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31. 发明公开

EP0016660A1 Thio-bis-(hydrocarbon-bisoxazolines) and analogs, process for their preparation and their use as oleaginous additives 失效
标题翻译：硫代 - 双 - （烃基二恶唑啉）及其类似物，它们的制备方法和它们作为油添加剂的用途。
公开(公告)号：EP0016660A1
公开(公告)日：1980-10-01
申请号：EP80300942.2
申请日：1980-03-26
申请人： EXXON RESEARCH AND ENGINEERING COMPANY
发明人： Brois, Stanley James , Gutierrez, Antonio
IPC分类号： C07D263/14 , C10L1/24 , C10M1/38
CPC分类号： C10L1/2493 , C07D263/14 , C07D307/60 , C10M135/32 , C10M2219/09 , C10N2210/06 , C10N2240/08 , C10N2270/02
摘要： Thio-bis-(hydrocarbon-bisoxazolines) and analogs, which are the reaction products of thio-bis-(hydrocarbon-substituted dicarboxylic acid material), for example, thio-bis-(polyisobutenyl succinic anhydride), with about 1 to 4 moles of 2,2-disubstituted-2-amino-l-alkanols, such as tris -(hydroxymethyl) amino-methane (THAM), and their derivatives are useful additives in oleaginous compositions, such as sludge dispersants for lubricating oil or anti-corrosion agents for fuels.
摘要翻译：硫代双（烃基双恶唑啉）和类似物，它们是硫代二（烃 - substituiertem二羧酸材料），对于实施例的反应产物，硫代双（，聚异丁烯酸酐），具有约1至4摩尔 2,2-二取代-2-氨基-1-烷醇，：如三 - （羟甲基）氨基甲烷（THAM），和它们的衍生物是在油质组合物，：如污泥分散剂有用的添加剂用于润滑油或防腐蚀剂为燃料。

32. 发明公开

EP0002812A2 Phenoxy-alkyl-oxazoline, ihre Herstellung, sie enthaltende Mittel sowie deren Verwendung als Herbizide 失效
标题翻译：苯氧基烷基 - 恶唑啉，它们的制备，含有它们和它们作为除草剂的用途的组合物。
公开(公告)号：EP0002812A2
公开(公告)日：1979-07-11
申请号：EP78101806.4
申请日：1978-12-21
申请人： CIBA-GEIGY AG
发明人： Föry, Werner, Dr. , Rempfler, Hermann, Dr. , Pissiotas, Georg, Dr. , Rohr, Otto, Dr. , Böhner, Beat, Dr.
IPC分类号： C07D263/14 , C07D413/12 , A01N43/76
CPC分类号： C07D263/14 , A01N43/76
摘要： Es werden neue Phenoxy-alkyl-oxazoline und Verfahren zu deren Herstellung offenbart. Diese Oxazoline entsprechen der Formel
worin

R Wasserstoff oder Methyl
Z einen substituierten Phenyl- oder Pyridylrest,

R, Halogen, Trifluormethyl, Cyano, Nitro,
R 2 Wasserstoff, Halogen, Cyano,
R 3 Halogen, Trifluormethyl, Cyano und
n die Zahl 1 oder 2 bedeuten. Diese Verbindungen haben herbizide Wirkung.
摘要翻译： Phenoxyalkyloxyzolines对应于式 worin R是氢或甲基，Z为苯基或吡啶基 R 1为卤素，三氟甲基，氰基或硝基R 2是氢，卤素或氰基R 3为卤素三氟甲基或氰基和n 为1或2是有效的除草剂是对谷物宽容。

33. 发明公开

EP0001492A1 Certain oxazolines as load-carrying additives for gear oils 失效
标题翻译： Oxazolinderivate alsZusätzefürdie Belastungseigenschaften vonGetriebeölen。
公开(公告)号：EP0001492A1
公开(公告)日：1979-04-18
申请号：EP78300423.7
申请日：1978-09-27
申请人： MOBIL OIL CORPORATION
发明人： Andress, Harry John Jr.1501 E. Elm Street
IPC分类号： C10M1/32 , C10M3/26 , C07D263/14
CPC分类号： C07D263/14 , C10M133/48 , C10M2201/14 , C10M2203/06 , C10M2205/026 , C10M2205/028 , C10M2207/04 , C10M2207/281 , C10M2207/282 , C10M2207/283 , C10M2207/286 , C10M2207/34 , C10M2209/00 , C10M2209/02 , C10M2209/10 , C10M2209/104 , C10M2209/105 , C10M2211/02 , C10M2215/102 , C10M2215/22 , C10M2215/221 , C10M2215/225 , C10M2215/226 , C10M2215/30 , C10M2223/04 , C10M2223/042 , C10M2227/02 , C10M2227/04 , C10M2227/081 , C10M2229/02 , C10M2229/05 , C10N2240/02 , C10N2240/08
摘要： Load-carrying properties of gear oils are increased by the addition of a naphthenyl oxazoline or an alkenylsuccinyl mono- or bis-oxazoline.
摘要翻译：通过加入萘并恶唑啉或链烯基琥珀酰基单 - 或双 - 恶唑啉来增加齿轮油的载重性能。

34. 发明授权

EP2321269B1 PROCESS FOR PREPARING OXAZOLINE-PROTECTED AMINODIOL COMPOUNDS USEFUL AS INTERMEDIATES TO FLORFENICOL 有权
公开(公告)号：EP2321269B1
公开(公告)日：2018-09-19
申请号：EP09790863.6
申请日：2009-07-28
申请人： Intervet International B.V.
发明人： PAQUETTE, Leo, A. , TOWSON, James, C.
IPC分类号： C07D263/14 , C07C315/04 , C07D263/16
CPC分类号： C07C315/04 , C07B2200/07 , C07D263/14 , C07D263/16 , C07C317/32
摘要： Processes for preparing oxazoline compounds are disclosed. These oxazoline compounds are useful intermediates in the preparation of Florfenicol and related compounds.

35. 发明公开

EP3138844A1 COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT 有权
标题翻译：化合物用于生产免疫学AJDUVANS
公开(公告)号：EP3138844A1
公开(公告)日：2017-03-08
申请号：EP16192172.1
申请日：2006-06-30
申请人： Eisai R&D Management Co., Ltd.
发明人： FANG, Francis G. , FOY, James E. , HAWKINS, Lynn , LEMELIN, Charles , LESCARBEAU, Andre , NIU, Xiang , WU, Kuo-ming
IPC分类号： C07F9/09 , C07F9/24 , C07F9/141 , C07D263/14 , C07C271/16 , C07C217/28
CPC分类号： C07D263/14 , C07C217/28 , C07C271/16 , C07F9/091 , C07F9/1411 , C07F9/2408
摘要： The present invention provides synthetic intermediates useful in preparing preparing TLR-4 receptor agonist E6020 .
摘要翻译：本发明提供了在制备制备TLR-4受体激动剂E6020有用的合成中间体。

36. 发明授权

EP1910387B1 COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT 有权转让
标题翻译：化合物用于免疫佐剂生产
公开(公告)号：EP1910387B1
公开(公告)日：2016-11-16
申请号：EP06785934.8
申请日：2006-06-30
申请人： Eisai R&D Management Co., Ltd.
发明人： FANG, Francis G. , FOY, James E. , HAWKINS, Lynn , LEMELIN, Charles , LESCARBEAU, Andre , NIU, Xiang , WU, Kuo-ming
IPC分类号： C07F9/09 , C07F9/24 , C07F9/141 , C07D263/14 , C07C271/16 , C07C217/28
CPC分类号： C07D263/14 , C07C217/28 , C07C271/16 , C07F9/091 , C07F9/1411 , C07F9/2408

37. 发明公开

EP2671877A1 METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND OR SALT THEREOF 审中-公开
标题翻译：工艺制备光学活性化合物或其盐
公开(公告)号：EP2671877A1
公开(公告)日：2013-12-11
申请号：EP12742476.0
申请日：2012-01-31
申请人： Nagasaki University
发明人： ONOMURA, Osamu , TSUDA, Yutaro , KURIYAMA, Masami , YANAGI, Toshiharu , KODAMA, Kazuya
IPC分类号： C07D263/14 , C07B61/00
CPC分类号： C07D263/14 , C07B53/00 , C07D413/04 , C07D417/04
摘要： Provided is a production process in which an optically active oxazoline is synthesized from an optically inactive compound as a starting compound with fewer production steps. In particular, provided is a process for producing an optically active compound represented by Formula (3):

(wherein R 1 is an alkyl group, an alkynyl group, an alkenyl group, an aliphatic heterocyclic group, a cycloalkyl group, an aryl group, an aralkyl group, or an aromatic heterocyclic group, and any hydrogen atom of R 1 may be replaced with a substituent; R 2 is a hydrogen atom or a group which is not reactive in the reaction below; and * represents a chiral center) or a salt thereof by subjecting a compound represented by Formula (1):

(wherein R 1 and R 2 have the same meanings as defined in Formula (3)) to a ring closure reaction in the presence of a chiral ligand having 1 or more coordination sites, a Lewis acid represented by Formula (2):

MmZn (2)

(wherein M is a metal ion, Z is a counter anion of M, and m and n are integers of 1 to 4), and a sulfonyl halide having an optionally substituted alkyl or phenyl group.
摘要翻译：提供了一种在其中光学活性的恶唑啉是从光学非活性化合物的合成为用较少的制造工序的原料化合物的制造方法。特别地，提供了一种用于在由式I表示的光学活性化合物来制造方法（3）：（其中R 1是烷基，在炔基，在链烯基，在脂肪族杂环基，环烷基，以芳基，在芳烷基，或芳族杂环基团，且R 1中的任意氢原子可以被取代基取代; R 2为氢原子或基团的所有这不是在下面的反应的反应性;和* darstellt手性中心）或其盐通过使由通式表示的化合物（1）：（worin R 1和R 2具有定义（式3）相同的含义），以在手性配体的存在具有1个或多个协调闭环反应位点，路易斯酸由式（2）表示：€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒMmZn€ƒ€ƒ€ƒ€ƒ€ƒ（2）（其中M是金属离子， Z是m的平衡阴离子，m和n分别为1〜4），以及具有在任选取代的烷基或苯基磺酰卤整数。

38. 发明公开

EP2307337A2 NUCLEOPHILIC FLUORINATION OF AROMATIC COMPOUNDS 有权
标题翻译：核氟化芳烃
公开(公告)号：EP2307337A2
公开(公告)日：2011-04-13
申请号：EP09788911.7
申请日：2009-07-13
申请人： The Regents Of The University Of California
发明人： SATYAMURTHY, Nagichettiar , BARRIO, Jorge, R.
IPC分类号： C07B59/00 , C07D233/32 , C07D263/14 , C07D263/18 , C07D277/66 , C07C269/06
CPC分类号： C07B59/00 , C07C17/093 , C07C45/63 , C07C201/12 , C07C223/02 , C07C229/36 , C07C251/24 , C07C253/30 , C07C271/22 , C07D233/32 , C07D263/14 , C07D263/18 , C07D277/66 , C07C25/18 , C07C25/13 , C07C47/55 , C07C49/807 , C07C255/50 , C07C205/12
摘要： Iodylbenzene derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are used as precursors in aromatic nucleophilic substitution reactions. The iodyl group (IO
2 ) is regiospecifically substituted by nucleophilic fluoride to provide the corresponding fluoroaryl derivatives. No-carrier-added [F-18] fluoride ion derived from anhydrous [F- 18]KF/Kryptofix, [F-18]CsF or a quaternary ammonium fluoride (e.g., Me
4 NF, Et
4 NF, n-Bu
4 NF, (PhCH
2 )
4 NF) exclusively substitutes the iodyl moiety in these derivatives and provides high specific activity F- 18 labeled fluoroaryl analogs. Iodyl derivatives of a benzothiazole analog and 6-iodyl-L-dopa derivatives have been synthesized as precursors and have been used in the preparation of no-carrier-added [F-18]fluorobenzothiazole as well as 6-[F-18]fluoro-L-dopa.

39. 发明公开

EP1802593A2 POLYMER-FILLER COUPLING ADDITIVES 有权
标题翻译：连接附件用于聚合物填料
公开(公告)号：EP1802593A2
公开(公告)日：2007-07-04
申请号：EP05815966.6
申请日：2005-10-20
申请人： Bridgestone Corporation
发明人： FUKUSHIMA, Yasuo , HERGENROTHER, William , KOCH, Russell , ARAKI, Sunji
IPC分类号： C07D263/14 , C07D277/10 , C08K5/32 , C08K5/3415 , C08L21/00
CPC分类号： C08K5/353 , C07D263/14 , C07D277/10 , C08K5/32 , C08L21/00
摘要： The dispersion of fillers such as carbon black, oxidized carbon black, silica, other mineral fillers, or mixtures thereof in polymeric compositions is improved by the use of a polymer-filler coupling compound, Q-A-B. In polymer-filler coupling compound Q-A-B, Q is a dipolar nitrogen-containing moiety that can form a 1,3 dipolar addition to an unsaturated carbon-carbon bond; B is an oxazoline, thiazoline, alkoxysilane or allyltin moiety, and A is a linking atom or group that forms a bridge between Q and B.

40. 发明公开

EP1698617A4 METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLOALKYLIDENE BISOXAZOLINE COMPOUND AND INTERMEDIATE THEREOF 审中-公开
标题翻译：方法制备光学活性CYCLOALKYLIDENBISOXAZOLINVERBINDUNG和中间THEREFOR
公开(公告)号：EP1698617A4
公开(公告)日：2007-01-24
申请号：EP04808018
申请日：2004-12-21
申请人： SUMITOMO CHEMICAL CO
发明人： ITAGAKI MAKOTO
IPC分类号： C07C233/60 , C07D263/12 , C07D263/14
CPC分类号： C07D263/52 , C07C233/60 , C07D263/12 , C07D263/14
摘要： Disclosed is an optically active cycloalkylidene bisamidoalcohol compound represented by the following formula (3): (3) (wherein R1 represents a C1-6 alkyl group, an optionally substituted phenyl group, an optionally substituted aralkyl group or a hydrogen atom, or two R1s bonded to a same carbon atom form a ring together with the carbon atom; R2 represents a C1-6 alkyl group, an optionally substituted aralkyl group or an optionally substituted phenyl group; and * represents an asymmetric center). Also disclosed is a method for producing such an optically active cycloalkylidene bisamidoalcohol compound. Further disclosed is a method for producing an optically active cycloalkylidene bisoxazoline compound represented by the following formula (4): (4) (wherein R1, R2 and * are as defined above).

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