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1. 发明公开

EP2707087A4 METHOD AND APPARATUS FOR CONTROLLING A NEURAL STIMULUS - E 有权
标题翻译：用于控制神经刺激的方法和设备 - E
公开(公告)号：EP2707087A4
公开(公告)日：2014-10-29
申请号：EP12785483
申请日：2012-05-11
申请人： SALUDA MEDICAL PTY LTD
发明人： PARKER JOHN LOUIS , LAIRD JAMES HAMILTON , KARANTONIS DEAN MICHAEL , OBRADOVIC MILAN , GORMAN ROBERT BRUCE
IPC分类号： A61N1/05 , A61B5/04
CPC分类号： A61N1/36071 , A61B5/04001 , A61B5/4041 , A61B5/407 , A61B5/4821 , A61B5/4824 , A61B5/4836 , A61N1/0551 , A61N1/36139 , A61N1/3615
摘要： An implantable device applies and controls a neural stimulus. The device has a plurality of electrodes, and a stimulus source for providing a stimulus to be delivered from the electrodes to a neural pathway in order to evoke an action potential on the neural pathway, such as the spinal cord. A control unit controls application of a neural stimulus as defined by a set of parameter values and measures via measurement circuitry an evoked neural compound action potential response. The control unit determines from the measured evoked response a feedback variable, and compares it to a therapy map. The therapy map defines a therapeutic relationship of control variable to feedback variable. One or more of the stimulus parameter values are altered to effect the required change in the control variable. This process is performed iteratively to improve alignment of the feedback variable with the therapy map over time.
摘要翻译：可植入装置应用和控制神经刺激。该装置具有多个电极和用于提供从电极传递到神经通路的刺激的刺激源，以便引起诸如脊髓的神经通路上的动作电位。控制单元控制由一组参数值定义的神经刺激的应用，并通过测量电路测量诱发的神经复合动作电位响应。控制单元根据测量的诱发响应确定反馈变量，并将其与治疗图进行比较。治疗图定义了控制变量与反馈变量的治疗关系。刺激参数值中的一个或多个被改变以实现控制变量中所需的改变。迭代地执行该过程以改善反馈变量与治疗映射随时间的对准。

2. 发明公开

EP2908904A4 METHOD AND SYSTEM FOR CONTROLLING ELECTRICAL CONDITIONS OF TISSUE 有权
标题翻译：方法和系统，用于控制电力和组织的条件
公开(公告)号：EP2908904A4
公开(公告)日：2016-07-20
申请号：EP13852669
申请日：2013-11-06
申请人： SALUDA MEDICAL PTY LTD
发明人： SINGLE PETER SCOTT VALLACK , LAIRD JAMES HAMILTON
IPC分类号： A61N1/36 , A61B5/04
CPC分类号： A61B5/04001 , A61B5/04004 , A61B5/0428 , A61B5/4848 , A61B5/686 , A61B5/7217 , A61N1/36132
摘要： An implantable device for controlling electrical conditions of body tissue. A feedback sense electrode and a compensation electrode are positioned proximal to the tissue to make electrical contact with the tissue. A feedback amplifier is referenced to ground, and takes as an input a feedback signal from the feedback sense electrode. The output of the feedback amplifier is connected to the compensation electrode. The feedback amplifier thus drives the neural tissue via the compensation electrode in a feedback arrangement which seeks to drive the feedback signal to ground, or other desired electrical value.

3. 发明公开

EP2707095A4 METHOD AND APPARATUS FOR APPLICATION OF A NEURAL STIMULUS - I 有权
标题翻译： VERFAHREN UND VORRICHTUNG ZUR ANWENDUNG EINES NEURONALEN STIMULUS - I
公开(公告)号：EP2707095A4
公开(公告)日：2014-11-26
申请号：EP12785619
申请日：2012-05-11
申请人： SALUDA MEDICAL PTY LTD
发明人： PARKER JOHN LOUIS , LAIRD JAMES HAMILTON
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/36071 , A61N1/36175
摘要： A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fiber population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fiber population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronized or desynchronized to give directional control over responses evoked.
摘要翻译：施加具有植入电极阵列的神经刺激的方法包括施加构造成产生治疗效果同时抑制心理物理副作用的刺激序列。刺激序列被配置为使得第一刺激物招募纤维群体的一部分，并且第二刺激在第一刺激之后的不应期内递送，并且第二刺激被配置为招募纤维群体的另外部分。使用电极阵列和刺激的合适的相对定时，诱发反应的上升或下降的波浪可以被选择性地同步或去同步以给出诱发的响应的方向控制。

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