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61. 发明授权

EP0848712B1 DIHYDROPYRAN DERIVATIVES AS VIRAL NEURAMINIDASE INHIBITORS 失效
标题翻译：二氢吡喃衍生物作为抑制剂病毒神经氨酸酶
公开(公告)号：EP0848712B1
公开(公告)日：2004-10-13
申请号：EP96925607.2
申请日：1996-08-07
申请人： BIOTA SCIENTIFIC MANAGEMENT PTY. LTD.
发明人： ANDREWS, David Glaxo Wellcome Research and , JONES, Paul Glaxo Wellcome Research and , HUMBER, David
IPC分类号： C07D309/28 , A61K31/35 , A61K31/655
CPC分类号： C07D309/28
摘要： Compounds of formula (I), wherein R1 represents NR5R6, wherein R5 represents H or a hydrocarbon group optionally substituted by one or more of Br, Cl, F, I, CF¿3?, NR?7R8, CO¿2R?9, CONR7R8, COR9, OR10 or SR10¿, or a heteroaromatic group; and R6 represents a hydrocarbon group optionally substituted by one or more of Br, Cl, F, I, CF¿3?, NR?7R8, CO¿2R?9, CONR7R8, COR9, OR10 or SR10¿, or a heteroaromatic group; R2 represents a group SO¿2?R?9 or COR9; R3¿ represents H, C¿1-6?alkyl or C(=NR?11)NR12R13; R4¿ represents H or C¿1-6?alkyl; R?7 and R8¿ each independently represent H, C¿1-6?alkyl or COR?9; R9¿ represents C¿1-6?alkyl optionally substituted by one or more halogen atoms; R?10¿ represents H, C¿1-6?alkyl or phenyl; R?11, R12 and R13¿ each independently represent H, C¿1-6? alkyl, amino, hydroxy, cyano or nitro; and X represents O or S; and their pharmaceutically acceptable derivatives are neuraminidase inhibitors useful in the treatment of viral infections.

62. 发明授权

EP0764023B1 COMPOUNDS AND COMPOSITIONS FOR ADMINISTRATION VIA ORAL INHALATION OR INSUFFLATION 失效
标题翻译： VERBINDUNNGEN和经由吸入施用和INSUFFLIERUNG组合物
公开(公告)号：EP0764023B1
公开(公告)日：2002-08-07
申请号：EP95920874.5
申请日：1995-05-24
申请人： BIOTA SCIENTIFIC MANAGEMENT PTY. LTD.
发明人： EFTHYMIOPOULOS, Constantin
IPC分类号： A61K31/35
CPC分类号： A61K31/351
摘要： 5-Acetamido-2,3,4,5-tetradeoxy-4-guanidino- D -glycero- D -g alacto-non-2-enopyranosonic acid exhibits antiviral activity in animals, in particular in humans, when administered by mouth via inhalation or insufflation.

63. 发明公开

EP1165541A1 DIMERIC COMPOUNDS AND AS INHIBITORS OF NEURAMINIDASE 有权
标题翻译：二甲基化合物和作为神经氨酸酶的抑制剂
公开(公告)号：EP1165541A1
公开(公告)日：2002-01-02
申请号：EP00907354.5
申请日：2000-03-09
申请人： BIOTA SCIENTIFIC MANAGEMENT PTY. LTD.
发明人： WU, Wen-Yang , JIN, Betty
IPC分类号： C07D309/28 , A61K31/7012 , A61K31/351 , A61P31/16
CPC分类号： C07D309/28 , A61K31/00 , A61K31/351 , A61K47/54 , A61K47/55 , A61K47/59 , A61K47/595 , A61K47/60
摘要： This invention relates to novel dimeric compounds, methods for their preparation, pharmaceutical formulations thereof, and their use as antiviral agents. The compounds are particularly useful against influenza virus. In particular the invention provides a dimeric compound which comprises two neuraminidase binding groups attached to a spacer or linking group. Preferably the dimeric molecule comprises two neuraminidase-binding neuraminic acid (sialic acid) or cyclopentyl or cyclohexenyl carboxylic acid derivatives covalently attached to a common spacer group. Pharmaceutical compositions and methods of treatment, prophylaxis and diagnosis are disclosed and claimed.
摘要翻译：本发明涉及新的二聚化合物，其制备方法，其药物制剂以及它们作为抗病毒剂的用途。这些化合物对流感病毒特别有用。具体而言，本发明提供了一种二聚化合物，其包含两个与间隔基或连接基团连接的神经氨酸酶结合分子。优选地，二聚体分子包含共价连接至共同间隔基团的两个神经氨酸酶结合神经氨酸（唾液酸）或环戊基或环己烯基羧酸衍生物。公开并要求保护的药物组合物和治疗方法，预防和诊断。

64. 发明授权

EP0662966B1 SYNTHESIS OF N-ACETYL NEURAMINIC ACID DERIVATIVES 有权转让
标题翻译：生产乙酰NEURAMINICSÄUREN导数的
公开(公告)号：EP0662966B1
公开(公告)日：2000-05-24
申请号：EP93921839.2
申请日：1993-09-23
申请人： BIOTA SCIENTIFIC MANAGEMENT PTY. LTD.
发明人： WEIR, Niall, Galbraith, Glaxo Group Research Ltd. , CHANDLER, Malcolm, Glaxo Group Research Ltd. , BAMFORD, Mark, James, Glaxo Group Research Ltd.
IPC分类号： C07D309/28
CPC分类号： C07D309/28
摘要： A method for the preparation of 5-acetamido-2,3,4,5-tetradeoxy-4-guanidino-D^_-glycero-D^_-galacto-non-2-eno-pyranosonic acid which comprises amination of 5-acetamido-4-cyanoamide-2,3,4,5-tetradeoxy-D^_-glycero-D^_-galacto-non-2-enopyranosonic acid.

65. 发明公开

EP0951480A1 METHOD AND NOVEL COMPOUNDS FOR USE THEREIN 失效
标题翻译：过程和在此过程中新的路由可以被使用的。
公开(公告)号：EP0951480A1
公开(公告)日：1999-10-27
申请号：EP97911065.0
申请日：1997-11-13
申请人： BIOTA SCIENTIFIC MANAGEMENT PTY. LTD.
发明人： REECE, Phillip, A. , WATSON, Keith, Geoffrey , WU, Wen-Yang , JIN, Betty , KRIPPNER, Guy, Y.
IPC分类号： A61K31 , A61K38 , A61K39 , A61K45 , A61P31 , C07K14 , C07K16 , C08B37 , C08F8 , C08G63 , C08G65 , C08G69 , C08G85 , G01N33
CPC分类号： G01N33/56983 , C08B37/0021 , C08F8/30 , G01N2333/11 , G01N2333/924
摘要： The invention provides novel macromolecules, methods for their preparation, pharmaceutical formulations thereof and their use as anti-influenza agents. The invention also provides a novel diagnostic method which can be used for detection of all types of influenza A and B virus. The macromolecular compound of the invention has attached to it one or more molecules (neuraminidase binders) which bind to the active site of influenza virus neuraminidase but which are not cleaved by the neuraminidase.

66. 发明公开

EP0833825A1 6-CARBOXAMIDO DIHYDROPYRAN DERIVATIVES 失效
标题翻译： -6-甲酰二氢吡喃衍生物
公开(公告)号：EP0833825A1
公开(公告)日：1998-04-08
申请号：EP96911872.0
申请日：1996-05-13
申请人： BIOTA SCIENTIFIC MANAGEMENT PTY. LTD.
发明人： CHERRY, Peter Glaxo Wellcome , HOWES, Peter Glaxo Wellcome , SMITH, Paul Glaxo Wellcome , SOLLIS, Stephen Glaxo Wellcome
IPC分类号： A61K31 , A61P31 , C07D309 , C07D405 , C07D409
CPC分类号： C07D405/12 , C07D309/28 , C07D409/12
摘要： Compounds of formula (I), wherein R1 represents OR?5, SR5, NR5R6, N(OR5)R6¿ or N(NR5R6)R6; X represents OH, N¿3?, NR?3R4 or NR4CO¿2R15; Y represents H or NHR2; R2 represents a group SO¿2?R?7 or COR7; R3¿ represents H, C¿1-6?alkyl or C(=NR?8)NR9R10; R4¿ represents H or C¿1-6?alkyl; R?5¿ represents H, C¿1-20?alkyl, C3-8cycloalkyl, C2-20alkenyl, C2-20alkynyl, CHR?11COR12¿ or C¿1-20?alkyl substituted by one or more groups selected from NR?13R14, NR13COR14, CO¿2R?13, OR13, C¿3-8cycloalkyl and optionally substituted aryl; each R6 independently represents H, C¿1-6?alkyl, C3-8cycloalkyl, C2-6alkenyl, C2-20alkynyl, aryl or C1-4alkyl substituted by one or more groups selected from NR?13R14, COR13, C¿3-8cycloalkyl, CN, N3, OR13 and optionally substituted aryl; or R?5 and R6¿ together form a C¿2-6? hydrocarbon chain which may optionally contain a group NR?13¿ which chain is optionally substituted by 1, 2, 3 or 4 groups selected from oxo and C¿1-6?alkyl groups which groups may optionally be substituted by hydroxy or optionally substituted aryl; R?7¿ represents C¿1-6?alkyl optionally substituted by one or more halogen atoms, C3-8cycloalkyl or optionally substituted aryl; R?8, R9 and R10¿ each independently represent H, C¿1-6?alkyl, amino, hydroxy, cyano or nitro; R?11¿ represents the side chain of a D- or L-amino acid; R12 represents NR?13R14, OR13 or R13¿; each R13 and each R14 independently represents H, C¿1-6?alkyl or optionally substituted arylC1-4alkyl; R?15¿ represents C¿1-6?alkyl; and their pharmaceutically acceptable derivatives are neuraminidase inhibitors useful in the treatment of viral infections.

67. 发明授权

EP0526543B1 DERIVATIVES AND ANALOGUES OF 2-DEOXY-2,3-DIDEHYDRO-N-ACETYL NEURAMINIC ACID AND THEIR USE AS ANTIVIRAL AGENTS 有权转让
标题翻译：衍生物和2-脱氧-2,3-二脱氢-N-乙酰基神经酸类似物和它们作为抗病毒剂
公开(公告)号：EP0526543B1
公开(公告)日：1997-12-17
申请号：EP91908682.7
申请日：1991-04-24
申请人： BIOTA SCIENTIFIC MANAGEMENT PTY. LTD.
发明人： VON ITZSTEIN, Laurence, Mark , WU, Wen-Yang , PHAN, Tho, Van , DANYLEC, Basil , JIN, Betty , Colman, Peter Malcolm , Varghese, Joseph Noozhumurry
IPC分类号： C07D309/30 , C07D309/28 , A61K31/35
CPC分类号： C07D309/30 , C07D309/28
摘要： Derivatives and analogues of 2-deoxy-2,3-didehydro-N-acetyl neuraminic acid, pharmaceutical formulations thereof, methods for their preparation and their use in the treatment of viral infections, in particular influenza, are described.

68. 发明公开

EP0526543A1 DERIVATIVES AND ANALOGUES OF 2-DEOXY-2,3-DIDEHYDRO-N-ACETYL NEURAMINIC ACID AND THEIR USE AS ANTIVIRAL AGENTS 有权转让
标题翻译：衍生物和2-脱氧-2,3-二脱氢-N-乙酰基神经酸类似物和它们作为抗病毒剂的用途。
公开(公告)号：EP0526543A1
公开(公告)日：1993-02-10
申请号：EP91908682.0
申请日：1991-04-24
申请人： BIOTA SCIENTIFIC MANAGEMENT PTY. LTD.
发明人： VON ITZSTEIN, Laurence, Mark , WU, Wen-Yang , PHAN, Tho, Van , DANYLEC, Basil , JIN, Betty
IPC分类号： C07D , C07D309 , A61K31 , A61P31 , C07C47 , C07C225 , C07C233 , C07C309 , C07C317 , C07C321 , C07D211 , C07D239 , C07D257 , C07D335 , C07D401 , C07D405 , C07D409 , C07D498 , C07F9 , C07H7
CPC分类号： C07D309/30 , C07D309/28
摘要： On décrit des dérivés et analogues d'acide 2-déoxy-2,3-didéhydro-N-acétyle neuraminique et leur utilisation comme agents antiviraux, leurs formulations pharmaceutiques, procédés de préparation et leur utilisation pour le traitement d'infections virales, en particulier de la grippe.

69. 发明公开

EP0389607A1 CHROMONE DERIVATIVES 失效
标题翻译： CHROMONDERIVATE。
公开(公告)号：EP0389607A1
公开(公告)日：1990-10-03
申请号：EP89910594.0
申请日：1989-09-14
申请人： BIOTA SCIENTIFIC MANAGEMENT PTY. LTD.
发明人： VON ITZSTEIN, Laurence, Mark , WHITE, Hume, Forrest
IPC分类号： C07D311
CPC分类号： C07D311/24
摘要： Le nouveau dérivé de chromone décrit est représenté par la formule générale (I) où R1 représente H, Na ou les esters méthyles ou éthyle correspondant; R2 représente OH, NHR3, CH2OH, CH2NHR3, CHXCH2OH, CHXCH2NHR3, CH2CHXCH2OH ou CH2CHXCH2NHR3 où X représente halogène, NHR3 ou OH et R3 représente H, acétyle, benzyle ou un groupe alkyle linéaire ou cyclique comprenant 1 à 6 atomes de carbone. Des procédés de synthèse, des préparations pharmaceutiques et des procédés de traitement utilisant de tels composés sont également décrits et revendiqués.

70. 发明公开

EP0318488A1 STIMULATION OF ANGIOGENESIS AND PROMOTION OF ENDOTHELIALISATION 失效
标题翻译：刺激血管生成和内皮推广。
公开(公告)号：EP0318488A1
公开(公告)日：1989-06-07
申请号：EP87905152.0
申请日：1987-08-10
申请人： BIOTA SCIENTIFIC MANAGEMENT PTY. LTD.
发明人： McAUSLAN, Brian, Richard
IPC分类号： A61K31 , A61K45 , A61P9 , A61P43
CPC分类号： A61K31/60 , A61K31/19 , A61K31/195 , A61K31/40 , A61K31/425
摘要： Un procédé, permettant de stimuler l'angiogénèse ou l'endothélialisation chez un mammifère, consiste à administrer audit mammifère un composé anti-inflammatoire. Celui-ci a de préférence un effet angiogène agissant directement; les composés préférés comportent de l'acide salicyclique, de l'acide anthranilique, de l'acide acétique de phényle et de l'acide acétique de thiazole. Un composé anti-inflammatoire peut être administré en même temps qu'un second stimulateur de l'angiogénèse. Des compositions et des articles sont également revendiqués.

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