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61. 发明公开

EP3659623A1 METHODS FOR TREATING EOSINOPHILIC ESOPHAGITIS BY ADMINISTERING AN IL-4R INHIBITOR 审中-公开
公开(公告)号：EP3659623A1
公开(公告)日：2020-06-03
申请号：EP19217695.6
申请日：2014-07-10
申请人： Regeneron Pharmaceuticals, Inc.
发明人： KOSTIC, Ana , KELLY, Ludmila , LUI, Xia , CLASSON, Brendan J.
IPC分类号： A61K39/395 , C07K16/28 , A61K31/56 , A61K39/00 , A61P1/04 , A61P1/06 , A61P1/08 , A61P1/12 , A61P1/14 , A61P11/06 , A61P17/00 , A61P27/02 , A61P37/08
摘要： The present invention provides methods for treating, preventing or reducing the severity of eosinophilic esophagitis. The methods of the present invention comprise administering to a subject in need thereof a therapeutic composition comprising an interleukin-4 receptor (IL-4Rα) inhibitor such as an anti-IL-4Rα antibody.

62. 发明公开

EP3658193A1 ANTI-CD8 ANTIBODIES AND USES THEREOF 审中-实审
公开(公告)号：EP3658193A1
公开(公告)日：2020-06-03
申请号：EP18752377.4
申请日：2018-07-23
申请人： Regeneron Pharmaceuticals, Inc.
发明人： GIURLEO, Jason T. , MA, Dangshe , OLSON, William , TAVARE, Richard , THURSTON, Gavin
IPC分类号： A61K49/00 , A61K49/16 , A61K51/10 , C07K16/28 , G01N33/53 , A61K39/00

63. 发明公开

EP3633383A1 FAST PROTEIN SEQUENCING 有权
公开(公告)号：EP3633383A1
公开(公告)日：2020-04-08
申请号：EP19201518.8
申请日：2019-10-04
申请人： Regeneron Pharmaceuticals, Inc.
发明人： MAO,, Yuan , QIANGWEI,, Xia , LICHAO,, Zhang
IPC分类号： G01N33/68 , C07K1/12
摘要： Methods of sequencing a protein using a novel digestion-on-emitter technology are provided.

64. 发明公开

EP3626819A1 TRANSGENIC MOUSE WHICH PRODUCES HYBRID ANTIBODIES CONTAINING HUMAN VARIABLE REGIONS AND MOUSE CONSTANT REGIONS 有权转让
公开(公告)号：EP3626819A1
公开(公告)日：2020-03-25
申请号：EP19203913.9
申请日：2002-02-15
申请人： Regeneron Pharmaceuticals, Inc.
发明人： MURPHY, Andrew J. , YANCOPOULOS, George D. , ECONOMIDES, Aris , KAROW, Margaret , MACDONALD, Lynn , STEVENS, Sean , VALENZUELA, David
IPC分类号： C12N15/00 , C12N15/09 , C12N15/63 , C12N15/74 , C12N5/00 , C12N5/16 , C12P21/06 , C12P21/04 , A01K67/027 , C07K16/28 , C07K16/46 , C07K16/00 , C12P21/00 , C12N15/67 , C12N15/90 , C12N15/85
摘要： A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification.

65. 发明公开

EP3626291A1 NEEDLE SHIELD GRIP DEVICE 审中-实审
公开(公告)号：EP3626291A1
公开(公告)日：2020-03-25
申请号：EP19194858.7
申请日：2019-09-02
申请人： Regeneron Pharmaceuticals, Inc.
发明人： GRYGUS, Bryan , GILDERSLEEVE, Richard Jeff , VARGHESE, Shaina
IPC分类号： A61M5/32
摘要： A needle guard grip device may include a body extending from a first end to a second end along a central longitudinal axis of the body. The body may include a plurality of ribs extending perpendicularly to the central longitudinal axis. The plurality of ribs may include a first set of longitudinally spaced ribs disposed on a first side of the central longitudinal axis, and a second set of longitudinally spaced ribs disposed on a second side of the central longitudinal axis that is opposite of the first side. Moving along the central longitudinal axis, ribs of the first set of longitudinally spaced ribs may alternate with ribs of the second set of longitudinally spaced ribs. The body may include an interior cavity extending from an opening in the first end of the body to a wall extending perpendicularly to the central longitudinal axis. One rib of the plurality of ribs may be positioned closer to the second end of the body than the wall. A first rib of the first set of longitudinally spaced ribs may include a convex external surface, and a second rib of the first set of longitudinal spaced ribs may include a concave external surface. Additionally, a retainer may be disposed within the interior cavity and may have a tab extending from a portion of the retainer closest to the first end of the body. The tab may extend toward the central longitudinal axis and at an angle to the central longitudinal axis.

66. 发明公开

EP3613432A1 METHODS FOR TREATING NASAL POLYPOSIS BY ADMINISTERING AN IL-4R ANTAGONIST 审中-实审
公开(公告)号：EP3613432A1
公开(公告)日：2020-02-26
申请号：EP19187112.8
申请日：2014-06-20
申请人： Sanofi Biotechnology , Regeneron Pharmaceuticals, Inc.
发明人： MANNENT, Leda , PIROZZI, Gianluca , RADIN, Allen , GANDHI, Namita , EVANS, Robert
IPC分类号： A61K39/395 , C07K16/28 , A61K31/167 , A61K31/56 , A61K31/137 , A61K31/58 , A61K45/06 , A61K39/00
摘要： The present invention provides methods for treating nasal polyposis. The methods include administering to a subject in need thereof a therapeutic composition comprising an interleukin-4 receptor (IL-4R) antagonist such as an anti-IL-4R antibody or antigen binding fragment thereof.

67. 发明授权

EP3152312B1 METHODS AND COMPOSITIONS FOR MODIFYING A TARGETED LOCUS 有权
公开(公告)号：EP3152312B1
公开(公告)日：2020-02-12
申请号：EP15729724.3
申请日：2015-06-05
申请人： Regeneron Pharmaceuticals, Inc.
发明人： AUERBACH, Wojtek , FRENDEWEY, David , DROGUETT, Gustavo , GAGLIARDI, Anthony , KUNO, Junko , VALENZUELA, David M.
IPC分类号： C12N15/90 , A01K67/027 , C12N15/64 , C07K14/725

68. 发明公开

EP3597038A1 HUMANIZED RODENTS THAT EXPRESS HEAVY CHAINS CONTAINING VL DOMAINS 有权
公开(公告)号：EP3597038A1
公开(公告)日：2020-01-22
申请号：EP19191081.9
申请日：2013-02-01
申请人： Regeneron Pharmaceuticals, Inc.
发明人： MACDONALD, Lynn , GURER, Cagan , MEAGHER, Karolina A , STEVENS, Sean , MURPHY, Andrew J
IPC分类号： A01K67/027 , C07K16/46 , C12N9/64
摘要： Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity functional in a rodent (e.g., a mouse), wherein the non-human animals rearrange human immunoglobulin light chain gene segments in the context of heavy chain constant regions and express immunoglobulin-like molecules comprising human immunoglobulin light chain variable domains fused to heavy chain constant domains that are cognate with human immunoglobulin light chain variable domains fused to light chain constant domains.

69. 发明授权

EP2790681B1 METHOD OF MANUFACTURING AN EXTENDED RELEASE PHARMACEUTICAL FORMULATION COMPRISING POLYMER COATED PROTEIN MICROPARTICLES USING SPRAY-DRYING 有权
公开(公告)号：EP2790681B1
公开(公告)日：2020-01-22
申请号：EP12795967.4
申请日：2012-11-18
申请人： Regeneron Pharmaceuticals, Inc.
发明人： CHEN, Hunter , WALSH, Scott
IPC分类号： A61K9/50 , A61K38/17 , A61K39/00 , A61P27/02 , A61K9/16

70. 发明授权

EP3169353B1 METHODS FOR TREATING PATIENTS WITH HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HEFH) 有权
公开(公告)号：EP3169353B1
公开(公告)日：2019-12-18
申请号：EP15753227.6
申请日：2015-07-16
申请人： Sanofi Biotechnology , Regeneron Pharmaceuticals, Inc.
发明人： BACCARA-DINET, Marie , HANOTIN, Corinne , BESSAC, Laurence , CHAUDHARI, Umesh , PORDY, Robert , SASIELA, William , SCHWEMMER GIPE, Daniel A.
IPC分类号： A61K39/00 , A61K39/395 , A61P9/10 , C07K16/40

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