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71. 发明公开

EP3082852A1 MICROMOLDED OR 3-D PRINTED PULSATILE RELEASE VACCINE FORMULATIONS 无效
标题翻译： MICRO或形状3D打印机疫苗制剂PULSATING RELEASE
公开(公告)号：EP3082852A1
公开(公告)日：2016-10-26
申请号：EP14830756.4
申请日：2014-12-16
申请人： Massachusetts Institute of Technology , Tokitae LLC
发明人： JAKLENEC, Ana , GATES, William , ECKHOFF, Philip, A. , NIKOLIC, Boris , WOOD, Lowell, L. , LANGER, Robert, S. , NORMAN, James J , NGUYEN, Thanh Duc , TZENG, Stephany Yi
IPC分类号： A61K39/00 , A61K39/12
CPC分类号： A61K39/39 , A61K39/00 , A61K39/12 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/6093 , C12N2770/32634 , Y02A50/466
摘要： Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.

72. 发明公开

EP2771319A1 AMINO ACID DERIVATIVES FUNCTIONALIZED ON THE N- TERMINAL CAPABLE OF FORMING DRUG INCAPSULATING MICROSPHERES 有权
标题翻译：在N个末端官能化的氨基衍生物FOR地层药物包封微球
公开(公告)号：EP2771319A1
公开(公告)日：2014-09-03
申请号：EP12783791.2
申请日：2012-10-26
申请人： Massachusetts Institute Of Technology
发明人： DONG, Yizhou , LOVE, Kevin, Thomas , LANGER, Robert, S. , ANDERSON, Daniel, Griffith , CHEN, Delai , CHEN, Yi , VEGAS, Arturo, Jose , ALABI, Akinleye , ZHANG, Yunlong
IPC分类号： C07D207/16 , C07D209/20 , C07D233/64 , C07D241/08 , C07D403/06 , C07D487/06 , C07C227/18 , C07C229/12 , C07C229/16 , C07C229/22 , C07C229/26 , C07C229/28 , A61K48/00 , C12N15/87
CPC分类号： A61K31/7105 , A61K31/711 , A61K47/22 , A61K2121/00 , C07C229/12 , C07C229/22 , C07C229/24 , C07C229/26 , C07C229/36 , C07C237/08 , C07C237/12 , C07C271/22 , C07C279/14 , C07C323/58 , C07D207/16 , C07D209/20 , C07D209/24 , C07D233/64 , C07D241/08 , C07D265/32 , C07D403/06 , C07D413/06 , C07D487/04 , C07D487/06 , C12N15/87 , C12N15/88 , C12Q1/025 , G01N33/15
摘要： Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as "APPLs". Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R', R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.
摘要翻译： worin M，N，P，R”，R1，R2，R3，R4，R5，R8，Z，W，Y，和Z如在定义。

73. 发明公开

EP2714747A1 MODIFIED ALGINATES FOR CELL ENCAPSULATION AND CELL THERAPY 有权转让
标题翻译：修改藻酸盐电池封装和细胞治疗
公开(公告)号：EP2714747A1
公开(公告)日：2014-04-09
申请号：EP12728887.6
申请日：2012-06-04
申请人： Massachusetts Institute Of Technology
发明人： VEGAS, Arturo, J. , MA, Minglin , BRATLIE, Kaitlin, M. , ANDERSON, Daniel, G. , LANGER, Robert, S.
IPC分类号： C08B37/00 , C40B50/00 , A61K47/00
摘要： Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for the encapsulation and transplantation of cells. Also disclosed are high throughput methods for the characterizing the biocompatibility and physiochemical properties of modified alginate polymers.

74. 发明公开

EP2609135A2 POLY(BETA-AMINO ALCOHOLS), THEIR PREPARATION, AND USES THEREOF 审中-公开
标题翻译： POLY（β-氨基醇），生产及其应用
公开(公告)号：EP2609135A2
公开(公告)日：2013-07-03
申请号：EP11820727.3
申请日：2011-08-26
申请人： Massachusetts Institute Of Technology
发明人： MA, Minglin , LIU, Wendy, F. , LANGER, Robert, S. , ANDERSON, Daniel, Griffith
IPC分类号： C08G73/00 , C08G65/22 , A61K31/16 , A61L31/10 , C09D5/14
CPC分类号： C08G73/0206 , A61K9/1273 , A61K31/7088 , A61K47/34 , A61K47/59 , A61L31/10 , C08G59/22 , C08G59/306 , C08G59/50 , C08G73/02 , C09D5/1637 , C09D179/02 , Y10T428/31725
摘要： A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.

75. 发明公开

EP2482922A1 PHOTOTRIGGERED NANOPARTICLES FOR CELL AND TISSUE TARGETING 审中-公开
标题翻译：光触发纳米粒子的细胞和组织TARGETING
公开(公告)号：EP2482922A1
公开(公告)日：2012-08-08
申请号：EP10821224.2
申请日：2010-09-30
申请人： Massachusetts Institute of Technology , President and Fellows of Harvard College , Children's Medical Center Corporation
发明人： DVIR, Tal , KOHANE, Daniel, S. , BANGHART, Matthew, Ryan , LANGER, Robert, S.
IPC分类号： A61N1/30 , A61N5/10
CPC分类号： A61K9/0009 , A61K9/5138 , A61K9/5146 , A61K9/5153 , A61K41/0042 , A61K47/6921 , A61K47/6935 , A61N5/0601 , A61N5/062
摘要： The present invention relates, in part, to a novel and simple particulate system that targets and binds any tissue selectively upon light illumination. The particulate system can be used for targeted delivery of substances to predefined cells or tissues in an individual.

76. 发明公开

EP2217269A2 VACCINE NANOTECHNOLOGY 有权转让
标题翻译： VAKZINE-NANOTECHNOLOGIE
公开(公告)号：EP2217269A2
公开(公告)日：2010-08-18
申请号：EP08839738.5
申请日：2008-10-12
申请人： Massachusetts Institute of Technology
发明人： VON ANDRIAN, Ulrich, H. , FAROKHZAD, Omid, C. , LANGER, Robert, S. , JUNT, Tobias , MOSEMAN, Ashley , ZHANG, Liangfang , BASTO, Pamela , IANNACONE, Matteo , ALEXIS, Frank
IPC分类号： A61K39/00
CPC分类号： A61K9/14 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K47/6911 , A61K47/6937 , A61K2039/555 , A61K2039/60 , Y02A50/464 , Y02A50/472
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one vaccine nanocarrier to a subject in need thereof.
摘要翻译：本发明提供了用于将纳米载体递送至免疫系统细胞的组合物和系统。本发明提供能够刺激T细胞和/或B细胞中的免疫应答的疫苗纳米载体，在一些实施方案中，包含至少一种免疫调节剂，并且任选地包含至少一种靶向部分和任选的至少一种免疫刺激剂。本发明提供包含疫苗纳米载体的药物组合物。本发明提供了疫苗纳米载体的设计，制造和使用方法及其药物组合物。本发明提供了预防和/或治疗疾病，病症和病症的方法，包括向有需要的受试者施用至少一种疫苗纳米载体。

77. 发明公开

EP2019691A2 POLYMERS FOR FUNCTIONAL PARTICLES 有权
标题翻译： POLYMEREFÜRFUNKTIONELLE PARTIKEL
公开(公告)号：EP2019691A2
公开(公告)日：2009-02-04
申请号：EP07794944.4
申请日：2007-05-15
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc.
发明人： GU, Frank, X. , TEPLY, Benjamin, A. , LANGER, Robert, S. , FAROKHZAD, Omid, C.
IPC分类号： A61K47/48
摘要： The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect of the invention is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other aspects of the invention are directed to methods using such libraries, methods of using or administering such polymeric conjugates, methods of promoting the use of such polymeric conjugates, kits involving such polymeric conjugates, or the like.
摘要翻译：一种方法包括制备具有高度控制性质的纳米颗粒的文库，其可通过将两种或更多种不同比例的大分子混合在一起形成。一个或多个大分子可以是部分与生物相容性聚合物的聚合物缀合物。纳米颗粒可以含有药物。该部分可以包括多肽或多核苷酸，例如适体。该部分可以是靶向部分，成像部分，螯合部分，带电部分或治疗部分。另一方面涉及制备这种聚合物共轭物的体系和方法。在一些实施方案中，将含有聚合物的溶液与液体（例如不混溶液体）接触以形成含有聚合物缀合物的纳米颗粒。其他方法使用这种文库，使用或施用这种聚合物缀合物，或促进使用这种聚合物缀合物。还描述了涉及这种聚合物共轭物的试剂盒。

78. 发明公开

EP1448656A2 BIODEGRADABLE POLYMER 有权
标题翻译：生物降解高分子
公开(公告)号：EP1448656A2
公开(公告)日：2004-08-25
申请号：EP02806686.8
申请日：2002-10-22
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： WANG, Yadong , AMEER, Guillermo , LANGER, Robert, S.
IPC分类号： C08G63/12
CPC分类号： C08G63/12
摘要： A biodegradable polymer comprising a condensation polymer of glycerol and a diacid. The polymer may be adapted for use as a tissue engineering construct. For example, it may be seeded with cells, or molecules may be attached to it to modify the metabolism and proliferation of cells or to modify the degradation rate and/or mechanism of the polymer. The polymer may also be exploited in a variety of medical and non-medical applications.

79. 发明授权

EP1056487B1 BIODEGRADABLE SHAPE MEMORY POLYMERS 有权
标题翻译：形状记忆聚合物可生物降解
公开(公告)号：EP1056487B1
公开(公告)日：2004-05-12
申请号：EP99908402.3
申请日：1999-02-23
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： LANGER, Robert, S. , LENDLEIN, Andreas , SCHMIDT, Annette , GRABLOWITZ, Hans
IPC分类号： A61L27/00 , A61L29/00 , A61L31/00
CPC分类号： A61L31/148 , A61B2017/00871 , A61L27/18 , A61L27/50 , A61L27/58 , A61L29/148 , A61L2400/16
摘要： Biodegradable shape memory polymer compositions, articles of manufacture thereof, and methods of preparation and use thereof are described. In one embodiment the compositions include at least one hard segment and at least one soft segment. The Ttrans of the hard segment is preferably between -30 and 270 °C. At least one of the hard or soft segments can contain a cross-linkable group, and the segments can be linked by formation of an interpenetrating network or a semi-interpenetrating network, or by physical interactions of the segments. Objects can be formed into a given shape at a temperature above the Ttrans of the hard segment, and cooled to a temperature below the Ttrans of the soft segment. If the object is subsequently formed into a second shape, the object can return to its original shape by heating the object above the Ttrans of the soft segment and below the Ttrans of the hard segment.

80. 发明授权

EP0710261B1 BIODEGRADABLE PARTICLES 失效
标题翻译：生物可降解粒子
公开(公告)号：EP0710261B1
公开(公告)日：2004-05-12
申请号：EP94922733.4
申请日：1994-07-22
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： GREF, Ruxandra , MINAMITAKE, Yoshiharu , LANGER, Robert, S.
IPC分类号： C08J3/14 , C08G63/664 , C08G81/00 , A61K9/51 , A61K9/16
CPC分类号： A61K9/5153 , A61K9/0019 , A61K9/1635 , A61K9/1647 , A61K9/5138 , A61K47/6935 , A61K49/223 , A61K51/1241 , A61K51/1251 , A61K2123/00 , B82Y5/00 , C08G63/664 , C08G81/00 , C08J3/14 , C08J2300/16 , C08J2367/04 , C08J2371/02 , Y10S514/963 , Y10T428/2985 , Y10T428/2989 , Y10T428/2991
摘要： Particles are provided that are not rapidly cleared from the blood stream by the macrophages of the reticuloendothelial system, and that can be modified to achieve variable release rates or to target specific cells or organs. The particles have a biodegradable solid core containing a biologically active material and poly(alkylene glycol) moieties on the surface. The terminal hydroxyl group of the poly(alkylene glycol) can be used to covalently attach onto the surface of the particles biologically active molecules, including antibodies targeted to specific cells or organs, or molecules affecting the charge, lipophilicity or hydrophilicity of the particle. The surface of the particle can also be modified by attaching biodegradable polymers of the same structure as those forming the core of the particles. The typical size of the particles is between 1 nm and 1000 nm, preferably between 1 nm and 100 nm, although microparticles can also be formed as described herein. The particles can include magnetic particles or radiopaque materials, such as air and other gases, for diagnostic imaging, biologically active molecules to be delivered to a site, or compounds for targeting the particles. The particles have a prolonged half-life in the blood compared to particles not containing poly(alkylene glycol) moieties on the surface.

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