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    • 47. 发明授权
    • MULTI-PROTOCOL TELECOMMUNICATIONS ROUTING OPTIMIZATION
    • 多协议电信路由优化
    • EP0931408B1
    • 2009-03-25
    • EP97913858.3
    • 1997-10-30
    • Connect One, Inc.
    • KAPLAN, Allen, D.McCARTHY, William, F.
    • H04M7/00H04M3/42H04L12/56
    • H04L45/123H04L12/5692H04L12/64H04L29/06H04L41/08H04L43/0852H04L45/124H04L69/18
    • A telecommunications switching system employing multi-protocol routing optimization which utilizes predetermined and measured parameters in accordance with a set of user priorities in determining the selection of a telecommunications path to be utilized for transmitting a data file to a remote destination. The switching system has a first memory for storing the data file to be transferred, a second memory for storing predetermined parameters such as cost data associated with each of the telecommunications paths, a third memory for storing a set of user priorities regarding the transmission of data files, and means for measuring the value of variable parameters such as file transfer speed associated with each of the telecommunications paths. Processor means are operatively associated with the second and third memories and the variable parameter measuring means for determining which of the plurality of telecommunications paths should be utilized for transferring the data file in accordance with the set of user priorities, the predetermined telecommunications path parameters, and the measured variable parameters. The switching system further comprises input means for allowing a user to change the user priorities in the third memory prior to transmitting a file.
    • 采用多协议路由优化的电信交换系统(10)根据一组用户优先级利用预定的和测量的参数来确定选择要用于传送数据文件到远程目的地的电信路径。 交换系统(10)具有用于存储数据文件的第一存储器(30),用于存储预定参数的第二存储器(22),用于存储一组用户优先级(32)的第三存储器,用于测量 与每个电信路径相关的可变参数的值以及处理器装置(26)与第二和第三存储器(22和23)以及用于确定多个电信路径中的哪一个应该被利用的可变参数 。
    • 50. 发明公开
    • INHIBITION OF THE TUMORIGENIC POTENTIAL OF TUMOR STEM CELLS BY LIF AND BMPS
    • HEMMUNG DES TUMORERZEUGENDEN潜力VON TUMOR-STAMMZELLEN DURCH LIF UND BMPS
    • EP1904093A2
    • 2008-04-02
    • EP06795317.4
    • 2006-07-19
    • Stemgen S.P.A.
    • VESCOVI, Angelo LuigiREYNOLDS, Brent Allan
    • A61K38/18A61P35/00
    • A61K38/2093A61K31/495A61K38/1875A61K45/06
    • The present disclosure includes methods and compositions for the treatment or prevention of diseases and disorders characterized by excessive or misregulated cellular proliferations, including methods for the treatment of tumors. The methods involve the use of pharmaceutical compositions comprising at least one agent selected from the group consisting of a LIF preparation, a BMP preparation, a BMPR signalling activator, and a LIFR signalling activator. The disclosure also includes LIF preparations, BMP preparations, BMPR signalling activator, and LIFR signalling activators, and methods for the identification of LIF preparations, BMP preparations, BMPR signalling activator, and LIFR signalling activators. The disclosure also includes pharmaceutical compositions comprising at least one agent selected from the group consisting of a LIF preparation, a BMP preparation, a BMPR signalling activator, and a LIFR signalling activator.
    • 本公开包括用于治疗或预防以过度或不正常的细胞增殖为特征的疾病和病症的方法和组合物,包括治疗肿瘤的方法。 所述方法包括使用包含至少一种选自LIF制剂,BMP制剂,BMPR信号传导激活剂和LIFR信号激活剂的药物组合物。 本公开还包括LIF制剂,BMP制剂,BMPR信号传导活化剂和LIFR信号传导激活剂,以及用于鉴定LIF制剂,BMP制剂,BMPR信号激活剂和LIFR信号传导激活剂的方法。 本公开还包括药物组合物,其包含至少一种选自LIF制剂,BMP制剂,BMPR信号传导激活剂和LIFR信号激活剂的药剂。