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71. 发明公开

EP2708229A1 NON-AQUEOUS PATCH 有权
标题翻译：非水性补丁
公开(公告)号：EP2708229A1
公开(公告)日：2014-03-19
申请号：EP11865320.3
申请日：2011-05-10
申请人： Itochu Chemical Frontier Corporation , Oishi Koseido Co., Ltd
发明人： MORI, Tatsuya , SAIDA, Naoyuki
IPC分类号： A61K31/167 , A61K9/70 , A61K47/10 , A61K47/12 , A61P23/00 , A61P29/00
CPC分类号： A61K9/0014 , A61K9/7053 , A61K9/7076 , A61K31/167 , A61K47/10 , A61K47/12
摘要： Non-aqueous patches comprising lidocaine, which is not dissolved and is present in a crystalline state, have poor permeability to the skin. Therefore, non-aqueous patches have a high concentration of lidocaine. It is pointed out that lidocaine has an adverse effect on the heart. Prolonged use of a high concentration of lidocaine causes side effects, such as shock, rubor, and irritating sensation. External preparations comprising more than 5 mass% of lidocaine are designated as powerful drugs, and cannot be used as household (nonprescription) medicine. Provided is a non-aqueous patch that is effective to relieve muscle pain, the non-aqueous patch comprising lidocaine and/or its reactant, and a dissolving agent composed of an organic acid and a polyalcohol, which are contained in a base.
摘要翻译：包含利多卡因的非水性贴剂，其不溶解并且以结晶状态存在，对皮肤的渗透性差。因此，非水性贴剂具有高浓度的利多卡因。有人指出利多卡因对心脏有不良影响。长时间使用高浓度的利多卡因引起副作用，如休克，红宝石和刺激性感觉。包含超过5质量％的利多卡因的外用制剂被指定为强效药物，并且不能用作家庭（非处方）药物。本发明提供可有效缓解肌肉疼痛的非水性贴剂，含有利多卡因和/或其反应物的非水性贴剂以及由有机酸和多元醇构成的溶解剂。

72. 发明公开

EP2692336A1 EXTERNALLY USED DRUG KIT 失效
标题翻译： EXZN ANGEWENDETES ARZNEIMITTELKIT
公开(公告)号：EP2692336A1
公开(公告)日：2014-02-05
申请号：EP12763468.1
申请日：2012-03-27
申请人： Shiseido Company, Ltd.
发明人： KISHIMOTO, Satoko , TAKASHIMIZU, Chisato , YAGYU, Kazuhiro , YASUGI, Daisuke
IPC分类号： A61K8/73 , A61K8/02 , A61K8/60 , A61K8/65 , A61K8/81 , A61K9/70 , A61K47/36 , A61K47/38 , A61Q19/00
CPC分类号： A61M35/00 , A61K8/0204 , A61K8/0208 , A61K8/042 , A61K8/60 , A61K8/65 , A61K8/73 , A61K8/731 , A61K8/732 , A61K8/737 , A61K8/8129 , A61K9/7076 , A61K47/36 , A61K47/38 , A61Q19/00
摘要： An external preparation kit is provided, which has a gel sheet having excellent water-releasing property and elongation, and a water-soluble sheet having excellent solubility.
Thus, an external preparation kit according to the invention comprises:
(I) a gel sheet containing:
(a) 1-6% by mass of a composition comprising 10-80% by mass of carrageenan, 5-50% by mass of locust bean gum, 5-50% by mass of xanthan gum, and 5-50% by mass of mannan; and
(b) water; and

(II) a water-soluble sheet containing one or more component(s) selected from the group consisting of a cellulose derivative, polyvinyl alcohol, collagen, starch, gelatin, agar, and sugar.
摘要翻译：提供了具有优异的脱水性和延伸性的凝胶片和溶解性优异的水溶性片的外用剂试剂盒。因此，本发明的外用剂包含：（I）凝胶片，其含有：（a）1-6质量％的包含10-80质量％角叉菜胶，5-50质量％蝗虫豆胶，5-50质量％的黄原胶和5-50质量％的甘露聚糖; 和（b）水; 和（II）含有选自纤维素衍生物，聚乙烯醇，胶原，淀粉，明胶，琼脂和糖中的一种或多种成分的水溶性片材。

73. 发明授权

EP1621188B1 ULTRAVIOLET-SHIELDING TYPE PATCH 有权转让
标题翻译：石膏紫外线防护类型的
公开(公告)号：EP1621188B1
公开(公告)日：2013-07-10
申请号：EP04731709.4
申请日：2004-05-07
申请人： Hisamitsu Pharmaceutical Co., Inc.
发明人： HASHIMOTO, Yoshiaki, HISAMITSU PHARMAC. CO., INC. , TAKADA, Yasunori, HISAMITSU PHARMAC. CO., INC. , TSURUDA, Kiyomi, HISAMITSU PHARMAC. CO., INC
IPC分类号： A61K9/70 , A61K47/22 , A61K47/32 , A61K45/00 , A61K31/192 , A61P29/00
CPC分类号： A61K9/7053 , A61K9/7076 , A61K31/192 , A61K47/22

74. 发明公开

EP2609913A1 Patch preparation 审中-公开
标题翻译：补丁准备
公开(公告)号：EP2609913A1
公开(公告)日：2013-07-03
申请号：EP12199165.7
申请日：2012-12-21
申请人： Nitto Denko Corporation
发明人： Aoyagi, Kazuhiro , Iwao, Yoshihiro , Matsuoka, Kensuke , Tanaka, Tomoya
IPC分类号： A61K9/70 , A61F13/02
CPC分类号： A61K9/7038 , A61F13/0259 , A61F2013/00646 , A61K9/703 , A61K9/7053 , A61K9/7076
摘要： The present invention relates to a patch preparation having a central part and a peripheral part surrounding the central part, the patch preparation comprising: a patch preparation main body having a support and an adhesive layer which contains a drug and is formed on the support; and a release liner laminated on the adhesive layer, wherein the peripheral part has a predetermined area, and a peel force between the adhesive layer and the release liner in the predetermined area is greater than a peel force between the adhesive layer and a release liner in the central part.
摘要翻译：本发明涉及一种贴片制剂，其具有中央部分和围绕该中央部分的周边部分，该贴剂制剂包括：贴剂制剂主体，其具有载体和形成在该载体上的含有药物的粘附层; 以及层压在所述粘合剂层上的剥离衬垫，其中所述周边部分具有预定面积，并且所述预定区域中所述粘合剂层和所述剥离衬垫之间的剥离力大于所述粘合剂层和所述剥离衬垫之间的剥离力中央部分。

75. 发明公开

EP2561865A2 TRANSDERMAL ABSORPTION PREPARATION 审中-公开
公开(公告)号：EP2561865A2
公开(公告)日：2013-02-27
申请号：EP11772254.6
申请日：2011-04-21
申请人： Icure Pharmaceutical Inc.
发明人： CHOI, Young Kweon , KIM, Jung Ju , KIM, Seong Su , LEE, Jung Sik , PARK, Seong Min
IPC分类号： A61K9/70 , A61K31/404 , A61P25/00
CPC分类号： A61K9/7061 , A61K9/7053 , A61K9/7076 , A61K31/4045
摘要： The present invention relates to a transdermal absorption preparation. The transdermal absorption preparation of the present invention comprises a drug-containing adhesive layer, a drug-protective layer and a release layer, wherein the drug-containing adhesive layer contains ropinirole or a salt thereof, rubber, an adhesion-imparting resin, an antioxidant, and a transdermal absorption promoter. Also, the present invention provides a transdermal absorption preparation comprising a drug-containing adhesive layer, a drug-protective layer, and a release layer, wherein the drug-containing adhesive layer contains ropinirole or a salt thereof, acrylic rubber, an anti-crystallization agent, and a transdermal absorption promoter. When the transdermal absorption preparation of the present invention is used for the treatment of Parkinson's disease or restless leg syndrome, no side effect due to an increase in the initial drug concentration in blood occurs and the skin penetration effect of the drug is excellent.
摘要翻译：本发明涉及透皮吸收制剂。本发明的透皮吸收制剂包含含药粘合剂层，药物保护层和释放层，其中含药粘合剂层含有罗匹尼罗或其盐，橡胶，粘合性树脂，抗氧化剂，和透皮吸收促进剂。另外，本发明提供一种透皮吸收制剂，其含有含药物粘合剂层，药物保护层和剥离层，其中含药物粘合剂层含有罗匹尼罗或其盐，丙烯酸橡胶，抗结晶剂和透皮吸收促进剂。当本发明的透皮吸收制剂用于治疗帕金森病或不宁腿综合征时，不会出现由于血液中初始药物浓度增加而产生的副作用，并且该药物的皮肤渗透效果极好。

76. 发明公开

EP1886675A4 SKIN PATCH 审中-公开
标题翻译： HAUTPFLASTER
公开(公告)号：EP1886675A4
公开(公告)日：2012-11-07
申请号：EP06747070
申请日：2006-06-01
申请人： NIPRO PATCH CO LTD
发明人： KAWAMURA NAOHISA , SAWADA HIDENORI , SAITOH TAKASHI , TAKIZAWA CHIHIRO , TSUCHIYA JUNKO
IPC分类号： A61K9/70 , A61K47/32
CPC分类号： A61K9/7053 , A61K9/7076 , C08K5/0016 , C08K5/01 , C08K5/3415 , C08L53/02 , C08L2201/00 , C08L2203/02 , C09J7/21 , C09J7/30 , C09J153/02 , C09J2201/60 , C09J2205/102 , C09J2453/00 , Y10T428/2883 , C08F236/08 , C08F236/10
摘要： A skin patch that can enhance the water resistance and handling easiness and can alleviate any irritation on the user. There is provided a skin patch comprising a flexible backing and, superimposed thereon, a plaster layer wherein the plaster layer contains a styrene-isoprene-styrene block copolymer and has a glass transition temperature (Tg) of -45° to -35°C and a tan ´ (lag angle) value, determined at dynamic viscoelasticity measurement (frequency 6.2832 rad/s) at 45°C, of 0.25 or less.
摘要翻译：皮肤贴剂可以增强耐水性和处理容易性，并可以减轻使用者的任何刺激。提供了一种皮肤贴片，其包括柔性背衬，并且叠加在其上的膏药层，其中所述膏药层含有苯乙烯 - 异戊二烯 - 苯乙烯嵌段共聚物，并且玻璃化转变温度（Tg）为-45℃至-35℃，以及在45℃下动态粘弹性测量（频率6.2832rad / s）测定的tan'（滞后角）值为0.25或更小。

77. 发明公开

EP2488166A2 TRANSDERMALE THERAPEUTISCHE SYSTEME ENTHALTEND 4-N-BUTYLRESORCIN 有权
标题翻译：传感器治疗系统包含4-N-BUTYLRESORCIN
公开(公告)号：EP2488166A2
公开(公告)日：2012-08-22
申请号：EP10734917.7
申请日：2010-07-14
申请人： Beiersdorf AG
发明人： SCHERNER, Cathrin , WÖLLER, Karl-Heinz , WOLBER, Rainer , KOLBE, Ludger
IPC分类号： A61K9/70
CPC分类号： A61L15/44 , A61K9/7053 , A61K9/7061 , A61K9/7076 , A61L2300/216 , A61L2300/404
摘要： The invention relates to transdermal therapeutic systems that contain 4-n-butylresorcinol as an active ingredient.
摘要翻译：含有4-正丁基间苯二酚作为活性成分的透皮治疗系统。

78. 发明公开

EP1872784A4 MEDICINAL PREPARATION FOR PERCUTANEOUS ABSORPTION 审中-公开
标题翻译：药物制剂的经皮吸收
公开(公告)号：EP1872784A4
公开(公告)日：2012-06-20
申请号：EP05734445
申请日：2005-04-20
申请人： SENJU PHARMA CO
发明人： KAWAHARA KOUJI , ARAMOMI YASUHIKO , SHIMADA NORIKO , OHTORI AKIRA , ISOWAKI AKIHARU
IPC分类号： A61K31/4535 , A61K9/70 , A61K47/14 , A61K47/16
CPC分类号： A61K31/4535 , A61K9/7053 , A61K9/7076 , A61K47/14

79. 发明授权

EP1477164B1 PERCUTANEOUS ABSORPTION TYPE PLASTER 有权
标题翻译：吸收型透皮贴剂
公开(公告)号：EP1477164B1
公开(公告)日：2012-06-06
申请号：EP03706968.9
申请日：2003-02-19
申请人： HISAMITSU PHARMACEUTICAL CO., INC.
发明人： Takada, Yasunori, Hisamitsu Pharmaceutical Co, Inc , Tanaka, Koji, Hisamitsu Pharmaceutical Co, Inc , Ikeura, Yasuhiro, Hisamitsu Pharmaceutical Co, Inc
IPC分类号： A61K9/70 , A61K47/32 , A61K31/196 , A61K47/12 , A61K47/14 , A61K47/34
CPC分类号： A61K9/7053 , A61K9/7076 , A61K31/196
摘要： A percutaneous absorption type plaster (1) having a support (2) and an adhesive layer (3) laminated the support (2), wherein the adhesive layer (3) contains a rosin type resin and a petroleum resin in such amounts that the rosin type resin and the petroleum resin are compounded in a total amount of 15 mass % to 50 mass %, and the compounding amount in mass of the petroleum resin is 1/3 to four times that of the rosin type resin.

80. 发明授权

EP1338276B1 Adhesive preparation for external use 有权
标题翻译：外用制剂的粘合剂
公开(公告)号：EP1338276B1
公开(公告)日：2012-04-18
申请号：EP00978013.1
申请日：2000-11-29
申请人： TEIKOKU SEIYAKU CO., LTD.
发明人： KAWAJI, Toshikuni
IPC分类号： A61K9/70 , A61K47/32 , A61K47/44
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076
摘要： An adhesive preparation comprising a plaster made of a hot-melt type hydrous pressure-sensitive adhesive which stably contains a water-soluble drug, satisfactorily releases the drug therefrom, and is high in bioavailability based on percutaneous absorption. The adhesive preparation is characterized by comprising a plaster made of a hot-melt type hydrous pressure-sensitive adhesive comprising as essential ingredients a styrene/isoprene/styrene block copolymer, a tackifier resin, an antioxidant, lanolin, and water. In the adhesive preparation for external use, the plaster contains a drug to be precutaneously absorbed.

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