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61. 发明公开

EP2681544A1 BIOSENSOR ARRAY FORMED BY JUNCTIONS OF FUNCTIONALIZED ELECTRODES 失效
标题翻译： ARRAY MADE OUT节点指向官能化电极
公开(公告)号：EP2681544A1
公开(公告)日：2014-01-08
申请号：EP12707463.1
申请日：2012-02-27
申请人： Lexogen GmbH
发明人： REDA, Torsten , HAGLMÜLLER, Jakob , SCHITTER, Georg , SEITZ, Alexander
IPC分类号： G01N27/327 , C12Q1/68
CPC分类号： C12Q1/686 , C12Q1/6837 , G01N27/3278
摘要： The present invention provides a sensor array device with multiple sensor junctions which have been created through the assembly of two or more differently functionalized surfaces. The functionalizing of the prospective sensor junction areas with sensor compounds occurred when the different surfaces were physically separated from each other before the assembly of the sensor array. By these means, sensor junctions can be built smaller than conventional deposition techniques like printing and photolithography would allow for otherwise. As a consequence, each individual sensor junction contains two potentially different sensor compounds. The sensor array identifies and quantifies different biomolecules.

62. 发明公开

EP2663862A2 SYSTEMS AND METHODS FOR SINGLE-MOLECULE DETECTION USING NANOTUBES 审中-公开
标题翻译： SYSTEM AND METHOD FOR单分子检测使用碳纳米管
公开(公告)号：EP2663862A2
公开(公告)日：2013-11-20
申请号：EP12734088.3
申请日：2012-01-11
申请人： The Trustees of Columbia University in the City of New York
发明人： SORGENFREI, Sebastian , SHEPARD, Kenneth , CHIU, Chien-yang , NUCKOLLS, Colin
IPC分类号： G01N33/50
CPC分类号： G01N27/041 , C12Q1/6816 , C12Q1/6874 , C12Q2563/116 , C12Q2563/157 , C12Q2565/607 , G01N27/3278
摘要： A method for single-molecule detection is provided and uses a carbon nanotube having a probe entity attached thereto to define a first state of the carbon nanotube. The carbon nanotube is introduced to a target entity to define a second state of the carbon nanotube. The electrical conductance of the carbon nanotube in the first and second states is compared to detect the presence of a biomolecular entity. A system for single-molecule detection including a carbon nanotube is also provided.

63. 发明公开

EP2521796A4 DNA SEQUENCING METHODS AND DETECTORS AND SYSTEMS FOR CARRYING OUT THE SAME 有权
标题翻译： DNA测序方法和竣工检测器和系统
公开(公告)号：EP2521796A4
公开(公告)日：2013-06-19
申请号：EP11728563
申请日：2011-01-04
申请人： LIFE TECHNOLOGIES CORP
发明人： SUN HONGYE , NORDMAN ERIC S , OLDHAM MARK F , O'NEILL JOHN R , CONNELL CHARLES , ULMANELLA UMBERTO , LAU ALDRICH N K , KOTSEROGLOU THEOFILOS , LIVAK KENNETH J
IPC分类号： C12Q1/68 , G01N27/414 , G01N33/50 , G01N33/543
CPC分类号： C12Q1/6869 , B01L3/502761 , G01N27/3278 , G01N27/414 , G01N27/4145 , G01N27/4146 , G01N33/5438 , Y10S977/924 , Y10T436/143333 , C12Q2565/631
摘要： In some embodiments, an analyte detection system is provided that includes a nanochannel, an electrode arrangement, and a plurality of nanoFET devices disposed in the nanochannel. A plurality of nucleic acid base detection components can be used that include a plurality of nanopores, a plurality of nanochannels, a plurality of hybridization probes, combinations thereof, and the like. According to other embodiments of the present teachings, different coded molecules are hybridized to a target DNA molecule and used to detect the presence of various sequences along the target molecule. A kit including mixtures of coded molecules is also provided. In some embodiments, devices including nanochannels, nanopores, and the like, are used for manipulating movement of DNA molecules, for example, in preparation for a DNA sequencing detection. Nanopore structures and methods of making the same are also provided as are methods of nucleic acid sequencing using the nanopore structures. Surface-modified nanopores are provided as are methods of making them. In some embodiments, surfaced-modified nanopores for slowing the translocation of single stranded DNA (ssDNA) through the nanopore are provided, as are nanopores configured to detect each of a plurality of different bases on an ssDNA strand.

64. 发明授权

EP2140256B1 BIOSENSOR CHIP 有权
标题翻译：生物传感器芯片
公开(公告)号：EP2140256B1
公开(公告)日：2012-06-20
申请号：EP08737943.4
申请日：2008-04-22
申请人： NXP B.V.
发明人： GARCIA TELLO, Pablo , GRIDELET, Evelyne , WIDDERSHOVEN, Franciscus
IPC分类号： G01N27/327
CPC分类号： G01N27/3278 , G01N33/5438 , H01L21/768 , H01L21/76883 , H01L23/53238 , H01L23/53295 , H01L2924/0002 , H01L2924/00
摘要： A biosensor chip (100) for detecting biological particles, the biosensor chip (100) comprising a sensor active region (101) being sensitive for the biological particles and being arranged in a Back End of the Line portion (102) of the biosensor chip (100).

65. 发明公开

EP2331950A4 NANOSTRUCTURED MICROELECTRODES AND BIOSENSING DEVICES INCORPORATING THE SAME 有权
标题翻译：纳米结构的微电极和SO BIOERFASSUNGSVORRICHTUNGEN
公开(公告)号：EP2331950A4
公开(公告)日：2012-02-08
申请号：EP09810953
申请日：2009-09-01
申请人： UNIV TORONTO
发明人： SOLEYMANI LEYLA , FANG ZHICHAO , KELLEY SHANA , SARGENT EDWARD , TAFT BRADFORD
IPC分类号： G01N27/327 , C12Q1/00 , C12Q1/68 , C40B60/00 , G01N27/30 , G01N27/403 , G01N27/416 , G01N33/53 , G01N33/543
CPC分类号： G01N27/3272 , G01N27/30 , G01N27/3275 , G01N27/3278 , G01N33/5438 , Y10S977/754 , Y10S977/925

66. 发明授权

EP1914755B1 Molehole embedded 3-D crossbar architecture used in electrochemical molecular memory device 有权
标题翻译： Eingebettete 3D-Molehole-Crossbar-Architekturfüreine elektrochemische molekulare Speichereinrichtung
公开(公告)号：EP1914755B1
公开(公告)日：2011-03-16
申请号：EP08001009.3
申请日：2002-10-07
申请人： The Regents of the University of California
发明人： Kuhr, Werner G. , Bocian, David F. , Yesseri, Amir , Liu, Zhiming
IPC分类号： G11C13/02 , H01M4/58 , H01M4/60
CPC分类号： H01L29/82 , B82Y10/00 , G01N27/3278 , G01N33/5438 , G11C11/5664 , G11C13/0009 , G11C13/0014 , G11C13/0016 , G11C2213/77 , H01M2/02 , H01M4/38 , H01M4/602 , H01M6/40 , H01M10/0436

67. 发明公开

EP2005148A4 DIELECTRIC SENSING METHOD AND SYSTEM 有权
标题翻译： DIYLEKTRISCHES WAHRNEHMUNGSVERFAHREN UND -SYSTEM
公开(公告)号：EP2005148A4
公开(公告)日：2010-07-21
申请号：EP07710757
申请日：2007-03-16
申请人： DHIRANI AL-AMIN , SUGANUMA YOSHINORI
发明人： DHIRANI AL-AMIN , SUGANUMA YOSHINORI
IPC分类号： G01N27/22 , G01N27/447 , G01N30/64 , G01R27/26
CPC分类号： G01N30/64 , G01N27/3278 , G01N2030/645
摘要： Sensing device and method for detecting presence and concentration of generic target analytes of interest. The device and method are based on detecting changes in effective dielectric induced by the target analytes of interest. Applications of the invention include, but are not restricted to, detecting and characterizing the presence of chemical and/or biological target analytes of interest as well as detecting and characterizing target analytes of interest from a separation apparatus. In one embodiment of the invention, the device comprises at least two electrodes in a rigid architecture such as a solid surface, where the electrodes have sizes and inter-electrode spacings that are on the order of sizes of target analytes of interest to improve sensitivity of the device. Changes in effective dielectric and, therefore, capacitance induced by a presence of the target analytes of interest are measured electronically. The changes are used to detect the presence of the target analytes of interest and to characterize their presence.
摘要翻译：用于检测感兴趣的通用目标分析物的存在和浓度的感测装置和方法。该装置和方法基于检测由目的目标分析物感兴趣的有效电介质的变化。本发明的应用包括但不限于检测和表征感兴趣的化学和/或生物目标分析物的存在以及从分离装置检测和表征感兴趣的目标分析物。在本发明的一个实施例中，该装置包括至少两个刚性结构中的电极，例如固体表面，其中电极具有大小和电极间距，其大小等于感兴趣的目标分析物的尺寸，以提高敏感度装置。通过电子方式测量有效电介质的变化，因此感兴趣的目标分析物的存在引起的电容的变化。这些变化用于检测感兴趣的目标分析物的存在并描述其存在。

68. 发明公开

EP2160600A2 METHOD AND APPARATUS FOR METAL NANOPARTICLE ELECTROCATALYTIC AMPLIFICATION 审中-公开
标题翻译：方法和设备电催化金属纳米粒子扩增
公开(公告)号：EP2160600A2
公开(公告)日：2010-03-10
申请号：EP08771076.0
申请日：2008-06-13
申请人： Board of Regents, The University of Texas System
发明人： FAN, Fu-ren , BARD, Allen, J. , XIAO, Xiaoyin
IPC分类号： G01N33/487 , G01F1/64 , B82B3/00
CPC分类号： B82Y5/00 , B82Y15/00 , B82Y30/00 , G01N27/3278
摘要： The present invention includes methods, compositions and kits for analyzing a chemical analyte having an electrochemical cell connected to a measuring apparatus. The electrochemical cell contains a solution having one or more nanoparticles, one or more chemical analytes, an indicator. In addition, the electrochemical cell contains one or more electrodes in communication with the solution. One or more electrocatalytic properties are generated by the interaction of the one or more nanoparticles and the liquid sample and measured at the one or more electrodes.

69. 发明公开

EP2008097A4 BIOSENSOR HAVING NANO WIRE AND MANUFACTURING METHOD THEREOF 有权
标题翻译：带的制备纳米线和工艺生物传感器
公开(公告)号：EP2008097A4
公开(公告)日：2009-08-26
申请号：EP07745810
申请日：2007-04-04
申请人： SEOUL NAT UNIV IND FOUNDATION , MITECH CORP
发明人： HONG SEUNG-HUN , LEE BYUNG-YANG , LEE DONG-JOON
IPC分类号： G01N33/53 , C12M1/00 , C12Q1/00
CPC分类号： G01N33/5438 , C12Q1/005 , G01N27/3278 , G01N33/02 , G01N33/9406
摘要： There is provided a biosensor capable of increasing a detecting sensitivity of a target substance by using a nano wire having excellent electrical characteristics and by immobilizing a receptor of the target substance to be detected on a substrate which is disposed between a nano wire and another nano wire and a method for manufacturing the same. A biosensor according to the present invention can be manufactured with an arrangement in which the nano wire is selectively arranged on a solid substrate in a matrix and, therefore, many materials can be detected at the same time. Particularly, since the degradation of electrical characteristics of the nano wire can be prevented in the present invention, a target substance is very sensitively detected through a small amount thereof .

70. 发明公开

EP2008098A1 BIOSENSOR HAVING NANO WIRE FOR DETECTING FOOD ADDITIVE MONO SODIUM GLUTAMATE AND MANUFACTURING METHOD THEREOF 有权
标题翻译：随着纳米线生物传感器NAHRUNGSMITTELZUSATZTES味精用于生产检测和过程
公开(公告)号：EP2008098A1
公开(公告)日：2008-12-31
申请号：EP07745811.5
申请日：2007-04-04
申请人： Seoul National University Industry Foundation , Mitech Corporation
发明人： HONG, Seung-Hun , LEE, Byung-Yang , LEE, Dong-Joon
IPC分类号： G01N33/53
CPC分类号： G01N33/5438 , C12Q1/005 , G01N27/3278 , G01N33/02 , G01N33/9406
摘要： There is provided a biosensor capable of increasing a detecting sensitivity of a target substance of glutamate, by using a nano wire having excellent electrical characteristics and by immobilizing a receptor of glutamate to be detected on a substrate which is disposed between a nano wire and another nano wire and a method for manufacturing the same. The biosensor for detecting glutamate according to the present invention can be manufactured with an arrangement in which the nano wire is selectively arranged on a solid substrate in a matrix. Since this biosensor can prevent the degradation of the nano wire in the electrical characteristic, it can sensitively detect glutamate even through a small amount thereof is contained in a food so that it can be effectively used in detecting the food additive existing in the processed foodstuffs.

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