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71. 发明公开

EP1161453A1 CYTOKINE-BINDING DOMAIN 审中-公开
标题翻译：细胞因子结合结构域
公开(公告)号：EP1161453A1
公开(公告)日：2001-12-12
申请号：EP00904705.1
申请日：2000-02-08
申请人： MEDVET SCIENCE PTY. LTD. , ST. VINCENTS INSTITUTE OF MEDICAL RESEARCH
发明人： BAGLEY, Christopher, James , ROSSJOHN, Jamie , McKINSTRY, William, John , WOODCOCK, Joanna, May , PARKER, Michael, William , LOPEZ, Angel, Francisco
IPC分类号： C07K14/715 , C07K16/24 , A61K39/395
摘要： The present invention provides a cytokine-binding domain or portion thereof which binds to at least one cytokine and is capable of transducing a cytokine signal through a single cytokine receptor, said domain comprising a portion of the B'-C' loop of domain 4 of a βc chain or analogous structure of a cytokine receptor. In another aspect of the invention there is provided a method of identifying a compound having cytokine agonist or antagonist activity, said method including subjecting a potential cytokine agonist and/or cytokine antagonist compound to a cytokine binding domain or portion thereof wherein said domain binds to at least one cytokine and is capable of transducing a cytokine signal through a single cytokine rectpor, said domain comprising a portion of the B'-C'loop of domain 4 of a βc chain or analogous structure of the cytokine recetoptor; and determining the presence of an agonist or antagonist response of the compound on the activity of a cytokine. In a preferred aspect there is provided a method of identitying a GM-CSF, IL-3 and IL-5 agonist or antagonist, said method including: subjecting a potential agonist or antagonist to a GM-CSF, IL-3 and IL-5 binding domain or portion thereof wherein said domain binds to at least one of the cytokines and is capable of transducing a cytokine signal through a single cytokine receptor, said domain comprising a portion of the B'-C' loop of domain 4 of a βc chain or analogous structure of the cytokine receptor; and determing the presence of an agonist or antagonist response from the compound on the activity of GM-CSF, IL-3 and IL-5.

72. 发明公开

EP1105426A1 MONOCLONAL ANTIBODY INHIBITOR OF GM-CSF, IL-3, IL-5 AND OTHER CYTOKINES, AND USES THEREOF 有权
标题翻译：一种单克隆抗体，如GM-CSF的抑制剂，IL-3，IL-5和其它细胞因子及其用途
公开(公告)号：EP1105426A1
公开(公告)日：2001-06-13
申请号：EP99941314.9
申请日：1999-08-13
申请人： MEDVET SCIENCE PTY. LTD.
发明人： LOPEZ, Angel,Hanson Centre for Cancer Research , D'ANDREA, Richard,Hanson Ctr. for Cancer Res.
IPC分类号： C07K16/24 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/73
摘要： A method of isolating a monoclonal antibody capable of inhibiting any one of IL-3, GM-CSF and IL-5 binding to the common receptor βc, or a monoclonal antibody capable of inhibiting the cytokines binding to a receptor analogous to βc. The method includes the steps of immunising an animal with a cytokine receptor or portion of a cytokine containing the critical binding site which portion includes the extracellular domain 4 or analogous domain in the analogous common receptor or part thereof. Antibodies producing cells from the animal are then isolated and fused with a myeloma cell line and then screened for a cell line that produces an antibody of the desired type. A monoclonal antibody, or fragments thereof capable of inhibiting the binding of the cytokines IL-3, GM-CSF and IL-5 to the βc receptor, and a hybridoma cell line producing the antibody are also claimed.

73. 发明公开

EP0715633A4 HAEMOPOIETIC GROWTH FACTOR ANTAGONISTS 失效
标题翻译：造血生长因子的拮抗剂
公开(公告)号：EP0715633A4
公开(公告)日：1997-11-19
申请号：EP94922181
申请日：1994-07-28
申请人： MEDVET SCIENCE PTY LTD
发明人： VADAS MATHEW ALEXANDER , LOPEZ ANGEL FRANCISCO , SHANNON MARY FRANCES
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61P7/00 , C07K14/505 , C07K14/52 , C07K14/535 , C07K14/54 , C12N1/21 , C12N15/19 , C12P21/02 , C12R1/91 , C07K14/475 , C07K14/55 , C12N15/24 , C12N15/26 , C12N15/27
CPC分类号： C07K14/505 , A61K38/00 , C07K14/535 , C07K14/54

74. 发明公开

EP0609280A4 HUMAN IL-3 VARIANTS. 失效
标题翻译：人类IL-3变种。
公开(公告)号：EP0609280A4
公开(公告)日：1994-09-14
申请号：EP92921235
申请日：1992-10-07
申请人： MEDVET SCIENCE PTY LTD
发明人： VADAS MATHEW ALEXANDER , LOPEZ ANGEL FRANCISCO , SHANNON MARY FRANCES
IPC分类号： A61K38/00 , C07K14/52 , C07K14/54 , C12N15/24
CPC分类号： C07K14/5403 , A61K38/00

75. 发明公开

EP0609280A1 HUMAN IL-3 VARIANTS 失效
标题翻译：人IL-3变体。
公开(公告)号：EP0609280A1
公开(公告)日：1994-08-10
申请号：EP92921235.0
申请日：1992-10-07
申请人： MEDVET SCIENCE PTY. LTD.
发明人： VADAS, Mathew, Alexander , LOPEZ, Angel, Francisco , SHANNON, Mary, Frances
IPC分类号： C07K14 , C12N15 , A61K38
CPC分类号： C07K14/5403 , A61K38/00
摘要： Des variants ou des mutants humains d'interleukine-3 sont caractérisés par le fait qu'un ou plusieurs acides aminés dans, ou à côté de la quatrième hélice alpha prévisible de la cellule h-IL-3 et/ou qu'un ou plusieurs acides aminés dans la première hélice alpha prévisible de la cellule hIL-3 est/sont remplacé(s) par un autre acide aminé. Ces variants ou mutants sont utiles dans la modulation de la prolifération, la différentiation de l'activation fonctionnelle des cellules hématopoïétiques ou non hématopoïétiques exprimant ou faite pour exprimer le récepteur IL-3.

76. 发明公开

EP0413721A1 HUMAN GM-CSF VARIANTS 失效
标题翻译：曼氏乳杆菌GM-CSF-VARIANTEN。
公开(公告)号：EP0413721A1
公开(公告)日：1991-02-27
申请号：EP89905045.0
申请日：1989-04-21
申请人： MEDVET SCIENCE PTY. LTD.
发明人： VADAS, Mathew, Alexander , LOPEZ, Angel, Francisco , SHANNON, Mary, Frances
IPC分类号： C12N15 , A61K38 , A61P35 , C07K14 , C12P21 , C12R1
CPC分类号： C07K14/535 , A61K38/00
摘要： L'invention concerne une variante ou un mutant de facteur de croissance des colonies de granulocyte-macrophages (GM-CSF), caractérisé en ce que l'amino acide 20 (gln) et/ou l'amino acide 21 (glu) de GM-CSF humain est/sont remplacés par un autre amino acide, et alternativement ou additionnellement, une quantité substantielle des amino acides de GM-CSF humain sont éliminés.
摘要翻译：人粒细胞 - 巨噬细胞集落刺激因子（GM-CSF）变体或突变体，其特征在于人GM-CSF的氨基酸20（gln）和/或氨基酸21（glu）被另一个氨基酸替代，或者或另外，缺少大量的人GM-CSF的氨基酸。

77. 发明公开

EP3304091A1 METHODS FOR SCREENING FOR FETAL TRISOMIES 有权转让
标题翻译：筛查胎儿三叉戟的方法
公开(公告)号：EP3304091A1
公开(公告)日：2018-04-11
申请号：EP16802248.1
申请日：2016-06-02
申请人： Medvet Science Pty Ltd
发明人： RANIERI, Enzo , RAMSAY, Steven , SHARP, Peter, Charles, Kinmont , FLETCHER, Janice
IPC分类号： G01N33/92 , G01N33/483
CPC分类号： G01N33/689 , G01N33/483 , G01N33/6848 , G01N33/92 , G01N2800/387 , G16H10/40
摘要： The present disclosure relates to methods for screening and identifying a fetal trisomy. Certain embodiments of the present disclosure provide a method of screening for a fetal trisomy in a pregnant female subject. The method comprises detecting one or more lipid markers from the subject, wherein the one or more markers is indicative of the risk of a fetal trisomy in the subject, and determining the risk of a fetal trisomy in the pregnant female subject on the basis of the one or more lipid markers detected.

78. 发明授权

EP2791324B1 CELL POPULATION FOR USE IN TREATING NEUROPSYCHIATRIC DISORDERS 失效
标题翻译：用于治疗神经过敏性疾病的细胞群
公开(公告)号：EP2791324B1
公开(公告)日：2017-05-10
申请号：EP12856927.4
申请日：2012-12-13
申请人： Medvet Science Pty Ltd
发明人： LOPEZ, Angel , SCHWARZ, Quenten
IPC分类号： C12N5/0793 , C12N5/0797 , A61K45/00 , A61P25/18 , A61P25/28
CPC分类号： A61K35/36 , A61K35/12 , A61K35/30 , A61K35/32 , C12N5/0623

79. 发明公开

EP2438167A1 THERAPEUTIC AND DIAGNOSTIC MOLECULES 有权
标题翻译：治疗和诊断分子
公开(公告)号：EP2438167A1
公开(公告)日：2012-04-11
申请号：EP10782840.2
申请日：2010-06-04
申请人： Centenary Institute Of Cancer Medicine And Cell Biology , The University Of Sydney , MEDVET SCIENCE PTY. LTD. , Wenkart Foundation
发明人： GAMBLE, Jennifer , VADAS, Mathew , GOODALL, Gregory , YOUNG, Jennifer
IPC分类号： C12N15/113 , A61P9/10 , C07H21/02 , A61K48/00 , A61P35/00
CPC分类号： C12N15/113 , A61K31/7088 , A61K31/7105 , C12N2310/113 , C12N2310/141 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , G01N33/6893 , G01N2800/7014
摘要： The present invention relates to methods for modulating angiogenesis, comprising administering to a subject, or cells or tissue derived therefrom: (i) one or more miRNA, or precursors or variants thereof, wherein at least one of said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to inhibit angiogenesis; or (ii) one or more antagonists of a miRNA, wherein said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to promote or induce angiogenesis. Also provided are methods of diagnosis of conditions associated with abnormal angiogenesis, or determining predisposition thereto. Suitable pharmaceutical compositions are also provided.

80. 发明授权

EP1432991B1 IDENTIFICATION AND ISOLATION OF SOMATIC STEM CELLS AND USES THEREOF 有权
标题翻译：鉴定和分离成体干细胞及其用途
公开(公告)号：EP1432991B1
公开(公告)日：2012-01-25
申请号：EP02750673.2
申请日：2002-08-15
申请人： Peter MacCallum Cancer Institute , MEDVET SCIENCE PTY. LTD.
发明人： SIMMONS, Paul, John
IPC分类号： G01N33/577 , G01N33/573 , C07K16/40
CPC分类号： G01N33/56966 , C07K16/40 , G01N33/5014 , G01N33/573 , G01N2333/948
摘要： The present invention relates to the identification of a specific population of cell types, in particular somatic stem cells including haematopoietic stem cells, mesenchymal stem cells and keratinocyte stem cells. The invention also provides for methods of isolation and uses of the stem cells. Derived from the methods of the present invention, there is provided a method of identifying a stem cell comprising the steps of: obtaining a cell sample including stem cells; detecting the presence of angiotensin converting enzyme (ACE) or a fragment thereof on a cell; and identifying the stem cells having ACE or a fragment thereof.

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