTY ASSAYS INC
发明人： KAUFMAN RICHARD A
IPC分类号： C12Q1/32 , C12Q1/61 , C07H19/207 , C12N9/96 , C12Q1/26 , C12Q1/54 , C12Q1/58
CPC分类号： C12Q1/61 , C12Q1/32
摘要： Kits and methods for measuring enzyme activities and metabolites using NAD analogs and NADP analogs are disclosed. The analogs can be used as replacements for NAD and NADP cofactors in analytical procedures. Preferred aspects of the invention include kits containing the NAD analogs and NADP analogs for use in the measurement of ethanol, lactic acid, 3-hydroxybutyric acid, glucose, glycerol, triglycerides, alpha-glycerophosphate, bile acids and glucose-6-phosphate dehydrogenase activity in analytical samples.

76. 发明授权

EP1102991B1 DIAGNOSTIC ASSAY REQUIRING A SMALL SAMPLE OF BIOLOGICAL FLUID 无效
标题翻译：诊断测试程序针对小样品体积
公开(公告)号：EP1102991B1
公开(公告)日：2002-11-13
申请号：EP99927176.0
申请日：1999-06-03
申请人： ABBOTT LABORATORIES
发明人： WONG, Sie, Ting , HILTIBRAN, Robert G. , HUANG, Tung-Ming
IPC分类号： G01N33/543 , G01N33/53 , C12Q1/54
CPC分类号： G01N33/54373 , G01N33/5304
摘要： A multiple-layer element method for monitoring the concentration of glucose in blood. The element comprises: (a) a core layer having two major surfaces, an optical reading chamber extending from a first opening in one of said two major surfaces to a second opening in the other of said two major surfaces, said, core layer further having a third opening therein and a flow channel, one end of which flow channel communicates with the third opening and the other end of which flow channel communicates with the optical reading chamber; and (b) a base layer in face-to-face contact with one major surface of said core layer; and (c) a cover layer in face-to-face contact with the other major surface of said core layer, said cover layer having an opening therein to vent the element. The method involves (a) obtaining a sample of biological fluid, e.g., interstitial fluid, from the body of a patient; (b) introducing the sample to article comprising a multiple-layer element having an optical reading chamber; (c) allowing reagents to react with an analyse of interest in the sample; and (d) measuring the concentration of analyse in the sample by means of an optical instrument.

77. 发明公开

EP1211512A3 Test strip for determining dialysate composition 有权
标题翻译：用于测定透析液组成的测试条
公开(公告)号：EP1211512A3
公开(公告)日：2002-11-06
申请号：EP01309864.5
申请日：2001-11-23
申请人： SERIM RESEARCH CORPORATION
发明人： Christner, James E. , Hout, Linda S.
IPC分类号： G01N33/52 , G01N33/84 , G01N33/66 , C12Q1/54
CPC分类号： G01N33/84 , C12Q1/54 , G01N33/66 , Y10T436/15
摘要： A test strip (10) for confirming a desired proportion of components in dialysate, including a first medium capable of indicating the concentration of bicarbonate ion, and a second medium capable of indicating the concentration of glucose. The test strip (10) defines a first region (11) impregnated with the first medium, and a second region (12) impregnated with the second medium. The test strip optionally includes a third medium capable of indicating the pH of the dialysate. The third medium is impregnated at a third region (13) on the test strip. Alternatively, the test strip (15) comprises a bicarbonate test pad attached to a first region (16), a glucose test pad attached to a second region (17), and optionally a pH test pad attached to a third region (18). The glucose test pad is impregnated with the first medium, the glucose test pad is impregnated with the second medium, and the pH test pad is impregnated with the third medium.
摘要翻译：一种用于确认透析液中所需组分比例的测试条（10），包括能够指示碳酸氢根离子浓度的第一介质和能够指示葡萄糖浓度的第二介质。测试条（10）限定了浸渍有第一介质的第一区域（11）和浸渍有第二介质的第二区域（12）。测试条任选地包括能够指示透析液的pH的第三介质。第三介质浸渍在测试条上的第三区域（13）处。或者，测试条（15）包括附着于第一区域（16）的碳酸氢盐测试垫，附着于第二区域（17）的葡萄糖测试垫，以及可选地附着于第三区域（18）的pH测试垫。用第一介质浸渍葡萄糖测试垫，用第二介质浸渍葡萄糖测试垫，并用第三介质浸渍pH测试垫。

78. 发明公开

EP1131631A4 IN SITU METHOD OF ANALYZING CELLS 有权
标题翻译：原位方法分析细胞
公开(公告)号：EP1131631A4
公开(公告)日：2002-11-04
申请号：EP99963904
申请日：1999-11-16
申请人： APPLIED SPECTRAL IMAGING LTD
发明人： GARINI YUVAL , MCNAMARA GEORGE , SOENKSEN DIRK G , CABIB DARIO , BUCKWALD ROBERT A
IPC分类号： C12Q1/68 , G01J3/02 , G01J3/12 , G01J3/26 , G01J3/28 , G01J3/44 , G01J3/453 , G01N1/30 , G01N21/64 , G01N21/78 , G01N33/50 , G01N33/53 , G01N33/533 , G01N33/535 , G01N33/569 , G01N33/58 , G06K9/00 , G06K9/76 , C12Q1/00 , C12Q1/28 , C12Q1/42 , C12Q1/54
CPC分类号： C12Q1/6841 , C12Q1/6883 , G01J3/02 , G01J3/12 , G01J3/1256 , G01J3/26 , G01J3/2823 , G01J3/4406 , G01J3/453 , G01J2003/2866 , G01N1/30 , G01N21/6428 , G01N21/6456 , G01N33/5005 , G01N33/53 , G01N33/56966 , G01N33/582 , G01N2021/6423 , G01N2021/6441 , G06K9/00127 , G06K9/76 , Y10S435/968
摘要： A method of in situ analysis of a biological sample comprising the steps of (a) staining the biological sample with N stains of which a first stain is selected from the group consisting of a first immunohistochemical stain, a first histological stain and a first DNA ploidy stain, and a second stain is selected from the group consisting of a second immunohistochemical stain, a second histological stain and a second DNA ploidy stain, with provisions that N is an integer greater than three and further that (i) if the first stain is the first immunohistochemical stain then the second stain is either the second histological stain or the second DNA ploidy stain; (ii) if the first stain is the first histological stain then the second stain is either the second immunohistochemical stain or the second DNA ploidy stain; whereas (iii) if the first stain is the first DNA ploidy stain then the second stain is either the second immunohistochemical stain or the second histological stain; and (b) using a spectral data collection device for collecting spectral data from the biological sample, the spectral data collection device and the N stains are selected so that a spectral component associated with each of the N stains is collectible. Figure (1) shows a block diagram illustrating the main components of an imaging spectrometer.

79. 发明授权

EP0800082B1 Reagent test strip for blood glucose determination 失效
标题翻译：试剂试验条来检测血液中葡萄糖
公开(公告)号：EP0800082B1
公开(公告)日：2002-08-14
申请号：EP97302306.2
申请日：1997-04-03
申请人： LIFESCAN, INC.
发明人： Smith, John L.
IPC分类号： G01N33/52 , C12Q1/54
CPC分类号： G01N21/8483 , G01N33/523 , Y10S435/808 , Y10S435/97

80. 发明公开

EP1019531A4 A METHOD TO ASSAY ENZYMATIC COVALENT BOND FORMATION AND CLEAVAGE 审中-公开
标题翻译：法测定酶活共价键结合，教育与SPLIT
公开(公告)号：EP1019531A4
公开(公告)日：2002-05-29
申请号：EP98942109
申请日：1998-08-18
申请人： INTERGEN COMPANY
发明人： WRIGHT DENNIS , PHELPS DAVID J
IPC分类号： G01N21/78 , C07D241/46 , C07D257/04 , C12Q1/26 , C12Q1/44 , C12Q1/48 , C12Q1/54 , C12Q1/60 , C12Q1/00 , G01N33/53
CPC分类号： C12Q1/26 , G01N2333/91057 , G01N2333/916 , G01N2333/924 , Y10S435/81
摘要： A non-radioactive method of detecting an enzyme-substrate reaction comprising coupling said reaction with a tetrazolium salt and the transfer of free electrons from the reaction to produce a single color or fluorescent formazan. The method is used for assaying a plurality of compounds for enzyme activity.

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