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61. 发明公开

EP3794132A1 TARGETED INTRACELLULAR DELIVERY OF LARGE NUCLEIC ACIDS 审中-公开
公开(公告)号：EP3794132A1
公开(公告)日：2021-03-24
申请号：EP19723132.7
申请日：2019-05-15
申请人： F. Hoffmann-La Roche AG
发明人： BRINKMANN, Ulrich , KILLIAN, Tobias
IPC分类号： C12N15/87 , A61K48/00

62. 发明公开

EP3704150A1 THE COMPBODY - A MULTIVALENT TARGET BINDER 审中-公开
公开(公告)号：EP3704150A1
公开(公告)日：2020-09-09
申请号：EP18795566.1
申请日：2018-10-30
申请人： F. Hoffmann-La Roche AG
发明人： GEORGES, Guy , PLATZER, Josef
IPC分类号： C07K16/22 , C07K16/46

63. 发明公开

EP3628685A1 HUMAN FCRN-BINDING MODIFIED ANTIBODIES AND METHODS OF USE 审中-实审
公开(公告)号：EP3628685A1
公开(公告)日：2020-04-01
申请号：EP19183116.3
申请日：2014-04-25
申请人： F. Hoffmann-La Roche AG
发明人： HARTMANN, Guido , REGULA, Joerg Thomas , RUETH, Matthias , SCHAEFER, Wolfgang , SCHLOTHAUER, Tilman
IPC分类号： C07K16/22 , C07K16/46 , A61K39/395 , A61P27/02
摘要： Herein is reported the use of an antibody comprising an Fc-region with abolished FcRn binding for the transport of a soluble receptor ligand from the eye over the blood-ocular-barrier into the blood circulation.

64. 发明公开

EP3625332A1 METHOD FOR THE PRODUCTION OF THYMOCYTE SUPERNATANT 有权
公开(公告)号：EP3625332A1
公开(公告)日：2020-03-25
申请号：EP18725474.3
申请日：2018-05-16
申请人： F. Hoffmann-La Roche AG
发明人： OFFNER, Sonja , HORVATH, Markus , SAAM, Ingried
IPC分类号： C12N5/0781

65. 发明公开

EP3611188A1 FC-REGION VARIANTS WITH MODIFIED FCRN-BINDING AND METHODS OF USE 有权
公开(公告)号：EP3611188A1
公开(公告)日：2020-02-19
申请号：EP19187251.4
申请日：2015-11-04
申请人： F. Hoffmann-La Roche AG
发明人： MOESSNER, Ekkehard , SCHLOTHAUER, Tilman
IPC分类号： C07K16/00
摘要： Herein is reported an IgG class Fc-region comprising a first variant Fc-region polypeptide and a second variant Fc-region polypeptide, wherein a) the first variant Fc-region polypeptide is derived from a first parent IgG class Fc-region polypeptide and the second variant Fc-region polypeptide is derived from a second parent IgG class Fc-region polypeptide, whereby the first parent IgG class Fc-region polypeptide is identical to or different from the second parent IgG class Fc-region polypeptide, and b) the first variant Fc-region polypeptide differs from the second variant Fc-region polypeptide in one or more amino acid residues other than those amino acid residues in which the first parent IgG class Fc-region polypeptide differs from the second parent IgG class Fc-region polypeptide, and c) the IgG class Fc-region comprising the first variant Fc-region polypeptide and the second variant Fc-region polypeptide has an affinity to a human Fc-receptor that is different than that of an IgG class Fc-region comprising the first parent IgG class Fc-region polypeptide of a) and the second parent IgG class Fc-region polypeptide of a), wherein either the first Fc-region polypeptide or the second Fc-region polypeptide or both Fc-region polypeptides comprise independently of each other one of the following combination of mutations: T307Q and V308P and N434Y and Y436H.

66. 发明公开

EP3559250A1 RE-USE OF ENZYMES IN IN VITRO GLYCOENGINEERING OF ANTIBODIES 审中-公开
公开(公告)号：EP3559250A1
公开(公告)日：2019-10-30
申请号：EP17836014.5
申请日：2017-12-19
申请人： F. Hoffmann-La Roche AG
发明人： FALKENSTEIN, Roberto , MALIK, Sebastian , GRUNERT, Ingrid , THOMANN, Marco , FREIHERR VON ROMAN, Matthias , WALCH, Heiko
IPC分类号： C12P21/08 , C07K17/00

67. 发明公开

EP2379601A1 ANTI-IDIOTYPE ANTIBODY AGAINST AN ANTIBODY AGAINST THE AMYLOID PEPTIDE 有权
标题翻译：抗独特型抗体产生抗抗体反对β-淀粉样肽
公开(公告)号：EP2379601A1
公开(公告)日：2011-10-26
申请号：EP09796629.5
申请日：2009-12-18
申请人： F. Hoffmann-La Roche AG
发明人： ESSIG, Ulrich , HOESEL, Wolfgang , STUBENRAUCH, Kay-Gunnar , VOGEL, Rudolf
IPC分类号： C07K16/42
CPC分类号： G01N33/686 , C07K16/4241 , C07K2317/56 , C07K2317/565 , G01N2333/4709 , G01N2469/20
摘要： The current invention is directed to an anti-idiotype antibody binding to the complementary determining region of an antibody against the amyloid β peptide. In one embodiment said antibody binds to the same epitope or an overlapping epitope as the antibody obtainable from the cell line DSM ACC2939. Also reported is an immunoassay for the determination of an antibody against the amyloid β peptide and for determination of an anti-idiotype antibody binding to an antibody against the amyloid β peptide.

68. 发明公开

EP2379108A1 IMMUNOGLOBULIN PURIFICATION 有权
标题翻译：免疫球蛋白清洁
公开(公告)号：EP2379108A1
公开(公告)日：2011-10-26
申请号：EP09796320.1
申请日：2009-12-18
申请人： F. Hoffmann-La Roche AG
发明人： POMPIATI, Marc , SCHAUBMAR, Andreas
IPC分类号： A61K39/395 , C07K16/06 , C07K1/18
CPC分类号： C07K16/065 , A61K39/39591 , C07K1/18 , C07K16/2803 , C07K16/2866
摘要： The current invention reports a method for purifying an immunoglobulin, wherein the method comprises applying an aqueous, buffered solution comprising an immunoglobulin in monomeric, in aggregated, and in fragmented form to an anion exchange chromatography material under conditions whereby the immunoglobulin in monomeric form does not bind to the anion exchange material, and recovering the immunoglobulin in monomeric form in the flow-through from the anion exchange chromatography material, whereby the buffered aqueous solution has a pH value of from 8.0 to 8.5. In one embodiment the anion exchange chromatography material is a membrane anion exchange chromatography material.

69. 发明公开

EP4416301A1 METHOD FOR THE DETERMINATION OF HYDROLYTIC ACTIVITY 审中-实审
公开(公告)号：EP4416301A1
公开(公告)日：2024-08-21
申请号：EP22823002.5
申请日：2022-11-29
申请人： F. Hoffmann-La Roche AG
发明人： EDELMANN, Franziska , FALKENSTEIN, Roberto , GRAF, Tobias , GUPTA, Sanjay , HILLRINGHAUS, Lars , KHAN, Tarik , LEISS, Michael , MEIER, Thomas , WIEDMANN, Michael
IPC分类号： C12Q1/34 , C12Q1/44
CPC分类号： C12Q1/34 , C12Q1/44

70. 发明授权

EP4085251B1 METHOD FOR DETERMINING THE AMOUNT OF A THERAPEUTIC ANTIBODY IN THE BRAIN 有权
公开(公告)号：EP4085251B1
公开(公告)日：2024-07-31
申请号：EP20842239.4
申请日：2020-12-29
IPC分类号： G01N33/50
CPC分类号： G01N33/5088

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