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    • 37. 发明公开
    • IMPROVED PROCESS FOR THE REDUCTIVE AMINATION AND SELECTIVE HYDROGENATION OF SUBSTRATES CONTAINING A SELECTED HALOGEN
    • 改进方法还原胺化和与选定的卤素与基体结合选择性加氢
    • EP3041819A1
    • 2016-07-13
    • EP14761968.8
    • 2014-08-26
    • Taminco bvba
    • MOONEN, KristofVANDEPUTTE, BartSCHELDEMAN, DaanDUMOLEIJN, Kim
    • C07C209/26C07C209/36C07C249/04
    • Disclosed is a process for performing a chemical reaction selected from reductive amination and hydrogenation of a first functional group in an organic feed substrate, which feed substrate comprises at least one further functional group containing a halogen atom, wherein the halogen atom is selected from the list consisting of chlorine, bromine, iodine, and combinations thereof, in the presence of hydrogen and a heterogeneous catalyst comprising at least one metal from the list of Pd, Rh, and Ru, together with at least a second metal from the list consisting of Ag, Ni, Co, Sn, Cu and Au. The process is preferably applied for the reductive amination of 2-chloro-benzaldehyde to form 2-chloro-benzyldimethylamine, as an intermediate in the production of agrochemically active compounds and microbiocides of the methoximinophenylglyoxylic ester series. Further disclosed is a composition rich in 2-chloro-benzyldimethylamine, further comprising an amount of 2-chloro-benzyl alcohol and being low in chlorotoluene isomers.
    • 公开的是用于执行在衬底从第一官能团的还原阿米娜灰和氢化选择的化学反应的方法上有机的,其中进料的基材包括至少一个另外的官能团包含卤素原子,worin的卤素原子是从该列表中选择进料 氯,溴,碘,以及它们的组合的具有来自所述列表由Ag中的至少一个第二金属组成物,在氢气和多相催化剂选自Pd,Rh和Ru中的列表中包括的至少一种金属的存在下,一起 ,镍,钴,锡,铜和金。 该方法优选在生产农用化学活性化合物和methoximinophenylglyoxylic酯系列的杀微生物剂的应用2-氯苯甲醛的还原性阿米娜和灰,以形成2-氯苄基,如在中间。 进一步游离缺失盘富含2-氯苄基的组合物,还包括2-氯苄醇的量的和是在氯甲苯异构体低。