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31. 发明授权

EP2225206B1 AMINOBENZAMIDE DERIVATIVES AS USEFUL AGENTS FOR CONTROLLING ANIMAL PARASITES 有权转让
公开(公告)号：EP2225206B1
公开(公告)日：2019-02-27
申请号：EP08865336.5
申请日：2008-12-09
申请人： Bayer CropScience AG
发明人： GÖRGENS, Ulrich , YANAGI, Akihiko , WADA, Katsuaki , MURATA, Tetsuya , WATANABE, Yukiyoshi , MIHARA, Jun , ARAKI, Koichi
IPC分类号： C07D213/60 , C07C237/42 , A01N37/22 , A01N43/40

32. 发明授权

EP3124472B1 FUSED TRICYCLIC COMPOUNDS AS RAF KINASE INHIBITORS 有权
公开(公告)号：EP3124472B1
公开(公告)日：2018-07-25
申请号：EP16167542.6
申请日：2011-12-31
申请人： BeiGene, Ltd.
发明人： ZHOU, Changyou , WANG, Shaohui , ZHANG, Guoliang
IPC分类号： C07D213/60 , C07D401/04 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , A61K31/4353 , A61K31/4427 , A61K31/506 , A61K31/519 , A61P35/00
CPC分类号： A61K31/5365 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/506 , A61K31/52 , C07D405/14 , C07D471/04 , C07D473/30 , C07D498/04 , C07D519/00
摘要： Provided are fused tricyclic compounds of formula V and salts thereof, compositions thereof, and methods of use therefor.

33. 发明授权

EP3000805B1 C7-FLUORO SUBSTITUTED TETRACYCLINE COMPOUNDS 失效
标题翻译： C7-氟取代的四环素化合物
公开(公告)号：EP3000805B1
公开(公告)日：2017-10-18
申请号：EP15180611.4
申请日：2009-08-07
申请人： Tetraphase Pharmaceuticals, Inc.
发明人： Zahler, Robert B. , Clark, Roger B. , Hunt, Diana Katharine , Plamondon, Louis , Xiao, Xiao-Yi , Zhou, Jingye
IPC分类号： C07C237/26 , C07C239/20 , C07C275/00 , C07C311/00 , C07D205/04 , C07D207/02 , C07D209/02 , C07D211/04 , C07D213/60 , C07D231/10 , C07D239/42 , C07D249/04 , C07D257/04 , C07D261/18 , C07D277/56 , C07D333/26 , C07D295/04 , A61K31/165 , A61K31/395 , A61P31/04
CPC分类号： C07C233/57 , A61K31/65 , A61K45/06 , C07C311/08 , C07C311/21 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/34 , C07D209/94 , C07D211/60 , C07D211/76 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/61 , C07D239/42 , C07D249/04 , C07D257/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D295/088 , C07D295/12 , C07D295/15 , C07D295/26 , C07D311/08 , C07D333/34 , C07D333/38 , C07D413/12 , Y02A50/402 , Y02A50/406 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要： The present invention is directed to a compound falling under Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.

34. 发明公开

EP2758375A1 AMIDE COMPOUNDS, COMPOSITIONS AND APPLICATIONS THEREOF 审中-公开
标题翻译： AMIDVERBINDUNGEN，ZUSAMMENSETZUNGEN UND ANWENDUNGEN DAVON
公开(公告)号：EP2758375A1
公开(公告)日：2014-07-30
申请号：EP12787909.6
申请日：2012-09-21
申请人： Advinus Therapeutics Limited
发明人： KHARUL, Rajendra , BHUNIYA, Debnath , MOOKHTIAR, Kasim A. , SINGH, Umesh , HAZARE, Atul , PATIL, Satish , DATRANGE, Laxmikant , THAKKAR, Mahesh
IPC分类号： C07D213/60 , C07D241/14 , C07D401/12 , C07D413/12 , A61K31/33 , A61P25/00
CPC分类号： C07D401/12 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/675 , A61K45/06 , C07D213/75 , C07D401/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07F9/65616
摘要： The present disclosure relates to substituted amide compounds that are inhibitors of Fatty Acid Amide Hydrolase (FAAH), their stereoisomers, tautomers, prodrugs, polymorphs, solvates, pharmaceutically acceptable salts, and pharmaceutical compositions containing them. These compounds are useful in the treatment, prevention, prophylaxis, management, or adjunct treatment of all medical conditions related to inhibition of Fatty Acid Amide Hydrolase (FAAH), such as pain including acute and post operative pain, chronic pain, cancer pain, cancer chemotherapy induced pain, neuropathic pain, nociceptive pain, inflammatory pain, back pain, pain due to disease of various origin such as: diabetic neuropathy, neurotropic viral disease including human immunodeficient virus (HIV), herpes zoster such as post herpetic neuralgia; polyneuropathy, neurotoxicity, mechanical nerve injury, carpal tunnel syndrome, immunologic mechanisms like multiple sclerosis; sleep disorders, anxiety and depression disorders, inflammatory disorders, weight and eating disorders, Parkinson's disease, addiction, spasticity, hypertension or other disorders. The disclosure also relates to the process of preparation of the amide compounds. Formula (1). The present disclosure also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.
摘要翻译：本公开涉及作为脂肪酸酰胺水解酶（FAAH），其立体异构体，互变异构体，前药，多晶型物，溶剂合物，药学上可接受的盐和含有它们的药物组合物的抑制剂的取代的酰胺化合物。这些化合物可用于治疗，预防，预防，治疗或辅助治疗与抑制脂肪酸酰胺水解酶（FAAH）相关的所有医学病症，如疼痛，包括急性和术后疼痛，慢性疼痛，癌症疼痛，癌症化疗引起的疼痛，神经性疼痛，伤害性疼痛，炎症性疼痛，背痛，各种原因疾病引起的疼痛，如：糖尿病性神经病，包括人类免疫缺陷病毒（HIV）在内的神经营养性病毒性疾病，疱疹后遗神经痛等带状疱疹; 多发性神经病，神经毒性，机械性神经损伤，腕管综合征，多发性硬化等免疫机制; 睡眠障碍，焦虑和抑郁症，炎性疾病，体重和进食障碍，帕金森病，成瘾，痉挛，高血压或其他障碍。本公开还涉及酰胺化合物的制备方法。本公开还涉及制备这些化合物的方法以及含有它们的药物组合物。

35. 发明授权

EP2439193B1 Dérivés de 5,6-bisaryl-2-pyridine-carboxamide, leur préparation et leur application en thérapeutique comme antagonistes des recepteurs a l'urotensine II 有权
标题翻译： 5,6-二芳基-2-吡啶甲酰胺衍生物，它们的制备和治疗用途作为尾加压素II受体拮抗剂
公开(公告)号：EP2439193B1
公开(公告)日：2014-04-23
申请号：EP11188580.2
申请日：2007-08-09
申请人： SANOFI
发明人： Altenburger, Jean-Michel , Fossey, Valerie , Lassalle, Gilbert , Petit, Frédéric , Vernieres, Jean-Claude , Janiak, Philip
IPC分类号： C07D213/60 , C07D241/10 , C07D401/04 , A61K31/435 , A61P9/00
CPC分类号： C07D213/81 , C07C235/42 , C07D213/82 , C07D241/24 , C07D241/26 , C07D241/28 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D417/04

36. 发明授权

EP1940814B1 PIPERAZINE DERIVATIVES AS ANTIMALARIAL AGENTS 有权
标题翻译：哌嗪衍生物作为抗疟疾资源
公开(公告)号：EP1940814B1
公开(公告)日：2013-05-22
申请号：EP06809659.3
申请日：2006-10-20
申请人： Actelion Pharmaceuticals Ltd.
发明人： BINKERT, Christoph , BOSS, Christoph , CORMINBOEUF, Olivier , GRISOSTOMI, Corinna , MEYER, Solange
IPC分类号： C07D295/18 , C07D209/04 , C07D209/16 , C07D213/26 , C07D213/38 , C07D213/40 , C07D213/60 , C07D213/74 , C07D217/04 , C07D217/14 , C07D233/54 , C07D239/42 , C07D277/28 , C07D307/14 , C07D317/58
CPC分类号： C07D295/185 , C07D209/04 , C07D209/16 , C07D213/26 , C07D213/38 , C07D213/40 , C07D213/60 , C07D213/74 , C07D217/04 , C07D217/14 , C07D233/64 , C07D239/42 , C07D277/28 , C07D307/14 , C07D317/58 , C07D333/20 , C07D333/28 , C07D333/58

37. 发明公开

EP2516396A1 THERAPEUTIC COMPOUNDS 审中-公开
标题翻译：治疗性化合物
公开(公告)号：EP2516396A1
公开(公告)日：2012-10-31
申请号：EP10798937.8
申请日：2010-12-23
申请人： Wayne State University , Sanford-Burnham Medical Research Institute , Fontana, Joseph A. , Dawson, Marcia , Xia, Zebin
发明人： FONTANA, Joseph, A. , DAWSON, Marcia , XIA, Zebin
IPC分类号： C07D213/06 , C07D213/60 , C07D239/26 , C07D239/42 , A61K31/435 , A61K31/495 , A61P35/02
CPC分类号： C07D241/12 , A61K31/4965 , A61K31/497 , A61K31/505 , C07D213/06 , C07D213/55 , C07D213/60 , C07D237/08 , C07D239/26 , C07D239/42
摘要： The invention provides compounds of formula I or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for inducing apoptosis or treating cancer using compounds of formula I.
摘要翻译：本发明提供如本文所述的式I的化合物或其盐。本发明还提供了包含式I化合物的药物组合物，制备式I化合物的方法，可用于制备式I化合物的中间体和使用式I化合物诱导细胞凋亡或治疗癌症的治疗方法。

38. 发明授权

EP2059508B1 DERIVES DE 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE COMME ANTAGONISTES DES RECEPTEURS A L'UROTENSINE II 有权
标题翻译： 5,6-双 - 芳基-2-甲酰胺吡啶衍生物及其在治疗学AS尾加压素II受体拮抗剂制备和用途
公开(公告)号：EP2059508B1
公开(公告)日：2012-04-11
申请号：EP07823409.3
申请日：2007-08-09
申请人： SANOFI
发明人： ALTENBURGER, Jean-Michel , FOSSEY, Valerie , LASSALLE, Gilbert , PETIT, Frédéric , VERNIERES, Jean-Claude , JANIAK, Philip
IPC分类号： C07D213/60 , C07D241/10 , C07D401/04 , A61K31/435 , A61P9/00
CPC分类号： C07D213/81 , C07C235/42 , C07D213/82 , C07D241/24 , C07D241/26 , C07D241/28 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D417/04
摘要： The invention relates to compounds having the formula (I): wherein X, Y, U, A, B, W, Z, R1 and R2 are as defined in the description. Method of preparation and application in therapeutics.

39. 发明授权

EP0400440B1 Amino acid derivative anticonvulsant 失效
标题翻译：抗惊厥氨基酸衍生物
公开(公告)号：EP0400440B1
公开(公告)日：2002-03-13
申请号：EP90109596.8
申请日：1990-05-21
申请人： RESEARCH CORPORATION TECHNOLOGIES, INC.
发明人： Kohn, Harold L. , Watson, Darrell
IPC分类号： C07D307/54 , C07D333/40 , C07D207/40 , C07D213/60 , A61K31/16 , A61K31/38 , A61K31/34 , A61K38/00 , A61P25/08
CPC分类号： C07D295/15 , C07C237/22 , C07D207/34 , C07D209/42 , C07D307/54 , C07D307/85 , C07D333/38 , C07D333/70

40. 发明公开

EP1077919A1 NEW COMPOUNDS, THEIR PREPARATION AND USE 审中-公开
标题翻译：新化合物，其生产和使用
公开(公告)号：EP1077919A1
公开(公告)日：2001-02-28
申请号：EP99917799.1
申请日：1999-05-04
申请人： NOVO NORDISK A/S
发明人： MURRAY, Anthony , HANSEN, John, Bondo
IPC分类号： C07C57/50 , C07C59/72 , C07C63/44 , C07C65/24 , C07D213/60 , C07D213/24 , A61K31/19 , A61K31/44
CPC分类号： C07C59/72 , C07C57/50 , C07C63/66 , C07C65/26
摘要： The present invention provides novel compounds of general formula (I) wherein R1, R2, W, Z and R5 to R9 are defined more fully in the description. The compounds are useful in the treatment of ailments and disorders where a reduction of the blood glucose is beneficial, such as diabetes.

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