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51. 发明公开

EP1797869A3 Solutions and methods for inhibition of pain, inflammation and cartilage degradation 审中-公开
标题翻译：解决方案和方法抑制疼痛炎症和软骨退化
公开(公告)号：EP1797869A3
公开(公告)日：2008-07-23
申请号：EP07005274.1
申请日：2000-07-21
申请人： Omeros Corporation
发明人： Demopulos, Gregory A. , Palmer, Pamela, Pierce , Herz, Jeffrey, M.
IPC分类号： A61K9/08 , A61K45/06 , A61K38/18
CPC分类号： A61K45/06 , A61K31/192 , A61K31/505 , A61K38/1841 , A61K38/1875 , A61K38/2066 , A61K31/165 , A61K2300/00
摘要： Methods and solutions for inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including arthroscopic procedures, and for inhibiting cartilage degradation are disclosed. The solutions preferably include multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution may be applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. Alternatively, for combinations of cartilage degradation inhibitors, the solutions may be injected directly into the joint.

52. 发明公开

EP1563838A2 Irrigation solution and method for inhibition of pain and inflammation 审中-公开
标题翻译：冲洗溶液和方法用于治疗疼痛和炎症的抑制
公开(公告)号：EP1563838A2
公开(公告)日：2005-08-17
申请号：EP05005561.5
申请日：1999-10-20
申请人： Omeros Corporation
发明人： Demopulos, Gregory, A. , Herz, Jeffrey, M. , Palmer, Pamela, P.
IPC分类号： A61K31/4174 , A61P29/00
CPC分类号： A61K31/4174 , A61K2300/00
摘要： A method and solution for perioperatively inhibiting a variety of pain and inflammation, processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes at least one α 2- receptor agonist and, optionally, additional multiple pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation, includes an α 2- receptor agonist, a serotonin 2 antagonist, a serotonin 3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin 1 antagonist, a neurokinin 2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin 1 antagonist, a bradykinin 2 antagonist and a µ-opioid agonist.
摘要翻译：一种用于在手术前后抑制各种疼痛和炎症的方法和溶液，在处理从包含口腔/牙齿程序一般外科手术伤口。该解决方案优选地包括至少一个±2受体激动剂和任选的附加的多个疼痛和炎症抑制剂在生理载体稀释浓度，颜色：如盐水或乳酸林格氏溶液。该溶液通过伤口的连续冲洗疼痛的抢先抑制的外科手术过程中和，同时避免与口服，肌内，皮下或更大剂量的药物的静脉内应用相关联的不期望的副作用的应用。一个优选的解决方案，以抑制疼痛和炎症，包括±2受体激动剂，血清素2，血清素3拮抗剂，组胺拮抗剂，血清素激动剂，环氧合酶抑制剂，神经激肽1拮抗剂，神经激肽2拮抗剂，拮抗剂嘌呤受体拮抗剂，ATP敏感性钾通道开放剂的拮抗剂，钙通道拮抗剂，缓激肽1，缓激肽2拮抗剂和μ阿片激动剂。

53. 发明公开

EP1434573A2 IRRIGATION SOLUTION AND METHOD FOR INHIBITION OF PAIN AND INFLAMMATION 审中-公开
标题翻译：冲洗液和工艺SCHMERZHINDERUNG和炎症抑制
公开(公告)号：EP1434573A2
公开(公告)日：2004-07-07
申请号：EP99970596.5
申请日：1999-10-20
申请人： Omeros Corporation
发明人： DEMOPULOS, Gregory, A. , PALMER, Pamela, P. , HERZ, Jeffrey, M.
IPC分类号： A61K31/00 , A61K31/4406 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/675 , A61K31/439 , A61K45/06 , A61P29/00 , A61K31/465
CPC分类号： A61K45/06 , A61K31/00 , A61K31/439 , A61K31/4406 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/465 , A61K31/55 , A61K31/675
摘要： A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes at least one neuronal nicotinic acetylcholine receptor agonist and, optionally, additional multiple pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a neuronal nicotinic acetylcholine receptor agonist, a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin1 antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin1 antagonist, a bradykinin2 antagonist and a ν-opioid agonist.

54. 发明公开

EP1257205A2 SOFT TISSUE REPAIR SYSTEM 有权
标题翻译：系统用于回收软组织
公开(公告)号：EP1257205A2
公开(公告)日：2002-11-20
申请号：EP01948931.9
申请日：2001-02-07
申请人： Omeros Corporation
发明人： DEMOPULOS, Gregory, A. , REED, Scott, W. , BACHMAN, Alan, B. , KARL, Frederick, T. , ALLEN, William, J. , ADAMS, Leland, R. , THATCHER, G., Lawrence
IPC分类号： A61B17/04
CPC分类号： A61B17/064 , A61B17/00491 , A61B2017/00004 , A61B2017/0646 , A61B2017/0647
摘要： A medical fastener (18), preferably bioabsorbable, is used for repairing torn soft tissue, particularly meniscal tissue (16). The fastener (18) can have an enlarged head (22) at the proximate end to engage meniscal tissue (16) adjacent to a tear (14), and a pointed distal tip (21) at the other end to ease insertion of the fastener (18) into the meniscus (16). The shank (20) of the fastener (18) bridges across the tear (14). Opposite ends of the shank (20) are secured in the meniscal tissue (16) by a medical adhesive, preferably bioabsorbable, and preferably at locations remote from the tear (14) so as not to interfere with healing of the tear (14). The fastener (18) can have a blind bore (24) opening through the head (22) of the fastener (18) and extending through the shank (20) to a location close to the tip (21) and generally radial holes (26) communicating between the bore (24) and the exterior of the shank (20). The medical adhesive can be injected through the bore (24) for passage outward through the holes (26).

55. 发明公开

EP4119577A3 COMPOSITIONS AND METHODS OF INHIBITING MASP-1 AND/OR MASP-2 AND/OR MASP-3 FOR THE TREATMENT OF VARIOUS DISEASES AND DISORDERS 审中-实审
公开(公告)号：EP4119577A3
公开(公告)日：2023-11-08
申请号：EP22177615.6
申请日：2013-06-18
申请人： Omeros Corporation , University of Leicester
发明人： Schwaeble, Hans-Wilhelm , Demopulos, Gregory A. , Dudler, Thomas , Gray, Patrick
IPC分类号： C07K16/18 , C07K16/40 , A61K39/00 , A61K45/06
摘要： In one aspect, the invention provides methods and compositions for inhibiting MASP-3-dependent complement activation in a subject suffering from or at risk for developing, a disease or disorder selected from the group consisting of paroxysmal nocturnal hemoglobinuria, age-related macular degeneration, arthritis, disseminated intravascular coagulation, thrombotic microangiopathy, asthma, dense deposit disease, pauci-immune necrotizing crescentic glomerulonephritis, traumatic brain injury, aspiration pneumonia, endophthalmitis, neuromyelitis optica and Behcet's disease by administering to the subject a composition comprising an amount of a MASP-3 inhibitory agent in an amount effective to inhibit MASP-3-dependent complement activation. In some embodiments, the subject is administered a MASP-2 inhibitory agent and a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent administered, a MASP-3 inhibitory agent and a MASP-1 inhibitory agent, or a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent.

56. 发明公开

EP3909572A1 STABLE PRESERVATIVE-FREE MYDRIATIC AND ANTI-INFLAMMATORY SOLUTIONS FOR INJECTION 审中-实审转让
公开(公告)号：EP3909572A1
公开(公告)日：2021-11-17
申请号：EP21167904.8
申请日：2013-10-23
申请人： Omeros Corporation
发明人： DEMOPULOS, Gregory, A. , SHEN, Hui-Rong , TEDFORD, Clark, E.
IPC分类号： A61K31/137 , A61K31/138 , A61K31/407 , A61K9/00 , A61P27/08
摘要： The present invention relates to stable, preservative- and antioxidant-free liquid formulations of phenylephrine and ketorolac for injection.

58. 发明授权

EP3057993B1 METHODS FOR TREATING CONDITIONS ASSOCIATED WITH MASP-2 DEPENDENT COMPLEMENT ACTIVATION 有权
公开(公告)号：EP3057993B1
公开(公告)日：2020-08-12
申请号：EP14853910.9
申请日：2014-10-17
申请人： Omeros Corporation , University of Leicester
发明人： DEMOPULOS, Gregory, A. , DUDLER, Thomas , SCHWAEBLE, Hans-Wilhelm
IPC分类号： C07K16/40

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