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51. 发明授权

EP1194479B1 PROCESS FOR MAKING FLUORINATED POLYMER ADSORBENT PARTICLES 有权
标题翻译：用于生产氟化吸收聚合物颗粒
公开(公告)号：EP1194479B1
公开(公告)日：2004-02-18
申请号：EP00938405.8
申请日：2000-06-12
申请人： Prometic Biosciences Inc.
发明人： Smiley, Leonard H. , Lowe, Christopher , Tucker, Julie
IPC分类号： C08J9/20 , B01J20/26 , B01D15/08 , C08J9/28
CPC分类号： B01D15/325 , B01D15/1807 , B01D15/366 , B01D15/3804 , B01D2215/021 , B01J20/26 , B01J20/286 , B01J20/287 , C12N15/1006 , C12N15/101 , G01N2030/042 , Y10S435/803

52. 发明公开

EP1345666A1 EXTRACORPOREAL CAPTURING OF SPECIFIC BIO-MACROMOLECULAR ENTITIES FROM EXTRACELLULAR BODY FLUIDS 审中-公开
标题翻译：体外收集按生物大分子单位FROM EXTRAZELLUALREN体液中
公开(公告)号：EP1345666A1
公开(公告)日：2003-09-24
申请号：EP01272621.2
申请日：2001-12-28
申请人： UPFRONT CHROMATOGRAPHY A/S
发明人： LIHME, Allan, Otto, Fog
IPC分类号： B01D15/00 , C07K1/00 , A61K35/14
CPC分类号： B01D15/1807 , A61M1/3679 , B01D15/02 , B01D2215/021 , B01J20/28004 , B01J20/28011 , B01J20/3242 , B01J41/04 , C07K1/22
摘要： The invention describes a method and devices for extracorporeal capturing of specific bio-macromolecular entities from extracellular body fluids. The method is a column-type process and comprise the extracorporeal circulation of the extracellular body fluids through a stabilised fluidised bed of an adsorbent medium characterized by having specific affinity towards one or more specific bio-macromolecular entities. Also described is a method comprising such extracorporeal circulation through an adsorbent medium in a continuous batch process, said adsorption medium characterised by having specific affinity towards one or more specific bio-macromolecular entities and further being characterised by comprising adsorbent particles having small diameters and high densities.

53. 发明公开

EP1250180A1 A METHOD FOR RECOVERING PIGMENTS FROM ALGAL CULTURES 有权
标题翻译： PROCESS恢复藻类培养颜料
公开(公告)号：EP1250180A1
公开(公告)日：2002-10-23
申请号：EP00901347.5
申请日：2000-01-10
申请人： Beta Carotene Investments Limited
发明人： KEATING, Peter, James
IPC分类号： B01D15/02 , B01J8/20 , C07C403/24
CPC分类号： B01J20/28009 , B01D15/02 , B01D2215/021 , B01J20/06 , C07C403/24 , C09B61/00
摘要： A method and apparatus (101) for the recovery of fat soluble compounds, such as beta carotene, is described. In one embodiment of the invention a solution (102) containing a fat soluble compound is passed through a fluidised bed (104) of crystalline metallic ore particles, such as magnetite, allowing the fat soluble compound to bind to the particles to form a complex (109). The fat soluble compound is released from the complex (109) by passing a wash solution (107) through the fluidised bed and subsequently collected in solution (108). The crystalline metallic ore particles may be reused.

54. 发明公开

EP1071500A1 SMALL DENSE MICROPOROUS SOLID SUPPORT MATERIALS, THEIR PREPARATION, AND USE FOR PURIFICATION OF LARGE MACROMOLECULES AND BIOPARTICLES 有权
标题翻译：密度微孔的固体载体材料，生产和需求的获得纯大分子和生物材料
公开(公告)号：EP1071500A1
公开(公告)日：2001-01-31
申请号：EP99916386.8
申请日：1999-04-05
申请人： Life Technologies, Inc.
发明人： VOUTE, Nicolas , BOSCHETTI, Egisto , GIROT, Pierre
IPC分类号： B01D15/08 , B01J20/00 , B01J8/18 , B01J8/10 , B01D15/02
CPC分类号： B01J20/26 , B01D15/1807 , B01D2215/021 , B01J20/06 , B01J20/262 , B01J20/264 , B01J20/267 , B01J20/28004 , B01J20/28097 , B01J20/286 , B01J20/3028 , B01J20/3042 , B01J20/3078 , B01J20/3204 , B01J20/327 , B01J20/3274 , B01J20/3276 , B01J20/3282 , B01J2220/42 , B01J2220/49 , B01J2220/52 , B01J2220/56 , C04B38/00 , C04B38/009 , C04B20/1029 , C04B38/0074
摘要： The present invention provides small, dense mineral oxide solid supports or microbeads, comprising dense microporous mineral oxides matrices in which a skin of polymers is rooted, and their use in downstream processing, especially for fluidized bed purification of bioparticles or high molecular weight macromolecules.

55. 发明公开

EP0978311A1 A method of fluid bed chromatography 失效
标题翻译：流化床色谱法
公开(公告)号：EP0978311A1
公开(公告)日：2000-02-09
申请号：EP99105046.9
申请日：1991-07-08
申请人： UPFRONT CHROMATOGRAPHY A/S
发明人： Lihme, Allan Otto Fog , Nielsen, Claus Schäfer , Bog-Hansen, Thorkild Christian
IPC分类号： B01J8/20 , B01D15/02 , B01D15/08
CPC分类号： B01J20/28019 , B01D15/1807 , B01D2215/021 , B01J2/16 , B01J8/008 , B01J8/085 , B01J8/1845 , B01J8/1872 , B01J8/1881 , B01J8/20 , B01J8/22 , B01J8/32 , B01J13/02 , B01J20/28004 , B01J20/28011 , B01J20/28014 , B01J20/28021 , B01J20/28026 , B01J20/2803 , B01J20/3219 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J20/3274 , B01J47/10 , C02F1/286 , C02F1/722 , C02F3/085 , C02F3/10 , C02F3/108 , C02F3/342 , Y02W10/15 , Y10S435/815 , Y10S530/811 , Y10S530/812 , Y10S530/813
摘要： A method of fluid bed chromatography in a liquid wherein molecules in the liquid are bound to at least one active substance which is chemically bound to fluid bed particles having pores allowing access of the molecules to the interior thereof, wherein the fluid bed particles consist of: (i) a single density controlling particle which is either (a) a hollow low density controlling particle which is impermeable to the liquid and has a density providing floatation of the fluid bed particle in the liquid, or (b) a high density controlling particle having a density providing sedimentation of the fluid bed particle in the liquid; and (ii) a matrix formed by consolidating at least one conglomerating agent selected from the group consisting of natural and synthetic organic monomers and polymers, said matrix having said single density controlling particle; and said matrix having the active substance for binding the molecules in the liquid covalently bound thereto; and wherein the fluid bed particles exhibit (i) a relative density with respect to the liquid which is less than 0.95 or greater than 1.1, and (ii) a particle size in the range of 1-1000 µm; said relative density and said particle size range of said fluid bed particles being selected to provide desired floatation/sedimentation properties of the fluid bed particles in the liquid; and to provide substantially no turbulence in the fluid bed.
摘要翻译：液体中的流化床色谱法，其中液体中的分子与至少一种活性物质结合，所述活性物质化学结合到流化床颗粒上，所述流化床颗粒具有允许分子进入其内部的孔，其中所述流化床颗粒由以下物质组成：（i）单一的密度控制颗粒，其是（a）中空的低密度控制颗粒，其是液体不可渗透的并具有提供流化床颗粒在液体中漂浮的密度，或（b）高密度控制颗粒具有使液体中的流化床颗粒沉降的密度; 和（ii）通过固结选自天然和合成有机单体和聚合物的至少一种凝聚剂而形成的基质，所述基质具有所述单一密度控制颗粒; 并且所述基质具有用于结合与其共价结合的液体中的分子的活性物质; 并且其中所述流化床颗粒表现出（i）相对于所述液体的相对密度小于0.95或大于1.1，和（ii）粒度在1-1000μm的范围内; 所述流化床颗粒的所述相对密度和所述颗粒大小范围被选择为提供所述流化床颗粒在所述液体中的期望的漂浮/沉降性质; 并在流化床中提供基本无紊流。

56. 发明授权

EP0722771B1 Method of distributing a liquid in a fluid bed reactor and fluid bed reactor 失效
标题翻译：将液体分配到流化床反应器和流化床反应器的方法
公开(公告)号：EP0722771B1
公开(公告)日：1999-09-29
申请号：EP96103637.3
申请日：1991-07-08
申请人： UPFRONT CHROMATOGRAPHY A/S
发明人： Lihme, Allan Otto Fog , Nielsen, Claus Schäfer , Bog-Hansen, Thorkild Christian
IPC分类号： B01J8/20 , B01J8/32
CPC分类号： B01J20/28019 , B01D15/1807 , B01D2215/021 , B01J2/16 , B01J8/008 , B01J8/085 , B01J8/1845 , B01J8/1872 , B01J8/1881 , B01J8/20 , B01J8/22 , B01J8/32 , B01J13/02 , B01J20/28004 , B01J20/28011 , B01J20/28014 , B01J20/28021 , B01J20/28026 , B01J20/2803 , B01J20/3219 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J20/3274 , B01J47/10 , C02F1/286 , C02F1/722 , C02F3/085 , C02F3/10 , C02F3/108 , C02F3/342 , Y02W10/15 , Y10S435/815 , Y10S530/811 , Y10S530/812 , Y10S530/813

57. 发明公开

EP0922489A3 Contact element for fluidised bed 失效
标题翻译：流化床接触元件
公开(公告)号：EP0922489A3
公开(公告)日：1999-07-07
申请号：EP98124304.1
申请日：1992-04-16
申请人： Pharmacia Biotech AB
发明人： Carlsson, Mats , Gustafsson, Jan-Gunnar , Hedman, Per , Pernemalm, Per-Ake , Lonngren, Jorgen , Lindgren, Annika
IPC分类号： B01J8/20 , B32B5/16 , B01D15/08 , B01J8/02 , B01J20/28 , B01J20/10
CPC分类号： B01J20/28026 , B01D15/1807 , B01D2215/021 , B01J8/20 , B01J20/10 , B01J20/28004 , B01J20/28011 , B01J20/28014 , B01J20/28019 , B01J2220/54 , G01N30/482
摘要： Use of beads for recovering a desired component from a sample solution, the beads:
having affinity for the component, comprising a polymer matrix into which glass or silica particles are incorporated, and being fluidised in a column in an upward-flowing liquid stream comprising the sample solution.
摘要翻译：使用珠从样品溶液中回收所需组分，所述珠：对组分具有亲和性，所述珠包含其中引入了玻璃或二氧化硅颗粒的聚合物基质，并且在向上流动的液体流中的柱中流动，所述向上流动的液体流包含样品溶液。

58. 发明公开

EP0828555A4 SEPARATION OF HYDROCARBONS AND WATER FROM MIXTURES THEREOF 失效
标题翻译： TRENNUNG VON KOHLENWASSERSTOFFEN UND WASSER AUS DEREN VERMISCHUNGEN
公开(公告)号：EP0828555A4
公开(公告)日：1998-10-07
申请号：EP96914791
申请日：1996-05-22
申请人： ARTHUR RONALD WILLIAM , CREELMAN ROBERT AUCHTERLONIE
发明人： ARTHUR RONALD WILLIAM , CREELMAN ROBERT AUCHTERLONIE
IPC分类号： B01D15/02 , C10M175/04 , B01J20/26 , B01D15/00
CPC分类号： B01D15/02 , B01D2215/021 , C10M175/04
摘要： A method and an apparatus for separating hydrocarbon (particularly oil) and water components from mixtures thereof, involving passing the mixture through a filter mass such as a fluidised bed (20) in a vertically elongate housing (10) divided into three chambers (13, 14 and 15) by sieves (16a and 16b) with chamber (14) containing the fluidized bed. The fluidised bed contains granules (17) of polymer material, such as rubber, suspended in a body of water, which granules have been activated by exposure to a substance, such as alcohol or an alcohol based substance, rendering the granules hydrophilic whereby the mixture flowing through the housing from an inlet conduit (18) contacts the granules and a large proportion of the oil content is retained by the granules to be separated from the water content which in turn discharges from the housing through a discharge conduit (22).
摘要翻译：一种用于从混合物中分离碳氢化合物（特别是油）和水组分的方法和设备，包括使混合物在垂直细长的壳体（10）中通过诸如流化床（20）的过滤物质（20），该壳体被分成三个腔室 14和15）通过具有包含流化床的室（14）的筛（16a和16b）。流化床包含悬浮在水体中的聚合物材料（例如橡胶）的颗粒（17），所述颗粒通过暴露于诸如醇或醇基物质的物质而被活化，使得颗粒具有亲水性，由此混合物从入口导管（18）流过壳体接触颗粒，并且大部分油含量被颗粒保留以与水含量分离，水含量又通过排放导管（22）从壳体排出。

59. 发明公开

EP0796142A1 PROCEDE ET INSTALLATION POUR EFFECTUER UNE REACTION EN CONTINU AVEC AU MOINS UNE PHASE LIQUIDE ET AU MOINS UN CATALYSEUR SOLIDE DANS UNE COLONNE PULSEE 失效
标题翻译：方法和装置之间至少有一个液相和至少一种固体催化剂的反应的在脉冲列持续实施
公开(公告)号：EP0796142A1
公开(公告)日：1997-09-24
申请号：EP95941778.0
申请日：1995-12-06
申请人： AGRICHIMIE
发明人： FAUGERAS, Pierre , LAPORTE, Françoise , NEAU, Marie-Claude , ROUX, Gabriel
IPC分类号： B01D15 , B01J8 , B01J19 , C13K3 , C13K11
CPC分类号： C13K11/00 , B01D15/02 , B01D2215/021 , B01J8/16 , B01J19/185 , B01J2208/00017 , B01J2208/00548 , C13K3/00
摘要： A method and an apparatus for performing a continuous reaction with at least one liquid reaction phase incorporating at least one starting compound in the presence of at least one solid-phase catalyst, wherein the phases to be contacted are circulated through at least one pulsed reaction column (1), the liquid reaction phase is continuously fed into the middle or lower portion of the pulsed column (1), the liquid phase is circulated upwards through the pulsed column (1), and a counterflow made up of lumps (9) of a solid selective extraction compound is continuously circulated. Furthermore, each solid catalyst is continuously circulated through the pulsed column (1) in contact with the liquid phase.

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