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41. 发明公开

EP2504060A2 OPTICAL STIMULATION THERAPY 审中-公开
标题翻译：光刺激疗法
公开(公告)号：EP2504060A2
公开(公告)日：2012-10-03
申请号：EP10785287.3
申请日：2010-11-23
申请人： Medtronic, Inc.
发明人： DENISON, Timothy, J. , KUNAL, Paralikar , MUNNS, Gordon, O. , SANTA, Wesley, A. , CONG, Peng , NIELSEN, Christian, S. , NORTON, John, D. , KEIMEL, John, G.
IPC分类号： A61N5/06
CPC分类号： A61N5/0601 , A61B2017/00084 , A61B2018/00839 , A61M5/14276 , A61N1/086 , A61N1/365 , A61N5/062 , A61N5/0622 , A61N2005/0612 , A61N2005/0626 , A61N2005/063 , A61N2005/0651
摘要： An implantable medical system comprises a therapy delivery module comprising a light source that generates light and a controller that controls the output of the light source, an optical light guide configured to deliver the light from the light source to a target tissue, a lead with a sense electrode for sensing bioelectric signals, and a sensing module configured to determine a patient therapeutic state based on the sensed bioelectric signals substantially simultaneously with the delivery of light from the light source, wherein the controller is configured to adjust the delivery of light to the target tissue based on the sensed patient therapeutic state.

42. 发明公开

EP2462907A1 System and method for determining dosimetry in ophthalmic photomedicine 有权
标题翻译：系统用于确定眼科照片医学剂量
公开(公告)号：EP2462907A1
公开(公告)日：2012-06-13
申请号：EP12158325.6
申请日：2007-11-13
申请人： Topcon Medical Laser Systems, Inc.
发明人： Palanker, Daniel , Andersen, Dan
IPC分类号： A61F9/008
CPC分类号： A61F9/00821 , A61B3/102 , A61B18/20 , A61B90/361 , A61B2018/20351 , A61F9/008 , A61F2009/00851 , A61F2009/00855 , A61F2009/00863 , A61F2009/00868 , A61F2009/00885 , A61F2009/00897 , A61N5/0622
摘要： A system and method for treating ophthalmic target tissue, including a light source for generating a beam of light, a beam delivery system that includes a scanner for generating patterns, and a controller for controlling the light source and delivery system to create a dosimetry pattern of the light beam on the ophthalmic target tissue. One or more dosage parameters of the light beam vary within the dosimetry pattern, to create varying exposures on the target tissue. A visualization device observes lesions formed on the ophthalmic target tissue by the dosimetry pattern. The controller selects dosage parameters for the treatment beam based upon the lesions resulting from the dosimetry pattern, either automatically or in response to user input, so that a desired clinical effect is achieved by selecting the character of the lesions as determined by the dosimetry pattern lesions.

43. 发明授权

EP1853347B8 LIGHT THERAPY DEVICE FOR TREATMENT OF BONE DISORDERS AND BIOSTIMULATION OF BONE AND SOFT TISSUE 有权
标题翻译：光疗法治疗骨质疏松症及骨软组织减速
公开(公告)号：EP1853347B8
公开(公告)日：2012-05-16
申请号：EP06710427.3
申请日：2006-02-17
申请人： Biolux Research Ltd.
发明人： Brawn, Peter Robert
IPC分类号： A61N5/06
CPC分类号： A61N5/0622 , A61N5/0613 , A61N2005/0647 , A61N2005/0652 , A61N2005/0659
摘要： The present invention provides an extra-oral light therapy device including an extra-oral bridge, an intra-oral tray removably connected to the extra-oral bridge, at least one extra-oral light emitting diode ('LED') array removably connected to the extra-oral bridge, and a programmable controller for controlling the extra-oral light therapy device. The present invention alternatively provides an extra-oral light therapy device including a head-set, at least one extra-oral LED array removably attached to the head-set, a connector for removably attaching the head-set to the at least one extra-oral LED array, and a programmable controller for controlling the extra-oral light therapy device. The present invention also provides an external light therapy device including a thin, molded substrate, at least one LED array mounted onto the thin, molded substrate, an attaching means for removably attaching the at least one LED array mounted onto the thin, molded substrate to the area of treatment, and a programmable controller for controlling the external light therapy device. The present invention further provides a method for treating jaw bone disorders and jaw osteonecrosis and biostimulating bone and soft tissue utilizing an extraoral light therapy device and a method for treating and stimulating soft and hard tissue and biostimulating bone utilizing an external light therapy device.
摘要翻译：本发明提供一种口外光疗装置，其包括口外桥，可移除地连接到口外桥的口腔内托盘，至少一个可移除地连接到口外发光二极管（LED）阵列的口外发光二极管（“LED”）阵列，外口桥，以及用于控制口外光疗设备的可编程控制器。本发明可选地提供了一种口腔外光疗装置，其包括头戴装置，至少一个可移除地附接到头戴装置的口外LED阵列，用于可移除地将头戴装置附接到至少一个额外口腔LED阵列的连接器，口腔LED阵列和用于控制口腔外光疗装置的可编程控制器。本发明还提供了一种外部光疗装置，其包括薄的模制衬底，安装在该薄的模制衬底上的至少一个LED阵列，用于将安装在该薄的模制衬底上的至少一个LED阵列可拆卸地附接到治疗区域以及用于控制外部光疗装置的可编程控制器。本发明进一步提供了利用口外光疗装置和利用外部光疗装置治疗和刺激软组织和生物刺激骨的方法来治疗颌骨病症和颌骨骨坏死以及生物刺激骨和软组织的方法。

44. 发明公开

EP2356134A4 OPTICALLY-BASED STIMULATION OF TARGET CELLS AND MODIFICATIONS THERETO 审中-公开
标题翻译： OPTISCHE刺激VIS ZIELZELLEN UND IHRE MODIFIZIERUNG
公开(公告)号：EP2356134A4
公开(公告)日：2012-05-09
申请号：EP09826819
申请日：2009-11-13
申请人： UNIV LELAND STANFORD JUNIOR
发明人： DEISSEROTH KARL , YIZHAR OFER , GUNAYDIN LISA , HEGEMANN PETER , BERNDT ANDRE
IPC分类号： C07K14/075
CPC分类号： A61K38/16 , A61K36/05 , A61K38/00 , A61K41/0023 , A61N5/0601 , A61N5/062 , A61N5/0622 , A61N2005/0651 , A61N2005/067 , C07K14/405 , C07K14/705 , C12N7/00 , C12N13/00 , C12N15/85 , C12N15/86 , C12N2740/15041
摘要： Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule comprising a nucleic acid sequence that codes for light-activated molecule. The light-activated molecule includes a modification to a location near the all-trans retinal Schiff base, e.g., to extends the duration time of the open state. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion channels or pumps or for controlling currents in a cell (e.g., in in vivo and in vitro environments).
摘要翻译：使用光，例如体内或体外，使用各种方法和装置来实现靶细胞的刺激。一个实例涉及用于递送包含编码光激活分子的核酸序列的光激活分子的载体。光活化分子包括对全反式视网膜席夫碱附近的位置的修饰，例如延长开放状态的持续时间。其他方面和实施方案涉及用于离子通道或泵的系统，方法，试剂盒，物质和分子组合物或用于控制细胞中的电流（例如，在体内和体外环境中）。

45. 发明公开

EP2310094A4 METHODS AND DEVICES FOR MODULATING CELLULAR ACTIVITY USING ULTRASOUND 有权
标题翻译：方法和调制细胞活性下降DEVICES借助超声波
公开(公告)号：EP2310094A4
公开(公告)日：2011-11-16
申请号：EP09798662
申请日：2009-07-14
申请人： ARIZONA BOARD REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY
发明人： TYLER WILLIAM JAMES P
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B5/0476 , A61B5/4836 , A61N5/0613 , A61N5/062 , A61N5/0622 , A61N2005/0651 , A61N2005/0652 , A61N2005/0653 , A61N2005/067 , A61N2007/0021 , A61N2007/0026 , A61N2007/0073 , A61N2007/0078 , C12N5/0619 , C12N13/00

46. 发明公开

EP2337489A1 DEVICES, APPARATUS AND METHOD FOR PROVIDING PHOTOSTIMULATION AND IMAGING OF STRUCTURES 审中-公开
标题翻译：设备，装置和方法中提供照片起搏和画面结构的
公开(公告)号：EP2337489A1
公开(公告)日：2011-06-29
申请号：EP09816957.6
申请日：2009-09-25
申请人： The Trustees of Columbia University in the City of New York
发明人： NIKOLENKO, Volodymyr , YUSTE, Rafael , WATSON, Brendon, O. , PETERKA, Darcy
IPC分类号： A61B5/00
CPC分类号： G02B27/46 , A61N5/0622 , G01N21/6458 , G01N2021/653 , G01N2201/0221 , G02B21/0004
摘要： According to exemplary embodiments of the present disclosure, it is possible to provide method, system, arrangement, computer-accessible medium and device to stimulate individual neurons in brain slices in any arbitrary spatio-temporal pattern, using two-photon uncaging of photo-sensitive compounds such as MNI- glutamate and/or RuBi-Glutamate with beam multiplexing. Such exemplary method and device can have single-cell and three-dimensional precision. For example, by sequentially stimulating up to a thousand potential presynaptic neurons, it is possible to generate detailed functional maps of inputs to a cell. In addition, it is possible to combine this exemplary approach with two-photon calcium imaging in an all-optical method to image and manipulate circuit activity. Further exemplary embodiments of the present disclosure can include a light-weight, compact portable device providing for uses in a wide variety of applications.

47. 发明公开

EP2040790A4 APPARATUS AND METHOD FOR STIMULATION OF BIOLOGICAL TISSUE 有权
标题翻译： DEVICE AND METHOD FOR起搏生物组织
公开(公告)号：EP2040790A4
公开(公告)日：2011-05-25
申请号：EP07798698
申请日：2007-06-18
申请人： HIGHLAND INSTRUMENTS INC
发明人： WAGNER TIMOTHY ANDREW , EDEN URI TZVI
IPC分类号： A61N1/36
CPC分类号： A61N1/36014 , A61B8/0816 , A61F7/00 , A61F2007/0002 , A61H1/005 , A61N1/20 , A61N1/32 , A61N1/36003 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/362 , A61N1/40 , A61N2/002 , A61N2/006 , A61N2/02 , A61N5/0622 , A61N7/00 , A61N7/02 , A61N2007/0026
摘要： An apparatus for generating focused currents in biological tissue is provided. The apparatus comprises an electric source capable of generating an electric field across a region of tissue and means for altering the permittivity of the tissue relative to the electric field, whereby a displacement current is generated. The means for altering the permittivity may be a chemical source, optical source, mechanical source, thermal source, or electromagnetic source.

48. 发明公开

EP1919497A4 LIGHT-ACTIVATED CATION CHANNEL AND USES THEREOF 审中-公开
标题翻译：光激活的阳离子通道及其用途
公开(公告)号：EP1919497A4
公开(公告)日：2009-04-15
申请号：EP06824781
申请日：2006-07-24
申请人： UNIV LELAND STANFORD JUNIOR
发明人： BOYDEN EDWARD S , DEISSEROTH KARL
IPC分类号： C12N5/06 , C12N5/10
CPC分类号： G01N33/6872 , A01K2217/05 , A01K2227/105 , A01K2227/40 , A01K2227/703 , A01K2227/706 , A61F2/18 , A61K31/137 , A61K31/353 , A61K31/405 , A61K31/4172 , A61K35/30 , A61K38/00 , A61K48/00 , A61L27/3604 , A61N5/0601 , A61N5/062 , A61N5/0622 , C07K14/405 , C07K14/705 , C07K2319/60 , C12N2740/15043 , C12N2740/15071 , G01N2500/04 , G01N2500/10 , Y02A90/26 , Y10S530/82 , A61K2300/00
摘要： The present invention provides compositions and methods for light-activated cation channel proteins and their uses within cell membranes and subcellular regions. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-activated cation channels to specific cells or defined cell populations. In particular the invention provides milliseconds-timescale temporal control of cation channels using moderate light intensities in cells, cell lines, transgenic animals, and humans. The invention provides for optically generating electrical spikes in nerve cells and other excitable cells useful for driving neuronal networks, drug screening, and therapy.

49. 发明公开

EP1853347A1 LIGHT THERAPY DEVICE FOR TREATMENT OF BONE DISORDERS AND BIOSTIMULATION OF BONE AND SOFT TISSUE 有权
标题翻译：光疗仪骨病治疗和生物刺激骨与软件
公开(公告)号：EP1853347A1
公开(公告)日：2007-11-14
申请号：EP06710427.3
申请日：2006-02-17
申请人： Brawn, Peter Robert
发明人： Brawn, Peter Robert
IPC分类号： A61N5/06
CPC分类号： A61N5/0622 , A61N5/0613 , A61N2005/0647 , A61N2005/0652 , A61N2005/0659
摘要： The present invention provides an extra-oral light therapy device including an extra-oral bridge, an intra-oral tray removably connected to the extra-oral bridge, at least one extra-oral light emitting diode ('LED') array removably connected to the extra-oral bridge, and a programmable controller for controlling the extra-oral light therapy device. The present invention alternatively provides an extra-oral light therapy device including a head-set, at least one extra-oral LED array removably attached to the head-set, a connector for removably attaching the head-set to the at least one extra-oral LED array, and a programmable controller for controlling the extra-oral light therapy device. The present invention also provides an external light therapy device including a thin, molded substrate, at least one LED array mounted onto the thin, molded substrate, an attaching means for removably attaching the at least one LED array mounted onto the thin, molded substrate to the area of treatment, and a programmable controller for controlling the external light therapy device. The present invention further provides a method for treating jaw bone disorders and jaw osteonecrosis and biostimulating bone and soft tissue utilizing an extraoral light therapy device and a method for treating and stimulating soft and hard tissue and biostimulating bone utilizing an external light therapy device.

50. 发明公开

EP1642609A1 Augenvorsatz für Stimulationsgerät 有权
标题翻译： AugenvorsatzfürStimulationsgerät
公开(公告)号：EP1642609A1
公开(公告)日：2006-04-05
申请号：EP05090275.8
申请日：2005-09-29
申请人： Klose, Markus
发明人： Klose, Markus
IPC分类号： A61M21/00
CPC分类号： A61M21/00 , A61M2021/0027 , A61M2021/0044 , A61N5/0618 , A61N5/0622 , A61N2005/063 , A61N2005/0648 , A61N2005/0651 , A61N2005/0654 , A61N2005/0663 , A61N2005/0666
摘要： In einem erfindungsgemäßen Augenvorsatz für ein Stimulationsgerät zum Stimulieren des Zentralnervensystems und der Gehirnströme eines Menschen mittels variierender Lichtsignale, welcher derart ausgestaltet ist, dass er vor den Augen getragen die Augen gegen Lichteinfall von außen abschirmt und der mindestens eine Lichtquelle (12) zum Abgeben der variierenden Lichtsignale umfasst, ist die mindestens eine Lichtquelle (12) derart am Augenvorsatz angeordnet oder in diesen integriert, dass ihr Licht die Augen nicht direkt erreicht. Außerdem ist wenigstens ein von der mindestens einen Lichtquelle (12) beleuchtetes Element (1) derart in den Augenvorsatz integriert oder an diesem angeordnet, dass das Licht der Lichtquelle (12) die Augen über das wenigstens eine beleuchtete Element (1) indirekt erreicht.
摘要翻译：用于通过用保持在具有上侧（2）的透明板（1）中的一个光源（12）呈现的变化的光元件来刺激人的中枢神经系统的眼睛分辨率。

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