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31. 发明公开

EP1709067A2 LAWSONIA INTRACELLULARIS SUBUNIT VACCINES 有权
标题翻译：恶性疟原虫亚单位疫苗
公开(公告)号：EP1709067A2
公开(公告)日：2006-10-11
申请号：EP05701094.4
申请日：2005-01-18
申请人： Intervet International BV
发明人： VERMEIJ, Paul
IPC分类号： C07K14/195 , C12N15/31 , C07K16/12 , C12Q1/68 , A61K39/02
CPC分类号： C07K14/195 , A61K39/00
摘要： The present invention relates i.a. to nucleic acids encoding novel Lawsonia intracellularis proteins. It furthermore relates to DNA fragments, recombinant DNA molecules and live recombinant carriers comprising these sequences. Also it relates to host cells comprising such nucleic acids, DNA fragments, recombinant DNA molecules and live recombinant carriers. Moreover, the invention relates to proteins encoded by these nucleotide sequences and to their use for the manufacturing of vaccines. The invention also relates to vaccines for combating Lawsonia intracellularis infections and methods for the preparation thereof. Finally the invention relates to diagnostic tests for the detection of Lawsonia intracellularis antigens and of antibodies against Lawsonia intracellularis.
摘要翻译：本发明涉及i.a. 涉及编码新型胞内劳森菌蛋白质的核酸。它还涉及DNA片段，重组DNA分子和包含这些序列的活重组载体。还涉及包含这样的核酸，DNA片段，重组DNA分子和活重组载体的宿主细胞。此外，本发明涉及由这些核苷酸序列编码的蛋白质及其用于制造疫苗的用途。本发明还涉及用于防治胞内劳森菌感染的疫苗及其制备方法。最后，本发明涉及用于检测胞内劳森氏菌抗原和针对胞内劳森氏菌的抗体的诊断测试。

32. 发明公开

EP1699483A1 COMBINATION VACCINE FOR POULTRY 有权
标题翻译：联合疫苗家禽
公开(公告)号：EP1699483A1
公开(公告)日：2006-09-13
申请号：EP04804958.9
申请日：2004-12-21
申请人： Intervet International BV
发明人： JACOBS, Antonius Arnoldus Christiaan , VAN EMPEL, Paul Cornelius Maria , NUIJTEN, Petrus Johannes Maria
IPC分类号： A61K39/116 , A61K39/295
CPC分类号： A61K39/02 , A61K39/0216 , A61K39/12 , A61K2039/522 , A61K2039/5254 , A61K2039/544 , A61K2039/552 , A61K2039/70 , C12N2760/18134 , C12N2770/20034
摘要： The present invention relates to a combination vaccine for the protection of poultry against Ornithobacterium rhinotracheale, to the use of a live over-attenuated Ornithobacterium rhinotracheale strain and a live attenuated poultry virus for the manufacturing of such a combination vaccine, to methods for the preparation of said combination vaccine and to vaccination kits for the immunization of poultry against Ornithobacterium rhinotracheale.

33. 发明公开

EP1694698A1 LAWSONIA INTRACELLULARIS 26 KD SUBUNIT VACCINE 审中-公开
标题翻译： WITH THE 26-KD亚基细胞内劳索尼亚菌疫苗
公开(公告)号：EP1694698A1
公开(公告)日：2006-08-30
申请号：EP04820075.2
申请日：2004-12-08
申请人： Intervet International BV
发明人： VERMEIJ, Paul
IPC分类号： C07K14/28 , C12N15/31 , G01N33/53 , A61K39/106
CPC分类号： C07K14/195 , A61K39/00
摘要： The present invention relates i.a. to nucleic acids encoding novel Lawsonia intracellularis proteins. It furthermore relates to DNA fragments, recombinant DNA molecules and live recombinant carriers comprising these sequences. Also it relates to host cells comprising such nucleic acids, DNA fragments, recombinant DNA molecules and live recombinant carriers. Moreover, the invention relates to proteins encoded by these nucleotide sequences and to their use for the manufacturing of vaccines. The invention also relates to vaccines for combating Lawsonia intracellularis infections and methods for the preparation thereof. Finally the invention relates to diagnostic tests for the detection of Lawsonia intracellularis antigens and of antibodies against Lawsonia intracellularis.

34. 发明公开

EP1541168A1 Method of regulating animal reproduction 有权转让
标题翻译： Methode zur Synchronisierung des Eisprungs bei Rindern
公开(公告)号：EP1541168A1
公开(公告)日：2005-06-15
申请号：EP04106364.5
申请日：2004-12-07
申请人： Akzo Nobel N.V.
发明人： Driancourt, Marc-Antoine
IPC分类号： A61K38/24 , A61P15/08
CPC分类号： A61K31/5575 , A61K31/57 , A61K38/00 , A61K38/24 , A61K2300/00
摘要： A method for synchronising ovulation in cattle by sequential administration of GnRH together with a progesterone delivery device, prostaglandin F 2α , and PMSG together with the removal of the progesterone delivery device, followed by fixed time artificial insemination.
摘要翻译：一种用于通过连同GnRH与孕激素递送装置，前列腺素F2α和PMSG连同施用以及去除孕酮递送装置，随后进行固定时间人工授精来同步排卵的方法。

35. 发明授权

EP1928820B1 A PROCESS FOR PREPARING ESTER OXAZOLIDINE COMPOUNDS AND THEIR CONVERSION TO FLORFENICOL 无效转让
标题翻译：用于生产酯化合物恶唑和转换在同氟苯尼考
公开(公告)号：EP1928820B1
公开(公告)日：2014-01-29
申请号：EP06824884.8
申请日：2006-08-31
申请人： Intervet International BV
发明人： TOWSON, James, C.
IPC分类号： C07C315/00
CPC分类号： C07C315/04 , C07D263/04 , C07D263/06 , C07C317/32
摘要： A process for preparing ester oxazolidine compounds is disclosed. These compounds are useful intermediates in processes for making Florfenicol.

36. 发明公开

EP2433646A1 Vaccine against Ehrlichia canis and associated methods 审中-公开
标题翻译： Impfstoff gegen Ehrlichia canis undzugehörigeVerfahren
公开(公告)号：EP2433646A1
公开(公告)日：2012-03-28
申请号：EP10178177.1
申请日：2010-09-22
申请人： Intervet International BV , The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
发明人： The designation of the inventor has not yet been filed
IPC分类号： A61K39/02
CPC分类号： A61K39/0233 , A61K2039/521 , A61K2039/552 , A61K2039/55566 , C07K16/1246
摘要： Vaccine and/or immunogenic compositions that comprise an effective immunizing amount of an antigen from E. canis are described. In addition, methods of immunizing a subject against E. canis by providing the vaccine and/or immunogenic compositions are also disclosed.
摘要翻译：描述了包含来自大肠杆菌的有效免疫量的抗原的疫苗和/或免疫原性组合物。此外，还公开了通过提供疫苗和/或免疫原性组合物免疫受试者对犬蛔虫的方法。

37. 发明公开

EP2381949A1 IMMUNOSTIMULATING SAPONINS FOR USE IN IN SITU TUMOR-DESTRUCTION THERAPY 有权
标题翻译：免疫刺激皂苷用于原位肿瘤破坏THERAPY
公开(公告)号：EP2381949A1
公开(公告)日：2011-11-02
申请号：EP09798927.1
申请日：2009-12-22
申请人： Intervet International BV , Stichting Katholieke Universiteit, Universitair Medisch Centrum St Radboud
发明人： SCHRIER, Carla Christina , NIERKENS, Stefan , ADEMA, Gosse , BROK den, Martijn , RUERS, Theodoor Jaques Marie
IPC分类号： A61K31/704 , A61K31/7088 , A61K39/39 , A61P35/00
CPC分类号： A61K39/0011 , A61K31/704 , A61K39/39 , A61K2039/5152 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577
摘要： The present invention relates to pharmaceutical compositions for use in
in situ tumor- destruction therapy comprising the steps of tumor destruction and administration of an immunostimulating amount of an immunopotentiator, and to the use of such pharmaceutical compositions in the manufacture of a medicament.

38. 发明公开

EP2355844A2 EIMERIA VACCINE FOR TURKEYS 审中-公开
标题翻译：土耳其 - 艾美耳球虫疫苗
公开(公告)号：EP2355844A2
公开(公告)日：2011-08-17
申请号：EP09752084.5
申请日：2009-11-11
申请人： Intervet International BV
发明人： FITZ-COY, Steve, Hewart , WITHANAGE, Gamini, Saman Kumara , MCGOWAN, Alexandria, Louise , COOK, Stephanie, M.
IPC分类号： A61K39/012 , C12Q1/04 , C12Q1/68
CPC分类号： C12Q1/6893 , A61K39/012 , A61K2039/552 , C07K14/455 , Y02A50/489
摘要： The present invention discloses a vaccine that provides protection to turkeys from coccidiosis, and methods of making and using the vaccine alone, or in combinations with other protective agents. In addition, the present invention discloses PCR primer sets that are useful in identifying the species of Eimeria in a biological sample.

39. 发明授权

EP1515763B1 NEEDLE-LESS INJECTOR 有权转让
标题翻译：无针注射
公开(公告)号：EP1515763B1
公开(公告)日：2011-08-17
申请号：EP03738001.1
申请日：2003-06-05
申请人： Intervet International BV
发明人： MEIJERING, Antonie, Hendrikus , JACOBS, Andreas, Johannes, Maria
IPC分类号： A61M5/30 , A61M5/20
CPC分类号： A61M5/30 , A61M5/204
摘要： The invention relates to a needle-less injector having a housing comprising: a chamber defined within said injector for containing liquid to be injected; a liquid outlet for said chamber positioned at the front end of the injector; a dispensing member in contact with the liquid in said chamber and movable in a first direction to reduce the volume of said chamber to cause the liquid contained therein to be expelled through said liquid outlet; drive means for actuating said injector, wherein the dispensing member is a spring-loaded piston movable in said chamber by the spring in the first direction to a preferred position at which the volume of said chamber is at a minimum and the spring is nearly unloaded, and which piston is movable in a second direction opposite to the first direction by actuation of the drive means whilst counteracting a force from the spring and moving the piston to a non-preferred position at which the spring is loaded.

40. 发明公开

EP2314171A1 Compositions and process for delivering an additive 有权
标题翻译： Zusammensetzungen und Verabreichungsprozessfüreinen Zusatzstoff
公开(公告)号：EP2314171A1
公开(公告)日：2011-04-27
申请号：EP10183638.5
申请日：2003-08-13
申请人： Intervet International BV
发明人： Huron, Sebastien Claude Jacques , Cady, Susan , Pieloch, Mark
IPC分类号： A23G3/00 , A23G3/02 , A23G3/36
摘要： Embodiments of the present invention generally relate to compositions and processes for the delivery of an additive to an organism in a form suitable for consumption, and in particular, in the form of a soft chew.
摘要翻译：本发明的实施方案通常涉及以适合于消费的形式，特别是软咀嚼形式将添加剂递送至生物体的组合物和方法。

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