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31. 发明公开

EP3870275A1 NEUROSTIMULATION ARTEFACT MINIMISATION 审中-实审
公开(公告)号：EP3870275A1
公开(公告)日：2021-09-01
申请号：EP19877459.8
申请日：2019-10-23
申请人： Saluda Medical Pty Ltd
发明人： SINGLE, Peter Scott Vallack , KARANTONIS, Dean , SCOTT, Jonathan Brereton
IPC分类号： A61N1/36 , A61N1/08 , A61B5/0484

32. 发明公开

EP3784338A1 NEUROSTIMULATION OF MIXED NERVES 有权转让
公开(公告)号：EP3784338A1
公开(公告)日：2021-03-03
申请号：EP19793420.1
申请日：2019-04-29
申请人： Saluda Medical Pty Ltd
发明人： PARKER, John Louis , GMEL, Gerrit Eduard
IPC分类号： A61N1/36 , A61N1/05 , A61B5/04

33. 发明公开

EP3357533A1 APPARATUS FOR CONTROLLING A NEURAL STIMULUS 有权
公开(公告)号：EP3357533A1
公开(公告)日：2018-08-08
申请号：EP18159680.0
申请日：2012-05-11
申请人： Saluda Medical Pty Ltd
发明人： PARKER, John Louis , LAIRD, James Hamilton , KARANTONIS, Dean Michael , OBRADOVIC, Milan , GORMAN, Robert Bruce
IPC分类号： A61N1/36 , A61B5/04 , A61B5/00 , A61N1/05
CPC分类号： A61N1/36071 , A61B5/04001 , A61B5/4041 , A61B5/407 , A61B5/4821 , A61B5/4824 , A61B5/4836 , A61N1/0551 , A61N1/36139 , A61N1/3615
摘要： An implantable device applies and controls a neural stimulus. The device has a plurality of electrodes, and a stimulus source for providing a stimulus to be delivered from the electrodes to a neural pathway in order to evoke an action potential on the neural pathway, such as the spinal cord. A control unit controls application of a neural stimulus as defined by a set of parameter values and measures via measurement circuitry an evoked neural compound action potential response. The control unit determines from the measured evoked response a feedback variable, and compares it to a therapy map (2302). The therapy map (2302) defines a therapeutic relationship of control variable to feedback variable. One or more of the stimulus parameter values are altered to effect the required change in the control variable. This process is performed iteratively to improve alignment of the feedback variable with the therapy map (2302) over time.

34. 发明公开

EP3229893A4 METHOD AND DEVICE FOR NEURAL IMPLANT COMMUNICATION 有权
公开(公告)号：EP3229893A4
公开(公告)日：2018-07-11
申请号：EP16739680
申请日：2016-01-19
申请人： SALUDA MEDICAL PTY LTD
发明人： PARKER JOHN LOUIS , STAPLES MARK
IPC分类号： A61N1/36 , A61B5/00 , A61B5/04 , A61N1/372 , G06F3/01
CPC分类号： A61N1/37217 , A61B5/0028 , A61B5/0031 , A61B5/04001 , A61B5/686 , A61B5/7475 , A61B2560/0487 , A61N1/37211 , G06F3/015
摘要： Communications along a neural pathway are provided. The neural pathway is stimulated at a first location, in order to evoke neural responses which propagate along the neural pathway, the neural responses being modulated with data. At a second location spaced apart from the first location along the neural pathway the evoked neural responses are sensed. The sensed neural responses are then demodulated to retrieve the data. The stimulation could comprise peripheral sensory stimulation, and the second location could be at an implanted electrode array.

35. 发明公开

EP3139999A4 IMPROVED NEURAL MEASUREMENT 有权
公开(公告)号：EP3139999A4
公开(公告)日：2018-02-28
申请号：EP15789515
申请日：2015-05-05
申请人： SALUDA MEDICAL PTY LTD
发明人： SINGLE PETER SCOTT VALLACK
IPC分类号： A61N1/36 , A61B5/04 , A61N1/05 , A61N1/372
CPC分类号： A61B5/04001 , A61B5/04004 , A61N1/0529 , A61N1/0541 , A61N1/0551 , A61N1/36128 , A61N1/36135 , A61N1/37252
摘要： where ZC is the sense electrode(s) constant phase element impedance, Vs1−Vs2 is the differential voltage arising on the sense electrode tissue interface, and VE is the neural response voltage seen at the sense electrode.

36. 发明公开

EP3171929A4 NEURAL STIMULATION DOSING 有权
公开(公告)号：EP3171929A4
公开(公告)日：2018-02-07
申请号：EP15825098
申请日：2015-07-27
申请人： SALUDA MEDICAL PTY LTD
发明人： PARKER JOHN LOUIS
IPC分类号： A61N1/05 , A61B5/04 , A61N1/06 , A61N1/34 , A61N1/36 , A61N1/372
CPC分类号： A61N1/3605 , A61N1/05 , A61N1/0551 , A61N1/06 , A61N1/36 , A61N1/36071 , A61N1/36146 , A61N1/36171 , A61N1/36175 , A61N1/36178 , A61N1/36185 , A61N1/37247 , A61N2001/34
摘要： Applying therapeutic neural stimuli involves monitoring for at least one of sensory input and movement of a user. In response to detection of sensory input or user movement, an increased stimulus dosage is delivered within a period of time corresponding to a duration of time for which the detected sensory input or user movement gives rise to masking, the increased stimulus dosage being configured to give rise to increased neural recruitment.

37. 发明公开

EP3215216A1 METHOD AND DEVICE FOR DETECTING A NEURAL RESPONSE IN NEURAL MEASUREMENTS 审中-实审
标题翻译：用于检测神经测量中的神经反应的方法和装置
公开(公告)号：EP3215216A1
公开(公告)日：2017-09-13
申请号：EP15861444.6
申请日：2015-11-17
申请人： Saluda Medical Pty Ltd
发明人： PARKER, John Louis , OBRADOVIC, Milan
IPC分类号： A61N1/05 , A61N1/36 , A61B5/0488
CPC分类号： A61B5/04001 , A61B5/407 , A61B5/4836 , A61B5/7203 , A61B5/7214 , A61B5/7282 , A61N1/36135
摘要： A method is provided for processing a neural measurement obtained in the presence of noise, in order to detect whether a locally evoked neural response is present in the neural measurement. A first neural measurement is obtained from a first sense electrode. A second neural measurement is contemporaneously obtained from a second sense electrode spaced apart from the first electrode along a neural pathway of the neural response. A neural response decay is determined, being a measure of the decay in the neural response from the first sense electrode to the second sense electrode. A ratio of the neural response decay to an amplitude normalising term is calculated. From the ratio it is determined whether a locally evoked neural response is present in the neural measurement.
摘要翻译：提供了一种用于处理在噪声存在下获得的神经测量的方法，以便检测神经测量中是否存在局部诱发的神经反应。第一神经测量从第一感测电极获得。第二神经测量同时从与神经反应的神经通路间隔开的第二感测电极获得。确定神经反应衰减，作为从第一感测电极到第二感测电极的神经应答衰减的量度。计算神经反应衰减与振幅归一化项的比率。根据比率确定神经测量中是否存在局部诱发的神经反应。

38. 发明公开

EP3122247A1 ASSESSING NEURAL STATE FROM ACTION POTENTIALS 审中-实审
标题翻译：中华帝国大学
公开(公告)号：EP3122247A1
公开(公告)日：2017-02-01
申请号：EP15768956.3
申请日：2015-03-27
申请人： Saluda Medical Pty Ltd
发明人： PARKER, John Louis
IPC分类号： A61B5/0476 , A61B5/04
CPC分类号： A61B5/4076 , A61B5/04001 , A61B5/0478 , A61B5/4041 , A61B5/407 , A61B5/4824 , A61B5/4836 , A61N1/36071 , A61N1/36135 , A61N1/36185
摘要： The neural health or state of a subject is assessed. A recording is obtained of a compound action potential arising in neural tissue of the subject. The recording is processed to determine whether a profile of the recorded compound action potential is anomalous, such as by exhibiting doublets, peak broadening or deformation, or other anomaly. An indication is output regarding the neural state of the subject based on determined anomalies in the recorded compound action potential.
摘要翻译：评估受试者的神经健康或状态。获得在受试者的神经组织中产生的复合动作电位的记录。处理记录以确定记录的化合物动作电位的轮廓是否是异常的，例如通过显示双峰，峰值变宽或变形或其他异常。基于记录的化合物动作电位中确定的异常，输出关于对象的神经状态的指示。

39. 发明公开

EP2908904A4 METHOD AND SYSTEM FOR CONTROLLING ELECTRICAL CONDITIONS OF TISSUE 有权
标题翻译：方法和系统，用于控制电力和组织的条件
公开(公告)号：EP2908904A4
公开(公告)日：2016-07-20
申请号：EP13852669
申请日：2013-11-06
申请人： SALUDA MEDICAL PTY LTD
发明人： SINGLE PETER SCOTT VALLACK , LAIRD JAMES HAMILTON
IPC分类号： A61N1/36 , A61B5/04
CPC分类号： A61B5/04001 , A61B5/04004 , A61B5/0428 , A61B5/4848 , A61B5/686 , A61B5/7217 , A61N1/36132
摘要： An implantable device for controlling electrical conditions of body tissue. A feedback sense electrode and a compensation electrode are positioned proximal to the tissue to make electrical contact with the tissue. A feedback amplifier is referenced to ground, and takes as an input a feedback signal from the feedback sense electrode. The output of the feedback amplifier is connected to the compensation electrode. The feedback amplifier thus drives the neural tissue via the compensation electrode in a feedback arrangement which seeks to drive the feedback signal to ground, or other desired electrical value.

40. 发明公开

EP2707095A4 METHOD AND APPARATUS FOR APPLICATION OF A NEURAL STIMULUS - I 有权
标题翻译： VERFAHREN UND VORRICHTUNG ZUR ANWENDUNG EINES NEURONALEN STIMULUS - I
公开(公告)号：EP2707095A4
公开(公告)日：2014-11-26
申请号：EP12785619
申请日：2012-05-11
申请人： SALUDA MEDICAL PTY LTD
发明人： PARKER JOHN LOUIS , LAIRD JAMES HAMILTON
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/36071 , A61N1/36175
摘要： A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fiber population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fiber population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronized or desynchronized to give directional control over responses evoked.
摘要翻译：施加具有植入电极阵列的神经刺激的方法包括施加构造成产生治疗效果同时抑制心理物理副作用的刺激序列。刺激序列被配置为使得第一刺激物招募纤维群体的一部分，并且第二刺激在第一刺激之后的不应期内递送，并且第二刺激被配置为招募纤维群体的另外部分。使用电极阵列和刺激的合适的相对定时，诱发反应的上升或下降的波浪可以被选择性地同步或去同步以给出诱发的响应的方向控制。

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