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31. 发明公开

EP1461330A1 3H-NAPHTHO 2,1-B]-PYRAN-DERIVATE SOWIE DEREN VERWENDUNG 有权
标题翻译： -3H-萘并[2,1-b]吡喃衍生物及其
公开(公告)号：EP1461330A1
公开(公告)日：2004-09-29
申请号：EP02796714.0
申请日：2002-12-20
申请人： Rodenstock GmbH
发明人： MANN, Claudia , MELZIG, Manfred , WEIGAND, Udo
IPC分类号： C07D311/92 , C07D405/04 , G03C1/73 , G02B5/23
CPC分类号： C07D405/04 , C07D311/92 , G02B5/23 , G03C1/73
摘要： The invention relates to specific photochromic 3H-naphtho[2,1-b]-pyrane derivatives and to the use of the same in all types of plastic, especially for ophthalmic purposes. The invention especially relates to photochromic compounds derived from 3H-naphtho[2,1-b]-pyranes, said compounds having especially long-wave absorption maxima in the open form thereof, enabling violet to blue tints to be obtained when used in phototropic lenses.

32. 发明公开

EP1426048A2 Treating hypertriglyceridemia with RXR agonists in combination with a PPARgamma agonist 失效
标题翻译：超分子甘油三酯在组合中的活性成分PPARgamma激动剂
公开(公告)号：EP1426048A2
公开(公告)日：2004-06-09
申请号：EP04002911.8
申请日：1996-09-17
申请人： LIGAND PHARMACEUTICALS, INC.
发明人： Heyman, Richard A. , Cesario, Rosemary , Mukherjee, Ranjan
IPC分类号： A61K31/192 , A61K31/4418 , A61K31/203 , A61K31/426 , A61K31/4439 , A61K31/455 , A61P3/06
CPC分类号： G01N33/5044 , A61K31/00 , A61K31/192 , A61K31/203 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/4439 , A61K31/455 , A61K38/28 , A61K45/06 , C07C57/50 , C07C59/72 , C07C63/49 , C07C63/66 , C07C65/28 , C07C65/36 , C07C251/48 , C07C2602/10 , C07C2603/24 , C07D221/08 , C07D265/34 , C07D311/92 , C07D317/30 , G01N33/5008 , G01N33/5038 , G01N33/5061 , G01N2500/00 , A61K2300/00
摘要： This invention relates to methods and compositions for the treatment of cardiovascular disease, hypertriglyceridemia, low levels of lipoprotein lipase, low levels of HDL cholesterol and for increasing adipocyte differentiation using an RXR agonist in combination with a PPARγ agonist such as a thiazolidinedione compound.
摘要翻译：本发明涉及用于治疗心血管疾病，高甘油三酯血症，低水平脂蛋白脂肪酶，低水平HDL胆固醇和使用RXR激动剂与PPARγ激动剂如噻唑烷二酮化合物联合来增加脂肪细胞分化的方法和组合物。

33. 发明公开

EP1324984A1 BUTENOLID- UND PENTENOLIDDERIVATE ALS KINASE INHIBITOREN 审中-公开
标题翻译： BUTENOLID-和PENTENOLIDDERIVATE作为激酶抑制剂
公开(公告)号：EP1324984A1
公开(公告)日：2003-07-09
申请号：EP01974335.0
申请日：2001-10-11
申请人： Morphochem AG
发明人： BECK, Barbara , DÖMLING, Alexander
IPC分类号： C07D207/38 , C07D307/58 , C07D309/38 , A61K31/351 , A61P29/00
CPC分类号： C07D403/12 , C07D207/38 , C07D211/78 , C07D307/68 , C07D309/38 , C07D311/76 , C07D311/92 , C07D401/12 , C07D405/12 , C07D409/04
摘要： The invention relates to novel compounds of general formula (I), a method for the production thereof, prodrugs, pharmacologically acceptable salts and medicinal compositions containing the same as active ingredients, and the use of said compounds as kinase inhibitors.

34. 发明公开

EP1265885A2 HYDROXYLATED/CARBOXYLATED NAPHTHOPYRANS 有权
标题翻译：羟丙基/羧甲基萘酚
公开(公告)号：EP1265885A2
公开(公告)日：2002-12-18
申请号：EP01912985.7
申请日：2001-02-23
申请人： TRANSITIONS OPTICAL, INC.
发明人： WALTERS, Robert W. , VAN GEMERT, Barry
IPC分类号： C07D311/92 , C07D311/94 , C07D311/96 , C09K9/02 , G02B5/23 , G03C1/685 , G03C1/73 , G02C7/02
CPC分类号： C07D311/96 , C07D311/92 , C07D311/94 , G02B5/23
摘要： Described are novel photochromic hydroxylated/carboxylated naphthopyran compounds, examples of which are certain 2H-naphtho[1,2-b]pyrans, 3H-naphtho[2,1-b]pyrans and indeno[2,1-f]naphtho[1,2-b]pyrans each having at least one hydroxylated/carboxylated substituent. Specific substituents are also present on the naphtho, indeno and/or pyrano portions of the compounds. These compounds may be represented by the graphic formulae (I), (II) and (III). Also described are various substrates, e.g., paper, glass, polymeric organic materials, etc., that contain or that are coated with such compounds. Optically clear articles such as contact lenses or other plastic transparencies that incorporate the novel naphthopyran compounds or combinations thereof with complementary photochromic compounds, e.g., certain other naphthopyrans, indenonaphthopyrans, benzopyrans, oxazine-type compounds, etc., are also described.

35. 发明公开

EP1214310A1 NOVEL PHOTOCHROMIC NAPHTHOPYRANS 有权
标题翻译：新型光致变色萤石
公开(公告)号：EP1214310A1
公开(公告)日：2002-06-19
申请号：EP00963533.5
申请日：2000-09-15
申请人： TRANSITIONS OPTICAL, INC.
发明人： NELSON, Clara, M. , CHOPRA, Anu , KNOWLES, David, B. , VAN GEMERT, Barry , KUMAR, Anil
IPC分类号： C07D311/92 , C07D493/04 , G02B5/23
CPC分类号： C07D311/92 , C07D493/04 , G02B5/23
摘要： Described are novel photochromic 2H-naphtho[1,2-b]pyran compounds essentially characterized by having two adjacent moderates to strong electron donor substituents at the 8 and 9 positions or a fused heterocyclic group formed by the substituents coming together, weak to moderate electron donors at the 2 position and a rating of at least 80 in the Relative ΔOD at Saturation Test. The compounds also have certain substituents at the 5 position and optionally at the 6 position of the naphtho portion of the compound. These compounds may be represented by graphic formula (I). Also are described polymeric organic host materials that contain or that are coated with such compounds. Optically clear articles such as ophthalmic lenses or adjacent plastic transparencies that incorporate the novel naphthopyran compounds or combinations thereof with complementary photochromic compounds, e.g., certain other naphthopyrans, benzopyrans, and spiro (indoline) type compounds, are also described.
摘要翻译：描述了新的光致变色2H-萘并[1,2-b]吡喃化合物，其基本特征在于在8和9位具有两个相邻的中等强度的强电子供体取代基或由取代基一起形成的稠合杂环基团，弱到中等电子在饱和度测试中相对ΔOD在2位置的供体和至少80的等级。该化合物在化合物的萘并部分的5位和任选6位上也具有某些取代基。这些化合物可以由图解式（I）表示。还描述了含有或被这种化合物涂覆的聚合物有机主体材料。还描述了光学透明制品，例如将新型萘并吡喃化合物或其组合与具有互补光致变色化合物（例如某些其他萘并吡喃类，苯并吡喃类和螺（二氢吲哚）类化合物）结合的眼科镜片或相邻塑料透明片。

36. 发明授权

EP0629620B1 New photochromic Naphto(2,1-b)pyrans and method for their preparation 失效
标题翻译：新的光致变色萘2,1-B吡喃和它们的制备方法
公开(公告)号：EP0629620B1
公开(公告)日：2002-04-17
申请号：EP94201528.0
申请日：1994-05-31
申请人： Great Lakes Chemical (Europe) GmbH
发明人： Allegrini, Pietro , Nodari, Nereo , Crisci, Luciana , Malatesta, Vincenzo
IPC分类号： C07D311/92 , C07D409/04 , C08K5/15 , C08K5/36
CPC分类号： C07D409/04 , C07D311/92 , C08K5/1545

37. 发明公开

EP1194424A1 PHOTOCHROME PYRANDERIVATE 有权
公开(公告)号：EP1194424A1
公开(公告)日：2002-04-10
申请号：EP01945257.2
申请日：2001-06-06
申请人： Optische Werke G. Rodenstock
发明人： MANN, Claudia , WEIGAND, Udo , MELZIG, Manfred
IPC分类号： C07D311/92 , G02B5/23
CPC分类号： G02B5/23 , C07D311/92
摘要： The invention relates to specific photochromic pyran derivatives and the use thereof in all forms of plastic, especially for ophthalmic purposes. The invention especially relates to spiro compounds with a fluorene structure which are derived from naphthopyrans. Said compounds are known as spirofluorenopyrans . According to the invention, only one strong electron-pushing or electron-attracting group is introduced in each case into specific positions on the periphery of the pyran dye in order to obtain photochromic compounds which are characterised, in their excited form, by an enlarged colour spectrum accompanied by comparatively good brightening speeds and behaviour in the shelf life test.
摘要翻译：本发明涉及特定的光致变色吡喃衍生物及其在所有形式的塑料中的用途，特别是用于眼科用途。本发明特别涉及衍生自萘并吡喃的具有芴结构的螺环化合物。所述化合物被称为螺旋芴吡喃。根据本发明，在每种情况下，只有一个强电子引入或吸电子基团被引入到吡喃染料的外围的特定位置，以便获得以其激发形式表征为增大的颜色的光致变色化合物光谱伴随着相对良好的光亮速度和保质期测试行为。

38. 发明公开

EP1185493A1 QUINONES FOR TREATMENT OF DISEASES 有权
标题翻译： CHINO化合物用于疾病治疗
公开(公告)号：EP1185493A1
公开(公告)日：2002-03-13
申请号：EP00928562.8
申请日：2000-04-27
申请人： SLIL Biomedical Corporation
发明人： BLOKHIN, Andrei, V. , FRYDMAN, Benjamin , MARTON, Laurence, J. , NEDER, Karen, M. , SUN, Jerry, Shunneng
IPC分类号： C07C50/10
CPC分类号： C07D295/185 , A61K38/00 , A61K47/65 , C07C45/00 , C07C45/46 , C07C46/00 , C07C50/32 , C07C67/343 , C07C69/708 , C07C69/96 , C07C229/22 , C07C233/31 , C07C237/22 , C07C255/54 , C07C305/20 , C07D207/34 , C07D219/10 , C07D235/18 , C07D307/79 , C07D307/92 , C07D311/92 , C07D317/70 , C07D493/04 , C07F9/12 , C07F9/65517 , C07F9/65522 , C07K5/1013 , C07K7/06 , C07C47/575 , C07C69/734
摘要： Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.

39. 发明公开

EP1177197A2 POLYAMINES AND THEIR USE IN THERAPY 有权
标题翻译： POLYAMINE UND IHRE THERAPEUTISCHE VERWENDUNG
公开(公告)号：EP1177197A2
公开(公告)日：2002-02-06
申请号：EP00928583.4
申请日：2000-04-27
申请人： Slil Biomedical Corporation
发明人： FRYDMAN, Benjamin , MARTON, Laurence, J. , REDDY, Venodhar, K. , VALASINAS, Aldonia , BLOKHIN, Andrei, V. , BASU, Hirak, S.
IPC分类号： C07D487/22 , C07C211/22 , C07C211/23 , C07C211/18 , C07C215/14 , C07C257/18 , A61P35/00 , A61K31/155 , A61K31/13 , A61K31/40
CPC分类号： C07C211/09 , A61K38/00 , A61K47/65 , C07C45/46 , C07C67/343 , C07C211/18 , C07C211/22 , C07C211/23 , C07C211/36 , C07C215/14 , C07C257/18 , C07C2601/04 , C07C2601/08 , C07D207/34 , C07D219/10 , C07D235/18 , C07D295/185 , C07D307/79 , C07D307/92 , C07D311/92 , C07D317/70 , C07D487/22 , C07D493/04 , C07K5/1013 , C07K7/06 , C07C47/575 , C07C69/734
摘要： Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. Also provided is a method of delivering these analogs specifically to tumor cells by covalently attaching polyamine analogs to porphyrin compounds, along with novel polyamine-porphyrin covalent conjugates.
摘要翻译：提供新的构象限制性多胺类似物，以及包含这些新型多胺类似物的组合物。还提供了将新型多胺类似物用于治疗诸如癌症的疾病的方法。还提供了通过将多胺类似物与卟啉化合物共价连接并与新型多胺 - 卟啉共价缀合物一起将这些类似物特异性递送至肿瘤细胞的方法。

40. 发明公开

EP1140892A1 PHOTOCHROMIC SUBSTIITUTED 2H-NAPHTHO[1,2-B]PYRANS 审中-公开
标题翻译：光致变色底物2H-NAPHTHO [1,2-B] PYRANS
公开(公告)号：EP1140892A1
公开(公告)日：2001-10-10
申请号：EP99954094.1
申请日：1999-10-29
申请人： JAMES ROBINSON LIMITED
发明人： CLARKE, David Allan , HERON, Bernard Mark , GABBUTT, Christopher David , HEPWORTH, John David , PARTINGTON, Steven Michael , CORNS, Stephen Nigel
IPC分类号： C07D311/92 , G02B5/23
CPC分类号： C07D311/92 , G02B5/23
摘要： A 2H-naphtho[1,2-b]pyran of general formula (I) wherein R5 is substituted and where R8 is selected from the substituents including hydrogen, linear or branched C¿1?-C20 alkyl, C3-C20 cycloalkyl, C4-C20 bicycloalkyl, C5-C20 polycycloalkyl, linear or branched C1-C20 haloalkyl, linear or branched C1-C20 perhaloalkyl, linear or branched C2-C20 alkenyl, linear or branched C4-C20 polyalkenyl, linear or branched C2-C20 alkynyl, linear or branched C4-C20 polyalkynyl, linear or branched C1-C20 hydroxyalkyl, linear or branched C1-C20 alkylcarbonyl, linear or branched C1-C20 polyhydroxyalkyl, linear or branched C1-C20 alkoxy, linear of branched C1-C20 alkylthio, linear or branched C1-C20(C1-C5 or C1-C10alkoxy)alkyl, linear or branched C1-C20(C1-C5 or C1-C10alkylthio)alkyl, benzoyl, aroyl, heteraroyl, phenyl, aryl, heteroaryl, halogen, hydroxyl, formyl, acetyl, linear or branched C3-C20 alkenoyl, linear or branched C5-C20 polyalkenoyl, nitrile, carboxyl, C1-C20 or C1-C5 alkoxycarbonyl, C1-C20 N-alkylamido, C1-C20 or C1-C5 N, N-dialkylamido, amido, nitro, amino, C1-C20 or C1-C5 alkylamino, C1-C20 dialkylamino, C2-C20 dialkenylamino, C4-C20di(polyalkenyl)amino, arylamino, diarylamino, C1-C20 alkylarylamino, cyclic-amino groups, arylsulfanyl, aryloxy, arylsulfinyl, arylsulfonyl, linear or branched C1-C20 alkylsulfonyl, and di-(C1-C10 or C1-C20 alkoxyalkyl)phosphonyl and X includes O, S, NH, or the function R?8¿X is selected from aziridino, mono- or poly- substituted linear or branched C¿1?-C20 alkyl aziridino, pyrrolidino, mono- or poly- substituted linear or branched C1-C20 alkyo pyrrolidino, piperidino, mono- or poly- substituted linear or branched C1-C20 alkyl piperidino, morpholino, mono- or poly- substituted linear or branched C1-C20 alkyl morpholino, thiomorpholino, mono- or poly- substituted linear or branched C1-C20 alkyl thiomorpholino, indolino, mono- or poly- substituted linear or branched C1-C20 alkyl indolino, piperazino, mono- or poly- substituted linear or branched C1-C20 alkyl piperazino, linear or branched C1-C20N-alkylpiperazino, linear or branched C1-C20N-hydroxyalkylpiperazino, N-phenylpiperazino, N-aryliperazino, homopiperidino, mono- or poly- substituted linear or branched C1-C20 alkyl homopiperidino, N-indolinyl, N-1,2,3,4-tetrahydroquinolinyl, N-1,2,3,4,4a-hexahydrocarbazolyl. The compounds may be combined with polymeric host material such as plastic or glass or make a sunglass lens, an ophthalmic lens or a window. The compounds may also be included in an ink or a fuel.
摘要翻译：通式（I）的2H-萘并[1,2-b]吡喃，其中R5是取代的，其中R8选自包括氢，直链或支链C1-C20烷基，C3-C20环烷基，C4 直链或支链C 1 -C 20卤代烷基，直链或支链C 1 -C 20全卤代烷基，直链或支链C 2 -C 20烯基，直链或支链C 4 -C 20聚烯基，直链或支链C 2 -C 20炔基，或直链或支链C 1 -C 20羟基烷基，直链或支链C 1 -C 20烷基羰基，直链或支链C 1 -C 20多羟基烷基，直链或支链C 1 -C 20烷氧基，直链或支链C 1 -C 20烷基硫基， C 1 -C 20（C 1 -C 5或C 1 -C 10烷氧基）烷基，直链或支链C 1 -C 20（C 1 -C 5或C 1 -C 10烷硫基）烷基，苯甲酰基，芳酰基，，直链或支链C 3 -C 20烯酰基，直链或支链C 5 -C 20聚烯酰基，腈，羧基，C 1 -C 20或C 1 -C 5烷氧基羰基，C 1 -C 20 Na 烷基氨基，C 1 -C 20二烷基氨基，C 2 -C 20二烷基氨基，C 4 -C 20二（聚链烯基）氨基，芳基氨基，C 1 -C 20烷基氨基，C 1 -C 20二烷基氨基，芳基磺酰基，芳基磺酰基，直链或支链的C 1 -C 20烷基磺酰基和二 - （C 1 -C 10或C 1 -C 20烷氧基烷基）膦酰基，X包括O，S，NH ，或功能R 18选自氮丙啶基，单或多取代的直链或支链C 1 -C 20烷基氮丙啶基，吡咯烷基，单或多取代的直链或支链C 1 -C 20烷基吡咯烷基，哌啶子基，单或多取代的直链或支链C 1 -C 20烷基哌啶子基，吗啉代，单或多取代的直链或支链C 1 -C 20烷基吗啉代，硫代吗啉代，单或多取代直链或支链C 1 -C 20烷基硫代吗啉代，吲哚啉，单或多取代的直链或支链C 1 -C 20烷基吲哚基，哌嗪并，单或多取代的直链或支链直链或支链C 1 -C 20 N-烷基哌嗪子基，直链或支链C 1 -C 20 N-羟基烷基哌嗪子基，N-苯基哌嗪子基，N-芳基哌嗪子基，高哌啶子基，单或多取代的直链或支链C 1 -C 20烷基高哌啶子基， N-二氢吲哚基，N-1,2,3,4-四氢喹啉基，N-1,2,3,4,4a-六氢咔唑基。这些化合物可以与聚合物主体材料例如塑料或玻璃结合，或者制成太阳镜镜片，眼科镜片或窗户。化合物也可以包含在油墨或燃料中。

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