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31. 发明公开

EP1709067A2 LAWSONIA INTRACELLULARIS SUBUNIT VACCINES 有权
标题翻译：恶性疟原虫亚单位疫苗
公开(公告)号：EP1709067A2
公开(公告)日：2006-10-11
申请号：EP05701094.4
申请日：2005-01-18
申请人： Intervet International BV
发明人： VERMEIJ, Paul
IPC分类号： C07K14/195 , C12N15/31 , C07K16/12 , C12Q1/68 , A61K39/02
CPC分类号： C07K14/195 , A61K39/00
摘要： The present invention relates i.a. to nucleic acids encoding novel Lawsonia intracellularis proteins. It furthermore relates to DNA fragments, recombinant DNA molecules and live recombinant carriers comprising these sequences. Also it relates to host cells comprising such nucleic acids, DNA fragments, recombinant DNA molecules and live recombinant carriers. Moreover, the invention relates to proteins encoded by these nucleotide sequences and to their use for the manufacturing of vaccines. The invention also relates to vaccines for combating Lawsonia intracellularis infections and methods for the preparation thereof. Finally the invention relates to diagnostic tests for the detection of Lawsonia intracellularis antigens and of antibodies against Lawsonia intracellularis.
摘要翻译：本发明涉及i.a. 涉及编码新型胞内劳森菌蛋白质的核酸。它还涉及DNA片段，重组DNA分子和包含这些序列的活重组载体。还涉及包含这样的核酸，DNA片段，重组DNA分子和活重组载体的宿主细胞。此外，本发明涉及由这些核苷酸序列编码的蛋白质及其用于制造疫苗的用途。本发明还涉及用于防治胞内劳森菌感染的疫苗及其制备方法。最后，本发明涉及用于检测胞内劳森氏菌抗原和针对胞内劳森氏菌的抗体的诊断测试。

32. 发明公开

EP1699483A1 COMBINATION VACCINE FOR POULTRY 有权
标题翻译：联合疫苗家禽
公开(公告)号：EP1699483A1
公开(公告)日：2006-09-13
申请号：EP04804958.9
申请日：2004-12-21
申请人： Intervet International BV
发明人： JACOBS, Antonius Arnoldus Christiaan , VAN EMPEL, Paul Cornelius Maria , NUIJTEN, Petrus Johannes Maria
IPC分类号： A61K39/116 , A61K39/295
CPC分类号： A61K39/02 , A61K39/0216 , A61K39/12 , A61K2039/522 , A61K2039/5254 , A61K2039/544 , A61K2039/552 , A61K2039/70 , C12N2760/18134 , C12N2770/20034
摘要： The present invention relates to a combination vaccine for the protection of poultry against Ornithobacterium rhinotracheale, to the use of a live over-attenuated Ornithobacterium rhinotracheale strain and a live attenuated poultry virus for the manufacturing of such a combination vaccine, to methods for the preparation of said combination vaccine and to vaccination kits for the immunization of poultry against Ornithobacterium rhinotracheale.

33. 发明公开

EP1694698A1 LAWSONIA INTRACELLULARIS 26 KD SUBUNIT VACCINE 审中-公开
标题翻译： WITH THE 26-KD亚基细胞内劳索尼亚菌疫苗
公开(公告)号：EP1694698A1
公开(公告)日：2006-08-30
申请号：EP04820075.2
申请日：2004-12-08
申请人： Intervet International BV
发明人： VERMEIJ, Paul
IPC分类号： C07K14/28 , C12N15/31 , G01N33/53 , A61K39/106
CPC分类号： C07K14/195 , A61K39/00
摘要： The present invention relates i.a. to nucleic acids encoding novel Lawsonia intracellularis proteins. It furthermore relates to DNA fragments, recombinant DNA molecules and live recombinant carriers comprising these sequences. Also it relates to host cells comprising such nucleic acids, DNA fragments, recombinant DNA molecules and live recombinant carriers. Moreover, the invention relates to proteins encoded by these nucleotide sequences and to their use for the manufacturing of vaccines. The invention also relates to vaccines for combating Lawsonia intracellularis infections and methods for the preparation thereof. Finally the invention relates to diagnostic tests for the detection of Lawsonia intracellularis antigens and of antibodies against Lawsonia intracellularis.

34. 发明公开

EP1541168A1 Method of regulating animal reproduction 有权转让
标题翻译： Methode zur Synchronisierung des Eisprungs bei Rindern
公开(公告)号：EP1541168A1
公开(公告)日：2005-06-15
申请号：EP04106364.5
申请日：2004-12-07
申请人： Akzo Nobel N.V.
发明人： Driancourt, Marc-Antoine
IPC分类号： A61K38/24 , A61P15/08
CPC分类号： A61K31/5575 , A61K31/57 , A61K38/00 , A61K38/24 , A61K2300/00
摘要： A method for synchronising ovulation in cattle by sequential administration of GnRH together with a progesterone delivery device, prostaglandin F 2α , and PMSG together with the removal of the progesterone delivery device, followed by fixed time artificial insemination.
摘要翻译：一种用于通过连同GnRH与孕激素递送装置，前列腺素F2α和PMSG连同施用以及去除孕酮递送装置，随后进行固定时间人工授精来同步排卵的方法。

35. 发明授权

EP2314171B1 COMPOSITIONS AND PROCESS FOR DELIVERING AN ADDITIVE 有权
公开(公告)号：EP2314171B1
公开(公告)日：2019-11-13
申请号：EP10183638.5
申请日：2003-08-13
申请人： Intervet International BV
发明人： Huron, Sebastien Claude Jacques , Cady, Susan , Pieloch, Mark
IPC分类号： A23G3/00 , A23G3/02 , A23G3/36

36. 发明授权

EP2231698B1 VACCINE ANTIGENS FROM PISCIRICKETTSIA SALMONIS 有权
标题翻译：来自PISCIRICKETKSETTSIA SALMONIS的疫苗抗原
公开(公告)号：EP2231698B1
公开(公告)日：2014-07-30
申请号：EP08862540.5
申请日：2008-12-18
申请人： Intervet International BV
发明人： KIRKE, David Francis , FRANCIS, Michael James
IPC分类号： A61K39/00 , A61K39/116 , C07K16/12 , A61K39/02 , C07K14/005 , C07K14/195
CPC分类号： A61K39/0233 , A61K39/00 , A61K39/0208 , A61K39/12 , A61K2039/521 , A61K2039/523 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C07K14/005 , C07K14/195 , C07K16/1246 , C12N2720/10022 , C12N2720/10034

37. 发明授权

EP1626739B1 COMPOSITIONS COMPRISING FLORFENICOL OR A STRUCTURALLY RELATED COMPOUND FOR TREATING INFECTION IN CATTLE AND SWINE 无效转让
标题翻译：药物组合物含氟苯尼考或结构相关连接到感染的治疗牛和猪
公开(公告)号：EP1626739B1
公开(公告)日：2014-05-21
申请号：EP04753639.6
申请日：2004-05-28
申请人： Intervet International BV
发明人： FREEHAUF, Keith, A. , WEINGARTEN, Allan, J. , SIMMONS, Robert, D. , VARMA, Kanwal, Jit
IPC分类号： A61K9/00 , A61K47/14 , A61K47/32 , A61K31/165
CPC分类号： A61K9/0019 , A61K31/10 , A61K31/16 , A61K31/165 , A61K31/195 , A61K31/21 , A61K31/4015 , A61K31/655 , A61K31/66 , A61K47/14 , A61K47/32 , Y10S514/947

38. 发明授权

EP1532253B1 STREPTOCOCCUS UBERIS PROTEIN, NUCLEIC ACID SEQUENCE ENCODING THE SAME AND ITS USE IN A MASTITIS VACCINE 有权
标题翻译：乳房链球菌蛋白的核酸序列编码，它的使用在疫苗抗乳腺炎
公开(公告)号：EP1532253B1
公开(公告)日：2014-04-30
申请号：EP03792264.8
申请日：2003-08-06
申请人： Intervet International BV
发明人： HENSEN, Selma, Marianne , NUIJTEN, Petrus, Johannes, Maria
IPC分类号： C07K14/315 , C12N15/31 , C12N1/21 , C12N15/63 , A61K39/00
CPC分类号： C07K14/315 , A61K39/00

39. 发明授权

EP1686971B1 USE OF 5-CHLORO-1-(2,6-DICHLORO-4-TRIFLUOROMETHYLPHENYL)-4-(4,5-DICYANO-1H-IMIDAZOL-2YL)-3-METHYL-1H-PYRAZOLE IN SYSTEMIC CONTROL OF ACARID INFESTATION ON ANIMALS 有权
标题翻译： HALOARYLPYRAZOL化合物用于感染寄生虫在动物中控制使用
公开(公告)号：EP1686971B1
公开(公告)日：2013-05-15
申请号：EP04818410.5
申请日：2004-11-03
申请人： Intervet International BV
发明人： MERTENS, Christina , DOHRMANN, Heike
IPC分类号： A61K31/4178 , A61P33/14
CPC分类号： A61K31/4178

40. 发明公开

EP2468096A1 Anthelmintic combinations 审中-公开
标题翻译： Anthelmintische Zusammensetzungen
公开(公告)号：EP2468096A1
公开(公告)日：2012-06-27
申请号：EP10196119.1
申请日：2010-12-21
申请人： Intervet International BV
发明人： Chaissaing, Christophe, Pierre, Alain , Heckeroth, Anja, Regina , von Oepen, Britta
IPC分类号： A01N43/60 , A01N43/40 , A01N43/52 , A01N47/12 , A01P5/00 , A61K31/4184
CPC分类号： A01N43/60 , A01N43/40 , A01N43/52 , A01N47/12 , A01N2300/00
摘要： The present invention relates to anthelmintic combinations comprising (1) an anthelmintic compound having the general formula (I)

wherein T is a bond and Y is N; orT is NR 8 and Y is CH; X is O or S; R 1 is CF 3 , OCF 3 , CN or NO 2 ; R 2 is H or CF 3 ; R 3 is NO 2 or CN; R 4 is CF 3 ; R 5 is H or (C 1-3 )alkyl; R 6 optionally represents 1-4 methyl substituents; R 7 is H or (C 1-3 )alkyl; R 8 is H or (C 1-3 )alkyl; or a pharmaceutically acceptable salt thereof; and (2) an anthelmintic benzimidazole carbamate selected from fenbendazole, albendazole (oxide), mebendazole, oxfendazole, parbendazole, oxibendazole, flubendazole and triclabendazole, as well as to the use of said combinations in the treatment of parasitic infections in an animal.
摘要翻译：本发明涉及驱肠剂组合，其包含（1）具有通式（I）的驱肠虫化合物，其中T为结合键，Y为N; 或T为NR 8，Y为CH; X为O或S; R 1为CF 3，OCF 3，CN或NO 2; R 2为H或CF 3; R 3为NO 2或CN; R 4为CF 3; R 5为H或（C 1-3）烷基; R 6任选地表示1-4个甲基取代基; R 7是H或（C 1-3）烷基; R 8为H或（C 1-3）烷基; 或其药学上可接受的盐; 和（2）选自芬苯达唑，阿苯哒唑（氧化物），甲苯达唑，奥芬达唑，苯苯达唑，奥苯达唑，氟苯达唑和三氯苯达唑的驱虫药苯并咪唑氨基甲酸酯，以及所述组合在动物治疗寄生虫感染中的用途。

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