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41. 发明公开

EP3065715A1 AMORPHOUS MAGNESIUM-SUBSTITUTED CALCIUM PHOSPHATE COMPOSITIONS AND THEIR USES 审中-公开
标题翻译： AMORPHE MAGNESIUM-SUBSTITUIERTE CALCIUMPHOSPHAT ZUSAMMENSETZUNGEN UND DEREN VERWENDUNGEN
公开(公告)号：EP3065715A1
公开(公告)日：2016-09-14
申请号：EP14799845.4
申请日：2014-11-05
申请人： Medical Research Council
发明人： POWELL, Jonathan Joseph , FARIA, Nuno Jorge Rodrigues , PELE, Laetitia , HEWITT, Rachel , THOMAS-MCKAY, Emma
IPC分类号： A61K9/16 , A61K47/02 , A61P35/00 , A61P1/00 , C01B25/32 , A61K9/51 , A61L27/38 , C01B25/16
CPC分类号： A61K9/501 , A61K9/1611 , A61K9/5115 , A61K39/00 , A61K47/02 , A61K49/0002 , C01B25/32
摘要： Amorphous magnesium-substituted calcium, phosphate compositions and their medical uses are described, in particular for use in delivering cargo materials, such as cargo molecules or cargo nanoparticles contained in pores of the amorphous magnesium-substituted calcium phosphate to cells of the immune system, for example as therapeutic approaches for the treatment of inflammatory bowel diseases, and in particular Crohn's disease, autoimmune diseases, allergy and for therapeutic vaccination.
摘要翻译：描述了非晶形镁取代的钙，磷酸盐组合物及其医疗用途，特别用于将含有无定形镁取代的磷酸钙的孔中的货物分子或货物纳米颗粒的货物运送到免疫系统的细胞，用于例如作为治疗炎症性肠病的治疗方法，特别是克罗恩病，自身免疫性疾病，变态反应和治疗性接种。

42. 发明授权

EP2411339B1 VERFAHREN ZUR ELIMINIERUNG VON SCHADSTOFFEN AUS KLÄRSCHLAMM UND VERFAHREN ZUR HERSTELLUNG VON PHOSPHATEN UND PHOSPHATHALTIGEN VERBINDUNGEN 有权转让
标题翻译： FOR消除污染物污水污泥和工艺方法用于生产磷酸盐和含氮化合物
公开(公告)号：EP2411339B1
公开(公告)日：2015-09-02
申请号：EP10711338.3
申请日：2010-03-19
申请人： Klose, Ingeborg , Zepke, Frank
发明人： Klose, Ingeborg , Zepke, Frank
IPC分类号： C05F7/00 , C05B13/06 , C05B13/04 , C02F101/20 , C02F101/10 , C02F11/06 , C02F1/70 , C01B25/32 , C02F11/10
CPC分类号： C02F11/10 , C01B25/32 , C02F1/70 , C02F11/06 , C02F2101/105 , C02F2101/20 , C02F2209/02 , C05B13/04 , C05B13/06 , C05F7/00 , Y02A40/213 , Y02W10/40

43. 发明公开

EP2143415A4 RECALCIFICATION PROMOTER AND COMPOSITION FOR ORAL CAVITY 审中-公开
标题翻译：复位器和口腔组合物
公开(公告)号：EP2143415A4
公开(公告)日：2015-07-01
申请号：EP08738521
申请日：2008-04-08
申请人： SANGI KK
发明人： SAKUMA SHUJI , ISHIZAKI TSUTOMU , ARAKAWA TADAYOSHI
IPC分类号： A61K8/24 , A61Q11/00 , C01B25/32
CPC分类号： A61K8/24 , A61K8/55 , A61K33/24 , A61Q11/00 , C01B25/322

44. 发明公开

EP2783707A4 PRODUCTION METHOD FOR BIOMEDICAL AND INDUSTRIAL MATERIAL USING CERAMIC DERIVED FROM BIRDS' BEAKS 有权
标题翻译：用于生物医学和工业材料使用关鸟喙生产过程中获得的陶瓷材料
公开(公告)号：EP2783707A4
公开(公告)日：2015-04-08
申请号：EP12850996
申请日：2012-11-23
申请人： NAT UNIV CHUNGBUK IND ACAD , KYUNGPOOK NAT UNIV IND ACAD , UNIV NAT CHONNAM IND FOUND
发明人： CHOI SEOK HWA , SON JUN SIK , KANG SEONG SOO , LEE CHANG HO
IPC分类号： A61L27/38 , A61L27/12 , C01B25/32 , C04B18/04 , C04B26/02 , C04B35/64
CPC分类号： A61L27/12 , A61L27/18 , A61L27/3608 , A61L27/46 , A61L2430/02 , C04B35/111 , C04B35/447 , C04B35/486 , C04B35/62204 , C04B35/62218 , C04B35/62231 , C04B35/62645 , C04B35/62655 , C04B35/634 , C04B35/64 , C04B38/0615 , C04B2111/00836 , C04B2235/3208 , C04B2235/3212 , C04B2235/3244 , C04B2235/36 , C04B2235/447 , C04B2235/5252 , C04B2235/5256 , C04B2235/5427 , C04B2235/5436 , C04B2235/5445 , C04B2235/5454 , C04B2235/604
摘要： The present invention relates to a method for preparing a ceramic powder from a bone of a bird's beak, a method for preparing biomedical or industrial ceramic materials by using the ceramic powder derived from a bone of a bird's beak, and a biomedical or industrial ceramic material prepared by the method thereof. The use of the present ceramic powder for manufacturing biomedical or industrial ceramic materials is safer than the use of the ceramic powder derived from allogenic bone or xenogeneic bone. In addition, the ceramic powder of the present invention can be prepared on a mass production basis. Furthermore, the ceramic material prepared using the ceramic powder of the present invention is more biocompatible than that prepared using artificially synthetic ceramic.

45. 发明公开

EP2837715A1 APATITE CRYSTAL 有权
公开(公告)号：EP2837715A1
公开(公告)日：2015-02-18
申请号：EP13775876.9
申请日：2013-03-21
申请人： Koito Manufacturing Co., Ltd.
发明人： ENOMOTO, Kiminori , DAICHO, Hisayoshi , SHINOMIYA, Yu
IPC分类号： C30B29/14 , C01B25/32 , C01B25/455 , C30B29/66
摘要： An apatite crystal is a single crystal expressed by a general formula (M 2 ) 5 (PO 4 ) 3 X. In this formula, M 2 indicates at least one type of element selected from the group consisting of bivalent alkaline-earth metals and Eu, and X indicates at least one type of element or molecule selected from the group consisting of halogen elements and OH. And the single crystal is of a tubular shape. The outer shape of the apatite may be a hexagonal prism. The shape of an opening of a hole formed in the upper surface or lower surface of the hexagonal prism may be a hexagon.
摘要翻译：磷灰石晶体是由通式（M2）5（PO4）3X表示的单晶。在该式中，M2表示选自由二价碱土金属和Eu组成的组中的至少一种元素，并且X表示选自由卤素和OH组成的组中的至少一种元素或分子。单晶是管状的。磷灰石的外形可以是六棱柱。形成在六棱柱的上表面或下表面中的孔的开口的形状可以是六边形。

46. 发明公开

EP2810917A1 A method for producing calcium hydroxyapatite nano-crystals of the desired morphology 有权
标题翻译：葛兰素ter ium ium ium ium ium ium ium ie ie ie ie ie ie ie ie ie ie ie ie ie ie ie
公开(公告)号：EP2810917A1
公开(公告)日：2014-12-10
申请号：EP14162300.9
申请日：2014-03-28
申请人： UAB Moksliniu Tyrimu Pletros Laboratorija
发明人： KAREIVA, Aivaras
IPC分类号： C01B25/32
CPC分类号： C01B25/324 , A61K8/025 , A61K8/0254 , A61K8/027 , A61K8/24 , A61K2800/413 , A61L27/12 , A61L2400/12 , A61L2430/02 , A61Q11/00 , C01P2004/10 , C01P2004/20 , C01P2004/32 , C01P2004/61 , C01P2004/62 , C01P2004/64
摘要： The proposed invention is intended to chemical compounds characterised by a porous structure, specifically, to producing calcium hydroxyapatite nano-crystals of the desired morphology intended for the treatment of skeletal disorders.
The goal of the proposed invention is to obtain calcium hydroxyapatite nano-crystals of the desired morphology and size.
The goal is achieved by preparing two solutions in the proposed method:
a) 2.5-5.0wt% of calcium acetate and 1.2-2.4wt% of diammonium hydrogen tetroxo-phosphate is separately dissolved in 80-120 ml of distilled water and stir them at a temperature of 25-65 °C; b) 1.15-2.25wt% of tartaric acid (TA) is dissolved in 90-100 ml of distilled water, and 4.4-8.8wt% of ethylenediaminetetraacetic acid (EDTA), 5.85-11.7wt% of 1,2- diaminocyclohexane-tetra-acetate (DCTA) is dissolved in 100 ml of water and 22 ml of 10% ammonia water solution, and stirred, pouring the solution b) into solution a), stirring for 15-20 hours at 65-75 °C, drying the obtained gel for 20-24 hours at 100 °C and, after it is grounded additionally heating for 5 hours at 900-1200 °C. By changing the molar ratios of the complex-forming reagents (DCTA, EDTA, and TA), it is possible to change the surface morphology of calcium hydroxyapatite.
摘要翻译：所提出的发明旨在以特征在于多孔结构的化合物，具体地说，涉及产生用于治疗骨骼疾病的所需形态的羟基磷灰石纳米晶体。所提出的发明的目的是获得所需形态和尺寸的羟基磷灰石纳米晶体。目标是通过在所提出的方法中制备两种方案来实现：a）将2.5-5.0重量％的乙酸钙和1.2-2.4重量％的四氢四铵磷酸盐分别溶解在80-120毫升的蒸馏水中，并将其搅拌温度25-65℃; b）将1.15-2.25重量％的酒石酸（TA）溶于90-100ml蒸馏水中，加入4.4-8.8wt％乙二胺四乙酸（EDTA），5.85-11.7wt％1,2-二氨基环己烷四乙酸乙酯（DCTA）溶解于100ml水和22ml 10％氨水溶液中，搅拌，将溶液b）倒入溶液a）中，在65-75℃下搅拌15-20小时，干燥在100℃下获得凝胶20-24小时，并且在900-1200℃下另外加热5小时后再接地。通过改变络合物形成试剂（DCTA，EDTA和TA）的摩尔比，可以改变钙羟基磷灰石的表面形态。

47. 发明公开

EP2598437A1 INTRINSICALLY MAGNETIC HYDROXYAPATITE 有权转让
标题翻译： INTRINSICH MAGNETISCHE HYDROXYLAPATIT
公开(公告)号：EP2598437A1
公开(公告)日：2013-06-05
申请号：EP11752344.9
申请日：2011-07-28
申请人： University of Santiago de Compostela
发明人： TAMPIERI, Anna , LANDI, Elena , SANDRI, Monica , PRESSATO, Daniele , RIVAS REY, José , BANOBRE LOPEZ, Manuel , MARCACCI, Maurilio
IPC分类号： C01B25/32 , C01B25/45 , A61L27/12
CPC分类号： A61K47/02 , A61K49/0002 , A61K49/08 , A61L27/12 , A61L27/54 , A61L2300/414 , A61L2300/64 , A61L2400/12 , A61L2430/02 , A61L2430/06 , C01B25/32 , C01B25/322 , C01B25/45 , C01P2004/62 , C01P2006/62 , C01P2006/64
摘要： The present invention relates to hydroxyapatite doped with Fe
2 + ions and Fe
3 + ions which partially substitute the calcium ions in the crystal lattice. The hydroxyapatite is characterized by an intrinsic magnetism of 0.05 to 8 emu/g, measured by applying a magnetic field of 34 Oe, due to the presence of magnetic nano-domains in the crystal lattice of HA, given the limited amount of magnetic secondary phases present, less than about 3% by volume. The intrinsically magnetic hydroxyapatite can be loaded with biological substances selected in the group consisting of proteins, genes, stem cells, growth factors, vascularization factors, active substances and drugs, under the control of an external magnetic field, as a carrier and release agent for biological substances or drugs, as a contrast agent in diagnostics or for bone or osteocartilage regeneration.
摘要翻译：本发明涉及掺杂有Fe2 +离子的羟基磷灰石和部分代替晶格中的钙离子的Fe 3+离子。由于在HA的晶格中存在磁性纳米结构域，所以羟基磷灰石的特征在于通过施加34Oe的磁场测量的0.05至8emu / g的固有磁性，因为有限量的磁性次级存在，小于约3体积％。本征磁性羟基磷灰石可以在外部磁场的控制下装载由蛋白质，基因，干细胞，生长因子，血管形成因子，活性物质和药物组成的组中选择的生物物质作为载体和脱模剂生物物质或药物，作为诊断或骨或骨软骨再生的造影剂。

48. 发明公开

EP2461840A1 ION SUBSTITUTED CALCIUM PHOSPHATE PARTICLES 审中-公开
标题翻译： IONENSUBSTITUIERTE CALCIUMPHOSPHATPARTIKEL
公开(公告)号：EP2461840A1
公开(公告)日：2012-06-13
申请号：EP10806713.3
申请日：2010-08-04
申请人： Biomatcell AB
发明人： ENGQVIST, Håkan , XIA, Wei
IPC分类号： A61L27/12 , A61L27/56 , C01B25/32 , A61K47/04 , A61K6/033 , A61K9/51 , A61K9/52 , A61Q11/00
CPC分类号： A61K8/24 , A61K6/0017 , A61K6/0038 , A61K6/0082 , A61K6/033 , A61K8/025 , A61K8/0279 , A61K2800/412 , A61K2800/56 , A61L27/12 , A61Q11/00 , C01B25/32
摘要： The present invention relates to a method for formation of spherical particles of ion substituted calcium phosphate. The method is based on precipitation of particles from a buffered solution under static, stirring or hydrothermal conditions. The invention also relates to the use of the formed materials and the particles in itself.

49. 发明公开

EP2001528A4 REVERSE PHASE OSTEOCONDUCTIVE COMPOSITION 审中-公开
标题翻译：骨传导REVERSE相组成
公开(公告)号：EP2001528A4
公开(公告)日：2012-04-04
申请号：EP07719411
申请日：2007-03-23
申请人： CITAGENIX INC
发明人： BOURGEOIS NICOLAS , CLOKIE CAMERON M L , TRITTHARDT UWE , MCMILLAN MICHAEL
IPC分类号： A61L27/18 , A61B17/00 , A61K33/00 , A61K33/42 , A61K47/34 , A61L27/00 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , C01B25/00 , C01B25/32 , C08K3/00 , C08K3/32 , C08L71/00 , C08L71/02
CPC分类号： A61L27/46 , A61B2017/00933 , A61L27/50 , A61L2430/02 , C08G2650/58 , C08L71/02 , C08L2666/54

50. 发明授权

EP1642599B1 POROUS COMPOSITE CONTAINING CALCIUM PHOSPHATE AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：多孔磷酸钙复合材料及其制造方法
公开(公告)号：EP1642599B1
公开(公告)日：2010-12-01
申请号：EP04745321.2
申请日：2004-05-26
申请人： HOYA Corporation , National Institute for Materials Science
发明人： KAWAMURA, Katsumi, Pentax Corporation , NAKAJIMA, Takehiko, Pentax Corporation , SHOJI, Daisuke, Pentax Corporation , TANAKA, Junzo, Nat. Inst. for MaterialsScience , KIKUCHI, M., Nat. Inst. for Materials Science , IKOMA, T., Nat. Inst. for Materials Science
IPC分类号： A61L27/12 , A61L27/40 , A61K6/033 , C01B25/32
CPC分类号： A61L27/56 , A61L27/12 , A61L27/425 , Y10T428/24752
摘要： A porous composite which comprises a porous layer comprising a calcium phosphate ceramic and, formed on part of the surface thereof, a dense layer having a smaller average pore diameter than the porous layer. The porous composite can be produced by (1) introducing a slurry containing a calcium phosphate ceramic/collagen composite and collagen into a mold having a high thermal conductivity, (2) rapidly freezing the slurry in the mold and drying it to form a porous object comprising a porous layer and a dense layer formed on the surface thereof, (3) crosslinking the collagen contained in the porous object, and (4) cutting the porous object to partly remove the dense layer and expose the porous layer so as to leave the dense layer in the area where the porous object comes into contact with a soft tissue after having been implanted in the body.

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