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31. 发明公开

EP1254242A1 17 HUMAN SECRETED PROTEINS 审中-公开
标题翻译： 17个人文分泌蛋白
公开(公告)号：EP1254242A1
公开(公告)日：2002-11-06
申请号：EP01910339.9
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES, INC.
发明人： ROSEN, Craig, A. , KOMATSOULIS, George, A. , BAKER, Kevin, P. , BIRSE, Charles, E. , SOPPET, Daniel, R. , OLSEN, Henrik, S. , MOORE, Paul, A. , WEI, Ping , EBNER, Reinhard , DUAN, D., Roxanne , SHI, Yanggu , CHOI, Gil, H. , FISCELLA, Michele , NI, Jian , RUBEN, Steven, M. , BARASH, Steven, C.
IPC分类号： C12N15/60 , C12N9/88 , A61K31/00
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/6424 , C12N2799/026 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

32. 发明公开

EP1254150A2 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：EP1254150A2
公开(公告)日：2002-11-06
申请号：EP01914332.0
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES, INC.
发明人： ROSEN, Craig, A. , BARASH, Steven, C. , RUBEN, Steven, M. , BRISE, Charles, E.
IPC分类号： C07H21/02 , C07H21/04 , C07K5/00 , C12Q1/68 , C12P21/06 , C12N1/20 , C12N15/63 , C12N5/00
CPC分类号： C07H21/02 , C07H21/04 , C07K5/00 , C07K14/00 , C07K14/47 , C07K16/18 , C12N1/00 , C12N1/20 , C12N5/00 , C12N15/63 , C12P21/06 , C12Q1/68
摘要： The present invention relates to novel ovarian related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as 'ovarian antigens', and the use of such ovarian antigens for detecting disorders of the ovaries and/or breast, particularly the presence of ovarian and/or breast cancer and ovarian and/or breast cancer metastases. More specifically, isolated ovarian associated nucleic acid molecules are provided encoding novel ovarian associated polypeptides. Novel ovarian polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human ovarian associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the ovaries and/or breast, including ovarian and/or breast cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新的卵巢相关多核苷酸和由本文统称为“卵巢抗原”的这些多核苷酸编码的多肽，以及这些卵巢抗原用于检测卵巢和/或乳房病症，特别是卵巢和/或乳房的存在，或乳腺癌和卵巢和/或乳腺癌转移。更具体地说，提供了编码新卵巢相关多肽的分离的卵巢相关核酸分子。提供了新的卵巢多肽和结合这些多肽的抗体。还提供了载体，宿主细胞以及用于生产人卵巢相关多核苷酸和/或多肽的重组和合成方法。本发明进一步涉及用于诊断，治疗，预防和/或预测与卵巢和/或乳房有关的病症（包括卵巢癌和/或乳腺癌）的诊断和治疗方法，以及用于治疗这些病症的治疗方法。本发明进一步涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制本发明多肽的产生和功能的方法和/或组合物。

33. 发明公开

EP1252326A1 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
公开(公告)号：EP1252326A1
公开(公告)日：2002-10-30
申请号：EP01908614.9
申请日：2001-01-17
申请人： Human Genome Sciences, Inc.
发明人： ROSEN, Craig, A. , BARASH, Steven, C. , RUBEN, Steven, M.
IPC分类号： C12P21/06 , C12P15/00 , C07K1/00 , C07H21/02 , C07H21/04
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells,and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

34. 发明公开

EP1252302A2 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译： NUCLEIC，蛋白质和抗体
公开(公告)号：EP1252302A2
公开(公告)日：2002-10-30
申请号：EP01910336.5
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES, INC.
发明人： ROSEN, Craig, A. , BARASH, Steven, C. , RUBEN, Steven, M.
IPC分类号： C12N15/00 , C07K1/00
CPC分类号： Y02A50/475
摘要： The present invention relates to novel ovarian and/or breast related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as 'ovarian and/or breast antigens', and the use of such ovarian and/or breast antigens for detecting disorders of the ovaries and/or breast, particularly the presence of ovarian and/or breast cancer and ovarian and/or breast cancer metastases. More specifically, isolated ovarian and/or breast associated nucleic acid molecules are provided encoding novel ovarian and/or breast associated polypeptides. Novel ovarian and/or breast polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human ovarian and/or breast associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the ovaries and/or breast, including ovarian and/or breast cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.

35. 发明公开

EP1252289A2 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译： NUCLEIC，蛋白质A及抗体
公开(公告)号：EP1252289A2
公开(公告)日：2002-10-30
申请号：EP01910326.6
申请日：2001-01-17
申请人： Human Genome Sciences, Inc.
发明人： ROSEN, Craig, A. , BARASH, Steven, C. , RUBEN, Steven, M.
IPC分类号： C12N1/00
CPC分类号： Y02A50/475
摘要： The present invention relates to novel colon related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as 'colon antigens', and the use of such colon antigens for detecting disorders of the colon, particularly the presence of colon cancer and colon cancer metastases. More specifically, isolated colon associated nucleic acid molecules are provided encoding novel colon associated polypeptides. Novel colon polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human colon associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the colon, including colon cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.

36. 发明公开

EP0981625A2 $i(ENTEROCOCCUS FAECALIS) POLYNUCLEOTIDES AND POLYPEPTIDES 失效
标题翻译：多核苷酸和粪肠球菌SEQUENCE
公开(公告)号：EP0981625A2
公开(公告)日：2000-03-01
申请号：EP98920173.6
申请日：1998-05-04
申请人： Human Genome Sciences, Inc.
发明人： KUNSCH, Charles, A. , DILLON, Patrick, J. , BARASH, Steven, C.
IPC分类号： C12N15/31 , C07K14/315 , C07K16/12 , C12Q1/68
CPC分类号： C07K14/24 , C07K14/315
摘要： The present invention provides polynucleotide sequences of the genome of Enterococcus faecalis, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.

37. 发明公开

EP1294769A1 ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO BLYS 有权转让
标题翻译：免疫特异性结合抗体BLYS
公开(公告)号：EP1294769A1
公开(公告)日：2003-03-26
申请号：EP01946365.2
申请日：2001-06-15
申请人： Human Genome Sciences, Inc. , Cambridge Antibody Technology Group PLC
发明人： RUBEN, Steven, M. , BARASH, Steven, C. , CHOI, Gil, H. , VAUGHAN, Tristan, , HILBERT, David
IPC分类号： C07K16/00
CPC分类号： C07K14/70575 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07K14/52 , C07K16/2875 , C07K2317/21 , C07K2317/622 , G01N33/564
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to BLyS. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant BLyS expression or inappropriate function of BLyS comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to BLyS. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant BLyS expression or inappropriate BLyS function comprising administering to an animal an effective amount of oune or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to BLyS.

38. 发明公开

EP1265582A2 COLON AND COLON CANCER ASSOCIATED POLYNUCLEOTIDES AND POLYPEPTIDES 审中-公开
标题翻译：与结肠癌和迪克相关的多核苷酸和多肽
公开(公告)号：EP1265582A2
公开(公告)日：2002-12-18
申请号：EP00966944.1
申请日：2000-09-28
申请人： HUMAN GENOME SCIENCES, INC.
发明人： RUBEN, Steven, M. , BARASH, Steven, C. , BIRSE, Charles, E. , ROSEN, Craig, A.
IPC分类号： A61K6/00
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： This invention relates to newly identified colon or colon cancer related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "colon cancer antigens", and the use of such colon cancer antigens for targeting specific cell types and/or diagnosing, detecting, preventing and treating disorders of the colon, particularly the presence of colon cancer and colon cancer metastases. This invention relates to colon cancer antigens as well as vectors, host cells, antibodies directed to colon cancer antigens and the recombinant or synthetic methods for producing the same. Also provided are diagnostic methods for diagnosing and treating, preventing and/or prognosing disorders related to the colon, including colon cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of colon cancer antigens of the invention. The present invention further relates to inhibiting the production and function of the polypeptides of the present invention.

39. 发明公开

EP1259642A1 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译： NUCLEIC，蛋白质和抗体
公开(公告)号：EP1259642A1
公开(公告)日：2002-11-27
申请号：EP01910334.0
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES, INC.
发明人： ROSEN, Craig, A. , BARASH, Steven, C. , RUBEN, Steven, M.
IPC分类号： C12Q1/68 , A61K38/00 , C07K1/00
CPC分类号： Y02A50/475
摘要： The present invention relates to novel respiratory system related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as 'respiratory system antigens', and the use of such respiratory system antigens for detecting disorders of the respiratory system, particularly the presence of cancer of respiratory system tissues and cancer metastases. More specifically, isolated respiratory system associated nucleic acid molecules are provided encoding novel respiratory system associated polypeptides. Novel respiratory system polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human respiratory system associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the respiratory system, including cancer of respiratory system tissues, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.

40. 发明公开

EP1259528A1 NUCLEIC ACIDS, PROTEINS AND ANTIBODIES 审中-公开
标题翻译： NUCLEIC，蛋白质和抗体
公开(公告)号：EP1259528A1
公开(公告)日：2002-11-27
申请号：EP01910333.2
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES, INC.
发明人： ROSEN, Craig, A. , BARASH, Steven, C. , RUBEN, Steven, M.
IPC分类号： C07H21/04 , C07H21/02 , C07K5/00 , C07K14/00 , C12Q1/68 , C12N1/21 , C12N15/63 , C12N15/85 , C12N15/86
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

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