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61. 发明公开

EP3027764A4 PLANAR CONFORMAL CIRCUITS FOR DIAGNOSTICS 无效转让
标题翻译： KONFORME PLANARE SCHALTUNGEN ZUR DIAGNOSE
公开(公告)号：EP3027764A4
公开(公告)日：2017-04-05
申请号：EP14832076
申请日：2014-07-31
申请人： UNIV TEXAS
发明人： PRASAD SHALINI , SELVAM ANJAN PANNEER
IPC分类号： C12Q1/06 , G01N27/02 , G01N27/327
CPC分类号： G01N27/028 , C12Q1/6825 , G01N27/026 , G01N27/3278 , G01N33/5438
摘要： The claimed invention is an apparatus and method for performing impedance spectroscopy with a handheld measuring device. Conformal analyte sensor circuits comprising a porous nanotextured substrate and a conductive material situated on the top surface of the solid substrate in a circuit design may be used alone or in combination with a handheld potentiometer. Also disclosed are methods of detecting and/or quantifying a target analyte in a sample using a handheld measuring device.
摘要翻译：所要求保护的发明是用手持测量装置进行阻抗光谱的装置和方法。包括多孔纳米纹理基片和在电路设计中位于固体基底的顶表面上的导电材料的保形分析物传感器电路可以单独使用或与手持电位计组合使用。还公开了使用手持测量装置检测和/或定量样品中的目标分析物的方法。

62. 发明公开

EP2668645A4 SYSTEM FOR COMMUNICATING INFORMATION FROM AN ARRAY OF SENSORS 有权转让
标题翻译：系统ZUR KOMMUNIKATION VON INFORMATIONEN AUS EINER SENSORREIHE
公开(公告)号：EP2668645A4
公开(公告)日：2017-01-04
申请号：EP11857055
申请日：2011-12-12
申请人： GENIA TECH INC
发明人： CHEN ROGER
IPC分类号： G01N33/487
CPC分类号： G01N27/3278 , C12Q1/6874 , G01N27/44791 , G01N33/48721
摘要： A system for communicating information from an array of sensors is disclosed. The system comprises a sensor array that includes a plurality of sensors, wherein each sensor senses a physical property of a material that is in communication with the sensor. The system further comprises signal processing circuitry associated with each sensor that integrates the output of the sensor over time and compares the integrated output to a threshold. The system further comprises a communication network coupled to the signal processing circuitry that outputs information indicating that the integrated output corresponding to a given sensor has reached the threshold.
摘要翻译：公开了一种用于检测分子复合物的电性能的系统。该系统包括电耦合到分子复合物的电极，其输出受分子复合物的电特性影响的电信号，其中分子复合物的电特性对电信号的影响的特征在于期望的带宽。该系统还包括积分放大器电路，其被配置为：从电极接收电信号。积分放大器电路还被配置为在预定带宽内随时间选择性地放大和积分电信号的一部分，其中至少部分地基于预期带宽来选择预定带宽。

63. 发明公开

EP3084411A1 CONDUCTIVE HYDROGELS FOR AFFINITY SENSING 审中-公开
标题翻译： LEITFÄHIGEHYDROGELE ZURAFFINITÄTSMESSUNG
公开(公告)号：EP3084411A1
公开(公告)日：2016-10-26
申请号：EP14872472.7
申请日：2014-12-19
申请人： The Regents of the University of California
发明人： REVZIN, Alexander , MATHARU, Zimple , YOU, Jungmok , KWON, Lydia , LIU, Ying , SHIN, Dong-Sik
IPC分类号： G01N27/327
CPC分类号： G01N33/5438 , B82Y30/00 , C08L65/00 , C12Q1/002 , C12Q1/003 , G01N27/3277 , G01N27/3278 , G01N33/54353 , G01N33/545 , G01N33/6866 , G01N2333/35 , G01N2333/57 , G01N2800/26
摘要： The present invention provides a sensor for detection of disease markers, and methods for detecting a disease marker, using a conductive hydrogel modified with a biorecognition element. In one embodiment, the present invention provides a sensor having a substrate; at least one electrode contacting the substrate; a nanoporous membrane covering the electrode; and a biorecognition element selected from the group consisting of a peptide, an antibody, an enzyme, and an aptamer, wherein the biorecognition clement is covalently bound to the electrode, or covalently bound to a PEDOT random copolymer embedded within the nanoporous membrane.
摘要翻译：本发明提供一种用于检测疾病标记的传感器，以及使用用生物识别元件修饰的导电水凝胶来检测疾病标记物的方法。

64. 发明公开

EP3039116A2 DEVICE FOR THERMALLY DENATURING BIOMOLECULE AND METHOD FOR PRODUCING DEVICE 审中-公开
标题翻译：设备用于生物分子和方法的热变性用于制造器件
公开(公告)号：EP3039116A2
公开(公告)日：2016-07-06
申请号：EP14839712.8
申请日：2014-08-26
申请人： Quantum Biosystems Inc.
发明人： KAWAI, Tomoji , FURUHASHI, Masayuki , TANIGUCHI, Masateru , OLDHAM, Mark , NORDMAN, Eric
IPC分类号： C12M1/00 , B01J19/00 , G01N25/00 , G01N37/00
CPC分类号： G01N33/48721 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L2200/0663 , B01L2200/10 , B01L2300/04 , B01L2300/0645 , B01L2300/0663 , B01L2300/0816 , B01L2300/0896 , B01L2300/12 , B01L2300/1827 , B01L2400/086 , C12Q1/6813 , C12Q1/6869 , G01N27/26 , G01N27/3278 , C12Q2527/107 , C12Q2527/137 , C12Q2563/159 , C12Q2565/629 , C12Q2565/631
摘要： The present disclosure provides methods and systems that can reduce the amount of sample necessary to detect or identify, or both detect and identify, a biomolecule, and increase the rate of denaturing of the biomolecule. A device for thermally denaturing a biomolecule may include: a substrate having low thermal conductivity; a heater disposed adjacent to the substrate; a temperature sensor disposed adjacent to the substrate; a semiconductor oxide film disposed adjacent to the substrate, a nanochannel formed in a region of the semiconductor oxide film, and a cover over the nanochannel.

65. 发明公开

EP3028334A1 BIOPILE A COMBUSTIBLE 审中-公开
标题翻译：生物可燃
公开(公告)号：EP3028334A1
公开(公告)日：2016-06-08
申请号：EP14777811.2
申请日：2014-07-30
申请人： Commissariat à l'Energie Atomique et aux Energies Alternatives
发明人： AUGER, Aurélien , HADDAD, Raoudha
IPC分类号： H01M8/16 , C12Q1/00 , G01N33/00 , H01M4/90
CPC分类号： H01M8/16 , C12N11/08 , G01N27/3278 , H01M4/8663 , H01M4/8828 , H01M4/90 , H01M4/9008 , H01M4/9075 , H01M2250/00 , Y02E60/527
摘要： The invention relates to nanoparticles, preferably metal oxides, at least partially coated on the surface by a silylated polymer, and functionalised by at least one molecule of an oxidation-reduction mediating agent, characterised in that the immobilisation of said molecule(s) of said mediating agent on the surface of said nanoparticles is enabled by non-covalent bonds, preferable π-π type interactions, established between ethylenic, acetylenic and/or aromatic patterns, respectively present in the region of said silylated polymer and said molecule(s) of the oxidation-reduction mediating agent.
摘要翻译：本发明涉及纳米颗粒，优选金属氧化物，其至少部分地被甲硅烷基化聚合物涂覆在表面上并且被至少一个氧化还原介导剂分子官能化，其特征在于所述一种或多种所述分子的固定化所述纳米颗粒表面上的介导剂可以通过分别存在于所述硅烷化聚合物和所述（多种）分子中的烯属，炔属和/或芳族图案之间的非共价键，优选π-π型相互作用实现。氧化还原介导剂。

66. 发明公开

EP2954315A2 PROCESSING OF NUCLEOTIDE SEQUENCES 审中-公开
标题翻译： VERARBEITUNG VON NUKLEOTIDSEQUENZEN
公开(公告)号：EP2954315A2
公开(公告)日：2015-12-16
申请号：EP14708942.9
申请日：2014-01-23
申请人： Koninklijke Philips N.V.
发明人： VAN DE STOLPE, Anja , FEITSMA, Harma Martine , VAN DER ZAAG, Pieter Jan , WIMBERGER-FRIEDL, Reinhold , DEN TOONDER, Jacob Marinus Jan , PIERIK, Anke , VAN HEMERT, Freek
IPC分类号： G01N27/327 , C12Q1/68 , B82Y15/00
CPC分类号： G01N27/3275 , B01J2219/00608 , B01J2219/00653 , B01J2219/00722 , B82Y15/00 , G01N27/3276 , G01N27/3278
摘要： The invention relates to a method and an apparatus (100) for the processing of nucleotide sequences. An apparatus (100) according to an embodiment of the invention comprises an array of electrodes (120a,120b,...), wherein at least one nanoball (NB) comprising replications of a nucleotide sequence (1,2) of interest is attached to an electrode to which only one nanoball (NB) of that size can be attached at the same time. Thus a unique association of electrodes (120a,120b,...) to nucleotide sequences (1,2) of interest can be achieved. The nanoballs (NB) are preferably produced by rolling circle amplification. Application of attractive and/or repulsive electric potentials to the electrodes (120a,120b,...) can be used to control the attachment of nanoballs (NB). The measurement of changes in the capacitance of electrodes (120a,120b,...) can be used to detect and monitor the incorporation of mono-or oligonucleotides provided sequentially by different solutions (A, T, G, C) into strands that are replicated in a nanoball (NB) at an electrode.
摘要翻译：本发明涉及一种用于处理核苷酸序列的方法和装置（100）。根据本发明的实施例的设备（100）包括电极阵列（120a，120b ...），其中连接包含感兴趣的核苷酸序列（1,2）的重复的至少一个纳米（NB）到只能够同时连接该尺寸的一个纳米（NB）的电极。因此，可以实现电极（120a，120b，...）与感兴趣的核苷酸序列（1,2）的独特关联。纳米球（NB）优选通过滚圆扩增产生。将吸引和/或排斥电位施加到电极（120a，120b ...）可用于控制纳米棒（NB）的附着。电极（120a，120b ...）的电容变化的测量可用于检测和监测由不同溶液（A，T，G，C）依次提供的单链或寡核苷酸的引入到在电极上复制在纳米（NB）中。

67. 发明公开

EP2785868A4 SYSTEMS AND METHODS FOR HIGH EFFICIENCY ELECTRONIC SEQUENCING AND DETECTION 失效转让
标题翻译：系统和高效率的电子测序和证明方法
公开(公告)号：EP2785868A4
公开(公告)日：2015-08-12
申请号：EP12852490
申请日：2012-12-03
申请人： GENAPSYS INC
发明人： ESFANDYARPOUR HESAAM
IPC分类号： G01N33/551 , C12Q1/68
CPC分类号： C12Q1/6874 , B01L3/502761 , B01L2200/0668 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2400/0415 , B01L2400/043 , B01L2400/086 , B03C1/286 , B03C1/288 , B03C5/005 , B03C5/02 , B03C5/022 , B03C5/026 , B03C2201/26 , C12Q1/6825 , C12Q1/6844 , C12Q1/6869 , G01N27/3278 , C12Q2565/629 , C12Q2535/122 , C12Q2563/116 , C12Q2565/607

68. 发明公开

EP2901163A1 SYSTEM AND METHOD FOR DETECTING LYSYL OXIDASE-LIKE 2 PROTEIN (LOXL2) AND BREAST CANCER 审中-公开
标题翻译：系统VERFAHRENFÜRDEN NACHWEIS VON LYSYLOXIDASE-LIKE-2-PROTEIN（LOXL2）UND BRUSTKREBS
公开(公告)号：EP2901163A1
公开(公告)日：2015-08-05
申请号：EP13840525.3
申请日：2013-09-30
申请人： Case Western Reserve University
发明人： LIU, Chung, Chiun , ZHANG, Yuan , JANYASUPAB, Metini , LIU, Cheng-Wei , DUDIK, Laurie
IPC分类号： G01N33/68 , G01N33/574 , C12Q1/26
CPC分类号： G01N27/3277 , A61B5/150755 , A61B10/007 , C12Q1/26 , G01N27/3278 , G01N33/57415 , G01N2333/90638 , G01N2800/365 , G01N2800/7028
摘要： A detection system for determining lysyl oxidase-like 2 protein (LOXL2) levels in a bodily sample, includes at least one reaction solution for generating H2O2 upon combination with LOXL2 in the bodily sample, the reaction solution including lysine that can be oxidatively deaminated by LOXL2 to generate α-aminoadipic-δ-semialdehyde (allysine) and hydrogen peroxide (H2O2).
摘要翻译：用于测定身体样品中的赖氨酰氧化酶样2蛋白（LOXL2）水平的检测系统包括至少一种用于在身体样品中与LOXL2组合时产生H 2 O 2的反应溶液，所述反应溶液包括可通过LOXL2氧化脱氨的赖氨酸产生α-氨基己二酸-δ-半醛（烯丙基）和过氧化氢（H 2 O 2）。

69. 发明公开

EP2875343A1 MICROFLUIDIC-NANOFLUIDIC DEVICES FOR DETECTION AND MEASUREMENT OF REDOX ACTIVE SUBSTANCES 有权
标题翻译：检测和测量氧化还原活性物质的微流控纳流控DEVICES
公开(公告)号：EP2875343A1
公开(公告)日：2015-05-27
申请号：EP13819564.9
申请日：2013-07-22
申请人： Northeastern University
发明人： GOLUCH, Edgar, D. , WEBSTER, Thaddaeus
IPC分类号： G01N27/00 , B82Y30/00
CPC分类号： G01N27/413 , B82Y10/00 , B82Y30/00 , G01N27/30 , G01N27/301 , G01N27/3278 , G01N27/403 , G01N33/48714
摘要： Devices including an electrode assembly within a nanofluidic channel are provided for electrochemical measurement of the concentration of a redox active substance. Also provided are methods of fabricating the devices and methods of measuring a concentration of a redox active substance using the devices. The devices and methods, and sensors embodying them, provide fast and sensitive detection of the presence of a microorganism by detecting a redox active substance produced by the microorganism while preventing access of the microoganism itself to the electrode assembly.

70. 发明公开

EP2803988A1 Nanostructured microelectrodes and biosensing devices incorporating the same 有权
标题翻译：纳米结构的微电极，从而Bioerfassungsvorrichtungen
公开(公告)号：EP2803988A1
公开(公告)日：2014-11-19
申请号：EP14176968.7
申请日：2009-09-01
申请人： The Governing Council of the University of Toronto
发明人： Soleymani, Leyla , Fang, Zhichao , Kelley, Shana , Sargent, Edward , Taft, Bradford
IPC分类号： G01N27/327 , G01N27/30 , G01N27/403 , G01N27/416 , G01N33/53 , C12Q1/68 , C12Q1/00 , C40B60/00 , G01N33/543
CPC分类号： G01N27/3272 , G01N27/30 , G01N27/3275 , G01N27/3278 , G01N33/5438 , Y10S977/754 , Y10S977/925
摘要： Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein.

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