专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明授权

EP3107952B1 METHOD FOR THE GENERATION OF CHEMICAL LIBRARIES 有权
公开(公告)号：EP3107952B1
公开(公告)日：2018-09-26
申请号：EP15702802.8
申请日：2015-02-06
申请人： ETH Zurich
发明人： BODE, Jeffrey , HUANG, Yi-Lin , NODA, Hidetoshi
IPC分类号： C08G69/00 , C07K16/18 , C40B40/10 , C40B50/08
CPC分类号： C12Q1/37 , C08G69/00 , G01N2500/04 , G01N2500/20
摘要： A method for the generation of oligomers or a mixture of oligomers to form a chemical library by amide-forming oligomerization comprises the steps of 1) reacting a mixture of at initiator (I) with monomer (M) to form a dimer of the initiator (I) and the monomer (M) or a pre-oligomer with an initiator (I) attached to a chain of more than one monomer (M) or a mixture thereof by amide-bond formation; 2) optionally adding at least one terminator (T) for the formation of a linear oligomer or a mixture of linear oligomers by amide-bond formation; or, for the formation of a cyclic oligomer or a mixture of cyclic oligomers by amide-bond formation, changing the reaction conditions relative to step 1) so as to form a linking covalent bond between the at least one initiator (I).

42. 发明公开

EP3107952A1 METHOD FOR THE GENERATION OF CHEMICAL LIBRARIES 审中-公开
标题翻译： VERFAHREN ZUR ERZEUGUNG VON CHEMISCHEN BIBLIOTHEKEN
公开(公告)号：EP3107952A1
公开(公告)日：2016-12-28
申请号：EP15702802.8
申请日：2015-02-06
申请人： ETH Zurich
发明人： BODE, Jeffrey , HUANG, Yi-Lin , NODA, Hidetoshi
IPC分类号： C08G69/00 , C07K16/18 , C40B40/10 , C40B50/08
CPC分类号： C12Q1/37 , C08G69/00 , G01N2500/04 , G01N2500/20
摘要： A method for the generation of oligomers or a mixture of oligomers to form a chemical library by amide-forming oligomerization comprises the steps of 1) reacting a mixture of at initiator (I) with monomer (M) to form a dimer of the initiator (I) and the monomer (M) or a pre-oligomer with an initiator (I) attached to a chain of more than one monomer (M) or a mixture thereof by amide-bond formation; 2) optionally adding at least one terminator (T) for the formation of a linear oligomer or a mixture of linear oligomers by amide-bond formation; or, for the formation of a cyclic oligomer or a mixture of cyclic oligomers by amide-bond formation, changing the reaction conditions relative to step 1) so as to form a linking covalent bond between the at least one initiator (I).
摘要翻译：通过酰胺形成低聚形成低聚物或低聚物混合物以形成化学文库的方法包括以下步骤：1）使引发剂（I）与单体（M）的混合物反应以形成引发剂的二聚体 I）和单体（M）或具有通过酰胺键形成连接到多于一个单体（M）的链或其混合物的引发剂（I）的预低聚物; 2）任选地通过酰胺键形成添加至少一个终止子（T）以形成线性低聚物或线性低聚物的混合物; 或者为了通过酰胺键形成形成环状低聚物或环状低聚物的混合物，相对于步骤1）改变反应条件，以便在至少一种引发剂（I）之间形成连接共价键。

43. 发明公开

EP3072968A1 METHOD OF MAKING NUCLEIC ACID LIBRARIES 无效
标题翻译：制备核酸文库的方法
公开(公告)号：EP3072968A1
公开(公告)日：2016-09-28
申请号：EP16156020.6
申请日：2011-02-22
申请人： Advanced Liquid Logic, Inc.
发明人： POLLACK, Michael G. , ECKHARDT, Allen E. , SUDARSAN, Arjun , SRINIVASAN, Vijay , ROUSE, Jeremy , YI, Uichong , TROTTA, Nicholas , DHOPESHWARKAR, Rahul , THWAR, Prasanna , SMITH, Gregory F. , NORTON, Scott , LINNARTZ, Peter
IPC分类号： C12N15/10 , C40B50/08 , C40B40/06 , C07H21/00 , C12Q1/68
CPC分类号： C12N15/1075 , B01J19/0046 , C12N15/1006 , C40B40/08 , C40B50/06
摘要： A method of preparing a nucleic acid library in droplets in contact with oil, including: (a) blunt-ending nucleic acid fragments in a droplet in the oil to yield blunt-ended nucleic acid fragments; (b) phosphorylating the blunt-ended nucleic acid fragments in a droplet in the oil to yield phosphorylated nucleic acid fragments; coupling A-tails to the phosphorylated nucleic acid fragments in a droplet in the oil to yield A-tailed nucleic acid fragments; and (d) coupling nucleic acid adapters to the A-tailed nucleic acid fragments in a droplet in the oil to yield the nucleic acid library comprising adapter-ligated nucleic acid fragments.
摘要翻译：制备与油接触的液滴中的核酸文库的方法，所述方法包括：（a）使油中的液滴中的核酸片段平端化以产生平末端的核酸片段; （b）使油中液滴中的平端核酸片段磷酸化以产生磷酸化的核酸片段; 将A尾连接至油中液滴中的磷酸化核酸片段以产生A尾加核酸片段; （d）将核酸衔接子与油中液滴中的A尾加核酸片段偶联以产生包含衔接子连接的核酸片段的核酸文库。

44. 发明公开

EP2986762A2 DIGITAL ANALYTE ANALYSIS 有权转让
标题翻译：分析物的数字分析
公开(公告)号：EP2986762A2
公开(公告)日：2016-02-24
申请号：EP14784827.9
申请日：2014-04-14
申请人： Raindance Technologies Inc.
发明人： LINK, Darren, Roy , MILLER, Benjamin
IPC分类号： C40B50/08
摘要： The invention generally relates to detecting target molecules.

45. 发明公开

EP2179080A4 ORGANO-CASCADE CATALYSIS: ONE-POT PRODUCTION OF CHEMICAL LIBRARIES 审中-公开
标题翻译： ORGANO CASSETTE CATALYSTS：STERLING CHEMICAL LIBRARIES
公开(公告)号：EP2179080A4
公开(公告)日：2015-04-15
申请号：EP08782114
申请日：2008-07-21
申请人： UNIV PRINCETON
发明人： MACMILLAN DAVID
IPC分类号： C40B50/08 , C40B40/04
CPC分类号： C07C45/61 , C40B40/04 , C40B50/08
摘要： A method for production of a chemical library is provided, where the method involves: reacting, in a single vessel, a) a plurality, x, of aldehydes and/or ketones; and b) either (i) a plurality, y, of nucleophiles, (ii) a plurality, z, of electrophiles or both (i) and (ii); in the presence of c) a cascade catalyst capable of catalyzing reaction between said plurality of aldehydes and/or ketones and said plurality of nucleophiles, said plurality of electrophiles or both; to obtain a mixture of x-y &bgr;-nucleophile substituted aldehydes and/or ketones, xz α-electrophile substituted aldehydes and/or ketones or xyz &bgr;-nucleophile substituted, α-electrophile substituted aldehydes and/or ketones; and the chemical libraries thus produced.
摘要翻译：提供了一种生产化学文库的方法，其中所述方法包括：在单个容器中使a）多个x的醛和/或酮酮反应; 和b）（i）多个y，亲核体，（ii）多个z，亲电子体，或（i）和（ii）两者; 在c）能够催化所述多种醛和/或酮和所述多种亲核试剂，所述多种亲电子体或两者之间的反应的级联催化剂的存在下，以获得x-y和bgr-亲核体取代的醛和/或酮的混合物，xzα-亲电取代的醛和/或酮或xyz和bgr-亲核体取代的α-亲电试剂取代的醛和/或酮; 和这样生产的化学文库。

46. 发明公开

EP2540389A1 Method of encapsulating a molecule and a microbead 审中-公开
标题翻译： Verfahren zur Kapselung vonMolekülenund Mikrokugeln
公开(公告)号：EP2540389A1
公开(公告)日：2013-01-02
申请号：EP12172466.0
申请日：2004-03-31
申请人： MEDICAL RESEARCH COUNCIL
发明人： Griffiths, Andrew , Abell, Chris , Hollfelder, Florian , Mastrobattista, Enrico
IPC分类号： B01J19/00 , G01N33/543 , C07K1/04 , C12N15/10 , C40B20/04 , C40B30/04 , C40B50/08 , B82Y30/00 , B82Y10/00 , B82Y5/00
CPC分类号： B01J19/0046 , B01J19/0093 , B01J2219/00497 , B01J2219/005 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00599 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01J2219/00835 , B01J2219/0086 , B01J2219/00894 , B01J2219/00903 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C07K1/047 , C12N15/1075 , C40B20/04 , C40B30/04 , C40B40/06 , C40B40/10 , C40B50/08 , G01N33/5432
摘要： The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets. The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.
摘要翻译：本发明描述了一种合成化合物的方法，包括以下步骤：（a）将两组或多组初级化合物分隔成微胶囊; 使得一部分微胶囊含有两种或更多种化合物; 和（b）通过来自不同组的主要化合物之间的化学反应在微胶囊中形成次级化合物。本发明还允许鉴定与生物化学体系的靶组分结合或调节靶的活性并且共分隔成微胶囊的化合物。

47. 发明公开

EP2315629A1 DROPLET LIBRARIES 失效转让
标题翻译： TRÖPFCHENBIBLIOTHEKEN
公开(公告)号：EP2315629A1
公开(公告)日：2011-05-04
申请号：EP09790559.0
申请日：2009-07-17
申请人： Raindance Technologies, Inc.
发明人： LINK, Darren , HUTCHINSON, Brain , WEINER, Michael , SAMUELS, Michael
IPC分类号： B01J19/00 , B01F13/00 , B01L3/00 , G01N33/53 , C40B40/04 , C40B40/06 , C40B50/08
CPC分类号： B01F3/0807 , B01F5/0646 , B01F5/0653 , B01F13/0062 , B01F2215/0037 , B01J19/0046 , B01J2219/00286 , B01J2219/00351 , B01J2219/00418 , B01J2219/00479 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00599 , B01J2219/0065 , B01J2219/00657 , B01J2219/00664 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/0074 , B01J2219/00743 , B01L3/502761 , B01L7/52 , B01L2200/027 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0681 , B01L2300/0864 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , C40B40/04 , C40B50/08 , G01N15/1459 , G01N33/5008 , G01N2015/1006 , G01N2500/00 , Y02A90/26
摘要： The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.
摘要翻译：本发明一般涉及液滴库以及用于形成液滴库的系统和方法。本发明还涉及在各种生物，化学或诊断测定中利用这些液滴文库的方法。

48. 发明公开

EP2175019A3 Quasirandom structure and function guided synthesis methods 审中-公开
标题翻译：通过准随机的结构和功能的合成方法被引导
公开(公告)号：EP2175019A3
公开(公告)日：2011-04-06
申请号：EP09177376.2
申请日：2003-12-19
申请人： Nuevolution A/S
发明人： Gouliaev, Alex, Haahr , Holtmann, Anette , Pedersen, Henrik , Franch, Thomas
IPC分类号： C12N15/10 , C12P1/00 , C12Q1/68 , C07K1/04 , C07B61/00 , C40B20/04 , C40B40/06 , C40B30/04 , C40B50/08
CPC分类号： C40B30/04 , C12N15/1068 , C40B20/04 , C40B40/06 , C40B50/04 , C40B50/08 , Y10T436/145555
摘要： The present invention is directed to the synthesis of molecules guided by connector polynucleotides (CPNs) capable of hybridizing to complementory connector polynucleotides (CCPNs) harbouring at least one functional entity comprising at least one reactive group. At least one of said CCPNs hybridize to at least two CPNs. Each CPN will "call" for one or more CCPNs capable of hybridising to the CPN. Following the formation of a supramolecular hybridization complex comprising a plurality of CPNs and a plurality of CCPNs, the reaction of functional entity reactive groups result in the formation of a molecule comprising covalently linked functional entities. The formation of the molecule involves the transfer of functional entities from one or more "donor CCPNs" to at least one "acceptor CCPN" with which the transferred functional entities were not associated prior to the transfer.

49. 发明公开

EP1534735A4 CODED NUCLEIC ACID CARRIERS 审中-公开
标题翻译： CODIERTETRûGERF RNUKLEINSûUREN
公开(公告)号：EP1534735A4
公开(公告)日：2008-02-06
申请号：EP03792043
申请日：2003-08-22
申请人： GENERA BIOSYSTEMS PTY LTD
发明人： TOOHEY BRENDAN JAMES , POETTER KARL FREDERICK
IPC分类号： C12N15/10 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B40/12 , C40B50/08 , C07K1/04 , G01N33/53 , G01N33/543
CPC分类号： C40B50/16 , B01J2219/00497 , B01J2219/005 , B01J2219/00504 , B01J2219/00511 , B01J2219/00572 , B01J2219/00576 , B01J2219/00581 , B01J2219/00585 , B01J2219/00596 , B01J2219/00599 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C12N15/1068 , C12Q1/6834 , C12Q2600/156 , C40B40/06 , C40B40/10 , C40B40/12 , C12Q2565/626 , C12Q2563/179 , C12Q2563/167
摘要： The present invention relates generally to coded solid or semi-solid nucleic acid carriers for use in multiplexing solid phase nucleic acid-based reactions. The use of coded carriers facilitates multiplexing due to the ability to deconvolute multiple nucleic acid-based events and to correlate these to particular experiments. The present invention further provides a method for identifying a nucleic acid molecule having a defined characteristic within a population of two or more different nucleic acid molecules using coded nucleic acid carriers. Conversely, the nucleic acid can be used as the code for a particular peptide, or other chemical, bound specifically to a microsphere with a specific oligonucleotide sequence. Alternatively, the method of the present invention permits screening for molecules which interact with target nucleic acid, or other, molecules. The method and the coded carriers of the present invention enable high throughput screening of nucleic acid, or other, molecules. The method may also be automated and/or controlled by computer software.
摘要翻译：本发明一般涉及用于复合基于固相核酸的反应的编码固体或半固体核酸载体。由于能够对多个基于核酸的事件进行去卷积并将这些事件与特定实验相关联，使用编码载体有助于多路复用。本发明进一步提供了使用编码的核酸载体鉴定在两种或更多种不同核酸分子的群体内具有确定特征的核酸分子的方法。相反，核酸可用作特定肽或其他化学物质的编码，其与特定的寡核苷酸序列特异性结合微球。或者，本发明的方法允许筛选与靶核酸或其他分子相互作用的分子。本发明的方法和编码的载体能够对核酸或其他分子进行高通量筛选。该方法也可以由计算机软件自动化和/或控制。

50. 发明公开

EP1372852A4 MULTI-WELL APPARATUS 审中-公开
标题翻译： MULTI阱器件
公开(公告)号：EP1372852A4
公开(公告)日：2006-04-12
申请号：EP02715071
申请日：2002-03-08
申请人： EXELIXIS INC
发明人： HAGER DAVID C , DONALDSON JEFFREY D , KEARNEY PATRICK , KELLER DOUGLAS O , LEAHY JAMES W , MERCER ROBERT D , MORRISSEY MICHAEL , SWARTWOOD TROY M
IPC分类号： G01N35/02 , B01J19/00 , B01L3/00 , C40B50/08 , C40B60/14 , B01L11/00 , G01N1/18
CPC分类号： B01L3/5635 , B01J19/0046 , B01J2219/00283 , B01J2219/00286 , B01J2219/00313 , B01J2219/00315 , B01J2219/00319 , B01J2219/00333 , B01J2219/00416 , B01J2219/00418 , B01J2219/00423 , B01J2219/00585 , B01J2219/00599 , B01L3/5025 , B01L3/50255 , B01L3/563 , B01L2200/025 , B01L2200/141 , B01L2300/0829 , C40B50/08 , C40B60/14 , Y10T436/25375 , Y10T436/2575
摘要： A multi-well assembly (10) comprises a multi-well block (12) and a guide plate.(14) The multi-well block (12) has a plurality of wells (18) each with a fluid-impermeable bottom surface (22). The guide plate (14) has a plurality of fluid passageways (34) corresponding to the wells (18) of the multi-well block (12). The guide plate (14) is configured to establish fluid communication between each well (18) and an associated fluid passageway (34) when the guide plate (14) is aligned with the multi-well block (12).

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式