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    • 31. 发明公开
    • Blood-treating device, and process for producing the same
    • 血液处理装置及其制造方法
    • EP0568968A3
    • 1994-02-23
    • EP93107183.1
    • 1993-05-04
    • TEIJIN LIMITED
    • Emi, ShingoSuzuki, KyojiIkada, Yoshito
    • A61M1/18B01D71/22A61M1/34
    • B01D67/0093B01D71/12B01D71/22C08B11/14C08B11/15C08B15/06
    • A cellulosic polymer wherein at least a part of the hydroxyl groups of the cellulosic polymer is modified as represented by the following general formula [I]:
      wherein R 1 and R 2 may be the same or different and each represents a hydrogen atom or a C 1 to C 5 alkyl group, X is a strong negative atomic group,
      and Y is
      wherein R 3 and R 4 may be the same or different and each represents a member selected from the group consisting of a hydrogen atom, a C 1 to C 5 alkyl group and a C 3 to C 6 cycloalkyl group, or
      Y is
      wherein R 5 , R 6 and R 7 may be the same or different and each represents a member selected from the group consisting of a hydrogen atom, a C 1 to C 5 alkyl group, a C 3 to C 6 cycloalkyl group and a C 6 to C 10 aryl group, and n is from 1 to 10. Using the cellulosic polymer, a blood-treating device is assembled.
    • 一种纤维素聚合物,其中纤维素聚合物的至少一部分羟基被如下述通式[I]所示改性:其中R1和R2可以相同或不同,并且各自代表氢原子或C1-C5 烷基,X是强负原子团,并且Y是其中R3和R4可以相同或不同,并且各自表示选自氢原子,C1-C5烷基和C3-C6烷基的成员 环烷基,或Y是其中R5,R6和R7可以相同或不同,并且各自表示选自氢原子,C1-C5烷基,C3-C6环烷基和C6-C20环烷基的成员, C10芳基,并且n为1至10.使用纤维素聚合物组装血液处理装置。
    • 32. 发明公开
    • Blood-treating device, and process for producing the same
    • Modifizierte Zellulose,Vorrichtung zur Blutbehandlung und Verfahren zu ihrer Herstellung。
    • EP0568968A2
    • 1993-11-10
    • EP93107183.1
    • 1993-05-04
    • TEIJIN LIMITED
    • Emi, ShingoSuzuki, KyojiIkada, Yoshito
    • A61M1/18B01D71/22A61M1/34
    • B01D67/0093B01D71/12B01D71/22C08B11/14C08B11/15C08B15/06
    • A cellulosic polymer wherein at least a part of the hydroxyl groups of the cellulosic polymer is modified as represented by the following general formula [I]:


      wherein R 1 and R 2 may be the same or different and each represents a hydrogen atom or a C 1 to C 5 alkyl group, X is a strong negative atomic group,
      and Y is

      wherein R 3 and R 4 may be the same or different and each represents a member selected from the group consisting of a hydrogen atom, a C 1 to C 5 alkyl group and a C 3 to C 6 cycloalkyl group, or
      Y is

      wherein R 5 , R 6 and R 7 may be the same or different and each represents a member selected from the group consisting of a hydrogen atom, a C 1 to C 5 alkyl group, a C 3 to C 6 cycloalkyl group and a C 6 to C 10 aryl group, and n is from 1 to 10. Using the cellulosic polymer, a blood-treating device is assembled.
    • 一种纤维素聚合物,其中纤维素聚合物的至少一部分羟基被改性,如以下通式[I]表示:其中R 1和R 2可以相同或不同,各自独立地表示 表示氢原子或C1〜C5烷基,X表示强负型原子团,Y表示,其中R 3和R 4可以相同或不同,表示选自 由氢原子,C1〜C5烷基和C3〜C6环烷基组成的基团,或Y为,其中R 5,R 6和R 7可以相同或不同, 表示选自氢原子,C1〜C5烷基,C3〜C6环烷基和C6〜C10芳基的成员,n为1〜10。使用纤维素系聚合物, 处理装置组装。
    • 33. 发明公开
    • Esters and amides of substituted pyrrole acetic acids
    • Pyrrol-Essigsäureesternund Amiden。
    • EP0485157A2
    • 1992-05-13
    • EP91310204.2
    • 1991-11-05
    • FGN, INC.THE UNIVERSITY OF ARIZONA
    • Pamukcu, RifatGross, PaulBrendel, Klaus
    • A61K47/48C08B37/08C08F8/00C07K13/00A61K37/02
    • C08F8/30A61K47/58C08B11/14C08B37/003
    • Esters and amides of substituted pyrrole acetic acids of the formula :
      wherein n is 0 or 1, and X represents a condensed phenyl ring ;

      one of R 1 and R 2 is independently selected from hydrogen, halogen, lower alkyl ; and the other of R 1 and R 2 is independently selected from substituted or unsubstituted phenyl, benzyl, thienyl, napthyl, pyridyl, furyl, biphenyl, benzoyl, cinnamoyl, thienylcarbonyl, napthylcarbonyl, pyridylcarbonyl, furylcarbonyl or biphenylcarbonyl wherein said substituents are selected from amino, halogen, lower alkyl, lower alkylthio, lower alkoxy or lower haloalkyl ;
      m is an integer from 1 to 3 ;
      R 3 is selected from hydrogen and lower alkyl, or one or more of hydrogen and lower alkyl when m is greater than 1 ;
      R 4 is one or more of hydrogen, lower alkyl, alkoxy, haloalkyl, alkylthio, and halogen ;
      p is an integer of at least 2 ;
      Q is the deprotonated residue of a polymer or macromolecular structure having at least two primary and/or secondary amines and/or hydroxy groups ; and
      when n is 0, R 5 is selected from hydrogen, halogen, lower alkyl, alkoxy, alkylthio, and halogen are useful in the treatment of colonic polyps.
    • 下式的取代吡咯乙酸的酯和酰胺:其中n为0或1,X为稠合苯环; R 1和R 2之一独立地选自氢,卤素,低级烷基; R 1和R 2中的另一个独立地选自取代或未取代的苯基,苄基,噻吩基,萘基,吡啶基,呋喃基,联苯基,苯甲酰基,肉桂酰基,噻吩基羰基,萘基羰基,吡啶基羰基,呋喃基羰基或联苯基羰基,其中所述取代基选自氨基, ,低级烷基,低级烷硫基,低级烷氧基或低级卤代烷基; m为1〜3的整数; 当m大于1时,R 3选自氢和低级烷基,或者一个或多个氢和低级烷基; R4是氢,低级烷基,烷氧基,卤代烷基,烷硫基和卤素中的一个或多个; p为至少2的整数; Q是具有至少两个伯和/或仲胺和/或羟基的聚合物或大分子结构的去质子化残基; 当n为0时,R5选自氢,卤素,低级烷基,烷氧基,烷硫基和卤素,可用于治疗结肠息肉。