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41. 发明公开

EP1384509A2 Protein crystallography hanging drop lid that individually covers each of the wells in a microplate 审中-公开
标题翻译： Abdeckung zum Halten von Tropfen zur Proteinkristallisation mittels Dampfdiffusion
公开(公告)号：EP1384509A2
公开(公告)日：2004-01-28
申请号：EP03076957.4
申请日：2003-06-24
申请人： Corning Incorporated
发明人： Sha, Ma , Youngbear, Kathy Marie
IPC分类号： B01L3/00
CPC分类号： B01L3/508 , B01L3/50853 , B01L2200/0689 , B01L2300/04 , B01L2300/0829 , B29C45/1676 , C30B7/00 , C30B29/58
摘要： A lid that individually covers each of the wells in a microplate and methods for fabricating and using the lid are described herein. The lid includes a series of downwardly protruding necks each of which is sized to fit and seal against one of the wells formed within the microplate. And, each neck has a surface covered with a rubber-like substance that ensures a relatively tight seal with each well. In operation, the lid and microplate are preferably used together to grow protein crystals using a hanging drop vapor diffusion crystallization process.
摘要翻译：本文描述了单独覆盖微孔板中的每个孔的盖子以及用于制造和使用盖子的方法。盖子包括一系列向下突出的颈部，每个颈部的尺寸被设计成适合和密封在微孔板内形成的一个孔中。并且，每个颈部具有覆盖有橡胶状物质的表面，其确保与每个孔相对紧密的密封。在操作中，优选使用盖和微孔板一起使用悬滴蒸气扩散结晶方法生长蛋白质晶体。

42. 发明公开

EP1249519A1 Protein crystallization apparatus and protein crystallization method 有权
标题翻译： Vorrichtung und VerfahrenfürProteinkristallisierung
公开(公告)号：EP1249519A1
公开(公告)日：2002-10-16
申请号：EP02007383.9
申请日：2002-04-09
申请人： Mitsubishi Heavy Industries, Ltd.
发明人： Uemura, Masaru, Kobe Shipyard & Machinery Works
IPC分类号： C30B7/00 , C30B29/58 , C30B7/14 , C30B30/08
CPC分类号： C30B7/00 , C30B29/58 , Y10T117/1024
摘要： A protein crystallization apparatus is comprised of a vessel supporting section (8) and a rotating unit (1). A vessel (2) is detachably fixed to the vessel supporting section. The rotating unit rotates the vessel supporting section around first and second rotation axes (4a, 6a). The vessel is comprised of a vessel section having an opening; a sealing section which seals said opening of said vessel section; an absorption member which is provided in the vessel section and in which precipitant solution is absorbed; and a button provided apart from the absorption member to hold protein solution. Precipitant evaporates and diffuses in an inside of the vessel section while the vessel supporting section is rotated. The precipitant is absorbed by the protein solution and a protein crystal is precipitated.
摘要翻译：容器支撑单元（8）具有含有蛋白质溶液的分离固定的容器（2）。三维绞肉器（1）使血管支撑单元（8）围绕水平轴和垂直轴旋转，使得蛋白质晶体在血管旋转时生长。包括蛋白质结晶法的独立权利要求。

43. 发明公开

EP1130138A4 CRYSTAL GROWING METHOD AND CRYSTAL GROWING APPARATUS 审中-公开
标题翻译：晶体生长的方法和装置
公开(公告)号：EP1130138A4
公开(公告)日：2001-12-19
申请号：EP99937038
申请日：1999-08-11
申请人： SUMITOMO METAL IND
发明人： SANJOH AKIRA
IPC分类号： C08J3/00 , C30B7/00 , C30B29/58 , C07H21/00 , C07K1/14 , C08H1/00 , C12N9/00
CPC分类号： C30B7/00 , C30B29/58
摘要： An apparatus for crystal growth includes: a solid-state element (22) having a region (22a) whose valence electrons are controlled so as to control the concentration of holes or electrons on a surface portion of the region in response to the environment of a solution (23) containing a macromolecular compound; and a heating element (24) provided in the vicinity of the region (22a). The region (22a) whose valence electrons are controlled is an impurity region formed on a silicon semiconductor substrate. The heating element (24) has an electrothermal line of Cr. In a crystal growth method, the solution (23) is heated by the heating element (24). Under an electric state generated on the surface of the region (22a), a crystal of the macromolecular compound is formed from the heated solution (23).

44. 发明公开

EP1114886A4 CRYSTAL GROWING METHOD AND CRYSTAL GROWING APPARATUS 审中-公开
标题翻译： KRISTALLZÜCHTUNGSVORRICHTUNGUND -VERFAHREN
公开(公告)号：EP1114886A4
公开(公告)日：2001-12-19
申请号：EP99937037
申请日：1999-08-11
申请人： SUMITOMO METAL IND
发明人： SANJOH AKIRA
IPC分类号： C08J3/00 , B01D9/02 , C30B7/00 , C30B29/58 , C07H21/00 , C07K1/14 , C08H1/00 , C12N9/00
CPC分类号： C30B7/00 , C30B29/58
摘要： An apparatus for crystal growth includes a solid-state component (42) having a region (42a) whose valence electrons have been controlled so as to control the concentration of holes or electrons of a surface portion in response to the environment of a solution (43) containing a macromolecular compound, a pair of counter electrodes (44a) and (44b) provided to hold therebetween a space above the region (42a), and electric insulating materials (46a) and (46b) supporting the counter electrodes (44a) and (44b). The region (42a) is an impurity region formed on a silicon semiconductor substrate. In the crystal growth method, an electric field is applied to the solution (43) across the counter electrodes (44a) and (44b). Under an electric state generated on the surface of the region (42a), a crystal of the macromolecular compound is formed from the solution (43) to which the electric field is applied.
摘要翻译：一种晶体生长设备包括具有区域（42a）的固态器件（42），其中价电子被如此控制，使得表面部分中的空穴或电子的密度根据含有（a）的溶液（43）的环境来控制高分子化合物，位于区域42a上方空间两侧的一对相对电极44a，44b以及支撑电极44a，44b的电绝缘构件46a，46b。区域（42a）是形成在硅半导体基板上的杂质区域。晶体生长方法包括通过相对电极（44a，44b）向溶液（43）施加电场。高分子化合物的晶体在电场中以区域（42a）的表面的电气状态在溶液（43）中生长。

45. 发明公开

EP0909841A4 CRYSTAL-GROWING METHOD AND SOLID ELEMENT AND DEVICE FOR CRYSTAL GROWTH USED IN THE METHOD 失效
标题翻译：晶体生长和固元以及为晶体生长为此使用的设备方法
公开(公告)号：EP0909841A4
公开(公告)日：2001-12-19
申请号：EP97927440
申请日：1997-06-23
申请人： SUMITOMO METAL IND
发明人： SANJOH AKIRA
IPC分类号： C30B7/00 , C30B29/58 , B01J19/00 , C07H21/00 , C07K1/14 , C08H1/00 , C12N9/00
CPC分类号： C30B7/00 , C30B29/58 , Y10T117/1024
摘要： Provided is a method which can facilitate crystallization of a biological macromolecule such as protein. A silicon crystal (70) whose valence electrons are controlled so that the concentration of holes or electrons in the surface part can be controlled in response to the environment of a buffer solution (72) containing a biological macromolecule such as protein is brought into contact with the solution (72), for depositing a crystal of the biological macromolecule on the surface of the silicon crystal (70). A plurality of grooves or holes whose sizes differ from each other are formed on the silicon crystal (70), and the valence electrons are so controlled that crystallization of the biological macromolecule is facilitated inside rather than outside the grooves or holes. The crystal of the biological macromolecule grows in the grooves or holes coming into contact with the solution (72).

46. 发明公开

EP1078261A1 PROCEDE DE FIXATION ET/OU DE CRISTALLISTATION DE MACROMOLECULES BIOLOGIQUES SUR DES NANOTUBES DE CARBONE ET SES APPLICATIONS 有权
标题翻译：程序对生物MACROMOLEKULEN的固定和自组织碳纳米管及其用途
公开(公告)号：EP1078261A1
公开(公告)日：2001-02-28
申请号：EP99917007.9
申请日：1999-05-07
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE , CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： BALAVOINE, Fabrice , MIOSKOWSKI, Charles , SCHULTZ, Patrick , RICHARD, Cyrille
IPC分类号： G01N33/543 , G01N33/547 , C12N11/06 , C07C235/20 , C07D495/04 , C07C233/40 , C07F1/00 , C07F15/04
CPC分类号： C07D495/04 , B82Y30/00 , C07C233/40 , C07C235/20 , C07C2603/24 , C07C2603/54 , C07F1/005 , C07F15/045 , C30B7/00 , C30B29/58 , G01N33/54353 , G01N33/54373 , G01N33/551 , Y10S977/729 , Y10S977/742 , Y10S977/746 , Y10S977/747 , Y10S977/793 , Y10S977/842 , Y10S977/848 , Y10S977/894 , Y10S977/896 , Y10S977/898 , Y10S977/92
摘要： The invention concerns a method for immobilising and/or crystallising macromolecules, chemical reagents used in said method, resulting products and uses of said products in the field of materials and structural biology, in particular as biosensors or as biomaterials. Said method essentially consists in incubating, without stirring, for at least 15 minutes, a biological macromolecule in solution with carbon nanotubes closed at their ends, in suitable temperature and pH conditions.

47. 发明公开

EP0686163A1 METAL-INTERFERON-ALPHA CRYSTALS 失效
标题翻译：金属干扰素α晶体
公开(公告)号：EP0686163A1
公开(公告)日：1995-12-13
申请号：EP94910703.0
申请日：1994-02-24
申请人： SCHERING CORPORATION
发明人： REICHERT, Paul , MCNEMAR, Charles , NAGABHUSHAN, Nagamani , NAGABHUSHAN, Tattanahalli L. , TINDALL, Stephen , HRUZA, Alan
IPC分类号： A61K38 , C07K14 , C30B7 , C30B28 , C30B29
CPC分类号： C07K14/56 , A61K38/212 , C30B7/00 , C30B29/58
摘要： The present invention provides for crystalline zinc-interferon alfa-2 (IFN alpha -2) having a monoclinic morphology. The present invention further provides for crystalline cobalt-IFN alpha -2, crystalline calcium-IFN alpha -2, and crystalline IFN alpha -2 having a serum half-life of at least about 12 hours when injected into a primate. The present invention further provides for a method for producing a crystalline IFN alpha -2 comprising forming a soluble metal-IFN alpha -2 complex, and equilibrating the soluble metal-IFN alpha -2 complex in solution with an acetate salt of the metal under conditions that will cause the metal-IFN alpha -2 solution to become supersaturated and form crystalline metal-IFN alpha -2. The present invention also includes crystalline metal-alfa interferon having monoclinic, plate and needle morphologies.

48. 发明授权

EP0314469B1 Process and apparatus for preparation of single crystal of biopolymer 失效
标题翻译：制备单晶生物聚合物的方法和装置
公开(公告)号：EP0314469B1
公开(公告)日：1993-06-23
申请号：EP88310097.6
申请日：1988-10-27
申请人： FUJITSU LIMITED
发明人： Fujita, Shozo , Asano, Koji , Hashitani, Takafumi
IPC分类号： C30B7/00 , C30B29/58
CPC分类号： C30B7/00 , C30B29/58 , Y10S117/901 , Y10T117/1024
摘要： A process for the preparation of a single crystal of a biopolymer by growth from a solution comprises continuously changing one factor having an influence on the conditions for crystallization of a solution of a biopolymer, fractionating the solution, and independently crystallizing the resultant fractions. The process may be carried out by an apparatus comprising a means for feeding a crystallizing agent solution, a means for feeding a biopolymer solution, a means for producing a series of changes of predetermined crystallization conditions, said means continuously changing at least one factor having an influence on the conditions for crystallization of the biopolymer solution, and a means for fractionating the solution and independently crystallizing the resultant fractions.

49. 发明授权

EP0357857B1 Human serum albumin crystals and method of preparation 失效
标题翻译：人血清白蛋白晶体和制备方法
公开(公告)号：EP0357857B1
公开(公告)日：1993-02-03
申请号：EP88402228.6
申请日：1988-09-05
申请人： NATIONAL AERONAUTICS AND SPACE ADMINISTRATION
发明人： Carter, Daniel Clark, Ph.D.
IPC分类号： C07K3/24 , C07K3/28 , C07K15/00
CPC分类号： C07K14/765 , C30B7/00 , C30B29/58 , Y10T428/30 , Y10T428/31536 , Y10T428/31768
摘要： HSA crystals are provided in the form of tetragonal plates having the space groups P4212, the crystals being grown to sizes in excess of 0.5 mm in two dimensions and a thickness of 0.1 mm. Growth of the crystals is carried out by a hanging drop method wherein a precipitant solution containing PEG and a phosphate buffer is mixed with an HSA solution, and a droplet of mixed solution is suspended over a well of precipitant solution. Crystals grow to the desired size in 3 to 7 days. Concentration or reagents, pH and other parameters are controlled within prescribed limits. The resulting crystals exhibit a size and quality such as to allow performance of x-ray diffraction studies and enable the conduct of drug binding studies as well as genetic engineering studies.

50. 发明授权

EP0274824B1 Novel lipid-protein compositions and articles and methods for their preparation 失效
标题翻译：新型脂蛋白组合物及其制备方法及其制备方法
公开(公告)号：EP0274824B1
公开(公告)日：1992-01-29
申请号：EP87309560.8
申请日：1987-10-29
申请人： Ribi, Hans O.
发明人： Ribi, Hans O.
IPC分类号： B05D1/20 , C30B7/04 , C30B29/58
CPC分类号： B82Y30/00 , B01J2219/00734 , B05D1/202 , B82Y10/00 , B82Y40/00 , C30B7/00 , C30B7/005 , C30B29/58 , G01N33/5438 , G01N33/54393 , Y10T428/31536 , Y10T428/31667 , Y10T428/31725 , Y10T428/31909
摘要： Novel articles are provided comprising at least one polymerized surfactant layer (20,22) and at least one protein layer (24) specifically bound to the surfactant layer (20,22). Depending upon the nature of the preparation of the layers, the layers may be formed as a plurality of substantially parallel layers, filaments, tubes, helices or other complex assembly. The articles may be used for improved determination of protein structure, electronic devices, enzyme reactors and in biosensors. Improved methods are provided for electron microscopic analysis of proteins.

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