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31. 发明公开

EP2985349A1 DEVICE FOR DETECTION OF ANALYTES 有权
标题翻译： VORRICHTUNG ZUR ERKENNUNG VON ANALYTEN
公开(公告)号：EP2985349A1
公开(公告)日：2016-02-17
申请号：EP15184922.1
申请日：2005-11-23
申请人： TechLab, Inc.
发明人： BOONE, James, H. , LYERLY, David, M. , WILKINS, Tracy, D.
IPC分类号： C12Q1/00 , G01N33/53 , G01N33/554 , G01N33/567 , C12M1/36 , C12M1/38 , C12M3/00 , G01N33/558 , G01N33/543
CPC分类号： G01N33/54366 , G01N33/573 , G01N33/6803 , G01N33/6845 , G01N2333/33 , G01N2333/79 , G01N2333/906 , G01N2333/90611 , G01N2333/90616 , G01N2333/91097
摘要： The present invention discloses a device for detecting at least one substance of interest in a liquid sample, the device comprising:
(a) a receptacle comprising a porous material for receiving the liquid sample, wherein the porous material is capable of absorbing and transmitting at least a portion of the liquid sample, and
(b) a porous membrane that comprises a specific binding pair member that is specific for the substance of interest or a substance bound to the substance of interest, wherein the specific binding pair member is an antibody,

wherein the receptacle and porous membrane are each shaped to permit the porous membrane to be in direct contact with the porous material over at least a portion of the porous membrane that comprises the specific binding pair member,
wherein the porous material is in physical contact with a bottom side of the porous membrane comprising the specific binding pair member, the specific binding pair member being located above the porous material, the porous membrane being in direct contact with the porous material at a site where the specific binding pair member is located.
摘要翻译：本发明公开了一种用于检测液体样品中至少一种感兴趣物质的装置，该装置包括：（a）容器，包括用于接收液体样品的多孔材料，其中多孔材料能够至少吸收和传播液体样品的一部分，和（b）多孔膜，其包含特异性结合对成员，所述特异性结合对成员对所述目的物质特异性或与所述目的物质结合的物质，其中所述特异性结合对成员是抗体，其中容器和多孔膜各自被成形为允许多孔膜在包括特定结合对构件的多孔膜的至少一部分上与多孔材料直接接触，其中多孔材料与底部物理接触所述多孔膜的一侧包括特定的结合对构件，所述特异性结合对构件位于多孔材料上方，在与特定结合对构件所处的位置处直接接触多孔材料。

32. 发明公开

EP2844283A1 CLOSTRIDIUM DIFFICILE ANTIGENS 有权转让
标题翻译：艰难梭菌抗原
公开(公告)号：EP2844283A1
公开(公告)日：2015-03-11
申请号：EP13715732.7
申请日：2013-04-04
申请人： The Secretary of State for Health
发明人： SHONE, Clifford , ROBERTS, April , MAYNARD-SMITH, Michael
IPC分类号： A61K39/08 , C07K14/33
CPC分类号： C07K14/33 , A61K39/08 , A61K39/40 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/55566 , C07K16/1282 , C07K16/40 , C07K2317/21 , C07K2317/54 , C07K2317/622 , C07K2317/76 , C12N9/1051 , G01N33/56911 , G01N33/573 , G01N2333/91097 , G01N2469/10 , G01N2469/20
摘要： The present invention relates to recombinant Clostridium difficile antigens based on a polypeptide, consisting of or comprising an amino acid sequence having at least 80% sequence identity with an amino acid sequence consisting of residues 1500-700 of a C. difficile Toxin A sequence or a C. difficile Toxin B sequence; though with the proviso that the polypeptide does not include one or more Repeat Unit (RU) located between amino acid residues 1851-2710 of C. difficile Toxin A and/or residues 1853-2366 of a C. difficile Toxin B protein that consists of or comprises a first amino acid sequence and a second amino acid. Also provided is the use of said antigens for the prevention/treatment/suppression of Clostridium difficile infection (CDI), together with methods for generating said antigens, methods for generating antibodies that bind to said antigens, and the use of said antibodies for the prevention/treatment/suppression of CDI.

33. 发明公开

EP2788371A2 BIOMARKERS AND TEST PANELS USEFUL IN SYSTEMIC INFLAMMATORY CONDITIONS 审中-公开
标题翻译：生物识别技术研究所FÜRSYSTEMISCHEENTZÜNDUNGSERKRANKUNGEN
公开(公告)号：EP2788371A2
公开(公告)日：2014-10-15
申请号：EP12806386.4
申请日：2012-12-07
申请人： Biocartis NV
发明人： VANPOUCKE, Griet , VERLEYSEN, Katleen , VAN HERREWEGE, Yven
IPC分类号： C07K14/00 , G01N33/68
CPC分类号： G01N33/6893 , G01N2333/47 , G01N2333/4727 , G01N2333/705 , G01N2333/70525 , G01N2333/70535 , G01N2333/70542 , G01N2333/7155 , G01N2333/75 , G01N2333/91097 , G01N2333/916 , G01N2333/96425 , G01N2333/96433 , G01N2800/26 , G01N2800/52 , G01N2800/7095
摘要： The application discloses new biomarkers or test panels useful in systemic inflammatory conditions such as sepsis; methods for the diagnosis, prediction, prognosis and/or monitoring systemic inflammatory conditions such as sepsis based on measuring said biomarkers or test panels; and related kits and devices.
摘要翻译：该应用公开了可用于全身炎症病症如败血症的新生物标志物或测试板; 用于诊断，预测，预后和/或监测系统性炎症状况的方法，例如基于测量所述生物标志物或测试板的败血症; 和相关工具包和设备。

34. 发明公开

EP2714923A2 METHODS AND COMPOSITIONS FOR THE DETECTION OF FUNCTIONAL CLOSTRIDIUM DIFFICILE TOXINS 审中-公开
标题翻译：方法和组合物功能艰难梭菌毒素检测
公开(公告)号：EP2714923A2
公开(公告)日：2014-04-09
申请号：EP12792248.2
申请日：2012-05-31
申请人： Board of Regents of the University of Texas System
发明人： DARKOH, Charles , DUPONT, Herbert L. , KAPLAN, Heidi B.
IPC分类号： C12Q1/04 , C12N1/20 , C12Q1/48
CPC分类号： C12Q1/04 , C12Q1/045 , C12Q1/48 , G01N2333/33 , G01N2333/91097 , G01N2500/04
摘要： Methods and compositions for the identification of functional C. difficile toxin, as among other things identifying individuals infected with toxigenic C. difficile and therefore in need of therapy. In specific embodiments, the methods and compositions provide colorimetric assays for cleavage activity of C. difficile toxin.

35. 发明授权

EP2187217B1 DETECTION METHOD OF GYNECOLOGIC CANCER 有权
标题翻译：过程识别妇科肿瘤
公开(公告)号：EP2187217B1
公开(公告)日：2013-11-06
申请号：EP08828673.7
申请日：2008-08-22
申请人： LSIP, LLC
发明人： YAMASHITA, Katsuko , SEKO, Akira , AOKI, Daisuke , SAKAMOTO, Masaru
IPC分类号： C12Q1/48 , C07K16/40 , G01N33/574
CPC分类号： G01N33/57449 , C07K16/40 , C12Q1/48 , G01N33/57442 , G01N2333/91097

36. 发明授权

EP1774037B1 ASSAYS AND METHODS USING BIOMARKERS 有权
标题翻译：测定以及使用生物标志物方法
公开(公告)号：EP1774037B1
公开(公告)日：2011-05-11
申请号：EP05788528.7
申请日：2005-08-03
申请人： Genentech, Inc.
发明人： WAGNER, Klaus W. , ASHKENAZI, Avi J.
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/00 , C07K16/00
CPC分类号： G01N33/573 , C07K16/2878 , C07K16/2896 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/57419 , G01N33/57438 , G01N33/57446 , G01N2333/91091 , G01N2333/91097 , G01N2510/00
摘要： Methods and assays examining expression of one or more biomarkers in a mammalian tissue or cell sample are provided. According to the disclosed methods and assays, detection of the expression of one or more such biomarkers is predictive or indicative that the tissue or cell sample will be sensitive to apoptosis-inducing agents such as Apo2L/TRAIL and anti-DR5 agonist antibodies. Certain biomarkers which may be examined include fucosyltransferases, in particular fucosyltransferase 3 (FUT3) and/or fucosyltransferase 6 (FUT6), as well as sialyl Lewis A and/or X antigens. Kits and articles of manufacture are also provided.

37. 发明公开

EP2270028A1 BIOMOLECULE-IMMOBILIZED CARRIER AND METHOD FOR IMMOBILIZING BIOMOLECULE ON CARRIER 有权
标题翻译： BIOMOLEKÜLIMMOBILISIERTE载体和方法用于生物分子的固定在载体
公开(公告)号：EP2270028A1
公开(公告)日：2011-01-05
申请号：EP09711582.8
申请日：2009-02-20
申请人： National University Corporation Hokkaido University
发明人： NISHIMURA, Shin-Ichiro, c/o Nat. Univ. Corp. Hokkaido University , NARUCHI, Kentaro, c/o National Univ. Corp. Hokkaido University,
IPC分类号： C07K14/00 , A61K9/16 , A61K47/02 , A61K47/24 , A61K47/26 , A61K47/42 , C07K1/113 , C12P21/00 , G01N33/543 , G01N33/553
CPC分类号： G01N33/54326 , C07K14/205 , C07K17/14 , C07K2319/03 , C12N9/1048 , C12N9/1051 , C12N9/2402 , C12N11/06 , C12Y204/01065 , C12Y302/01018 , G01N2333/91097
摘要： Provided are a biomolecule-immobilized carrier obtained by immobilizing a biomolecule having a membrane-binding peptide containing a C terminal polypeptide of fucosyltransferase derived from Helicobacter pylori or a membrane-binding molecule having the membrane-binding peptide and various biomolecules and a method for immobilizing a biomolecule to a carrier, particularly a biomolecule-immobilized magnetic microparticle, a probe-immobilized carrier using the biomolecule and/or the membrane-binding molecule are/is used as a probe, and a separating agent for a biomolecule to which the biomolecule-immobilized magnetic microparticle is applied. A biomolecule having a membrane-binding peptide containing either an amino acid sequence represented by SEQ ID NO: 1 or an amino acid sequence encoded by a base sequence represented by SEQ ID NO: 2 and/or a membrane-binding molecule having the membrane-binding peptide and the biomolecule are/is attached to a carrier coated with an organic membrane containing a phospholipid.
摘要翻译：本发明提供了通过固定具有膜结合肽含岩藻糖基的幽门螺杆菌或具有膜 - 结合肽和各种生物分子和用于固定的方法的膜结合分子衍生的C末端多肽的生物分子所获得的生物分子固定载体生物分子的载体，特别是生物分子固定化的磁性微粒，采用生物分子和/或膜结合分子是使用/作为样品固定有探针的载体，以及用于生物分子到其上的分离剂，该生物分子固定化的磁性微粒被应用。或通过由SEQ ID NO所示的碱基序列编码的氨基酸序列1：1：2和/或具有该膜 - 膜 - 结合分子具有膜结合肽包含由SEQ ID NO所代表的氨基酸序列的任意的生物分子结合肽和生物分子都/附接至涂有有机膜含有磷脂的载体。

38. 发明公开

EP2187217A1 DETECTION METHOD OF GYNECOLOGIC CANCER 有权
标题翻译：妇科肿瘤的检测方法
公开(公告)号：EP2187217A1
公开(公告)日：2010-05-19
申请号：EP08828673.7
申请日：2008-08-22
申请人： Tokyo Institute of Technology
发明人： YAMASHITA, Katsuko , SEKO, Akira , AOKI, Daisuke , SAKAMOTO, Masaru
IPC分类号： G01N33/574 , G01N33/573 , C07K16/40
CPC分类号： G01N33/57449 , C07K16/40 , C12Q1/48 , G01N33/57442 , G01N2333/91097
摘要： The object of the present invention is to provide a method for detecting gynecologic cancer and a kit for detecting the same.
The object can be solved by a method for detecting gynecologic cancer characterized in that β1,3-galactosyltransferase-5 and/or β1,3-galactosyltransferase-4, and GlcNAc 6-O-sulfotransferase-2 are analyzed. According to the detecting method, ovarian cancer and endometrial cancer patients can be detected at an early stage i.e. stages I and II, wherein patients have no subjective symptoms.
摘要翻译：本发明的目的是提供检测妇科癌症的方法和用于检测妇科癌症的试剂盒。该目的可通过检测妇科癌症的方法来解决，其特征在于分析β1,3-半乳糖基转移酶-5和/或β1,3-半乳糖基转移酶-4和GlcNAc6-O-磺基转移酶-2。根据该检测方法，卵巢癌和子宫内膜癌患者可以在早期阶段即I期和II期进行检测，其中患者没有主观症状。

39. 发明公开

EP2099822A2 ANTIKÖRPER GEGEN DIE EPITOPE GRWIRTQQHYYERDPKRIYYLSLEFYMGRTLQNTM ODER IFNQKIVNGWQVEEADDWLRYGNPWEKARP ODER GLGDVAEVRKSFNRHLHFTLVKDRNVATPRDYFFA ODER DSMATLGLAAYGYGIRYEFG 审中-公开
标题翻译： ANTIKÖRPERGEGEN DIE EPITOPE GRWIRTQQHYYERDPKRIYYLSLEFYMGRTLQNTM ODER IFNQKIVNGWQVEEADDWLRYGNPWEKARP ODER GLGDVAEVRKSFNRHLHFTLVKDRNVATPRDYFFA ODER DSMATLGLAAYGYGIRYEFG
公开(公告)号：EP2099822A2
公开(公告)日：2009-09-16
申请号：EP07856316.0
申请日：2007-11-30
申请人： Diagenics International Corporation
发明人： KAPETANOVIC, Ernest , YASTAS, Samir , BILSTEIN, Andreas , NOLL, Franz
IPC分类号： C07K16/00
CPC分类号： C07K16/40 , G01N33/573 , G01N33/6854 , G01N2333/91097 , G01N2800/22
摘要： Antibody to the epitope GRWIRTQQHYYERDPKRIYYLSLEFYMGRTLQNTM (E1) or IFNQKIVNGWQVEEADDWLRYGNPWEKARP (E2) or GLGDVAEVRKSFNRHLHFTLVKDRNVATPRDYFFA (E3) or DSMATLGLAAYGYGIRYEFG (E4), from human glycogen phosphorylase isoenzyme BB.
摘要翻译：来自人类糖原磷酸化酶同工酶BB的表位GRWIRTQQHYYERDPKRIYYLSLEFYMGRTLQNTM（E1）或IFNQKIVNGWQVEEADDWLRYGNPWEKARP（E2）或GLGDVAEVRKSFNRHLHFTLVKDRNVATPRDYFFA（E3）或DSMATLGLAAYGYGIRYEFG（E4）的抗体。

40. 发明公开

EP1674869A4 METHOD OF EXAMINING COLON CANCER AND COLON ADENOMA 有权
标题翻译：程序审查结肠癌和腺瘤
公开(公告)号：EP1674869A4
公开(公告)日：2008-05-21
申请号：EP04747273
申请日：2004-07-09
申请人： JAPAN SCIENCE & TECH AGENCY , LOCAL GAVERNMENT OF AICHI PREF , WAKO PURE CHEM IND LTD
发明人： KANNAGI REIJI , IZAWA MINEKO , MURAMATSU TAKASHI , UCHIMURA KENJI , HOSOKAWA HIDEAKI
IPC分类号： G01N33/574 , C07K16/40 , C12N15/09
CPC分类号： G01N33/57419 , G01N2333/91097 , G01N2400/02
摘要： It is intended to provide an examination method useful in diagnosing colon cancer and colon adenoma whereby a patient suffering from colon cancer and a patient with a high risk of colon cancer can be detected at a high ratio, and an examination reagent therefor. A remarkable difference in the distribution of sugar chain sulfating enzyme GlcNAc-6-sulfotransferase isozymes is found out between a noncancerous colon tissue and a colon cancer tissue/a colon adenoma tissue. Then, it is clarified that colon cancer and colon adenoma can be specifically detected by detecting GlcNAc-6-sulfated sugar chains in a definite range from tissues or fecal samples of patients by applying the above difference. By using MECA-79 antibody (Pharmingen Catalog No. 09961D, Becton Dickinson) reacting with GlcNAc-6-sufated sugar chains specifically formed by enzymes occurring in colon cancer and colon adenoma, colon caner and colon adenoma can be examined.

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