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71. 发明公开

EP0007687A1 Sulfonamides, processes for their preparation, compositions containing said sulfonamides and a method for controlling the growth of vegetation 有权
标题翻译：磺酰胺，它们的制备方法，涉及含有磺酰胺和方法用于影响植物生长的组合物。
公开(公告)号：EP0007687A1
公开(公告)日：1980-02-06
申请号：EP79300982.0
申请日：1979-05-29
申请人： E.I. DU PONT DE NEMOURS AND COMPANY
发明人： Levitt, George
IPC分类号： C07D239/69 , C07D251/42 , C07D253/06 , C07D265/28 , A01N47/36
CPC分类号： C07C311/65 , A01N47/28 , A01N47/36 , C07C317/00 , C07C323/00 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/48 , C07D239/52 , C07D251/14 , C07D251/16 , C07D251/18 , C07D251/46 , C07D251/52 , C07D253/06 , C07D253/07 , C07D253/075 , C07D521/00
摘要： Compounds of the formula
and their agriculturally suitable salts wherein

Q is O, S or

R, R z , R 3 , R 4 and R 6 are various organic groups, or in some cases H; R 5 is H, CH 3 or OCH 3 ;
R 1 , is a pyrimidine or tirazine residue; and
W is O or S:

are useful for the regulation of plant growth and/or as pre-emergance or post-emergence herbicides.
The compounds can be prepared e.g. by reacting an appropriate benzenesulfonyl isocyanate or isothiocyanate with an appropriate aminopyrimidine or aminotriazine. The compounds can be formulated for agricultural use in conventional manner. Also the production of isocyanates of the formula
wherein the substituents R, R 2 and R 3 are previously defined, is described, which are used as raw material for the preparation of the compounds with the above-mentioned formula.
摘要翻译：式及其农业上适用的盐worin Q为化合物O，S或 R，R2，R3，R4和R6是不同的有机基团，或在某些情况下H; R 5是H，CH 3或OCH 3; R1是嘧啶或tirazine残基; 且W为O或S; 是植物生长和/或作为预emergance或芽后除草剂的调节是有用的。所述化合物可以例如是制备通过在适当氨基嘧啶或氨基三嗪反应到适当的异氰酸酯苯或异硫氰酸酯与。化合物可以被配制用于以常规方式农业用途。还生产式 worin取代基R的异氰酸酯的，R2和R3如前定义，描述，被用作原料，用于与上述式I的化合物的制备。

72. 发明授权

EP2628724B1 ARYLOXYUREA COMPOUND AND PEST CONTROL AGENT 有权
公开(公告)号：EP2628724B1
公开(公告)日：2018-12-05
申请号：EP11832476.3
申请日：2011-10-06
申请人： Nippon Soda Co., Ltd.
发明人： FURUKAWA, Hironori , NAKAMURA, Takehiko , TAMAI, Tetsuo , HANAI, Daisuke
IPC分类号： C07C275/64 , A01N47/34 , A01P7/02 , A61K31/17 , A61K31/197 , A61K31/216 , A61K31/277 , A61K31/341 , A61K31/381 , A61K31/41 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409
CPC分类号： C07C275/64 , A01N47/28 , A01N47/30 , A01N47/32 , A01N47/34 , A61K31/17 , A61K31/197 , A61K31/216 , A61K31/277 , A61K31/341 , A61K31/381 , A61K31/41 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4412 , A61K31/4418 , A61K31/4439 , A61K31/4453 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/4965 , A61K31/498 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/53 , C07C271/40 , C07C317/22 , C07C381/10 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2602/08 , C07C2602/10 , C07D211/60 , C07D213/30 , C07D213/40 , C07D213/54 , C07D213/61 , C07D213/62 , C07D213/64 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/83 , C07D213/84 , C07D213/89 , C07D215/20 , C07D215/22 , C07D217/22 , C07D231/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/08 , C07D253/06 , C07D253/065 , C07D257/04 , C07D261/08 , C07D263/10 , C07D271/06 , C07D277/28 , C07D295/16 , C07D295/192 , C07D307/42 , C07D307/52 , C07D333/16 , C07D333/20 , C07D401/12 , C07D417/12
摘要： The present invention provides a pest control agent, acaricide or fungicide that contains, as the active ingredient thereof, at least one type of compound selected from the aryloxyurea compounds represented by formula (V) (wherein R 1 to R 5 each independently represents an alkyl group or the like, X is a halogen atom or the like, n is an integer of 0 to 5, and Z is an oxygen atom or sulfur atom) or salts thereof.

74. 发明公开

EP3353151A1 MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE 审中-公开
公开(公告)号：EP3353151A1
公开(公告)日：2018-08-01
申请号：EP16774993.6
申请日：2016-09-22
申请人： GlaxoSmithKline Intellectual Property (No. 2) Limited
发明人： CHONG, Pek Yoke , DE LA ROSA, Martha , DICKSON, Hamilton , KAZMIERSKI, Wieslaw Mieczyslaw , SAMANO, Vicente , TAI, Vincent Wing-Fai
IPC分类号： C07D213/74 , C07D309/14 , C07D333/20 , C07D235/30 , C07D239/42 , C07D241/20 , C07D253/06 , C07D263/48 , C07D263/58 , C07D277/82 , C07D285/00 , C07D307/66 , A61K31/44 , A61K31/433 , A61K31/421 , A61K31/426 , A61P31/18
CPC分类号： C07D263/58 , C07D213/74 , C07D235/30 , C07D239/42 , C07D241/20 , C07D253/06 , C07D263/48 , C07D277/82 , C07D285/00 , C07D307/66 , C07D309/14 , C07D333/20
摘要： Provided are compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of HIV; including the prevention of the progression of AIDS and general immunosuppression.

75. 发明授权

EP2229371B1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS 无效
标题翻译：循环和氮唑重氮钠通道阻滞剂
公开(公告)号：EP2229371B1
公开(公告)日：2015-12-23
申请号：EP09701748.7
申请日：2009-01-16
申请人： University of Greenwich
发明人： LEACH, Michael , HARBIGE, Laurence , RIDDALL, Dieter , FRANZMANN, Karl
IPC分类号： C07D253/06 , A61K31/53 , A61P25/00
CPC分类号： C07D253/075 , C07D253/06 , C07D253/07 , C07D253/10 , C07D401/04 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12
摘要： The invention relates to compounds of general formula (I), or a salt or solvate thereof; in which: X and Y are each N; A is an optionally substituted phenyl group or an optionally substituted sulphur containing heterocycle; Z is a single bond or a linking group which is a carbon atom carrying substituents R4 and R5, wherein R4 and R5 are independently selected from hydrogen, optionally substituted C 1-6 alkyl and another group A, provided that no more than one of R4 or R5 are hydrogen; R1 is hydrogen, or a substituent group selected from C 1-10 alkyl, C 2-10 alkenyl, benzyl, piperidine-methyl, thienyl-methyl, furyl-methyl or C 3-10 cycloalkyl, any of which is optionally substituted by hydroxy, halogen, carboxamide, halo C 1-4 alkyl, C 1-6 alkyl or C 1-6 alkoxy; or the Y nitrogen is unsubstituted; R2 is amino or a substituent group selected from optionally substituted alkyl or phenyl groups; and N* is =NH when R1 is hydrogen or a substituent group; or N* is a group NRaRb where Ra and Rb are independently H or an alkyl group; or N* is an optionally substituted piperazinyl ring. The compounds can be used to treat disorders in mammals that are susceptible to sodium channel blockers and antifolates, particularly disorders such as epilepsy, multiple sclerosis, glaucoma and uveitis, cerebral traumas and cerebral ischaemias, stroke, head injury, spinal cord injury, surgical trauma, neurodegenerative disorders, motor neurone disease, Alzheimer's disease, Parkinson's disease, chronic inflammatory pain, neuropathic pain, migraine, bipolar disorder, mood, anxiety and cognitive disorders, schizophrenia and trigeminal autonomic cephalalgias; for treatment of mammalian cancers; and for treatment of malaria.

76. 发明公开

EP2746255A1 Substituted [1,2,4]triazole and imidazole compounds 审中-公开
标题翻译：取代基[1,2,4] - 三唑并咪唑并二烷
公开(公告)号：EP2746255A1
公开(公告)日：2014-06-25
申请号：EP13195054.5
申请日：2013-11-29
申请人： BASF SE
发明人： Grammenos, Wassilios , Craig, Ian Robert , Boudet, Nadege , Müller, Bernd , Dietz, Jochen , Lauterwasser, Erica May Wilson , Lohmann, Jan Klaas , Grote, Thomas , Haden, Egon , Escribano Cuesta, Ana
IPC分类号： C07D233/56 , C07D233/68 , C07D233/84 , C07D253/06 , A01N43/50 , A01N43/653
CPC分类号： C07D233/56 , C07D233/68 , C07D233/84 , C07D253/06
摘要： The present invention relates to compounds of the formula I

wherein the substituents are as defined in the description and claims, their preparation and their uses.
摘要翻译：本发明涉及式I化合物，其中取代基如说明书和权利要求书中所定义，其制备及其用途。

77. 发明公开

EP2628724A4 ARYLOXYUREA COMPOUND AND PEST CONTROL AGENT 有权
标题翻译： ARYLOXYHARNSTOFF而为了农药
公开(公告)号：EP2628724A4
公开(公告)日：2014-02-26
申请号：EP11832476
申请日：2011-10-06
申请人： NIPPON SODA CO
发明人： FURUKAWA HIRONORI , NAKAMURA TAKEHIKO , TAMAI TETSUO , HANAI DAISUKE
IPC分类号： C07C275/64 , A01N47/34 , A01P7/02 , A61K31/17 , A61K31/197 , A61K31/216 , A61K31/277 , A61K31/341 , A61K31/381 , A61K31/41 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409
CPC分类号： C07C275/64 , A01N47/28 , A01N47/30 , A01N47/32 , A01N47/34 , A61K31/17 , A61K31/197 , A61K31/216 , A61K31/277 , A61K31/341 , A61K31/381 , A61K31/41 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4412 , A61K31/4418 , A61K31/4439 , A61K31/4453 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/4965 , A61K31/498 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/53 , C07C271/40 , C07C317/22 , C07C381/10 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2602/08 , C07C2602/10 , C07D211/60 , C07D213/30 , C07D213/40 , C07D213/54 , C07D213/61 , C07D213/62 , C07D213/64 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/83 , C07D213/84 , C07D213/89 , C07D215/20 , C07D215/22 , C07D217/22 , C07D231/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/08 , C07D253/06 , C07D253/065 , C07D257/04 , C07D261/08 , C07D263/10 , C07D271/06 , C07D277/28 , C07D295/16 , C07D295/192 , C07D307/42 , C07D307/52 , C07D333/16 , C07D333/20 , C07D401/12 , C07D417/12
摘要： The present invention provides a pest control agent, acaricide or fungicide that contains, as the active ingredient thereof, at least one type of compound selected from the aryloxyurea compounds represented by formula (V) (wherein R 1 to R 5 each independently represents an alkyl group or the like, X is a halogen atom or the like, n is an integer of 0 to 5, and Z is an oxygen atom or sulfur atom) or salts thereof.

78. 发明公开

EP2628724A1 ARYLOXYUREA COMPOUND AND PEST CONTROL AGENT 有权
标题翻译： ARYLOXYHARNSTOFF UNDSCHÄDLINGSBEKÄMPFUNGSMITTELDAMIT
公开(公告)号：EP2628724A1
公开(公告)日：2013-08-21
申请号：EP11832476.3
申请日：2011-10-06
申请人： Nippon Soda Co., Ltd.
发明人： FURUKAWA Hironori , NAKAMURA Takehiko , TAMAI Tetsuo , HANAI Daisuke
IPC分类号： C07C275/64 , A01N47/34 , A01P7/02 , A61K31/17 , A61K31/197 , A61K31/216 , A61K31/277 , A61K31/341 , A61K31/381 , A61K31/41 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409
CPC分类号： C07C275/64 , A01N47/28 , A01N47/30 , A01N47/32 , A01N47/34 , A61K31/17 , A61K31/197 , A61K31/216 , A61K31/277 , A61K31/341 , A61K31/381 , A61K31/41 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4412 , A61K31/4418 , A61K31/4439 , A61K31/4453 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/4965 , A61K31/498 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/53 , C07C271/40 , C07C317/22 , C07C381/10 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2602/08 , C07C2602/10 , C07D211/60 , C07D213/30 , C07D213/40 , C07D213/54 , C07D213/61 , C07D213/62 , C07D213/64 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/83 , C07D213/84 , C07D213/89 , C07D215/20 , C07D215/22 , C07D217/22 , C07D231/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/08 , C07D253/06 , C07D253/065 , C07D257/04 , C07D261/08 , C07D263/10 , C07D271/06 , C07D277/28 , C07D295/16 , C07D295/192 , C07D307/42 , C07D307/52 , C07D333/16 , C07D333/20 , C07D401/12 , C07D417/12
摘要： The present invention provides a pest control agent, acaricide or fungicide that contains, as the active ingredient thereof, at least one type of compound selected from the aryloxyurea compounds represented by formula (V) (wherein R 1 to R 5 each independently represents an alkyl group or the like, X is a halogen atom or the like, n is an integer of 0 to 5, and Z is an oxygen atom or sulfur atom) or salts thereof.
摘要翻译：本发明提供一种害虫防治剂，杀螨剂或杀真菌剂，其含有选自式（V）表示的芳氧基脲化合物中的至少一种化合物（其中R 1至R 5各自独立地表示烷基基团等，X为卤素原子等，n为0〜5的整数，Z为氧原子或硫原子）或其盐。

79. 发明公开

EP2593425A1 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE 有权转让
标题翻译： VERFAHREN ZU IHRER VERWENDUNG WIRKSTOFFZUSAMMENSETZUNGEN
公开(公告)号：EP2593425A1
公开(公告)日：2013-05-22
申请号：EP11738902.3
申请日：2011-07-15
申请人： Agios Pharmaceuticals, Inc.
发明人： POPOVICI-MULLER, Janeta , SALITURO, Francesco, G. , SAUNDERS, Jeffrey, O. , TRAVINS, Jeremey , YAN, Shunqi
IPC分类号： C07C237/22 , C07C271/22 , C07C271/44 , A61P43/00 , A61K31/16 , A61K31/18 , A61K31/357 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/4164 , A61K31/4192 , A61K31/426 , A61K31/435 , A61K31/495
CPC分类号： C07K5/06078 , A61K38/00 , C07C237/22 , C07C271/22 , C07C271/44 , C07C271/58 , C07C311/06 , C07C311/13 , C07C311/19 , C07C317/36 , C07C335/32 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/10 , C07D207/16 , C07D209/08 , C07D209/14 , C07D209/26 , C07D209/42 , C07D209/44 , C07D211/14 , C07D211/38 , C07D211/54 , C07D211/60 , C07D213/30 , C07D213/38 , C07D213/56 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/74 , C07D217/04 , C07D221/18 , C07D231/12 , C07D231/42 , C07D231/56 , C07D233/61 , C07D233/64 , C07D233/70 , C07D233/88 , C07D235/04 , C07D237/14 , C07D239/26 , C07D241/12 , C07D249/04 , C07D249/18 , C07D253/06 , C07D257/04 , C07D261/18 , C07D265/36 , C07D271/06 , C07D271/10 , C07D277/28 , C07D277/30 , C07D277/56 , C07D295/04 , C07D295/205 , C07D305/08 , C07D307/20 , C07D307/22 , C07D309/12 , C07D309/14 , C07D317/68 , C07D319/20 , C07D333/24 , C07D333/38 , C07D409/12 , C07D471/04
摘要： Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1 comprising administering to a subject in need thereof a compound described here.
摘要翻译：提供治疗特征为存在IDH1的突变等位基因的癌症的方法，包括向有需要的受试者施用本文所述的化合物。

80. 发明公开

EP2451803A2 METHOD FOR PREPARING 5-CHLORO-N-({(5S)-2-OXO-3-[4-(5,6-DIHYDRO-4H-[1,2,4]TRIAZIN-1-YL)PHENYL]-1,3-OXAZOLIDIN-5-YL}METHYL)THIOPHEN-2-CARBOXAMIDE DERIVATIVE AND INTERMEDIATE USED THEREIN 有权转让
标题翻译：用于制备5-氯-N - （{（5S）-2-氧代-3- [4-（5,6-二氢-4H- [1,2,4]三嗪-1-基）苯基] - -1,3-恶唑烷-5-基}甲基）噻吩-2-甲酰胺衍生物THEREIN AND中间体USED
公开(公告)号：EP2451803A2
公开(公告)日：2012-05-16
申请号：EP10797303.4
申请日：2010-07-07
申请人： Green Cross Corporation , Legochem Bioscience Ltd.
发明人： CHO, Young Lag , CHAE, Sang Eun , KIM, Seong Jin , SONG, Ho Young , PARK, Tae Kyo , WOO, Sung Ho , KIM, Yong Zu , LEE, Jinhwa , LEE, Suk Ho
IPC分类号： C07D403/08 , C07D403/06
CPC分类号： C07D413/14 , C07D253/06 , C07D409/12
摘要： Disclosed are : a method for preparing a 5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}-methyl)thiophen-2-carboxamide derivative, which is a inhibitor of blood coagulation factor Xa, in a high purity and yield; and a novel intermedicate used therein.

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