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1. 发明公开

EP3332776A1 PATCH 审中-实审
公开(公告)号：EP3332776A1
公开(公告)日：2018-06-13
申请号：EP16835083.3
申请日：2016-08-05
申请人： Kaneka Corporation
发明人： TANAKA Tatsuyoshi , MIZUTANI Masaya , OGINO Hiroyuki , AKAZAWA Mitsuji , FUJII Akio , IMAI Naohiro
IPC分类号： A61K9/70 , A61K31/167 , A61K47/06 , A61K47/32 , A61P23/02
CPC分类号： A61K9/7053 , A61K9/0014 , A61K9/70 , A61K9/7076 , A61K31/167 , A61K47/06 , A61K47/32 , A61P23/02
摘要： It is an object of the present invention to provide a patch having practical adhesive force and cohesive force as a pharmaceutical product, and also exhibiting a fast-acting anesthetic action. The present invention provides a patch formed from an adhesive layer comprising 5% by weight or more and less than 20% by weight of a mixture of lidocaine and another local anesthetic, wherein the adhesive layer comprises at least a rubber-based pressure-sensitive adhesive and liquid paraffin and a content of a tackifier in the adhesive layer is 10% by weight or less.

2. 发明授权

EP2934403B1 PATCH FOR TREATMENT OF EYELID DISEASES CONTAINING CLOBETASOL 失效
标题翻译：包含CLOBETASOL的睑缘疾病治疗的补丁
公开(公告)号：EP2934403B1
公开(公告)日：2018-03-21
申请号：EP13865975.0
申请日：2013-12-17
申请人： SENJU USA, INC. , Nichiban Co., Ltd.
发明人： OGAWA, Takahiro , ISOWAKI, Akiharu , KAWAHARA, Koji , HIRAOKA, Takao , TANAKA, Mariko , KENMOCHI, Chihiro
IPC分类号： A61F13/02 , A61K9/70 , A61L15/24 , A61L15/26 , A61L15/44 , A61L15/58
CPC分类号： A61M35/00 , A61K9/7053 , A61K9/7076 , A61L15/24 , A61L15/26 , A61L15/44 , A61L15/58 , C08L67/04 , C08L23/06
摘要： A patch for treatment of eyelid diseases that is provided with a support, a pressure-sensitive adhesive layer, and a release layer in this order, wherein (a) the pressure-sensitive adhesive layer includes the following (a-1) to (a-4): (a-1) a styrene-isoprene-styrene block copolymer, a tackifier resin, and a softening agent are contained; (a-2) a ratio (mass ratio) of the styrene-isoprene-styrene block copolymer and the tackifier resin is 1:2 to 1:4; (a-3) a content of the softening agent is 40% to 60% by mass; and (a-4) further 0.005% to 5% by mass of clobetasol or acid ester thereof is contained; and (b) the support has elastic modulus with a Young's modulus of 0.01 to 0.5 GPa: and a method for producing the patch for treatment of eyelid diseases including: forming a pressure-sensitive adhesive layer on a upper surface of a release layer.

3. 发明授权

EP2692336B1 EXTERNALLY USED DRUG KIT 失效
标题翻译：外部使用的药物成套工具
公开(公告)号：EP2692336B1
公开(公告)日：2017-05-31
申请号：EP12763468.1
申请日：2012-03-27
申请人： Shiseido Company, Ltd.
发明人： KISHIMOTO, Satoko , TAKASHIMIZU, Chisato , YAGYU, Kazuhiro , YASUGI, Daisuke
IPC分类号： A61K8/73 , A61K8/02 , A61K8/60 , A61K8/65 , A61K8/81 , A61K9/70 , A61K47/36 , A61K47/38 , A61Q19/00
CPC分类号： A61M35/00 , A61K8/0204 , A61K8/0208 , A61K8/042 , A61K8/60 , A61K8/65 , A61K8/73 , A61K8/731 , A61K8/732 , A61K8/737 , A61K8/8129 , A61K9/7076 , A61K47/36 , A61K47/38 , A61Q19/00

4. 发明授权

EP2431034B1 ADHESIVE PATCH-CONTAINING PACKAGE BAG AND METHOD FOR STORING ADHESIVE PATCH 有权
标题翻译：包装袋的书补丁和方法储存空间问题补丁
公开(公告)号：EP2431034B1
公开(公告)日：2016-08-10
申请号：EP10767158.8
申请日：2010-04-23
申请人： Hisamitsu Pharmaceutical Co., Inc.
发明人： UCHIDA Naoyuki , TAKAGI Yuka , TAKADA Yasunori
IPC分类号： A61K31/4045 , A61K9/70 , A61K47/30 , A61K47/32 , A61K47/34 , A61P25/16
CPC分类号： A61K9/7076 , A61K31/4045

5. 发明授权

EP1767218B1 ANTIINFLAMMATORY AND ANALGESIC PREPARATION FOR EXTERNAL USE 有权
标题翻译：抗炎镇痛制备用于外部使用
公开(公告)号：EP1767218B1
公开(公告)日：2016-08-10
申请号：EP05751470.5
申请日：2005-06-15
申请人： Hisamitsu Pharmaceutical Co., Inc.
发明人： KAWAMURA, Youichi , HONDA, Yusuke
IPC分类号： A61K47/08 , A61K9/06 , A61K9/107 , A61K31/192 , A61K31/196 , A61K47/10 , A61K47/14 , A61K47/16 , A61K47/22 , A61K47/32 , A61K47/34 , A61K9/12 , A61K9/70 , A61P17/00 , A61P29/00
CPC分类号： A61K9/107 , A61K9/0014 , A61K9/06 , A61K9/12 , A61K9/7053 , A61K9/7076 , A61K31/192 , A61K31/196 , A61K47/08 , A61K47/14

6. 发明公开

EP2934403A2 PATCH FOR TREATMENT OF EYELID DISEASES CONTAINING CLOBETASOL 失效
标题翻译：石膏眼睑疾病氯倍他索的治疗
公开(公告)号：EP2934403A2
公开(公告)日：2015-10-28
申请号：EP13865975.0
申请日：2013-12-17
申请人： SENJU USA, INC. , Nichiban Co., Ltd.
发明人： OGAWA, Takahiro , ISOWAKI, Akiharu , KAWAHARA, Koji , HIRAOKA, Takao , TANAKA, Mariko , KENMOCHI, Chihiro
IPC分类号： A61F13/02
CPC分类号： A61M35/00 , A61K9/7053 , A61K9/7076 , A61L15/24 , A61L15/26 , A61L15/44 , A61L15/58 , C08L67/04 , C08L23/06
摘要： A patch for treatment of ophthalmic diseases such as eyelid diseases that is provided with a support, a pressure-sensitive adhesive layer, and a release layer in this order, wherein (a) the pressure-sensitive adhesive layer includes the following (a-1) to (a-4): (a-1) a styrene-isoprene-styrene block copolymer, a tackifier resin, and a softening agent are contained; (a-2) a ratio (mass ratio) of the styrene-isoprene-styrene block copolymer and the tackifier resin is 1:2 to 1:4; (a-3) a content of the softening agent is 40% to 60% by mass; and (a-4) further 0.005% to 5% by mass of clobetasol or ester thereof is contained; and (b) the support has elastic modulus with a Young's modulus of 0.01 to 0.5 GPa: and a method for producing the patch for treatment of ophthalmic diseases such as eyelid diseases including: forming the pressure-sensitive adhesive layer on a upper surface of the release layer.

7. 发明公开

EP2926814A1 ROPINIROLE-CONTAINING ADHESIVE PATCH 有权
标题翻译：含有ROPINIROLE的粘合剂贴片
公开(公告)号：EP2926814A1
公开(公告)日：2015-10-07
申请号：EP13858468.5
申请日：2013-11-28
申请人： Teikoku Seiyaku Co., Ltd.
发明人： INOO, Katsuyuki , KATAYAMA, Akiko , TAKANO, Daiki
IPC分类号： A61K31/4045 , A61K9/70 , A61K47/06 , A61K47/14 , A61K47/32 , A61P25/16
CPC分类号： A61K9/7076 , A61K9/7053 , A61K9/7061 , A61K31/4045 , A61K47/06
摘要： A patch containing free ropinirole (ropinirole in free form) in an adhesive base is provided, in which the patch exhibits favorable and continuous transdermal absorbability, high drug stability, and excellent adhesiveness. A transdermal absorption patch includes free ropinirole added to an adhesive base that contains a styrene-isoprene-styrene block copolymer (SIS), one or two or more tackifier resins containing a rosin-based resin, and a softener. The transdermal absorption patch is characterized in that the compounding ratio of the rosin-based resin to the free ropinirole represented as the ratio of the weight of the combined rosin-based resin to the free ropinirole is 3.5 to 8.0. In particular, a ropinirole-containing patch wherein the rosin-based resin is a hydrogenated rosin glycerol ester and the softener is liquid paraffin is provided.
摘要翻译：提供了在粘合剂基质中含有游离罗匹尼罗（游离形式的罗匹尼罗）的贴剂，其中所述贴剂表现出良好且持续的透皮吸收性，高药物稳定性和优异的粘附性。透皮吸收贴剂包括加入到含有苯乙烯 - 异戊二烯 - 苯乙烯嵌段共聚物（SIS）的粘合剂基质中的游离罗匹尼罗，含有松香基树脂的一种或两种或更多种增粘剂树脂和软化剂。该经皮吸收贴剂的特征在于松香基树脂与游离罗匹尼罗的混合比表示为复合松香基树脂与游离罗匹尼罗的重量比为3.5至8.0。特别是提供松香类树脂为氢化松香甘油酯，软化剂为液体石蜡的罗匹尼罗贴剂。

8. 发明公开

EP2708229A4 NON-AQUEOUS PATCH 有权
标题翻译：不含水石膏
公开(公告)号：EP2708229A4
公开(公告)日：2014-11-19
申请号：EP11865320
申请日：2011-05-10
申请人： ITOCHU CHEMICAL FRONTIER CORP , OISHI KOSEIDO CO LTD
发明人： MORI TATSUYA , SAIDA NAOYUKI
IPC分类号： A61K9/70 , A61K31/167 , A61K47/10 , A61K47/12 , A61P23/00 , A61P29/00
CPC分类号： A61K9/0014 , A61K9/7053 , A61K9/7076 , A61K31/167 , A61K47/10 , A61K47/12
摘要： Non-aqueous patches comprising lidocaine, which is not dissolved and is present in a crystalline state, have poor permeability to the skin. Therefore, non-aqueous patches have a high concentration of lidocaine. It is pointed out that lidocaine has an adverse effect on the heart. Prolonged use of a high concentration of lidocaine causes side effects, such as shock, rubor, and irritating sensation. External preparations comprising more than 5 mass% of lidocaine are designated as powerful drugs, and cannot be used as household (nonprescription) medicine. Provided is a non-aqueous patch that is effective to relieve muscle pain, the non-aqueous patch comprising lidocaine and/or its reactant, and a dissolving agent composed of an organic acid and a polyalcohol, which are contained in a base.

9. 发明公开

EP2047845A4 ADHESIVE PREPARATION 有权
标题翻译：胶的制备
公开(公告)号：EP2047845A4
公开(公告)日：2013-10-30
申请号：EP07791748
申请日：2007-08-01
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： TSURUDA KIYOMI , YAMASOTO SHINJI , SHOHO KOUKI , NAKANISHI MASARU
IPC分类号： A61K9/70 , A61K31/045 , A61K31/618 , A61K47/10 , A61K47/34 , A61K47/46 , A61P25/02 , A61P29/00 , A61P43/00
CPC分类号： A61L15/44 , A61F13/00 , A61F15/00 , A61K9/7053 , A61K9/7076 , A61K31/045 , A61K31/618 , A61K31/695 , A61L15/24 , A61L15/58 , A61L2300/216 , B32B7/12 , Y10T428/28 , Y10T428/2852 , Y10T442/2738 , Y10T442/3561
摘要： An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m 2 ·24 hr measured at a temperature of 40°C and a relative humidity of 90%, and the methyl salicylate has a plasma AUC 0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean ± standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC 0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean ± standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m 2 and a contact area is 280 cm 2 .

10. 发明公开

EP2650019A1 NORADRENERGIC AND SPECIFIC SEROTONERGIC ANTIDEPRESSANT-CONTAINING TRANSDERMAL PATCH 有权
标题翻译：防毒素防腐剂HAUTPFLASTER
公开(公告)号：EP2650019A1
公开(公告)日：2013-10-16
申请号：EP11846481.7
申请日：2011-12-06
申请人： Yutoku Pharmaceutical Industries Co., Ltd.
发明人： YOSHITAKE, Makoto , OGAWA, Takayuki , YOSHITAKE, Takashi
IPC分类号： A61K45/00 , A61K9/70 , A61K31/55 , A61K45/08 , A61K47/10 , A61K47/14 , A61K47/32 , A61K47/34
CPC分类号： A61K9/7084 , A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/55
摘要： The invention is a transdermal patch containing a noradrenergic and specific serotonergic antidepressant (NaSSA) such as mirtazapine or the like as the active ingredient therein, and capable of transdermally and quantitatively administering the active ingredient. Further, the transdermal patch of the invention exhibits a sufficient therapeutical effect, can suppress side effects that are problematic in oral administration, improves patient compliance and quality of life (QOL), and can solve various problems. Preferably, the patch provided by the invention contains the active ingredient in an amount of from 2 to 30% by mass relative to the drug-containing layer.
摘要翻译：本发明是含有去甲肾上腺素能和特异性5-羟色胺能抗抑郁药（NaSSA）如米氮平等作为活性成分的透皮贴剂，能够透皮和定量施用活性成分。此外，本发明的透皮贴剂显示出足够的治疗效果，可以抑制口服给药有问题的副作用，提高患者依从性和生活质量（QOL），并且可以解决各种问题。优选地，本发明提供的贴剂含有相对于药物含有层为2〜30质量％的活性成分。

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